LOCUS       NM_013010               1611 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Rattus norvegicus protein kinase AMP-activated non-catalytic
            subunit gamma 1 (Prkag1), mRNA.
ACCESSION   NM_013010
VERSION     NM_013010.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1611)
  AUTHORS   Bai,W., Guo,T., Wang,H., Li,B., Sun,Q., Wu,W., Zhang,J., Zhou,J.,
            Luo,J., Zhu,M., Lu,J., Li,P., Dong,B., Han,S., Pang,X., Zhang,G.,
            Bai,Y. and Wang,S.
  TITLE     S-nitrosylation of AMPKgamma impairs coronary collateral
            circulation and disrupts VSMC reprogramming
  JOURNAL   EMBO Rep 25 (1), 128-143 (2024)
   PUBMED   38177907
  REMARK    GeneRIF: S-nitrosylation of AMPKgamma impairs coronary collateral
            circulation and disrupts VSMC reprogramming.
REFERENCE   2  (bases 1 to 1611)
  AUTHORS   Jeon,Y.H., He,M., Austin,J., Shin,H., Pfleger,J. and Abdellatif,M.
  TITLE     Adiponectin enhances the bioenergetics of cardiac myocytes via an
            AMPK- and succinate dehydrogenase-dependent mechanism
  JOURNAL   Cell Signal 78, 109866 (2021)
   PUBMED   33271223
  REMARK    GeneRIF: Adiponectin enhances the bioenergetics of cardiac myocytes
            via an AMPK- and succinate dehydrogenase-dependent mechanism.
REFERENCE   3  (bases 1 to 1611)
  AUTHORS   Dopie,J., Rajakyla,E.K., Joensuu,M.S., Huet,G., Ferrantelli,E.,
            Xie,T., Jaalinoja,H., Jokitalo,E. and Vartiainen,M.K.
  TITLE     Genome-wide RNAi screen for nuclear actin reveals a network of
            cofilin regulators
  JOURNAL   J Cell Sci 128 (13), 2388-2400 (2015)
   PUBMED   26021350
REFERENCE   4  (bases 1 to 1611)
  AUTHORS   Xiao,B., Sanders,M.J., Underwood,E., Heath,R., Mayer,F.V.,
            Carmena,D., Jing,C., Walker,P.A., Eccleston,J.F., Haire,L.F.,
            Saiu,P., Howell,S.A., Aasland,R., Martin,S.R., Carling,D. and
            Gamblin,S.J.
  TITLE     Structure of mammalian AMPK and its regulation by ADP
  JOURNAL   Nature 472 (7342), 230-233 (2011)
   PUBMED   21399626
REFERENCE   5  (bases 1 to 1611)
  AUTHORS   Zhu,L., Chen,L., Zhou,X.M., Zhang,Y.Y., Zhang,Y.J., Zhao,J.,
            Ji,S.R., Wu,J.W. and Wu,Y.
  TITLE     Structural insights into the architecture and allostery of
            full-length AMP-activated protein kinase
  JOURNAL   Structure 19 (4), 515-522 (2011)
   PUBMED   21481774
  REMARK    GeneRIF: Studies determine the three-dimensional reconstruction and
            subunit organization of the full-length rat AMPK
            (alpha1beta1gamma1) through single-particle electron
REFERENCE   6  (bases 1 to 1611)
  AUTHORS   Cheung,P.C., Salt,I.P., Davies,S.P., Hardie,D.G. and Carling,D.
  TITLE     Characterization of AMP-activated protein kinase gamma-subunit
            isoforms and their role in AMP binding
  JOURNAL   Biochem J 346 Pt 3 (Pt 3), 659-669 (2000)
   PUBMED   10698692
REFERENCE   7  (bases 1 to 1611)
  AUTHORS   Turnley,A.M., Stapleton,D., Mann,R.J., Witters,L.A., Kemp,B.E. and
            Bartlett,P.F.
  TITLE     Cellular distribution and developmental expression of AMP-activated
            protein kinase isoforms in mouse central nervous system
  JOURNAL   J Neurochem 72 (4), 1707-1716 (1999)
   PUBMED   10098881
REFERENCE   8  (bases 1 to 1611)
  AUTHORS   Woods,A., Cheung,P.C., Smith,F.C., Davison,M.D., Scott,J.,
            Beri,R.K. and Carling,D.
  TITLE     Characterization of AMP-activated protein kinase beta and gamma
            subunits. Assembly of the heterotrimeric complex in vitro
  JOURNAL   J Biol Chem 271 (17), 10282-10290 (1996)
   PUBMED   8626596
REFERENCE   9  (bases 1 to 1611)
  AUTHORS   Gao,G., Fernandez,C.S., Stapleton,D., Auster,A.S., Widmer,J.,
            Dyck,J.R., Kemp,B.E. and Witters,L.A.
  TITLE     Non-catalytic beta- and gamma-subunit isoforms of the
            5'-AMP-activated protein kinase
  JOURNAL   J Biol Chem 271 (15), 8675-8681 (1996)
   PUBMED   8621499
REFERENCE   10 (bases 1 to 1611)
  AUTHORS   Stapleton,D., Gao,G., Michell,B.J., Widmer,J., Mitchelhill,K.,
            Teh,T., House,C.M., Witters,L.A. and Kemp,B.E.
  TITLE     Mammalian 5'-AMP-activated protein kinase non-catalytic subunits
            are homologs of proteins that interact with yeast Snf1 protein
            kinase
  JOURNAL   J Biol Chem 269 (47), 29343-29346 (1994)
   PUBMED   7961907
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097940.1.
            
            On Jun 19, 2005 this sequence version replaced NM_013010.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097940.1, X95578.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1611
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1611
                     /gene="Prkag1"
                     /gene_synonym="Prkaac; Prkga1"
                     /note="protein kinase AMP-activated non-catalytic subunit
                     gamma 1"
                     /db_xref="GeneID:25520"
                     /db_xref="RGD:3388"
     exon            1..25
                     /gene="Prkag1"
                     /gene_synonym="Prkaac; Prkga1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1009
                     /gene="Prkag1"
                     /gene_synonym="Prkaac; Prkga1"
                     /note="AMP-activated protein kinase, noncatalytic gamma-1
                     subunit; protein kinase, AMP-activated, gamma 1
                     non-catalytic subunit; AMPKg; AMPK gamma-1 chain; AMPK
                     gamma1; AMPK subunit gamma-1; Protein kinase AMP-activated
                     gamma"
                     /codon_start=1
                     /product="5'-AMP-activated protein kinase subunit gamma-1"
                     /protein_id="NP_037142.1"
                     /db_xref="GeneID:25520"
                     /db_xref="RGD:3388"
                     /translation="MESVAAESAPAPENEHSQETPESNSSVYTTFMKSHRCYDLIPTS
                     SKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSAL
                     VQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESG
                     NTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGI
                     FVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVL
                     KCYLHETLEAIINRLVEAEVHRLVVVDEHDVVKGIVSLSDILQALVLTGGEKKP"
     exon            26..71
                     /gene="Prkag1"
                     /gene_synonym="Prkaac; Prkga1"
                     /inference="alignment:Splign:2.1.0"
     exon            72..181
                     /gene="Prkag1"
                     /gene_synonym="Prkaac; Prkga1"
                     /inference="alignment:Splign:2.1.0"
     exon            182..263
                     /gene="Prkag1"
                     /gene_synonym="Prkaac; Prkga1"
                     /inference="alignment:Splign:2.1.0"
     exon            264..322
                     /gene="Prkag1"
                     /gene_synonym="Prkaac; Prkga1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..368
                     /gene="Prkag1"
                     /gene_synonym="Prkaac; Prkga1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..423
                     /gene="Prkag1"
                     /gene_synonym="Prkaac; Prkga1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..550
                     /gene="Prkag1"
                     /gene_synonym="Prkaac; Prkga1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..716
                     /gene="Prkag1"
                     /gene_synonym="Prkaac; Prkga1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..754
                     /gene="Prkag1"
                     /gene_synonym="Prkaac; Prkga1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..901
                     /gene="Prkag1"
                     /gene_synonym="Prkaac; Prkga1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1584
                     /gene="Prkag1"
                     /gene_synonym="Prkaac; Prkga1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcgggtg ctagcaatgg agtcggttgc tgcagagagc gctccagctc cggagaatga
       61 acactctcaa gagaccccgg aatcgaacag tagtgtgtac accaccttca tgaagtctca
      121 tcgctgctat gacctgatcc ccacaagctc caagctggtg gtatttgata cttcgctgca
      181 ggtaaagaaa gccttctttg ccctggtgac taacggtgtt cgtgctgccc ctttgtggga
      241 tagtaagaag cagagctttg tgggcatgct gaccatcact gacttcatca atattctgca
      301 ccgatactac aagtcagccc tggtgcagat ctatgaactg gaggagcaca agatagagac
      361 ttggagagag gtctacctgc aagactcctt taagccactt gtctgcattt ctccaaatgc
      421 cagcttgttc gatgctgtct cttcattaat tcgaaataag atccacaggc ttccagttat
      481 tgacccggag tcaggcaaca ccttgtacat tcttactcac aagcggatcc tcaagttcct
      541 caagttgttt atcactgagt tccccaagcc ggaattcatg tctaagtctc tggaagagct
      601 acagattggc acctacgcca atattgccat ggtccgtacc actacacctg tctatgtggc
      661 tctgggcatc tttgtacagc accgagtctc cgccttgcct gtggtggatg agaaagggcg
      721 tgtggtggac atctactcca agtttgatgt gattaatttg gcagcagaaa agacatacaa
      781 caacctagat gtgtctgtga caaaagccct acagcaccgg tcacactact tcgagggtgt
      841 tctcaagtgc tacctacatg agactctaga agcaatcatc aatagactgg tggaagcaga
      901 ggttcaccgt ctggtggtgg tggatgaaca tgacgtggtc aagggcattg tatcgctgtc
      961 tgacatctta caggctctgg tgctcacagg tggagagaag aagccctgag catggggcgg
     1021 aacaggcagt gcctggggag atggccccct cactgcctgc ctgctgtaag agccggaatc
     1081 agatggaatc ctgagagaac ggagtcttcc ctcaggagct ccacgcccac tgtctagaac
     1141 tagagaaggg gaaaggagga gaaggactgt tagcttctct caccatcgtg ctacacttga
     1201 gaaaacactt gtcagcctag ccagccccag tcgctcgtca cagccccctt gtgggtgaac
     1261 catgggtttt gtgctcctca ggcagatcct gatctctaag agatccctag acctcaccac
     1321 gccccacctc tgtctctgcc cttactccac taagagaata gctctgcaga agtcttggta
     1381 aagtattttt attcctcttt cttcactctg tgtggaggag gctgggctgt ttgctgtcag
     1441 tccttcccat gagtctcggg aggtgcgtcc cggctcctgg gctgtgcaga cgaaggcaga
     1501 tggctctgtg gaggagggcg gtgggtaggg agccaagatt aatgcttttt gtggcgaacc
     1561 taattaaatg acaaggtttc atcaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
