LOCUS       NM_001398879            3487 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protein kinase AMP-activated non-catalytic
            subunit gamma 2 (Prkag2), transcript variant 1, mRNA.
ACCESSION   NM_001398879 XM_006235952
VERSION     NM_001398879.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3487)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   2  (bases 1 to 3487)
  AUTHORS   Scott,J.W., Ross,F.A., Liu,J.K. and Hardie,D.G.
  TITLE     Regulation of AMP-activated protein kinase by a pseudosubstrate
            sequence on the gamma subunit
  JOURNAL   EMBO J 26 (3), 806-815 (2007)
   PUBMED   17255938
REFERENCE   3  (bases 1 to 3487)
  AUTHORS   Li,J., Coven,D.L., Miller,E.J., Hu,X., Young,M.E., Carling,D.,
            Sinusas,A.J. and Young,L.H.
  TITLE     Activation of AMPK alpha- and gamma-isoform complexes in the intact
            ischemic rat heart
  JOURNAL   Am J Physiol Heart Circ Physiol 291 (4), H1927-H1934 (2006)
   PUBMED   16648175
  REMARK    GeneRIF: results indicate that ischemia activates catalytic alpha1
            and alpha2 isoforms similarly in gamma1 and gamma2
            isoform-containing AMPK complexes and that gamma1-isoform complexes
            account for most of the AMPK activity in the ischemic heart
REFERENCE   4  (bases 1 to 3487)
  AUTHORS   Laforet,P., Richard,P., Said,M.A., Romero,N.B., Lacene,E.,
            Leroy,J.P., Baussan,C., Hogrel,J.Y., Lavergne,T., Wahbi,K.,
            Hainque,B. and Duboc,D.
  TITLE     A new mutation in PRKAG2 gene causing hypertrophic cardiomyopathy
            with conduction system disease and muscular glycogenosis
  JOURNAL   Neuromuscul Disord 16 (3), 178-182 (2006)
   PUBMED   16487706
REFERENCE   5  (bases 1 to 3487)
  AUTHORS   Ahmad,F., Arad,M., Musi,N., He,H., Wolf,C., Branco,D.,
            Perez-Atayde,A.R., Stapleton,D., Bali,D., Xing,Y., Tian,R.,
            Goodyear,L.J., Berul,C.I., Ingwall,J.S., Seidman,C.E. and
            Seidman,J.G.
  TITLE     Increased alpha2 subunit-associated AMPK activity and PRKAG2
            cardiomyopathy
  JOURNAL   Circulation 112 (20), 3140-3148 (2005)
   PUBMED   16275868
REFERENCE   6  (bases 1 to 3487)
  AUTHORS   Hardie,D.G.
  TITLE     The AMP-activated protein kinase pathway--new players upstream and
            downstream
  JOURNAL   J Cell Sci 117 (Pt 23), 5479-5487 (2004)
   PUBMED   15509864
  REMARK    Review article
REFERENCE   7  (bases 1 to 3487)
  AUTHORS   Hardie,D.G., Scott,J.W., Pan,D.A. and Hudson,E.R.
  TITLE     Management of cellular energy by the AMP-activated protein kinase
            system
  JOURNAL   FEBS Lett 546 (1), 113-120 (2003)
   PUBMED   12829246
  REMARK    Review article
REFERENCE   8  (bases 1 to 3487)
  AUTHORS   Arad,M., Benson,D.W., Perez-Atayde,A.R., McKenna,W.J., Sparks,E.A.,
            Kanter,R.J., McGarry,K., Seidman,J.G. and Seidman,C.E.
  TITLE     Constitutively active AMP kinase mutations cause glycogen storage
            disease mimicking hypertrophic cardiomyopathy
  JOURNAL   J Clin Invest 109 (3), 357-362 (2002)
   PUBMED   11827995
REFERENCE   9  (bases 1 to 3487)
  AUTHORS   Gollob,M.H., Seger,J.J., Gollob,T.N., Tapscott,T., Gonzales,O.,
            Bachinski,L. and Roberts,R.
  TITLE     Novel PRKAG2 mutation responsible for the genetic syndrome of
            ventricular preexcitation and conduction system disease with
            childhood onset and absence of cardiac hypertrophy
  JOURNAL   Circulation 104 (25), 3030-3033 (2001)
   PUBMED   11748095
REFERENCE   10 (bases 1 to 3487)
  AUTHORS   Cheung,P.C., Salt,I.P., Davies,S.P., Hardie,D.G. and Carling,D.
  TITLE     Characterization of AMP-activated protein kinase gamma-subunit
            isoforms and their role in AMP binding
  JOURNAL   Biochem J 346 Pt 3 (Pt 3), 659-669 (2000)
   PUBMED   10698692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 27, 2021 this sequence version replaced XM_006235952.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223364.1, BC079017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-771               JAXUCZ010000004.1  10744695-10745465
            772-843             JAXUCZ010000004.1  10813901-10813972
            844-1123            JAXUCZ010000004.1  10819487-10819766
            1124-1338           JAXUCZ010000004.1  10899550-10899764
            1339-1408           JAXUCZ010000004.1  10939560-10939629
            1409-1512           JAXUCZ010000004.1  10962463-10962566
            1513-1594           JAXUCZ010000004.1  10968263-10968344
            1595-1653           JAXUCZ010000004.1  10970535-10970593
            1654-1699           JAXUCZ010000004.1  10972249-10972294
            1700-1754           JAXUCZ010000004.1  10974180-10974234
            1755-1881           JAXUCZ010000004.1  10975388-10975514
            1882-2047           JAXUCZ010000004.1  10977664-10977829
            2048-2085           JAXUCZ010000004.1  10978030-10978067
            2086-2232           JAXUCZ010000004.1  10979647-10979793
            2233-2326           JAXUCZ010000004.1  10982867-10982960
            2327-3487           JAXUCZ010000004.1  10984779-10985939
FEATURES             Location/Qualifiers
     source          1..3487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..3487
                     /gene="Prkag2"
                     /note="protein kinase AMP-activated non-catalytic subunit
                     gamma 2"
                     /db_xref="GeneID:373545"
                     /db_xref="RGD:727782"
     exon            1..771
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
     CDS             658..2358
                     /gene="Prkag2"
                     /note="isoform 1 is encoded by transcript variant 1; AMPK
                     gamma 2; adenosine monophosphate-activated protein kinase
                     gamma 2-subunit; AMP-activated protein kinase gamma2
                     subunit; 5'-AMP-activated protein kinase subunit gamma-2;
                     protein kinase, AMP-activated, gamma 2 non-catalytic
                     subunit"
                     /codon_start=1
                     /product="5'-AMP-activated protein kinase subunit gamma-2
                     isoform 1"
                     /protein_id="NP_001385808.1"
                     /db_xref="GeneID:373545"
                     /db_xref="RGD:727782"
                     /translation="MGSAAMDTKKKKEVSSPGGSSGKKNPSLKRRSLRVHIPDLSSFA
                     MPLLDGDVENSEKHSSRKVDSPFSSGSPSRGLFSRGPQPRPSSPVSAPVRPKMSPGSP
                     KTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPSTSPGGIRFFSRSRKTSSVS
                     SSPSTPTQVTKQHPFPLESYKQEPERLESRIYASSSPPDTGQRFCLAFQSPVRLPLAS
                     PTHHAPLRTAALAAAPGPAEAGMLEKLEFQEEEDSESGVYMRFMRSHKCYDIVPTSSK
                     LVVFDTTLQVKKAFFALVANGVRAAPLWESKKQSFVGMLTITDFINILHRYYKSPMVQ
                     IYELEEHKIETWRELYLQETFKPLVNISPDASLFDAVYSLIKNKIHRLPVIDPISGNA
                     LYILTHKRILKFLQLFMSDMPKPAFMKQNLDELGIGTYHNIAFIHPNTPIIKALNIFV
                     ERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKC
                     SKLETLETIVDRIVRAEVHRLVVVNEADSIVGIISLSDILQALILTPAGAKQKETETE
                     "
     exon            772..843
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1123
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1338
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1408
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1512
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1594
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1653
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1699
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1754
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1881
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2047
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2085
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2232
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2326
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..3487
                     /gene="Prkag2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacccagc cagccgccgc cacagtttat ccctgcggcc acgcgccagc ccaattgcga
       61 cgagtcttcg cctttgcacc tcctcttccc cctctgccct ccctcttgcc caaagaggag
      121 gccctccggg tcccaggctc cctgccgctt tattgtgcgg cccagggtta tgcatttctc
      181 cactaagtgt ctctggccac tgtttccaac caggcagaga caagggtagg ttgttttcca
      241 aattgctgtt gttaattgca cctgcctggc cgattacctc tgggaatctg tgggaggagc
      301 cgagaggtgg aaaatgttgc ttcgctttgc agcaggagga aaactttatc acccagcacg
      361 agacttctgc cacgcgtaac caaaagcagc actggccgcg acgctgcacc cgatgattct
      421 gtaggagaaa gaggacgctc caacccggca ttccgcggac cgccagcccc tcgggtggag
      481 ccccgcgtgt tacctgcgcc acccgccctc cccgcggaag tccccacgag gtgttttcag
      541 ggtgggagga cagtcataaa aagcgcgtgg ctacagtgta acggcagcag ccctgggggg
      601 cagcgagggg cccgaacccc gggaacaagg caccggaatt aacttctagc taaagttatg
      661 ggaagcgcag ccatggacac caagaagaag aaagaggttt ccagccctgg cgggagcagt
      721 ggcaaaaaga accctagcct gaagaggcgg tcactgcgag tgcacattcc ggacctgagt
      781 tcctttgcca tgcccctcct ggatggagat gtggagaact cagagaagca ttcttctcgg
      841 aaggtggaca gtccctttag ctcaggcagc ccttccagag gactcttctc caggggcccc
      901 cagccccggc cctccagccc tgtgtctgct cctgtgaggc ccaagatgag ccctggctct
      961 cccaaaactg tgttcccgtt ctcctaccag gaatcccctc cacgctctcc acgccggatg
     1021 agcttcagtg ggatcttccg ctcctcatcc aaagagtctt cgcccaactc caacccgtct
     1081 acctctcccg ggggcatcag gttcttctcg cggtccagaa aaacctccag cgtctcctcc
     1141 tctccatcaa cacccaccca agtgaccaag cagcacccat ttcccctgga gtcctacaag
     1201 caggagcctg aacgcctaga aagccgcatc tatgcctcct catccccacc ggacaccggc
     1261 cagcgcttct gcctggcctt ccagagcccg gtccggcttc ctctggcatc tcccacacac
     1321 catgctcctt tgagaaccgc ggcgctggcg gcggccccgg gacccgcgga agccggcatg
     1381 ctggagaagc tggagttcca ggaggaagaa gactcagaga gtggcgttta tatgcgattc
     1441 atgaggtcac acaagtgtta tgacatcgtt ccaaccagct caaagcttgt tgtcttcgac
     1501 actacgttgc aagttaaaaa ggccttcttt gctttggtag ccaacggagt ccgtgcagcg
     1561 ccgctgtggg aaagtaaaaa gcagagcttc gtaggaatgc tcacaattac agatttcata
     1621 aacatactac acagatacta taaatccccc atggtacaga tttatgaatt ggaggaacat
     1681 aagattgaaa cgtggaggga actgtactta caagaaacct tcaagccttt ggtgaatatc
     1741 tctccagatg cgagcctctt cgatgctgta tactcgttga tcaaaaataa aatccacaga
     1801 ttgccagtta ttgaccctat cagtgggaat gcactttata tacttaccca caaaagaatc
     1861 ctcaagttcc tccagctttt tatgtctgac atgccaaagc ccgccttcat gaagcagaac
     1921 ctggatgagc tcggaatagg aacatatcac aatattgcct tcattcaccc gaataccccc
     1981 atcatcaaag ccttgaacat ctttgtggag agacggatat ctgcgctgcc tgtggtggat
     2041 gagtcaggaa aagttgtaga tatttactcc aagtttgatg taattaatct tgctgctgag
     2101 aaaacgtaca ataacctaga catcacggtg acccaggccc tgcagcaccg ctcacagtat
     2161 tttgagggtg tggtcaagtg cagtaagctg gaaacactgg agaccattgt ggacagaata
     2221 gtgagagccg aggtccatcg gttggtggta gtgaatgaag cagatagtat tgtgggtatt
     2281 atctccctgt cagacatcct gcaagccctg atcctcacac cagcaggtgc caaacagaag
     2341 gagacagaga ccgaatgacc accgcaagtg tagacgccct cacaggagaa cttgaacaaa
     2401 gtctcggggt cacgttttgc ctcatgaaca ctggctgcaa tagaaagaga ataaaatggc
     2461 taagaatgta tatcagagtt tagcgatggg tatttttcca gtgatttgta agtataggaa
     2521 aagattgtat gtgcttgaag attcaggctt gcgttcaaag actgtcctca gacccgtgtg
     2581 aagggtttcc aatgctgtat gtcattaaag tgcactgtat cctgaaatag tactactttt
     2641 catttcaaag aagtcattgg gatggagcag gtgacagaga gtgagtgaac ggcacgtcca
     2701 gatcacggtg ccttatgtcc aaacgcagta tgtcaccgcc gctgccgcac gcccctaagt
     2761 gctgctgaag agacgcccgg cccaagtgtg agcatcttca aacctttacc cagcttcctc
     2821 ctctgcaccc agtgggttga aaagttttca tttgagcaga ggcaaccgaa aacgccacgt
     2881 gctgcttctg agtgctacgt gtcctgttct ggctgccgcg tcggcgaggc tggcttggca
     2941 acctcgcttt atttattttt ttctctcatg caggttttct acacatcttt tggtgagtgg
     3001 acttcaccat acctacgaat aaaaccttga tcgttctcct aagtggaaaa tctctcgaga
     3061 ttttagtttg gatctggaaa ggctatgcct tccaaaacaa gctcctgggg ctggagagat
     3121 ggctcagcca ttaaaggcca ggctcacacc aaacagccac tgttgggtct tttaaacgtt
     3181 catggaaaca ggccgaggtc gcagggatga agtaccagaa gacgtctgtg ttgttttttt
     3241 ttttttttat tgtgtgttga aatgtaaact catgatgttt gtgtgaccgc tgacaagacg
     3301 cttgtaactt ttattgtgac acataaagca gtaagggaaa ctgtcccctc gtgtcagtgc
     3361 tctgaaaatg ttgacactat atctgtgtgt gtatatatga gcagagtttg ggggtttgtt
     3421 tggggggttt gttttgtttt ccagatcgaa aattaaaata aatcctatct accagtttgc
     3481 taaagtt
//
