LOCUS       NM_001077645            1122 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus protein kinase cAMP-activated catalytic subunit
            beta (Prkacb), mRNA.
ACCESSION   NM_001077645 XM_001059642 XM_001077254 XM_215070
VERSION     NM_001077645.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1122)
  AUTHORS   Tuson,M., He,M. and Anderson,K.V.
  TITLE     Protein kinase A acts at the basal body of the primary cilium to
            prevent Gli2 activation and ventralization of the mouse neural tube
  JOURNAL   Development 138 (22), 4921-4930 (2011)
   PUBMED   22007132
REFERENCE   2  (bases 1 to 1122)
  AUTHORS   Yger,M. and Girault,J.A.
  TITLE     DARPP-32, Jack of All Trades em leader Master of Which?
  JOURNAL   Front Behav Neurosci 5, 56 (2011)
   PUBMED   21927600
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1122)
  AUTHORS   Aksaas,A.K., Larsen,A.C., Rogne,M., Rosendal,K., Kvissel,A.K. and
            Skalhegg,B.S.
  TITLE     G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear
            RNA-binding protein regulated by protein kinase A
  JOURNAL   J Mol Signal 6, 10 (2011)
   PUBMED   21880142
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1122)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   5  (bases 1 to 1122)
  AUTHORS   Lignitto,L., Carlucci,A., Sepe,M., Stefan,E., Cuomo,O., Nistico,R.,
            Scorziello,A., Savoia,C., Garbi,C., Annunziato,L. and Feliciello,A.
  TITLE     Control of PKA stability and signalling by the RING ligase praja2
  JOURNAL   Nat Cell Biol 13 (4), 412-422 (2011)
   PUBMED   21423175
REFERENCE   6  (bases 1 to 1122)
  AUTHORS   Guthrie,C.R., Skalhegg,B.S. and McKnight,G.S.
  TITLE     Two novel brain-specific splice variants of the murine Cbeta gene
            of cAMP-dependent protein kinase
  JOURNAL   J Biol Chem 272 (47), 29560-29565 (1997)
   PUBMED   9368018
REFERENCE   7  (bases 1 to 1122)
  AUTHORS   Huang,Y.Y., Kandel,E.R., Varshavsky,L., Brandon,E.P., Qi,M.,
            Idzerda,R.L., McKnight,G.S. and Bourtchouladze,R.
  TITLE     A genetic test of the effects of mutations in PKA on mossy fiber
            LTP and its relation to spatial and contextual learning
  JOURNAL   Cell 83 (7), 1211-1222 (1995)
   PUBMED   8548807
REFERENCE   8  (bases 1 to 1122)
  AUTHORS   Kiryu,S., Morita,N., Ohno,K., Maeno,H. and Kiyama,H.
  TITLE     Regulation of mRNA expression involved in Ras and PKA signal
            pathways during rat hypoglossal nerve regeneration
  JOURNAL   Brain Res Mol Brain Res 29 (1), 147-156 (1995)
   PUBMED   7769990
REFERENCE   9  (bases 1 to 1122)
  AUTHORS   Shuntoh,H., Sakamoto,N., Matsuyama,S., Saitoh,M. and Tanaka,C.
  TITLE     Molecular structure of the C beta catalytic subunit of rat
            cAMP-dependent protein kinase and differential expression of C
            alpha and C beta isoforms in rat tissues and cultured cells
  JOURNAL   Biochim Biophys Acta 1131 (2), 175-180 (1992)
   PUBMED   1610898
REFERENCE   10 (bases 1 to 1122)
  AUTHORS   Roth,J.S., Hsieh,L.L., Peraino,C. and Weinstein,I.B.
  TITLE     Isolation of a complementary DNA encoding the catalytic subunit of
            protein kinase A and studies on the expression of this sequence in
            rat hepatomas and regenerating liver
  JOURNAL   Cancer Res 50 (6), 1675-1680 (1990)
   PUBMED   2306720
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D10770.1.
            
            On or before Nov 10, 2006 this sequence version replaced
            XM_215070.4, XM_001059642.1, XM_001077254.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10770.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1122
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..1122
                     /gene="Prkacb"
                     /note="protein kinase cAMP-activated catalytic subunit
                     beta"
                     /db_xref="GeneID:293508"
                     /db_xref="RGD:1310574"
     exon            1..100
                     /gene="Prkacb"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1110
                     /gene="Prkacb"
                     /EC_number="2.7.11.11"
                     /note="PKA C-beta; protein kinase, cAMP dependent,
                     catalytic, beta; protein kinase, cAMP-dependent, beta
                     catalytic subunit"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     beta"
                     /protein_id="NP_001071113.1"
                     /db_xref="GeneID:293508"
                     /db_xref="RGD:1310574"
                     /translation="MGNTAIAKKGSEVESVKEFLAKAKEDFLRKWENPPPSNAGLEDF
                     ERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFP
                     FLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS
                     LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNK
                     AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV
                     DLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEE
                     EIRVSITEKCGKEFCEF"
     exon            101..162
                     /gene="Prkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            163..291
                     /gene="Prkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            292..390
                     /gene="Prkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            391..473
                     /gene="Prkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            474..600
                     /gene="Prkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            601..696
                     /gene="Prkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            697..819
                     /gene="Prkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            820..984
                     /gene="Prkacb"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1122
                     /gene="Prkacb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacggccc cggtcccctc ccctccgtca ctcctgctta cggactcccg ggtcatgggg
       61 aacacggcga tcgccaagaa aggcagcgaa gtggagagcg tgaaagaatt cctagccaaa
      121 gccaaagaag actttctgag gaaatgggag aaccctcccc cgagtaatgc tgggcttgag
      181 gattttgaaa ggaaaaaaac ccttggaacg ggttccttcg gaagagtcat gctggtaaag
      241 cataaagcca ctgagcagta ctacgccatg aagatcttag acaagcagaa ggtcgttaag
      301 ctaaagcaaa tagagcacac tctgaatgag aagagaatcc tgcaggcagt ggagttcccg
      361 ttccttgttc ggctggagta ttcttttaag gataattcta atttatacat ggttatggaa
      421 tacgttcctg ggggggaaat gttttcacat ctaagaagaa ttggaaggtt cagtgaaccc
      481 catgctcgtt tctatgcagc tcagatcgtg ctaacatttg agtacctcca ttccctcgac
      541 ctcatctaca gagatctcaa gccggaaaac ctcttaattg accaccaggg ttacatccag
      601 gtcacagatt ttgggttcgc caagagagtc aagggcagga cttggacatt gtgtggcacc
      661 ccagagtacc tggccccaga gatcatcctc agcaagggtt acaataaggc agtggactgg
      721 tgggcattgg gtgtactgat ctacgagatg gctgctggct accccccgtt ctttgctgac
      781 cagccaattc agatttatga gaagattgtt tccggaaagg tccgcttccc gtcgcacttc
      841 agttccgatc tcaaggacct tctgcggaat ctgctgcagg tggatctgac aaagcggttt
      901 gggaacctga agaatggcgt gagtgacatc aagacccaca agtggtttgc tacgaccgac
      961 tggatcgcga tttaccagag aaaggttgag gctccattca taccaaaatt cagaggctct
     1021 ggcgatacca gcaacttcga tgactatgaa gaagaagaaa tccgagtgtc tataacagaa
     1081 aaatgtggaa aggagttttg tgaattttag ggaggagaag ga
//
