LOCUS       NM_031976               1974 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus protein kinase AMP-activated non-catalytic
            subunit beta 1 (Prkab1), mRNA.
ACCESSION   NM_031976
VERSION     NM_031976.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1974)
  AUTHORS   Rivas,P.M.S., Vechiato,F.M.V., Borges,B.C., Rorato,R.,
            Antunes-Rodrigues,J. and Elias,L.L.K.
  TITLE     Increase in hypothalamic AMPK phosphorylation induced by prolonged
            exposure to LPS involves ghrelin and CB1R signaling
  JOURNAL   Horm Behav 93, 166-174 (2017)
   PUBMED   28576646
REFERENCE   2  (bases 1 to 1974)
  AUTHORS   Christensen,M., Jensen,J.B., Jakobsen,S., Jessen,N., Frokiaer,J.,
            Kemp,B.E., Marciszyn,A.L., Li,H., Pastor-Soler,N.M., Hallows,K.R.
            and Norregaard,R.
  TITLE     Renoprotective Effects of Metformin are Independent of Organic
            Cation Transporters 1 &2 and AMP-activated Protein Kinase in the
            Kidney
  JOURNAL   Sci Rep 6, 35952 (2016)
   PUBMED   27782167
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1974)
  AUTHORS   Mottillo,E.P., Desjardins,E.M., Crane,J.D., Smith,B.K., Green,A.E.,
            Ducommun,S., Henriksen,T.I., Rebalka,I.A., Razi,A., Sakamoto,K.,
            Scheele,C., Kemp,B.E., Hawke,T.J., Ortega,J., Granneman,J.G. and
            Steinberg,G.R.
  TITLE     Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic
            Steatosis through Brown and Beige Adipose Tissue Function
  JOURNAL   Cell Metab 24 (1), 118-129 (2016)
   PUBMED   27411013
REFERENCE   4  (bases 1 to 1974)
  AUTHORS   DiTommaso,T., Jones,L.K., Cottle,D.L., Gerdin,A.K., Vancollie,V.E.,
            Watt,F.M., Ramirez-Solis,R., Bradley,A., Steel,K.P., Sundberg,J.P.,
            White,J.K. and Smyth,I.M.
  CONSRTM   WTSI Mouse Genetics Program
  TITLE     Identification of genes important for cutaneous function revealed
            by a large scale reverse genetic screen in the mouse
  JOURNAL   PLoS Genet 10 (10), e1004705 (2014)
   PUBMED   25340873
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1974)
  AUTHORS   Zhu,L., Chen,L., Zhou,X.M., Zhang,Y.Y., Zhang,Y.J., Zhao,J.,
            Ji,S.R., Wu,J.W. and Wu,Y.
  TITLE     Structural insights into the architecture and allostery of
            full-length AMP-activated protein kinase
  JOURNAL   Structure 19 (4), 515-522 (2011)
   PUBMED   21481774
  REMARK    GeneRIF: Studies determine the three-dimensional reconstruction and
            subunit organization of the full-length rat AMPK
            (alpha1beta1gamma1) through single-particle electron
REFERENCE   6  (bases 1 to 1974)
  AUTHORS   Turnley,A.M., Stapleton,D., Mann,R.J., Witters,L.A., Kemp,B.E. and
            Bartlett,P.F.
  TITLE     Cellular distribution and developmental expression of AMP-activated
            protein kinase isoforms in mouse central nervous system
  JOURNAL   J Neurochem 72 (4), 1707-1716 (1999)
   PUBMED   10098881
REFERENCE   7  (bases 1 to 1974)
  AUTHORS   Mitchelhill,K.I., Michell,B.J., House,C.M., Stapleton,D., Dyck,J.,
            Gamble,J., Ullrich,C., Witters,L.A. and Kemp,B.E.
  TITLE     Posttranslational modifications of the 5'-AMP-activated protein
            kinase beta1 subunit
  JOURNAL   J Biol Chem 272 (39), 24475-24479 (1997)
   PUBMED   9305909
REFERENCE   8  (bases 1 to 1974)
  AUTHORS   Woods,A., Cheung,P.C., Smith,F.C., Davison,M.D., Scott,J.,
            Beri,R.K. and Carling,D.
  TITLE     Characterization of AMP-activated protein kinase beta and gamma
            subunits. Assembly of the heterotrimeric complex in vitro
  JOURNAL   J Biol Chem 271 (17), 10282-10290 (1996)
   PUBMED   8626596
REFERENCE   9  (bases 1 to 1974)
  AUTHORS   Gao,G., Fernandez,C.S., Stapleton,D., Auster,A.S., Widmer,J.,
            Dyck,J.R., Kemp,B.E. and Witters,L.A.
  TITLE     Non-catalytic beta- and gamma-subunit isoforms of the
            5'-AMP-activated protein kinase
  JOURNAL   J Biol Chem 271 (15), 8675-8681 (1996)
   PUBMED   8621499
REFERENCE   10 (bases 1 to 1974)
  AUTHORS   Stapleton,D., Gao,G., Michell,B.J., Widmer,J., Mitchelhill,K.,
            Teh,T., House,C.M., Witters,L.A. and Kemp,B.E.
  TITLE     Mammalian 5'-AMP-activated protein kinase non-catalytic subunits
            are homologs of proteins that interact with yeast Snf1 protein
            kinase
  JOURNAL   J Biol Chem 269 (47), 29343-29346 (1994)
   PUBMED   7961907
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031976.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U42411.1, BC062008.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JAXUCZ010000012.1  46249095-46249378
            285-448             JAXUCZ010000012.1  46251599-46251762
            449-542             JAXUCZ010000012.1  46252711-46252804
            543-657             JAXUCZ010000012.1  46253056-46253170
            658-791             JAXUCZ010000012.1  46255022-46255155
            792-860             JAXUCZ010000012.1  46258083-46258151
            861-1974            JAXUCZ010000012.1  46258357-46259470
FEATURES             Location/Qualifiers
     source          1..1974
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1974
                     /gene="Prkab1"
                     /note="protein kinase AMP-activated non-catalytic subunit
                     beta 1"
                     /db_xref="GeneID:83803"
                     /db_xref="RGD:71057"
     exon            1..284
                     /gene="Prkab1"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..938
                     /gene="Prkab1"
                     /note="5'-AMP-activated protein kinase, beta subunit;
                     AMPKb; AMPK beta-1 chain; protein kinase, AMP-activated,
                     beta 1 non-catalytic subunit; 5'-AMP-activated protein
                     kinase 40 kDa subunit; AMPK subunit beta-1;
                     5-AMP-activated protein kinase beta subunit"
                     /codon_start=1
                     /product="5'-AMP-activated protein kinase subunit beta-1"
                     /protein_id="NP_114182.2"
                     /db_xref="GeneID:83803"
                     /db_xref="RGD:71057"
                     /translation="MGNTSSERAALERQAGHKTPRRDSSGGTKDGDRPKILMDSPEDA
                     DIFHTEEMKAPEKEEFLAWQHDLEVNEKAPAQARPTVFRWTGGGKEVYLSGSFNNWSK
                     LPLTRSQNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDF
                     EVFDALMVDSQKCSDVSELSSSPPGPYHQEPYISKPEERFKAPPILPPHLLQVILNKD
                     TGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI"
     exon            285..448
                     /gene="Prkab1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..542
                     /gene="Prkab1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..657
                     /gene="Prkab1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..791
                     /gene="Prkab1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..860
                     /gene="Prkab1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1974
                     /gene="Prkab1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgcggtc caagcaggta aagcggggct cggcgaacgc gcgcgacccg aggggcgtgg
       61 tccgcggtcc cgggggtccc ggcccggccc ttcccgcttc cctgtgtccc cgcagacact
      121 tcgccatggg caatacgagc agcgagcgcg ccgcgctgga gcggcaggct ggccataaga
      181 cgccgcggag ggacagctcg gggggcacca aggatgggga caggcccaag atcctgatgg
      241 acagccccga agacgccgac atcttccaca ccgaggaaat gaaggctcca gagaaggagg
      301 agttcctggc gtggcagcac gacctcgagg tgaatgagaa agcccccgcc caggctcggc
      361 ccaccgtatt tcgatggaca gggggtggaa aggaggtcta cttgtctgga tccttcaaca
      421 actggagcaa attgcccctc actagaagcc aaaacaactt cgtagccatc ctggacctgc
      481 cggaaggaga gcatcagtac aagttctttg tggatggcca gtggacccac gatccttccg
      541 agccaatagt aaccagccag cttggcacag ttaacaacat cattcaagtg aagaaaactg
      601 actttgaagt atttgatgct ttaatggtgg attcccaaaa gtgctccgat gtatctgagc
      661 tgtccagttc ccccccagga ccctaccacc aggagcctta catctctaaa ccagaggagc
      721 ggttcaaggc cccgcccatc ctcccgcctc acctgctgca ggtcatcttg aacaaggaca
      781 cgggcatctc ttgtgatcca gcgctgcttc cggagcccaa ccacgtcatg ctgaaccacc
      841 tctatgcact ctctatcaag gatggagtga tggtgctcag tgcgacccat cggtacaaga
      901 aaaagtacgt caccaccctc ctctacaagc ccatatgaga ggatgagcca gccgtgggcc
      961 acgggacagc aggcgggcgg cgctgggctc tccgtgtgca tgcgcatcct cactccggga
     1021 catctcaccc ccacatagtc ctccttgaag gtctgtccag gcacagccag aaatcggatg
     1081 gacggcagcc cgtggtccca gcaccgcagg cagtgcgcca ggctctagtg ctctaagcat
     1141 catccctctg ctggcccgag atgtctacag ccagacctga atgctggttc ctgctagaaa
     1201 acctaggaca ggaactgaag tcaccaaagc cctcatcatc cctgctgaag cctggcttgg
     1261 aagaaagcag tgctcggtct tgcctgtcct tccgaatcac agcagtagat tgtagactcc
     1321 atggaatttc agtgtccaat ttccagatgc agcttcgcaa tcgattcctg acactgtgca
     1381 ctgagacctt cttaaccaga gtggctggct gtccactctc acttaaggca ataagtcacc
     1441 aggacgagac tataggtcat gtgactactg agcaataatc gttctcaaac agacatcaga
     1501 aaccactgcc atttctccat caagccagac gatcctgagg actgaccacc atgggaggtt
     1561 gtccacctta tttcagttgc agtgttggcc atgttaccgt gacaacctgg tcgaagtgcc
     1621 cgccctcttt ttagttctag cacgtgctac tcagctgggg gccgtgtctc cagtgagcag
     1681 agagtgtcac ggtggttact attgcctgat ctaagagagc ttggcaccct gcggcagact
     1741 gctaggttcc agcagggttg gcacgagtga acctatcgtg tgctcagtgt gatttccaca
     1801 gtgatgtcac agacgtgccc attggtacag gctcctgtca cctgtcagca taggtaggca
     1861 caagctctgt ggtgtccgct atttggttaa acctgagttt tgggtacctt ttgttactgt
     1921 tttcaaaaca cggacttgct gtcatcttga tgtacaagtt tcaataaagc tttg
//
