LOCUS       NM_199396               4485 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Rattus norvegicus prickle planar cell polarity protein 1
            (Prickle1), transcript variant 4, mRNA.
ACCESSION   NM_199396 XM_001057421 XM_001057488 XM_001075319 XM_235609
VERSION     NM_199396.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4485)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   2  (bases 1 to 4485)
  AUTHORS   Paemka,L., Mahajan,V.B., Skeie,J.M., Sowers,L.P., Ehaideb,S.N.,
            Gonzalez-Alegre,P., Sasaoka,T., Tao,H., Miyagi,A., Ueno,N.,
            Takao,K., Miyakawa,T., Wu,S., Darbro,B.W., Ferguson,P.J.,
            Pieper,A.A., Britt,J.K., Wemmie,J.A., Rudd,D.S., Wassink,T.,
            El-Shanti,H., Mefford,H.C., Carvill,G.L., Manak,J.R. and
            Bassuk,A.G.
  TITLE     PRICKLE1 interaction with SYNAPSIN I reveals a role in autism
            spectrum disorders
  JOURNAL   PLoS One 8 (12), e80737 (2013)
   PUBMED   24312498
  REMARK    GeneRIF: these findings suggest PRICKLE1 mutations contribute to
            ASD by disrupting the interaction with SYN1 and regulation of
            synaptic vesicles.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4485)
  AUTHORS   Tao,H., Inoue,K., Kiyonari,H., Bassuk,A.G., Axelrod,J.D.,
            Sasaki,H., Aizawa,S. and Ueno,N.
  TITLE     Nuclear localization of Prickle2 is required to establish cell
            polarity during early mouse embryogenesis
  JOURNAL   Dev Biol 364 (2), 138-148 (2012)
   PUBMED   22333836
REFERENCE   4  (bases 1 to 4485)
  AUTHORS   Bosoi,C.M., Capra,V., Allache,R., Trinh,V.Q., De Marco,P.,
            Merello,E., Drapeau,P., Bassuk,A.G. and Kibar,Z.
  TITLE     Identification and characterization of novel rare mutations in the
            planar cell polarity gene PRICKLE1 in human neural tube defects
  JOURNAL   Hum Mutat 32 (12), 1371-1375 (2011)
   PUBMED   21901791
REFERENCE   5  (bases 1 to 4485)
  AUTHORS   McClelland,S., Flynn,C., Dube,C., Richichi,C., Zha,Q., Ghestem,A.,
            Esclapez,M., Bernard,C. and Baram,T.Z.
  TITLE     Neuron-restrictive silencer factor-mediated
            hyperpolarization-activated cyclic nucleotide gated channelopathy
            in experimental temporal lobe epilepsy
  JOURNAL   Ann Neurol 70 (3), 454-464 (2011)
   PUBMED   21905079
REFERENCE   6  (bases 1 to 4485)
  AUTHORS   Kuratomi,S., Kuratomi,A., Kuwahara,K., Ishii,T.M., Nakao,K.,
            Saito,Y. and Takano,M.
  TITLE     NRSF regulates the developmental and hypertrophic changes of HCN4
            transcription in rat cardiac myocytes
  JOURNAL   Biochem Biophys Res Commun 353 (1), 67-73 (2007)
   PUBMED   17173866
  REMARK    GeneRIF: We conclude that the NRSE-NRSF system was implicated in
            HCN4 expression in cardiac myocytes.
REFERENCE   7  (bases 1 to 4485)
  AUTHORS   Jones,C. and Chen,P.
  TITLE     Planar cell polarity signaling in vertebrates
  JOURNAL   Bioessays 29 (2), 120-132 (2007)
   PUBMED   17226800
  REMARK    Review article
REFERENCE   8  (bases 1 to 4485)
  AUTHORS   Chan,D.W., Chan,C.Y., Yam,J.W., Ching,Y.P. and Ng,I.O.
  TITLE     Prickle-1 negatively regulates Wnt/beta-catenin pathway by
            promoting Dishevelled ubiquitination/degradation in liver cancer
  JOURNAL   Gastroenterology 131 (4), 1218-1227 (2006)
   PUBMED   17030191
REFERENCE   9  (bases 1 to 4485)
  AUTHORS   Shimojo,M. and Hersh,L.B.
  TITLE     Characterization of the REST/NRSF-interacting LIM domain protein
            (RILP): localization and interaction with REST/NRSF
  JOURNAL   J Neurochem 96 (4), 1130-1138 (2006)
   PUBMED   16417580
REFERENCE   10 (bases 1 to 4485)
  AUTHORS   Shimojo,M. and Hersh,L.B.
  TITLE     REST/NRSF-interacting LIM domain protein, a putative nuclear
            translocation receptor
  JOURNAL   Mol Cell Biol 23 (24), 9025-9031 (2003)
   PUBMED   14645515
  REMARK    GeneRIF: appears to serve as a nuclear receptor for REST/NRSF,
            REST4, and possibly other transcription factors
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH474027.1.
            
            On or before Oct 24, 2008 this sequence version replaced
            XM_001057488.1, XM_001057421.1, XM_235609.4, XM_001075319.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132264, SAMD00132268
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4485
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q35"
     gene            1..4485
                     /gene="Prickle1"
                     /gene_synonym="Rilp"
                     /note="prickle planar cell polarity protein 1"
                     /db_xref="GeneID:315259"
                     /db_xref="RGD:735090"
     exon            1..573
                     /gene="Prickle1"
                     /gene_synonym="Rilp"
                     /inference="alignment:Splign:2.1.0"
     exon            574..760
                     /gene="Prickle1"
                     /gene_synonym="Rilp"
                     /inference="alignment:Splign:2.1.0"
     CDS             629..3124
                     /gene="Prickle1"
                     /gene_synonym="Rilp"
                     /note="REST/NRSF-interacting LIM domain protein 1;
                     prickle-like 1; prickle homolog 1"
                     /codon_start=1
                     /product="prickle-like protein 1"
                     /protein_id="NP_955428.1"
                     /db_xref="GeneID:315259"
                     /db_xref="RGD:735090"
                     /translation="MPLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQ
                     IQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSA
                     QRKKEALGRGTIKLLSRAMMHAVCEQCGLQMNGGEVAVFASRAGPGVCWHPSCFVCFT
                     CNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCC
                     LECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATE
                     ACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDIHASDSSDSAFQSARSRDSRRSV
                     RMGRSSRSADQCRQSLLLSPALNYKFPGLSGSADDTLSRKLDDVSLSGQGAGFAHEEF
                     WKARVDQEASEDPEEWAEHEDYMTQLLLKFGDKNLFQQPPSEVDMRASEHWIPDNMVT
                     NKPEAKQNHQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELDLDHGAAG
                     YNHDQTQWYEDSLECLSDLKPEQSVRDSMDSLALSNITGASVDGESKPRPSLYSLQNF
                     EEIEAEDCEKMSNMGTLNSSMLHRSAESLKSLNSELCPEKIIPEEKPVHLPVLRRSKS
                     QSRPQQVKFSDDVIDNGSYDIEIRQPPMSERTRRRVYHFEERGSRPHHHRHRRSRKSR
                     SDNALNLVTERKYSAKDRLRLYTPDNYEKFIQSKGARELQAYMQNANLYGQYAHTTSD
                     YALQNPGMTRFLGLYGDDDDSWCSSSTSSSDSEEEGYFLGQPIPQPRPQRFTYYTDDL
                     SSPASALPTPQFNQRTTKSKKKKGHRGKNCIIS"
     exon            761..874
                     /gene="Prickle1"
                     /gene_synonym="Rilp"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1012
                     /gene="Prickle1"
                     /gene_synonym="Rilp"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1216
                     /gene="Prickle1"
                     /gene_synonym="Rilp"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1403
                     /gene="Prickle1"
                     /gene_synonym="Rilp"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..2267
                     /gene="Prickle1"
                     /gene_synonym="Rilp"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..4485
                     /gene="Prickle1"
                     /gene_synonym="Rilp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgcttttg cccccgttta ctgataaaaa caaatctccg gctctaagcc gcaggaattg
       61 cttttaaatg cgagaaagtc ttaaggggga gaattcgtat gctaatgagc ctttccaagt
      121 gagaactggg tggaacgcgc catttgctgg cattgttatg gacagcctag agatgattcg
      181 tgtattgctg tagccctgtg gggctggggg tgtaaagccc agcctagctc ctccccagcc
      241 cagcgtgtgg ggccgtgagt tcgaggctca gcaccgcccc ctcgcacact cgcgtgcacc
      301 tgcgggcggg ggaagtttac agaagcttcc aggggcgtct gcagcgcgct ggccacagtt
      361 ctgtgccacc ggggatggag tgcggcgggc ggcggagctc cggcgtctgg gtaacttttc
      421 taggaatgcc gtgctcgggc gggcccgggt ggacacctgc cagaggacgg tcagcgtgac
      481 agttcctgga aagctagcgg agcgaccgca accggcggcc ccgagccgga gccgagctgg
      541 aggtggagca cggagcggag gcgaacacaa acgccactgt ctttggatgt cctgtgactg
      601 agaagccaga gttttgaacc tcattattat gcctttggag atggagccca aaatgagcaa
      661 actggccttt gggtgccaga gaagttccac atcagacgac gattccgggt gcgccctgga
      721 agagtatgcc tgggtcccac cgggcctcag gcctgagcag atccagctct atttcgcatg
      781 cttgccagag gaaaaggttc cttacgttaa cagccctgga gagaaacacc ggattaaaca
      841 gcttttgtac cagttgccac cacacgataa cgaggtgagg tactgccagt ctttaagcga
      901 agaggagaag aaggaattgc aggtgttcag tgctcagagg aagaaagaag ctctcggaag
      961 aggaaccatt aaactcttgt ccagagcaat gatgcacgca gtgtgtgagc agtgtgggtt
     1021 gcagatgaac ggaggggagg tcgcagtgtt tgcctcccgt gcgggtcctg gagtgtgctg
     1081 gcatccatcc tgctttgtct gcttcacgtg taatgaacta ctggtcgacc tcatctattt
     1141 ctatcaggat ggaaaaatcc actgtggcag gcaccatgcc gaactgctca aacctcggtg
     1201 ctcagcctgt gacgagatca tttttgcgga cgagtgcaca gaggccgagg gccgccactg
     1261 gcacatgaag catttctgct gcctagaatg tgaaacggtc ctgggagggc agagatatat
     1321 catgaaggat ggccgcccct tctgctgcgg ctgcttcgag tctctctacg cggagtactg
     1381 cgaaacctgt ggcgagcata ttggtgtgga ccatgcccag atgacctatg acggacaaca
     1441 ttggcatgcc accgaggcct gcttttcctg tgctcaatgt aaggcctctt tgctgggatg
     1501 ccccttcctc ccaaaacaag gtcagatcta ctgctccaag acctgcagcc ttggggaaga
     1561 catccacgcc tccgattcct ctgactctgc cttccagtca gcccgatcga gagactcccg
     1621 gagaagtgtg aggatgggca gaagcagccg ctctgctgac cagtgcaggc agtctctcct
     1681 tctgtctccc gctctgaact acaagttccc gggtctttct ggcagtgctg acgacactct
     1741 ctctcggaag ctggacgacg tgagcctctc cgggcaggga gcgggctttg ctcatgagga
     1801 attctggaaa gccagagtgg atcaggaagc ctctgaagac cctgaagaat gggctgagca
     1861 cgaagattat atgacacagc tcctcctcaa gtttggtgat aaaaacctct tccagcagcc
     1921 gcccagcgag gtggacatga gagccagtga gcactggata cccgacaaca tggttacgaa
     1981 taagccggag gcaaagcaga atcaccagag ccttgcgagt aaaaagtatc agtcggatat
     2041 gtactgggcc cagtcccaag acgggctggg tgactccgcc tacggcagcc acccaggccc
     2101 tgccagcagc cgaaggctgc aagagctaga tctggaccac ggtgctgcgg ggtataacca
     2161 tgaccaaacc cagtggtatg aagactccct ggagtgcctg tctgacttga aaccagagca
     2221 gagtgtccgg gattctatgg attctctggc gttgtccaac atcacagggg catccgtgga
     2281 cggagaaagc aagccaaggc catcattata ctctctccaa aacttcgagg agatagaggc
     2341 agaagactgt gagaaaatga gcaatatggg aactctgaat tcttccatgc tgcacaggag
     2401 cgcagagtcc ttaaaaagtc tgaattcaga actgtgccca gaaaaaatta taccggagga
     2461 aaaaccagtg cacctgccgg tgctcagaag atccaagtct cagtcccgac cacagcaggt
     2521 caagttttca gatgacgtca tcgacaacgg aagctacgac atcgaaatcc ggcagcctcc
     2581 aatgagtgaa aggactcgga gacgagtgta tcactttgaa gagaggggat ccaggcctca
     2641 ccaccatcgc caccggagaa gcagaaagtc gcggtccgac aacgccctga acctggtcac
     2701 agaaaggaag tactccgcca aggacagact tcggctgtac acccccgata actatgagaa
     2761 attcatacag agtaagggcg cccgggagct ccaagcatac atgcagaatg ccaacctcta
     2821 cggccagtat gcccacacca catcggatta tgccctgcag aacccaggaa tgaccaggtt
     2881 cctggggctc tacggggacg acgatgactc ctggtgttca tcctccactt cctcctccga
     2941 ctcagaagaa gaaggctatt ttcttggaca gccaatccct cagcctcggc cacaaagatt
     3001 cacctactat acggatgacc tttctagtcc ggcttctgca ctgcccaccc cacagtttaa
     3061 tcagaggaca actaaatcca agaagaaaaa gggacacagg ggcaaaaact gtatcatttc
     3121 ttaaccaagt agacagggag attgtctaaa acttagtcat ttagcctgga ctttgacctt
     3181 gtattcgtca taggaaagtc gctaaaatag tgtaaagtgc tttcttggcc tatataaatg
     3241 agagccccac tgtgtttaca gccaggttaa cacacaaaag gggtggtttc tccagtctcg
     3301 gtgccatagt aacacagtct cgtgccccca tggcaggtca attacagtct ccagtccaca
     3361 agagaatact ccagaaactg ccggcaggtg attggacaga gcgtgtgcta gaagatggat
     3421 agccaccttt gtaagcaata gtgcttgtcg ttaattcagt caggttggct caggtcctga
     3481 ctggtgtctt gtgaggcatg cacgtgtcac catgacgacc tagctaacac tgtgtgctcc
     3541 attgtgtaag gcgaacttgt tctccttcag cccttattag ccaggtaaac atattgtatc
     3601 cctcccagct acagaccgaa aggacttgct atttatatgt agtgtttcat agacctaagt
     3661 gtattcctaa tttaacggtg caaatattga tgtatatact gtacagctca gattttaaag
     3721 ctgatatttt tatatccctg aactgcaagg tgtttgttac actgccgtgc tcgatttgct
     3781 aggaaaccag aaacagcatc catggatgag atgactgctt gtattttagt cagggcttag
     3841 aagtttagac agtcgattta tattgcttag tgatggaaag ttggtttttt tttttccttc
     3901 cttcaatatt aaaaaaaggc tctgtatgca tggtggggct atgtacatac tcggtactga
     3961 gccctgttaa tctcacaagt gttatttatg gttcaagctt tgtaaactgt ataaatgtaa
     4021 aaaacaaacc ccacacatac ctctggagta tatggtaaaa ccgaggagaa gctatgaggc
     4081 gaccttcccc gtgcaggggg gagcggtctc agcaggtggt aacgtccaca caaggggctt
     4141 tctgtggcag tctgtgtaga cttactatgt acagagaggt tatttcttct gccccttttc
     4201 cttccaactt cttgttggcc tttaaaagca attttgaaaa ctgggtttcc agttgcggtt
     4261 ttcttttgag atttttcagg aagaatgagc cggagtactc ccaagttcat gagactctgg
     4321 ttgaatggag agccatgtca gatttgaact aacgagcggg tagtttggtc tgtgctgtcc
     4381 ttgcatttac atctcggtcc taactaaagg tcctggtgtc atcctgggcc tttcagggag
     4441 gtgtttaata aaggcttaat aaatgataaa ctacctttcc gagtc
//
