LOCUS       NM_001106921            2742 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus protein kinase AMP-activated non-catalytic
            subunit gamma 3 (Prkag3), mRNA.
ACCESSION   NM_001106921 XM_001057174 XM_237293
VERSION     NM_001106921.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2742)
  AUTHORS   Yao,C., Shi,X., Zhang,Z., Zhou,S., Qian,T., Wang,Y., Ding,F., Gu,X.
            and Yu,B.
  TITLE     Hypoxia-Induced Upregulation of miR-132 Promotes Schwann Cell
            Migration After Sciatic Nerve Injury by Targeting PRKAG3
  JOURNAL   Mol Neurobiol 53 (8), 5129-5139 (2016)
   PUBMED   26399639
  REMARK    GeneRIF: miR-132 downregulated PRKAG3 through binding to its
            3'-UTR, and PRKAG3 knockdown compromised the reducing effect of
            miR-132 inhibition on Schwann cell migration under normal or
            hypoxia condition.
REFERENCE   2  (bases 1 to 2742)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 2742)
  AUTHORS   Barnes,B.R., Glund,S., Long,Y.C., Hjalm,G., Andersson,L. and
            Zierath,J.R.
  TITLE     5'-AMP-activated protein kinase regulates skeletal muscle glycogen
            content and ergogenics
  JOURNAL   FASEB J 19 (7), 773-779 (2005)
   PUBMED   15857891
REFERENCE   4  (bases 1 to 2742)
  AUTHORS   Hardie,D.G.
  TITLE     The AMP-activated protein kinase pathway--new players upstream and
            downstream
  JOURNAL   J Cell Sci 117 (Pt 23), 5479-5487 (2004)
   PUBMED   15509864
  REMARK    Review article
REFERENCE   5  (bases 1 to 2742)
  AUTHORS   Mahlapuu,M., Johansson,C., Lindgren,K., Hjalm,G., Barnes,B.R.,
            Krook,A., Zierath,J.R., Andersson,L. and Marklund,S.
  TITLE     Expression profiling of the gamma-subunit isoforms of AMP-activated
            protein kinase suggests a major role for gamma3 in white skeletal
            muscle
  JOURNAL   Am J Physiol Endocrinol Metab 286 (2), E194-E200 (2004)
   PUBMED   14559719
  REMARK    GeneRIF: the observation that the AMPKgamma3 isoform is expressed
            primarily in white skeletal muscle, in which it is the predominant
            gamma-isoform, strongly suggests that gamma3 has a key role in this
            tissue.
REFERENCE   6  (bases 1 to 2742)
  AUTHORS   Hardie,D.G., Scott,J.W., Pan,D.A. and Hudson,E.R.
  TITLE     Management of cellular energy by the AMP-activated protein kinase
            system
  JOURNAL   FEBS Lett 546 (1), 113-120 (2003)
   PUBMED   12829246
  REMARK    Review article
REFERENCE   7  (bases 1 to 2742)
  AUTHORS   Cheung,P.C., Salt,I.P., Davies,S.P., Hardie,D.G. and Carling,D.
  TITLE     Characterization of AMP-activated protein kinase gamma-subunit
            isoforms and their role in AMP binding
  JOURNAL   Biochem J 346 Pt 3 (Pt 3), 659-669 (2000)
   PUBMED   10698692
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474004.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_237293.4, XM_001057174.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate :: PMID: 14559719
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2742
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..2742
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /note="protein kinase AMP-activated non-catalytic subunit
                     gamma 3"
                     /db_xref="GeneID:301518"
                     /db_xref="RGD:1308698"
     exon            1..140
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1589
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /note="AMP-activated protein kinase gamma 3 subunit;
                     protein kinase, AMP-activated, gamma 3 non-catatlytic
                     subunit; protein kinase, AMP-activated, gamma 3
                     non-catalytic subunit"
                     /codon_start=1
                     /product="5'-AMP-activated protein kinase subunit gamma-3"
                     /protein_id="NP_001100391.1"
                     /db_xref="GeneID:301518"
                     /db_xref="RGD:1308698"
                     /translation="MEPELEHTLPGTLTWSHSGGPESQEMDFLEPEENSWPSPTVATS
                     SERTCAIRGVKASRWTRQEAVEEAEPPGLGEGAQSGPAAESTRQKATFPKATPLAQAV
                     PLADAETSTTGWDLFLPDCAASAVGSSTGDLELTIEFPGPEVWDCELKGLEQDRPRPC
                     PSPQAPLLSLSWDDELQKPGAQIYMHFMQEHTCYDAMATSSKLVIFDTTLEIKKAFFA
                     MVANGVRAAPLWDSKKQSFVGMLTITDFILVLHRYYRSPLVQIYEIEEHKIETWRGFS
                     AEIYLQGCFKPLVSISPNDSLFEAVYALIKNRIHRLPVLDPVSGTVLYILTHKRLLKF
                     LHIFGALLPRPSFLCRTIQDLGIGTFRDLAVVLETAPILTALDIFVDRRVSALPVVNE
                     SGQVVGLYSRFDVIHLAAQQTYNHLDMSVGEALRQRTLCLEGVLSCQPHESLGEVIDR
                     IAREQVHRLVLVDETQHLLGVVSLSDILQALVLSPAGIDALSA"
     exon            141..180
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /inference="alignment:Splign:2.1.0"
     exon            181..333
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /inference="alignment:Splign:2.1.0"
     exon            334..740
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /inference="alignment:Splign:2.1.0"
     exon            741..822
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..881
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /inference="alignment:Splign:2.1.0"
     exon            882..927
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /inference="alignment:Splign:2.1.0"
     exon            928..994
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1121
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1287
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1325
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1472
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1713
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..2742
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagagaac ccgatacccc gagggcctgc cgccaaacga ccggcccaga atagtgccac
       61 cccgccgcag cccgtcgcgc atttgctaac agactagagc tggccacatg gagcccgagc
      121 tggagcacac actgcctggg accctgacct ggagccacag tgggggtcca gagagccaag
      181 agatggactt cttagaacca gaagaaaact catggccatc gccaactgtg gccaccagct
      241 cagagagaac ctgtgctata cggggagtca aagcttccag atggacgaga caggaggccg
      301 tagaggaagc agagccacca ggtttgggag aaggtgccca gtctggacca gctgctgagt
      361 ccaccaggca gaaggccaca ttcccaaagg ccacaccctt ggctcaagct gttcccttgg
      421 ctgacgcgga gacctccacc acagggtggg acctgttctt gcccgactgt gcagcctcag
      481 cagtgggctc cagcacaggt gacctggagc tgaccataga gttcccaggc ccagaggtct
      541 gggactgtga gctcaaaggc ctggagcagg acaggcctcg gccttgcccc tccccgcagg
      601 ctccacttct cagcctgagt tgggacgatg agcttcagaa acctggagcc cagatctata
      661 tgcacttcat gcaagagcac acctgttatg atgccatggc caccagctct aaactggtca
      721 tctttgacac cacactggag ataaagaaag ctttctttgc catggtggcc aacggtgtga
      781 gggcagcccc tctgtgggac agcaagaagc agagctttgt gggcatgctc accatcacgg
      841 acttcatcct ggtgctgcac cgttactaca gatctcccct ggtccagatc tatgagattg
      901 aagaacacaa gattgagacc tggaggggtt tttctgcaga gatctaccta caaggttgct
      961 tcaagcctct ggtctccatc tctccaaatg acagtctatt tgaagctgtc tatgccctca
     1021 tcaagaaccg aatccaccgc ctgccggtcc tggaccctgt ctctggcact gtgctctaca
     1081 tactcacaca caagaggcta ctcaagttcc tgcatatatt tggtgccctg ttgccccggc
     1141 cctccttcct ctgccgcact atccaagact tgggcatcgg cacattccga gatttagctg
     1201 tagttctgga aacagctcct atcctgactg cgctggacat ctttgtggac cgacgagtgt
     1261 ctgcactgcc tgtggtcaat gaatctggtc aagtcgtggg cctctactcc cgctttgatg
     1321 tcattcactt ggctgcacaa caaacttaca accacctaga catgagtgtg ggagaagctc
     1381 tgaggcagag gacactgtgt ctggagggcg ttctctcctg ccagcctcac gagagcctag
     1441 gtgaagtcat tgacaggatt gcacgggaac aggtgcatag gctggtgttg gtggatgaga
     1501 cccagcatct tctgggtgtg gtctccctct ctgacatact tcaagcgctg gtactcagcc
     1561 ctgctggcat cgatgccctc agtgcctgag acctgagtcc tcatacccaa gccatcttct
     1621 tcacctgaaa accaatgaaa ggaccttgga acctgaaggg gaattggctt tcatcttctc
     1681 tcaaccccat ctgctggttc tgctctggta caggctctcc agccctccta attgcccctg
     1741 ctataaccta tactcccaga agccttcggg catgcccggt gcaccaggac agtgaaagag
     1801 caatggagtc agacctgcaa gtccctgaac cagagaccct gcaatcagtc ttggatcatc
     1861 tgtgtgccct gtccctactc actcctttcc ctgctcctgg gtcagggttg agctcagtgg
     1921 gacagtgagc ctgcaagcct atggatttag atgggggcct gaaaggcttg gtttctggac
     1981 catgtacact caggttccca gctcctggga gccttggctg ttctttccct gtgggagcta
     2041 ctattgtgtc accaccatcc acaagcctac tcccatggca ctcccaagat gcttgaggcc
     2101 aacactgaac agccctggag tctagagctg tctgctggag tgggtgctcc tgatactgtt
     2161 acatgggctg gggggtgcgg gggaggctcc tcagccatca ccaatgagca ttgttccatc
     2221 cccttggtct cttcccacta gactgagggt cttgtattca gatccttaat gaacaatcaa
     2281 gaaaaaagaa acaaaggagc gagccacagt cttggaggcc ataggcttgc tccactgcta
     2341 cagtcattga ggtgaacgtg tgccaatctc cgtatgtctc ctgaattcaa agacttgaag
     2401 gaaaatctgc aagtggcaaa agctgcaagt ggcctttctt ttgtgcatcg aatgttattc
     2461 tgccaacagt tttttttaat ctttgatttg taacaaaatg ataagaagag tgtttattaa
     2521 ttaattgttc acatagtagg tgaaacccag tctacaaatg ggagtctgca ggaaacatcg
     2581 ctgatcctgt aacactggat gtaatttctg ccatgacacc cattcaccag gtagaaagaa
     2641 attaatctca gtcaattttg ggtctcttca tctgccttta ccttcccctg tgacgacctg
     2701 ggccctcaga tccaggggtc caatgcagag agagtggatt cg
//
