LOCUS       NP_001385808             566 aa            linear   ROD 31-MAR-2024
DEFINITION  5'-AMP-activated protein kinase subunit gamma-2 isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001385808 XP_006236014
VERSION     NP_001385808.1
DBSOURCE    REFSEQ: accession NM_001398879.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 566)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   2  (residues 1 to 566)
  AUTHORS   Scott,J.W., Ross,F.A., Liu,J.K. and Hardie,D.G.
  TITLE     Regulation of AMP-activated protein kinase by a pseudosubstrate
            sequence on the gamma subunit
  JOURNAL   EMBO J 26 (3), 806-815 (2007)
   PUBMED   17255938
REFERENCE   3  (residues 1 to 566)
  AUTHORS   Li,J., Coven,D.L., Miller,E.J., Hu,X., Young,M.E., Carling,D.,
            Sinusas,A.J. and Young,L.H.
  TITLE     Activation of AMPK alpha- and gamma-isoform complexes in the intact
            ischemic rat heart
  JOURNAL   Am J Physiol Heart Circ Physiol 291 (4), H1927-H1934 (2006)
   PUBMED   16648175
  REMARK    GeneRIF: results indicate that ischemia activates catalytic alpha1
            and alpha2 isoforms similarly in gamma1 and gamma2
            isoform-containing AMPK complexes and that gamma1-isoform complexes
            account for most of the AMPK activity in the ischemic heart
REFERENCE   4  (residues 1 to 566)
  AUTHORS   Laforet,P., Richard,P., Said,M.A., Romero,N.B., Lacene,E.,
            Leroy,J.P., Baussan,C., Hogrel,J.Y., Lavergne,T., Wahbi,K.,
            Hainque,B. and Duboc,D.
  TITLE     A new mutation in PRKAG2 gene causing hypertrophic cardiomyopathy
            with conduction system disease and muscular glycogenosis
  JOURNAL   Neuromuscul Disord 16 (3), 178-182 (2006)
   PUBMED   16487706
REFERENCE   5  (residues 1 to 566)
  AUTHORS   Ahmad,F., Arad,M., Musi,N., He,H., Wolf,C., Branco,D.,
            Perez-Atayde,A.R., Stapleton,D., Bali,D., Xing,Y., Tian,R.,
            Goodyear,L.J., Berul,C.I., Ingwall,J.S., Seidman,C.E. and
            Seidman,J.G.
  TITLE     Increased alpha2 subunit-associated AMPK activity and PRKAG2
            cardiomyopathy
  JOURNAL   Circulation 112 (20), 3140-3148 (2005)
   PUBMED   16275868
REFERENCE   6  (residues 1 to 566)
  AUTHORS   Hardie,D.G.
  TITLE     The AMP-activated protein kinase pathway--new players upstream and
            downstream
  JOURNAL   J Cell Sci 117 (Pt 23), 5479-5487 (2004)
   PUBMED   15509864
  REMARK    Review article
REFERENCE   7  (residues 1 to 566)
  AUTHORS   Hardie,D.G., Scott,J.W., Pan,D.A. and Hudson,E.R.
  TITLE     Management of cellular energy by the AMP-activated protein kinase
            system
  JOURNAL   FEBS Lett 546 (1), 113-120 (2003)
   PUBMED   12829246
  REMARK    Review article
REFERENCE   8  (residues 1 to 566)
  AUTHORS   Arad,M., Benson,D.W., Perez-Atayde,A.R., McKenna,W.J., Sparks,E.A.,
            Kanter,R.J., McGarry,K., Seidman,J.G. and Seidman,C.E.
  TITLE     Constitutively active AMP kinase mutations cause glycogen storage
            disease mimicking hypertrophic cardiomyopathy
  JOURNAL   J Clin Invest 109 (3), 357-362 (2002)
   PUBMED   11827995
REFERENCE   9  (residues 1 to 566)
  AUTHORS   Gollob,M.H., Seger,J.J., Gollob,T.N., Tapscott,T., Gonzales,O.,
            Bachinski,L. and Roberts,R.
  TITLE     Novel PRKAG2 mutation responsible for the genetic syndrome of
            ventricular preexcitation and conduction system disease with
            childhood onset and absence of cardiac hypertrophy
  JOURNAL   Circulation 104 (25), 3030-3033 (2001)
   PUBMED   11748095
REFERENCE   10 (residues 1 to 566)
  AUTHORS   Cheung,P.C., Salt,I.P., Davies,S.P., Hardie,D.G. and Carling,D.
  TITLE     Characterization of AMP-activated protein kinase gamma-subunit
            isoforms and their role in AMP binding
  JOURNAL   Biochem J 346 Pt 3 (Pt 3), 659-669 (2000)
   PUBMED   10698692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 27, 2021 this sequence version replaced XP_006236014.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223364.1, BC079017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..566
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     Protein         1..566
                     /product="5'-AMP-activated protein kinase subunit gamma-2
                     isoform 1"
                     /note="AMPK gamma 2; adenosine monophosphate-activated
                     protein kinase gamma 2-subunit; AMP-activated protein
                     kinase gamma2 subunit; 5'-AMP-activated protein kinase
                     subunit gamma-2; protein kinase, AMP-activated, gamma 2
                     non-catalytic subunit"
                     /calculated_mol_wt=62853
     Region          266..403
                     /region_name="CBS_euAMPK_gamma-like_repeat1"
                     /note="Two tandem repeats of the cystathionine
                     beta-synthase (CBS pair) domains found in AMP-activated
                     protein kinase gamma-like proteins, repeat 1; cd04618"
                     /db_xref="CDD:341388"
     Site            order(274,276..278,300..302,381,395,397,399..400,403)
                     /site_type="other"
                     /note="ligand binding site II [chemical binding]"
                     /db_xref="CDD:341388"
     Region          274..347
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341388"
     Site            order(300,314,318..319,322,359,381..383,399)
                     /site_type="other"
                     /note="ligand binding site I [chemical binding]"
                     /db_xref="CDD:341388"
     Region          359..403
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341388"
     Region          429..552
                     /region_name="CBS_euAMPK_gamma-like_repeat2"
                     /note="CBS pair domain found in 5'-AMP (adenosine
                     monophosphate)-activated protein kinase; cd04641"
                     /db_xref="CDD:341399"
     Site            order(430,432..434,456..458,528,541,543,545..546,549)
                     /site_type="other"
                     /note="ligand binding site II [chemical binding]"
                     /db_xref="CDD:341399"
     Region          430..495
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341399"
     Site            order(456,469,473..474,477,506,528..530,545)
                     /site_type="other"
                     /note="ligand binding site I [chemical binding]"
                     /db_xref="CDD:341399"
     Region          506..549
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341399"
     CDS             1..566
                     /gene="Prkag2"
                     /coded_by="NM_001398879.1:658..2358"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:373545"
                     /db_xref="RGD:727782"
ORIGIN      
        1 mgsaamdtkk kkevsspggs sgkknpslkr rslrvhipdl ssfamplldg dvensekhss
       61 rkvdspfssg spsrglfsrg pqprpsspvs apvrpkmspg spktvfpfsy qespprsprr
      121 msfsgifrss skesspnsnp stspggirff srsrktssvs sspstptqvt kqhpfplesy
      181 kqeperlesr iyasssppdt gqrfclafqs pvrlplaspt hhaplrtaal aaapgpaeag
      241 mleklefqee edsesgvymr fmrshkcydi vptssklvvf dttlqvkkaf falvangvra
      301 aplweskkqs fvgmltitdf inilhryyks pmvqiyelee hkietwrely lqetfkplvn
      361 ispdaslfda vysliknkih rlpvidpisg nalyilthkr ilkflqlfms dmpkpafmkq
      421 nldelgigty hniafihpnt piikalnifv errisalpvv desgkvvdiy skfdvinlaa
      481 ektynnldit vtqalqhrsq yfegvvkcsk letletivdr ivraevhrlv vvneadsivg
      541 iislsdilqa liltpagakq ketete
//
