LOCUS       NM_001105962            4233 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Rattus norvegicus proteoglycan 4 (Prg4), mRNA.
ACCESSION   NM_001105962 XM_001070215 XM_213903
VERSION     NM_001105962.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4233)
  AUTHORS   Zhou,W., Wang,N., Dong,S., Huan,Z., Sui,L. and Ge,X.
  TITLE     PRG4 mitigates hemorrhagic shock-induced cardiac injury by
            inhibiting mitochondrial dysregulation, oxidative stress and
            NLRP3-mediated pyroptosis
  JOURNAL   Int Immunopharmacol 137, 112507 (2024)
   PUBMED   38897120
  REMARK    GeneRIF: PRG4 mitigates hemorrhagic shock-induced cardiac injury by
            inhibiting mitochondrial dysregulation, oxidative stress and
            NLRP3-mediated pyroptosis.
REFERENCE   2  (bases 1 to 4233)
  AUTHORS   Ravalli,S., Roggio,F., Magri,B., Lauretta,G., Broggi,G.,
            Caltabiano,R., Vecchio,G.M., Magro,G., Loreto,C., Castorina,A. and
            Musumeci,G.
  TITLE     Immunohistochemical evaluation of autotaxin and lubricin in mild
            osteoarthritic rat model performing moderate physical activity
  JOURNAL   Acta Histochem 124 (6), 151936 (2022)
   PUBMED   35917632
  REMARK    GeneRIF: Immunohistochemical evaluation of autotaxin and lubricin
            in mild osteoarthritic rat model performing moderate physical
            activity.
REFERENCE   3  (bases 1 to 4233)
  AUTHORS   Solakyildirim,K., Li,Y., Bayer,A.S., Sullam,P.M., Xiong,Y.Q.,
            Lebrilla,C.B. and Bensing,B.A.
  TITLE     Proteoglycan 4 (lubricin) is a highly sialylated glycoprotein
            associated with cardiac valve damage in animal models of infective
            endocarditis
  JOURNAL   Glycobiology 31 (11), 1582-1595 (2021)
   PUBMED   34459483
  REMARK    GeneRIF: Proteoglycan 4 (lubricin) is a highly sialylated
            glycoprotein associated with cardiac valve damage in animal models
            of infective endocarditis.
REFERENCE   4  (bases 1 to 4233)
  AUTHORS   Ji,X., Ito,A., Nakahata,A., Nishitani,K., Kuroki,H. and Aoyama,T.
  TITLE     Effects of in vivo cyclic compressive loading on the distribution
            of local Col2 and superficial lubricin in rat knee cartilage
  JOURNAL   J Orthop Res 39 (3), 543-552 (2021)
   PUBMED   32716572
  REMARK    GeneRIF: Effects of in vivo cyclic compressive loading on the
            distribution of local Col2 and superficial lubricin in rat knee
            cartilage.
REFERENCE   5  (bases 1 to 4233)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   6  (bases 1 to 4233)
  AUTHORS   Novince,C.M., Koh,A.J., Michalski,M.N., Marchesan,J.T., Wang,J.,
            Jung,Y., Berry,J.E., Eber,M.R., Rosol,T.J., Taichman,R.S. and
            McCauley,L.K.
  TITLE     Proteoglycan 4, a novel immunomodulatory factor, regulates
            parathyroid hormone actions on hematopoietic cells
  JOURNAL   Am J Pathol 179 (5), 2431-2442 (2011)
   PUBMED   21939632
REFERENCE   7  (bases 1 to 4233)
  AUTHORS   Cheng,J., Wang,Y., Wang,Z., Yang,M. and Wu,Y.
  TITLE     Differential regulation of proteoglycan-4 expression by IL-1alpha
            and TGF-beta1 in rat condylar chondrocytes
  JOURNAL   Tohoku J Exp Med 222 (3), 211-218 (2010)
   PUBMED   21041994
  REMARK    GeneRIF: PRG4 is synthesized and secreted by condylar cartilage
            chondrocytes and its expression is differentially regulated by
            IL-1alpha and TGF-beta1.
REFERENCE   8  (bases 1 to 4233)
  AUTHORS   Elsaid,K.A., Machan,J.T., Waller,K., Fleming,B.C. and Jay,G.D.
  TITLE     The impact of anterior cruciate ligament injury on lubricin
            metabolism and the effect of inhibiting tumor necrosis factor alpha
            on chondroprotection in an animal model
  JOURNAL   Arthritis Rheum 60 (10), 2997-3006 (2009)
   PUBMED   19790069
  REMARK    GeneRIF: Blocking TNFalpha resulted in a chondroprotective effect,
            exemplified by increased lubricin deposition on articular cartilage
            and a decrease in sGAG release from articular cartilage in an
            animal model of posttraumatic arthritis.
REFERENCE   9  (bases 1 to 4233)
  AUTHORS   Alazami,A.M., Al-Mayouf,S.M., Wyngaard,C.A. and Meyer,B.
  TITLE     Novel PRG4 mutations underlie CACP in Saudi families
  JOURNAL   Hum Mutat 27 (2), 213 (2006)
   PUBMED   16429407
REFERENCE   10 (bases 1 to 4233)
  AUTHORS   Rhee,D.K., Marcelino,J., Baker,M., Gong,Y., Smits,P., Lefebvre,V.,
            Jay,G.D., Stewart,M., Wang,H., Warman,M.L. and Carpten,J.D.
  TITLE     The secreted glycoprotein lubricin protects cartilage surfaces and
            inhibits synovial cell overgrowth
  JOURNAL   J Clin Invest 115 (3), 622-631 (2005)
   PUBMED   15719068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Mar 11, 2021 this sequence version replaced NM_001105962.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760400, SAMEA5760475
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000013.1  65054138-65054225   c
            89-191              JAXUCZ010000013.1  65053725-65053827   c
            192-314             JAXUCZ010000013.1  65050187-65050309   c
            315-434             JAXUCZ010000013.1  65048659-65048778   c
            435-578             JAXUCZ010000013.1  65046229-65046372   c
            579-698             JAXUCZ010000013.1  65045563-65045682   c
            699-3146            JAXUCZ010000013.1  65041957-65044404   c
            3147-3224           JAXUCZ010000013.1  65041296-65041373   c
            3225-3361           JAXUCZ010000013.1  65040067-65040203   c
            3362-3518           JAXUCZ010000013.1  65039649-65039805   c
            3519-3719           JAXUCZ010000013.1  65038905-65039105   c
            3720-3845           JAXUCZ010000013.1  65038435-65038560   c
            3846-4233           JAXUCZ010000013.1  65037363-65037750   c
FEATURES             Location/Qualifiers
     source          1..4233
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..4233
                     /gene="Prg4"
                     /note="proteoglycan 4"
                     /db_xref="GeneID:289104"
                     /db_xref="RGD:1308976"
     exon            1..88
                     /gene="Prg4"
                     /inference="alignment:Splign:2.1.0"
     exon            89..191
                     /gene="Prg4"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..3943
                     /gene="Prg4"
                     /note="proteoglycan 4, (megakaryocyte stimulating factor,
                     articular superficial zone protein, camptodactyly,
                     arthropathy, coxa vara, pericarditis syndrome); lubricin"
                     /codon_start=1
                     /product="proteoglycan 4 precursor"
                     /protein_id="NP_001099432.4"
                     /db_xref="GeneID:289104"
                     /db_xref="RGD:1308976"
                     /translation="MGWKILPICLSMLLPVFLIQQVSSQDISSCAGRCGEGYSRDATC
                     NCDYNCQHYMECCPDFKRVCTTELSCKGRCFESFARGRECDCDSQCKQYGKCCADYNS
                     FCEEVHNPTSPPPKTAPPPPGASRTIKSTTKRSPKSPKKKTKKVVESEEITEEHSVSE
                     NQESSSSSSSSSSTIRKIKSSKNSANRELQKNPKVKDNKKNTPKKKPNPEPPVVDEAG
                     SGLDNGEPKLTPPPDPPTPHNKVTASPKTTAAKPVTPKPSLAPNSETSKEASSTSNKE
                     TTVETKETTETNKQSSASKKEKTTSAKETRSAENTSAKDVEPTSTTPKNSAPTTTKKP
                     VTTTKEPVPTTTKGPEPTSKEPAPTTPKEPELTIPKEPAPTTKKPAPTTPKEPAPTTP
                     KEPEPTTPKESAPTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPAPTTKKP
                     EPTTPKEPAPTTPKEPAPTTPKEPAPNTPKEPAPTTPKEPAPTTPKEPESTTPKEPAP
                     TTPKEPAPTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPAPTT
                     PKEPVPTTPKEPASTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPAPTTPKEPAPTTPK
                     EPALTTPKEPAPTPKEPEPTTPKEPAPTTPKEPAPTTPKEPAPTTKKPELTIPKEPVP
                     TTPKEPAPTTPKEPAPTTTKKPELSTPKEPTSTNPKEPEPTLPKEPELTLPEEPEPSN
                     PETSDELIAELAEAPTPKALENNPKEPTVPTETPEVSKPEMTTAKEKTTEKDTTQTTT
                     TVTPKTTTETTIIPEETTEPRASTTTRITSTAQDTTSPQMTTLKATTLAAKVTAPTEE
                     IQSKPEETTLTTPALEGSDASKTTLKPQKPTKAPKKPASTKKPTKAPKKPTSTKKPKT
                     PKGRKPKTTPSPLKTSTMSEQNTTPLEVMLPTTTVPKQTPNSETAEVNPAHEDADGGE
                     GEKPLIPRPPVLSPTAVPGTDLLVERLNPGINIHPMFSDETNICNGKPVDGLTTLRNG
                     TLVAFRGHYFWMLNPFRPPSPPRRITEVWGIPSPIDTVFTRCNCEGKTFFFKDSQYWR
                     FTNDVMDAGYPKLIVKGFGGLTGKIVAALSIAKYKDRPESVYFFKRGGNIQQYTYKQE
                     PVRKCTGRQPAINYSVYGQAAQVRRRRFERAVGPFQTHTFRIHYSVPIKASYQDKGFL
                     HNEVKVSTLWRGFPNVVTSAITLPNIRKPDGYDYYAFSKDQYYNIDVPTRTARAITTR
                     SGQTLSRVWYNCP"
     exon            192..314
                     /gene="Prg4"
                     /inference="alignment:Splign:2.1.0"
     exon            315..434
                     /gene="Prg4"
                     /inference="alignment:Splign:2.1.0"
     exon            435..578
                     /gene="Prg4"
                     /inference="alignment:Splign:2.1.0"
     exon            579..698
                     /gene="Prg4"
                     /inference="alignment:Splign:2.1.0"
     exon            699..3146
                     /gene="Prg4"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3224
                     /gene="Prg4"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3361
                     /gene="Prg4"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3518
                     /gene="Prg4"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..3719
                     /gene="Prg4"
                     /inference="alignment:Splign:2.1.0"
     exon            3720..3845
                     /gene="Prg4"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..4233
                     /gene="Prg4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggaaagaca actccaccgc tatcactaaa ctcgatttta ttgaagctgc acatttttct
       61 ctccaggaca tgatttaagc ctcgccctgc aagggcgttg catccaagaa caaccatggg
      121 gtggaaaata cttcccatct gcttgtcgat gctgcttcct gttttcctga ttcaacaagt
      181 ttcatctcaa gatatatcaa gttgtgcagg gagatgtggg gaagggtatt ctagagacgc
      241 cacctgcaac tgtgattata actgccaaca ctacatggag tgctgtcctg atttcaagag
      301 agtctgcact acagagctct cctgcaaagg acgctgcttc gagtccttcg cacgagggag
      361 ggagtgtgac tgtgactccc agtgtaaaca gtatggcaaa tgctgtgcag actacaacag
      421 cttctgcgaa gaagtgcata atcccacatc accacctcca aagactgcac ccccgcctcc
      481 aggagcgtct cgcaccatca aatcaaccac caaacgttca cccaaatcac caaaaaagaa
      541 gactaagaaa gttgtagagt ctgaggaaat aacagaagaa cattctgttt ctgaaaatca
      601 agagtcctcc tcctcctcct cttcctcctc ttcaactatt cggaaaatca agtcttccaa
      661 aaattcagct aatagagaat tacagaagaa cccaaaagta aaagataaca agaaaaacac
      721 cccgaaaaag aaacctaatc cagaaccacc agtcgtggat gaagctggaa gtggtctgga
      781 caatggtgag cccaagctta ccccacctcc tgaccctcct actccacaca acaaagtcac
      841 cgcatctccc aagactacag cggcaaaacc agtaactcct aaacccagtc ttgcacctaa
      901 ttctgagact tccaaagagg catcttcaac ttccaataaa gagacaacag ttgaaacaaa
      961 ggagaccact gaaacaaata aacagtcttc cgccagtaaa aaagagaaga ctacttcagc
     1021 taaagagaca cggagtgcag agaacacatc tgctaaagac gttgaaccca catctacaac
     1081 tcccaagaac tcagctccca ctaccaccaa gaagcctgta actacaacca aggaacctgt
     1141 tcctaccact accaaggggc ctgaacccac ctccaaggag ccagctccca ccacccctaa
     1201 ggagcctgaa ctcaccattc ccaaagaacc agctcccacc accaagaagc cagctcccac
     1261 cacccccaag gagccagctc ccaccacccc caaggagcct gaacccacca cccctaagga
     1321 gtcagctccc accaccccta aggagccagc tcccaccacc cctaaggagc cagctcctac
     1381 cacccccaag gagccagctc ccaccacccc taaggagcca gctcccacca cccccaagga
     1441 gccagctccc accaccaaga agcctgaacc caccacacct aaggagccag ctcccaccac
     1501 ccccaaggag ccagctccca ccacccccaa ggagccagct cccaataccc ctaaggagcc
     1561 agctcccacc acccccaagg agccagctcc caccacccct aaggagcctg aatccaccac
     1621 ccccaaggaa ccagctccca ccacccccaa ggagccagct cccaccaccc ccaaggagcc
     1681 agctcccacc acccctaagg agcctgctcc cactacccct aaggagccag ctcccaccac
     1741 ccccaaggag cctgctccta ctacccctaa ggagccagct cccaccaccc ctaaggagcc
     1801 agctcccacc acccccaagg agccagttcc caccaccccc aaggagccag cttccactac
     1861 ccccaaggag ccagctccca ctacccccaa ggagccagct cccactaccc ccaaggagcc
     1921 agctcccacc acccccaagg agcctgctcc cactacccct aaggagccag ctcccaccac
     1981 ccccaaggag ccagctctta ctacccctaa ggagccagct cccaccccca aagagcctga
     2041 acccaccacc cctaaggagc cagctcccac cacccctaag gagccagctc ccaccacccc
     2101 taaggagcca gctcccacca ccaagaagcc tgaactcacc atccccaagg agccagttcc
     2161 taccaccccc aaagaaccag ctcctaccac tcccaaagag cctgcaccca ccaccaccaa
     2221 gaagcctgaa ctcagcaccc ctaaggagcc cacatctact aaccccaagg aacctgaacc
     2281 caccctcccc aaggagcctg aactcaccct ccccgaggag cctgaaccca gcaaccccga
     2341 gacatccgat gaattaatag ctgagcttgc tgaggcaccc acaccaaagg ctcttgaaaa
     2401 taatcccaag gaacccactg taccaactga gactcctgag gtaagcaagc ctgaaatgac
     2461 aactgctaaa gagaagacaa cagaaaaaga cacaacccaa actacaacaa cagtaacccc
     2521 taagacaaca acagagacaa caatcatacc ggaagagact actgaaccaa gagcaagtac
     2581 caccactcga ataacgtcta cagctcaaga taccacatca ccccaaatga ctactctgaa
     2641 agctacaact cttgcagcca aagtaactgc tccaacagaa gagattcaga gcaaaccaga
     2701 agaaacaact ttaacaactc ctgcattgga aggttctgat gcttctaaga caaccctaaa
     2761 acctcagaaa ccaaccaaag cgcccaagaa gcccgcctct accaaaaagc caaccaaagc
     2821 gcccaagaag cccacctcta ccaaaaagcc aaagacacca aaagggagaa aaccaaaaac
     2881 cacaccatct cctcttaaga cttcaacaat gtctgaacag aataccactc ctctagaagt
     2941 catgctgcca accaccaccg tccctaaaca aactccaaac tctgaaacag ctgaagtgaa
     3001 tccagctcat gaagatgcag atggaggtga aggagaaaaa cctctgattc ccaggccccc
     3061 tgtgctatcc cccactgctg ttccaggaac cgatctcttg gttgagagac tcaatccagg
     3121 cattaacatc catcccatgt tttcagatga gaccaatata tgcaatggta agccagtgga
     3181 tggactgacc actctgcgca acgggacgtt agttgcattt cgaggtcatt atttctggat
     3241 gctgaaccca ttcagaccac catctccacc acgcagaatc actgaagtct ggggtattcc
     3301 ctctcccatt gacacggttt ttactagatg taactgtgaa ggaaaaactt tcttctttaa
     3361 ggattctcag tactggcgct ttaccaacga tgtaatggat gctgggtatc ctaaactaat
     3421 tgtcaaaggc tttggaggac taacagggaa gatagtggct gctctttcaa tagccaagta
     3481 caaggacaga cctgaatctg tgtacttctt caagagaggt ggcaacatcc agcagtacac
     3541 ttacaaacag gagcccgtga ggaagtgcac agggaggcag cctgccatca actactcagt
     3601 gtatgggcag gcagcacagg tcaggaggcg ccgctttgag cgtgctgttg gacctttcca
     3661 gacacacacc ttcaggatcc attactcggt gcccatcaaa gcctcttatc aagacaaagg
     3721 cttcctccac aatgaagtca aagtgagcac actgtggaga gggttcccaa atgtcgttac
     3781 ttccgcgata acactgccca acattagaaa acctgacggc tatgattact acgccttttc
     3841 caaagatcaa tactataaca tcgatgtgcc tactagaaca gcaagagcaa tcaccacgcg
     3901 ctcagggcag accctctcca gagtctggta caactgtcct taacctgact ggcaaagaag
     3961 aatgaaatga aatgaagaaa acagtgatac cttttgacat tgaaatacat tttattaata
     4021 aagaatgttg aaatgagcat acctatttaa atacaaaaca cttctcaact tgacaattat
     4081 attaaaacag attcgccaat cttattcaca agtgtcacag ttcatagatc ccttaattaa
     4141 tattccctct atttattcct cctcttcctc ccattgcatg gcttatacct gtagaaggaa
     4201 ataataaaat tcatgttcag aagaaatatc taa
//
