LOCUS       NM_001415881            8138 bp    mRNA    linear   ROD 04-JAN-2023
DEFINITION  Rattus norvegicus prickle planar cell polarity protein 2
            (Prickle2), transcript variant 3, mRNA.
ACCESSION   NM_001415881 XM_039107623
VERSION     NM_001415881.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8138)
  AUTHORS   Nagaoka T, Tabuchi K and Kishi M.
  TITLE     PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only
            a limited role in the synaptic localisation of Vangl2
  JOURNAL   Sci Rep 5, 12916 (2015)
   PUBMED   26257100
  REMARK    GeneRIF: The PDZ interaction enhanced the protein interactions
            between PSD-95 and Prickle2, which is another planar cell polarity
            factor that is localised at the postsynaptic density.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8138)
  AUTHORS   Tao H, Inoue K, Kiyonari H, Bassuk AG, Axelrod JD, Sasaki H, Aizawa
            S and Ueno N.
  TITLE     Nuclear localization of Prickle2 is required to establish cell
            polarity during early mouse embryogenesis
  JOURNAL   Dev Biol 364 (2), 138-148 (2012)
   PUBMED   22333836
REFERENCE   3  (bases 1 to 8138)
  AUTHORS   Fujimura L, Watanabe-Takano H, Sato Y, Tokuhisa T and Hatano M.
  TITLE     Prickle promotes neurite outgrowth via the Dishevelled dependent
            pathway in C1300 cells
  JOURNAL   Neurosci Lett 467 (1), 6-10 (2009)
   PUBMED   19788910
REFERENCE   4  (bases 1 to 8138)
  AUTHORS   Deans MR, Antic D, Suyama K, Scott MP, Axelrod JD and Goodrich LV.
  TITLE     Asymmetric distribution of prickle-like 2 reveals an early
            underlying polarization of vestibular sensory epithelia in the
            inner ear
  JOURNAL   J Neurosci 27 (12), 3139-3147 (2007)
   PUBMED   17376975
REFERENCE   5  (bases 1 to 8138)
  AUTHORS   Jones C and Chen P.
  TITLE     Planar cell polarity signaling in vertebrates
  JOURNAL   Bioessays 29 (2), 120-132 (2007)
   PUBMED   17226800
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000148.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001415881.2.
            
            On Jan 4, 2023 this sequence version replaced XM_039107623.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760396,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-568               JACYVU010000148.1  22319729-22320296   c
            569-752             JACYVU010000148.1  22299002-22299185   c
            753-866             JACYVU010000148.1  22268111-22268224   c
            867-1004            JACYVU010000148.1  22264841-22264978   c
            1005-1208           JACYVU010000148.1  22262445-22262648   c
            1209-1395           JACYVU010000148.1  22259134-22259320   c
            1396-2277           JACYVU010000148.1  22249479-22250360   c
            2278-8138           JACYVU010000148.1  22199661-22205521   c
FEATURES             Location/Qualifiers
     source          1..8138
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..8138
                     /gene="Prickle2"
                     /note="prickle planar cell polarity protein 2"
                     /db_xref="GeneID:312563"
                     /db_xref="RGD:1306723"
     exon            1..568
                     /gene="Prickle2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..752
                     /gene="Prickle2"
                     /inference="alignment:Splign:2.1.0"
     CDS             609..3152
                     /gene="Prickle2"
                     /note="prickle-like 2; prickle homolog 2"
                     /codon_start=1
                     /product="prickle-like protein 2"
                     /protein_id="NP_001402810.1"
                     /db_xref="GeneID:312563"
                     /db_xref="RGD:1306723"
                     /translation="MVTVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEYAWVPPGL
                     KPEQVHQYYSCLPEEKVPYVNSPGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELK
                     LFSNQRKRENLGRGNVRPFPVTMTGAICEQCGGQIKGGDIAVFASRAGHGICWHPPCF
                     ICTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAACDEIIFADECTEAEGRHWHMR
                     HFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIGIDQGQMTYDGQHW
                     HATENCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSAFQNARAKES
                     RRSAKIGKNKGKTEETMLNQHSQLQVSSNRLSADVDPLSVQMDLLSLSSQTPSLNRDP
                     IWRSRDEPFHYGNKMEQNQSQSPLQLLSQCNIRTSYSPGGQAAGAQPDMWAKHFSNPK
                     RSSSMALKGHGGSFIQECREDYYPGRLMSQESYSDMSSQSFSETRGSIPVPKYEEEEE
                     EEEEEGGISTQQCRPRRPLSSLKYTEDMTPTEQTPRGSMESLALSNATGLSAEGGAKR
                     QEHLSRFSMPDLSKDSGMNVSEKLSNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNL
                     HQLSNPLGYRDLQSHGRMHQSFDFDGGIASSKLPGQEGVHIQPMSERTRRRTTSRDDN
                     RRFRPHRSRRSRRSRSDNALHLASEREVIARLKDRPPLRAREDYDQFVRQRSFQESMG
                     QGSRRDLYSQCPRTVSDLALQNAFGERWGPYFTEYDWCSTCSSSSESDNEGYFLGEPI
                     PQPARLRYVTSDELLHKYSSYGVPKSSTLGGRGQLHSRKRQKSKNCIIS"
     exon            753..866
                     /gene="Prickle2"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1004
                     /gene="Prickle2"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1208
                     /gene="Prickle2"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1395
                     /gene="Prickle2"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..2277
                     /gene="Prickle2"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..8138
                     /gene="Prickle2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggaggatg caggcattgg aactgcgaac agcgacttct ccagctctgc caggcgctcc
       61 gtgacagtta ttattatttt ttggatgagc tgcacatttc ctggttcagt ggcccgggct
      121 ttgtgagcag ctgactggtc tcccaggtct ggctcaggat cagctgatga cgcagagact
      181 ggggtctgtg acttccttca gataatcgtg aagtcggcga gtttagagga gaagggttct
      241 tgagaagaca attccaggac tcaggcaggc ctagaacaag ggcacaagtc gcactctctg
      301 gcttggtgga tctctagcag ggtctgcttt cagggagggc gttctctcgg agggaatgca
      361 aaagaagacc ggtttgggtt tgagcctgct gcctgcctcc ggaagggctc agattcgcag
      421 agactctgta aaggagatgt ttgggctgcc tggggtcctg cttgcatttt ctggtaccag
      481 ctccaggggg aaagtgaact ggggcaactg accagatcaa gactcggtgg cggcttcttc
      541 taaagcttcg cggctcatcc tctaggagga agatctgcct gcactgcaag tgtccccagg
      601 aggagcacat ggtgacagtg atgccgctgg agatggagaa gaccattagc aagctcatgt
      661 ttgacttcca gaggaattca acctcagatg acgactcggg ctgtgctttg gaagaatatg
      721 cctgggtccc cccggggctg aagcctgagc aggtgcacca gtattatagc tgcctcccag
      781 aagagaaagt tccctatgtc aacagccctg gagagaaatt gcgaatcaag cagctactgc
      841 accagctgcc accccacgac aatgaggttc ggtattgcaa ctccctggac gaggaggaga
      901 agcgggagct gaagctgttc agcaaccaga ggaaacgtga gaacctgggc cgaggcaatg
      961 tcaggccctt ccccgtcacc atgacagggg ctatttgcga acagtgtgga ggtcagatta
     1021 agggcggcga catcgctgtg tttgcatcac gtgctggcca tggcatctgc tggcatccac
     1081 catgctttat atgcacagtc tgcaatgagc ttctggttga cctgatctac ttttaccaag
     1141 atgggaagat ctactgtggc aggcaccatg ctgagtgcct gaagccgcgc tgtgcagcct
     1201 gtgatgagat catctttgca gatgagtgca cagaggctga aggacgacat tggcacatga
     1261 gacacttctg ctgcttcgag tgtgagacgg tgctgggggg ccagcgctac atcatgaagg
     1321 agggaagacc ctactgctgt cactgctttg agtccctgta tgcagaatat tgtgacacct
     1381 gtgcccaaca tataggaatt gaccaaggtc aaatgaccta tgacggccaa cactggcatg
     1441 ctacggagaa ctgtttctgc tgtgctcatt gtaagaagtc tctcctgggg cggccattcc
     1501 tcccgaagca aggccagata ttctgctcac gggcctgtag tgctggggag gaccccaatg
     1561 gctctgactc atctgattca gccttccaga atgccagagc caaggagtct cgccgcagtg
     1621 ccaaaattgg caagaacaag ggcaaaacag aggaaaccat gctgaaccag cacagccagc
     1681 tgcaggtgag ttctaaccgg ctctcagctg atgtggaccc cctgtcagtg cagatggatc
     1741 tcctcagcct gtccagccag acgcccagcc tcaaccggga ccccatttgg aggagccggg
     1801 atgagccctt ccattacggg aacaagatgg agcagaacca atcccagagt cctttgcagc
     1861 tcctcagcca gtgcaacatc agaacgtcct acagtccagg agggcaggca gcaggagccc
     1921 agcctgacat gtgggccaag cacttcagca accccaagag aagctcatca atggccctga
     1981 aggggcacgg tggcagtttt atccaggaat gtcgtgagga ctattaccca gggaggctga
     2041 tgtcccagga gagctacagc gatatgtcta gccaaagctt tagtgaaacc cgaggcagca
     2101 tcccggttcc caagtatgag gaggaggagg aggaggagga ggaagaaggt ggcatatcta
     2161 cccagcagtg ccggccccgg cgtccactca gctccctgaa atacacagag gacatgacac
     2221 ccacagaaca gactcctcgt ggctctatgg aatcactggc cctgtcaaat gcaacaggcc
     2281 tgtctgctga aggtggtgcc aagcgccagg agcacctatc ccggttttcc atgcctgacc
     2341 tcagcaaaga ctctggaatg aatgtctcgg aaaagctgag caacatgggc actctcaact
     2401 cctcaatgca attcaggagc gcagagtctg tccgcagcct actgtctgcg caacagtacc
     2461 aggagatgga gggaaacctt caccagctca gcaaccccct ggggtacagg gacctacagt
     2521 cccatggaag gatgcaccag agctttgatt ttgatggcgg catagcgagc agcaagctac
     2581 cagggcagga aggtgttcac atccagccca tgagtgagcg cacccggagg agaactactt
     2641 ccagggatga caaccgccgc ttccgccctc accggtccag gaggtcccga cgctcacgtt
     2701 cagacaacgc cctgcaccta gccagcgagc gggaagtcat cgctcggttg aaggataggc
     2761 cccctctgag agccagggag gactatgacc agttcgtgcg ccaacgcagt tttcaggaga
     2821 gcatggggca gggttcccgg cgggatctgt acagccagtg tcccaggact gtgtcagacc
     2881 tggctttgca gaatgccttt ggggaacgat ggggacccta cttcacggag tatgattggt
     2941 gctccacctg ctcctcctct tcagagtccg acaatgaggg ctacttccta ggagaaccca
     3001 tcccccagcc agcccgccta cgatatgtca caagtgatga gctcctgcac aagtacagct
     3061 cttacggtgt ccccaaatcc tccaccttag gtggcagagg acagttgcac agcaggaaaa
     3121 gacagaagag caaaaactgt atcatttcgt aatgtgatgg tggttgggga atcggggaga
     3181 tgggagctaa gaatgtaaac tcagaaacgt gcactgttgt gaattctcaa gtgctcttgg
     3241 ggatggttca tggaggagag atggagaatg ctctcagttg agggaggcaa ggctgcaggt
     3301 tgacttggta gatacacttg gtgtcacagt ttgggacgtg ttaaatatga tttgcacatt
     3361 tcactttgga aacacaggct gtggaggcca gggtaggtca tgtcctttcc aaggtggagt
     3421 ggccattaac cagatgacac actgtaacct gctcacttat attctttctg gttctcttcc
     3481 ttttaggatc ccttttccag taaatacttt attagccagg accccagact aagttattta
     3541 catgttcatt gtaaatgcaa tgtaaatgag agttctgata aaatattttt gtattttgta
     3601 ataacaacag aatttctata tcgtaggatt cagtggggac ttgcatgcct gtccaccagt
     3661 accttcgagt gatagtaaac ggtggcccag gaccacctgg tgtttgttgt ttgttttgat
     3721 ttggtttggt tttctttcta tacaaatctg ttacatgtca gtgagactgt tttcaaagga
     3781 gtatattcaa tttggctttt tgtggctgaa aaagaaaatt ttaactatcc tacccaaggc
     3841 attctatgct ctagttcatc taaaggtccg tctttaagtt cactcccacc ctcagtagaa
     3901 tttattctct acaaagtaag tagggttttt ttttctttta aatttttttt ttattgcaaa
     3961 tgtcgctttt gctgattaga tgacaaccag tgtcagtcca gttctgtgag aaatgccatc
     4021 cttgtttgga accttgaagt tgcttaatgt cgatctgtcc ctcaggggta gtcgcagtga
     4081 ctgtgagcgg tgccggtgta tgtgtcagca tggccttgtt ttgagtgtgg aactgtttgg
     4141 tgctcatgtt tcctggattg tattttctgc tttcttcttc caaggcagac ggagctgctg
     4201 ccttagcctg acaactgttt gtcctcatag caaatgagcg tcaacgttta gcactgaggg
     4261 acaagaagat gctggggtgg ggaggggctc tgggtgcact gggttggtgc acattataca
     4321 aggggatttg aaaactaaaa gcaggtagat gctgaaaggg ggaatatgaa ggaaagtcag
     4381 ggagaaagaa cttttaggaa gaaatagagg tgacagtcac cttgactagt ccccagtgct
     4441 ttagagagaa tccaatctga caagcttagt caccacaggg gccggcttct taccctggag
     4501 ggtcaagctg ctgagatgat aggtaacaac atggaaaaac agaccttgtg gcaagagaga
     4561 tttccatttt gaactttgag gactgttggt cagacagaaa ggctcaagag taagtttgct
     4621 taaagaagac atttcattgc aggtgagata aatatatagt gaaaaaaaaa aaaccttctt
     4681 gcctcgcttc agtttttaaa aaaaaaaaaa aatgaagccc ttgctcttgg tccattttct
     4741 ccctctcctc agtggattgt ggcaaaaatc catcggagga cccacctttt gtgagatgtg
     4801 ctgtcccctt atgcacagtg tgtctcagtg gccatttgcc gtgatggcga gcatggtctc
     4861 ttttcagtat agtacttaac attttctagg gttttttttt taatggagag aatgggaaga
     4921 gtggcttttc agacaccatg ctaaatgggt ctggggtcga gggaggctgt aaaggatatg
     4981 gtgatgatac cccatccagg atgtattaaa atgatttgct ttataggtat taataccaca
     5041 tttgtcattg tcactgactt tttttttaaa gaagcaatgc aaatgttggt tgtggctgtt
     5101 ttccgcatgc tatcttcata tctaagtgtt tcattaatta tccaagcctc tggagaatta
     5161 actctattac gtttgtacag taagttaata aagctgcttg acaaactgtt taagagataa
     5221 atatgcagca ccgtgccact cgggtggcag gtttctggta gacattgggt gagtccaatt
     5281 tggagcattg agtctgttga ttggtgagaa ttagaaaggc gctattggga aaagaaaaga
     5341 ggggagcgta gatcacttag caaatggttg aaaccatgta tcctctctgg ccccaaatcc
     5401 aacgaacaaa atttccccac tggaagtcgt tttctcactc tgtccttggc agagtacctc
     5461 ttacgtttcc cagatatgtt tttgaccagc cctcagccca aagaagaaag caatatagaa
     5521 actgcttaag ttacatcgag tctagctgtc cagagaacat tcaagctctt tctaaccaaa
     5581 acttaaaata taatgagata caggcttcag ggtcaaacgg tccaccagca agatcatccc
     5641 cttctgtcga accactgaag attgcttccc attctaaaag cagccaggtg ccctacagag
     5701 aatgtcacct gaggaaggcc aggtcctcac aatggtagta ggtccttaaa gctactgccc
     5761 atgttgtgac agtaaactag aatttctcta ccttgaagta acaacttaag agatttaaca
     5821 cccggaatct cattcccaaa attcaagtgc attcttttct gaggtgagaa tttagggtcc
     5881 tccctgattc ttctagtata tcccttacct gctaccagcc aagtttccct gaggagtcag
     5941 gcctgtactc agttccccta ggtcgttgtt ttatcttctg cagactggct ttcagaagag
     6001 ccatctttct cccctttctc gtctctgatg atttggctat tttttcccat ctctcctctt
     6061 attgggctga cttctattta gaactacagc tctagagttc agttcgtgtc acactgctgc
     6121 cagatccagc accagctaag ccagccccct tctccgggcc aaggagcgtg tacatcattg
     6181 aaagtttctg agtgcacatc ccacctttgg tcctgcaaaa agggttcatg ctgaagtgcg
     6241 gtagcttcca gcatccatcg tggccttcag agacccgccc ttctgtcctg tgtagttcta
     6301 gattctctac catgagtgtg aaggtcaatg gggtgaggaa aatcggacct catttcctgg
     6361 tttttaacat acctaaagga gaattgctgg tgttggttgt ttgaaaccct catttaccgt
     6421 ctaagcagct gtctgaacag attggagttt tctaatagga aaagtcacag tcttttccta
     6481 cagaaggctc cccctacaga gctgtaggaa gatggcgttc tgtgcgcccc ttctaggagt
     6541 tcctacttcc tatgacctag ttggccatct ttcatcaggt ggagccatgg tggcatgaat
     6601 gtagcacttt ctatgtgtgc tctacctgcc accttagtgg atgacaagca gtggattact
     6661 gcactttcca aggagagcag actctcatcc caggtatctt cacaaaactc caacaagcca
     6721 gggctgattg actagagccg gtctcctctg tcttatgaca gatcttattc ataagctgac
     6781 tctttcctga ttccctggga aaggagtaca ccagacatat aggaagcatc caaaaccaag
     6841 aattgggaga cccccccatt ccttcccaca ctgtggaagc tacaggaagc tgacctctta
     6901 ggccaaacaa ggctcccttt ggcctacttc ttcgtgctca gggtctttgc cagttatgtg
     6961 agcagctcct gctcactttg cagaagtcag ctaagagtct gttttctcat cccagtccat
     7021 attagaggga cacaggacac ttaaattcca aagcagagtg ttctctgcat tcgcctaaca
     7081 gagaccagac gctgtgcctc acaaagatcc acctatgacc aagggaaata gaaaactgag
     7141 ccagtggcct gaatgtcgca tgcaaacaga gttgttcctg gcccctgcct ggcaccttca
     7201 ggcagatcct gttccacagg cttctattac tgatctagaa ggcagttgca cattatcacc
     7261 ttttggaaag tacatttctt tgagcataca ggaaatagga atgagacctt tgccttcttg
     7321 tcagtggttc accccagagt atgtgtgtac gaccatccag acgccaagaa ggtcaggatg
     7381 gaggaagaat tgatttattt ttctgttttc tcatattaga agcccagtca acacaacacc
     7441 cctatagagc acgactatcg gaagctatta ctctgatata aatttatttc ctgcttccaa
     7501 aaccagcctc cctcagagga ataaaaagga ggttggaagg tcatgtgcta ttaacagaca
     7561 tctctgtggt tcagatgtga taaactcaca agatagatgt ctagttctat ctcgagcaat
     7621 ttctaagaaa accttcatgg tctaggcatt tggccatggg ggttcaatag gtcaccaacc
     7681 aaatgtttct aaattttggg aggttacttg ccaatatgac cgcttcttgt gtttatctag
     7741 ttggttccca tagttttcaa taaagtattc tggtttaatc ctgaccctga gctaacaaca
     7801 taagaccagt gactctcctg tagtcttcag caaagtaggc cagcatttat tctccctaaa
     7861 ctcgtttgtt cctgcagagt tgctttgctc agatcctatt taattccaca tgcataaaca
     7921 aaacctcaga gggcccaaga aggcgaagca ggctggagtc tgtgttatct gtcaagtgtc
     7981 aagctgtttg ttaagaaggc ctgtcacggg cttttggcgt gggatctgcc agagactgtt
     8041 ctgaactctt tgcttgagat ccgtgccctg taaagtggat atgatgtttt actgattctg
     8101 gaatacattt gtaaacttcc aataaaattt gaataaaa
//
