LOCUS       NP_001100391             493 aa            linear   ROD 24-JUN-2024
DEFINITION  5'-AMP-activated protein kinase subunit gamma-3 [Rattus
            norvegicus].
ACCESSION   NP_001100391 XP_001057174 XP_237293
VERSION     NP_001100391.1
DBSOURCE    REFSEQ: accession NM_001106921.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 493)
  AUTHORS   Yao,C., Shi,X., Zhang,Z., Zhou,S., Qian,T., Wang,Y., Ding,F., Gu,X.
            and Yu,B.
  TITLE     Hypoxia-Induced Upregulation of miR-132 Promotes Schwann Cell
            Migration After Sciatic Nerve Injury by Targeting PRKAG3
  JOURNAL   Mol Neurobiol 53 (8), 5129-5139 (2016)
   PUBMED   26399639
  REMARK    GeneRIF: miR-132 downregulated PRKAG3 through binding to its
            3'-UTR, and PRKAG3 knockdown compromised the reducing effect of
            miR-132 inhibition on Schwann cell migration under normal or
            hypoxia condition.
REFERENCE   2  (residues 1 to 493)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (residues 1 to 493)
  AUTHORS   Barnes,B.R., Glund,S., Long,Y.C., Hjalm,G., Andersson,L. and
            Zierath,J.R.
  TITLE     5'-AMP-activated protein kinase regulates skeletal muscle glycogen
            content and ergogenics
  JOURNAL   FASEB J 19 (7), 773-779 (2005)
   PUBMED   15857891
REFERENCE   4  (residues 1 to 493)
  AUTHORS   Hardie,D.G.
  TITLE     The AMP-activated protein kinase pathway--new players upstream and
            downstream
  JOURNAL   J Cell Sci 117 (Pt 23), 5479-5487 (2004)
   PUBMED   15509864
  REMARK    Review article
REFERENCE   5  (residues 1 to 493)
  AUTHORS   Mahlapuu,M., Johansson,C., Lindgren,K., Hjalm,G., Barnes,B.R.,
            Krook,A., Zierath,J.R., Andersson,L. and Marklund,S.
  TITLE     Expression profiling of the gamma-subunit isoforms of AMP-activated
            protein kinase suggests a major role for gamma3 in white skeletal
            muscle
  JOURNAL   Am J Physiol Endocrinol Metab 286 (2), E194-E200 (2004)
   PUBMED   14559719
  REMARK    GeneRIF: the observation that the AMPKgamma3 isoform is expressed
            primarily in white skeletal muscle, in which it is the predominant
            gamma-isoform, strongly suggests that gamma3 has a key role in this
            tissue.
REFERENCE   6  (residues 1 to 493)
  AUTHORS   Hardie,D.G., Scott,J.W., Pan,D.A. and Hudson,E.R.
  TITLE     Management of cellular energy by the AMP-activated protein kinase
            system
  JOURNAL   FEBS Lett 546 (1), 113-120 (2003)
   PUBMED   12829246
  REMARK    Review article
REFERENCE   7  (residues 1 to 493)
  AUTHORS   Cheung,P.C., Salt,I.P., Davies,S.P., Hardie,D.G. and Carling,D.
  TITLE     Characterization of AMP-activated protein kinase gamma-subunit
            isoforms and their role in AMP binding
  JOURNAL   Biochem J 346 Pt 3 (Pt 3), 659-669 (2000)
   PUBMED   10698692
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474004.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_237293.3, XP_001057174.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate :: PMID: 14559719
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     Protein         1..493
                     /product="5'-AMP-activated protein kinase subunit gamma-3"
                     /note="AMP-activated protein kinase gamma 3 subunit;
                     protein kinase, AMP-activated, gamma 3 non-catatlytic
                     subunit; protein kinase, AMP-activated, gamma 3
                     non-catalytic subunit"
                     /calculated_mol_wt=54306
     Region          192..333
                     /region_name="CBS_euAMPK_gamma-like_repeat1"
                     /note="Two tandem repeats of the cystathionine
                     beta-synthase (CBS pair) domains found in AMP-activated
                     protein kinase gamma-like proteins, repeat 1; cd04618"
                     /db_xref="CDD:341388"
     Site            order(200,202..204,226..228,311,325,327,329..330,333)
                     /site_type="other"
                     /note="ligand binding site II [chemical binding]"
                     /db_xref="CDD:341388"
     Region          200..273
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341388"
     Site            order(226,240,244..245,248,289,311..313,329)
                     /site_type="other"
                     /note="ligand binding site I [chemical binding]"
                     /db_xref="CDD:341388"
     Region          289..333
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341388"
     Region          359..482
                     /region_name="CBS_euAMPK_gamma-like_repeat2"
                     /note="CBS pair domain found in 5'-AMP (adenosine
                     monophosphate)-activated protein kinase; cd04641"
                     /db_xref="CDD:341399"
     Site            order(360,362..364,386..388,458,471,473,475..476,479)
                     /site_type="other"
                     /note="ligand binding site II [chemical binding]"
                     /db_xref="CDD:341399"
     Region          360..425
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341399"
     Site            order(386,399,403..404,407,436,458..460,475)
                     /site_type="other"
                     /note="ligand binding site I [chemical binding]"
                     /db_xref="CDD:341399"
     Region          436..479
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341399"
     CDS             1..493
                     /gene="Prkag3"
                     /gene_synonym="Ampkg3"
                     /coded_by="NM_001106921.1:108..1589"
                     /db_xref="GeneID:301518"
                     /db_xref="RGD:1308698"
ORIGIN      
        1 mepelehtlp gtltwshsgg pesqemdfle peenswpspt vatssertca irgvkasrwt
       61 rqeaveeaep pglgegaqsg paaestrqka tfpkatplaq avpladaets ttgwdlflpd
      121 caasavgsst gdleltiefp gpevwdcelk gleqdrprpc pspqapllsl swddelqkpg
      181 aqiymhfmqe htcydamats sklvifdttl eikkaffamv angvraaplw dskkqsfvgm
      241 ltitdfilvl hryyrsplvq iyeieehkie twrgfsaeiy lqgcfkplvs ispndslfea
      301 vyaliknrih rlpvldpvsg tvlyilthkr llkflhifga llprpsflcr tiqdlgigtf
      361 rdlavvleta piltaldifv drrvsalpvv nesgqvvgly srfdvihlaa qqtynhldms
      421 vgealrqrtl clegvlscqp heslgevidr iareqvhrlv lvdetqhllg vvslsdilqa
      481 lvlspagida lsa
//
