LOCUS       NP_001099432            1275 aa            linear   ROD 12-AUG-2024
DEFINITION  proteoglycan 4 precursor [Rattus norvegicus].
ACCESSION   NP_001099432 XP_001070215 XP_213903
VERSION     NP_001099432.4
DBSOURCE    REFSEQ: accession NM_001105962.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1275)
  AUTHORS   Zhou,W., Wang,N., Dong,S., Huan,Z., Sui,L. and Ge,X.
  TITLE     PRG4 mitigates hemorrhagic shock-induced cardiac injury by
            inhibiting mitochondrial dysregulation, oxidative stress and
            NLRP3-mediated pyroptosis
  JOURNAL   Int Immunopharmacol 137, 112507 (2024)
   PUBMED   38897120
  REMARK    GeneRIF: PRG4 mitigates hemorrhagic shock-induced cardiac injury by
            inhibiting mitochondrial dysregulation, oxidative stress and
            NLRP3-mediated pyroptosis.
REFERENCE   2  (residues 1 to 1275)
  AUTHORS   Ravalli,S., Roggio,F., Magri,B., Lauretta,G., Broggi,G.,
            Caltabiano,R., Vecchio,G.M., Magro,G., Loreto,C., Castorina,A. and
            Musumeci,G.
  TITLE     Immunohistochemical evaluation of autotaxin and lubricin in mild
            osteoarthritic rat model performing moderate physical activity
  JOURNAL   Acta Histochem 124 (6), 151936 (2022)
   PUBMED   35917632
  REMARK    GeneRIF: Immunohistochemical evaluation of autotaxin and lubricin
            in mild osteoarthritic rat model performing moderate physical
            activity.
REFERENCE   3  (residues 1 to 1275)
  AUTHORS   Solakyildirim,K., Li,Y., Bayer,A.S., Sullam,P.M., Xiong,Y.Q.,
            Lebrilla,C.B. and Bensing,B.A.
  TITLE     Proteoglycan 4 (lubricin) is a highly sialylated glycoprotein
            associated with cardiac valve damage in animal models of infective
            endocarditis
  JOURNAL   Glycobiology 31 (11), 1582-1595 (2021)
   PUBMED   34459483
  REMARK    GeneRIF: Proteoglycan 4 (lubricin) is a highly sialylated
            glycoprotein associated with cardiac valve damage in animal models
            of infective endocarditis.
REFERENCE   4  (residues 1 to 1275)
  AUTHORS   Ji,X., Ito,A., Nakahata,A., Nishitani,K., Kuroki,H. and Aoyama,T.
  TITLE     Effects of in vivo cyclic compressive loading on the distribution
            of local Col2 and superficial lubricin in rat knee cartilage
  JOURNAL   J Orthop Res 39 (3), 543-552 (2021)
   PUBMED   32716572
  REMARK    GeneRIF: Effects of in vivo cyclic compressive loading on the
            distribution of local Col2 and superficial lubricin in rat knee
            cartilage.
REFERENCE   5  (residues 1 to 1275)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   6  (residues 1 to 1275)
  AUTHORS   Novince,C.M., Koh,A.J., Michalski,M.N., Marchesan,J.T., Wang,J.,
            Jung,Y., Berry,J.E., Eber,M.R., Rosol,T.J., Taichman,R.S. and
            McCauley,L.K.
  TITLE     Proteoglycan 4, a novel immunomodulatory factor, regulates
            parathyroid hormone actions on hematopoietic cells
  JOURNAL   Am J Pathol 179 (5), 2431-2442 (2011)
   PUBMED   21939632
REFERENCE   7  (residues 1 to 1275)
  AUTHORS   Cheng,J., Wang,Y., Wang,Z., Yang,M. and Wu,Y.
  TITLE     Differential regulation of proteoglycan-4 expression by IL-1alpha
            and TGF-beta1 in rat condylar chondrocytes
  JOURNAL   Tohoku J Exp Med 222 (3), 211-218 (2010)
   PUBMED   21041994
  REMARK    GeneRIF: PRG4 is synthesized and secreted by condylar cartilage
            chondrocytes and its expression is differentially regulated by
            IL-1alpha and TGF-beta1.
REFERENCE   8  (residues 1 to 1275)
  AUTHORS   Elsaid,K.A., Machan,J.T., Waller,K., Fleming,B.C. and Jay,G.D.
  TITLE     The impact of anterior cruciate ligament injury on lubricin
            metabolism and the effect of inhibiting tumor necrosis factor alpha
            on chondroprotection in an animal model
  JOURNAL   Arthritis Rheum 60 (10), 2997-3006 (2009)
   PUBMED   19790069
  REMARK    GeneRIF: Blocking TNFalpha resulted in a chondroprotective effect,
            exemplified by increased lubricin deposition on articular cartilage
            and a decrease in sGAG release from articular cartilage in an
            animal model of posttraumatic arthritis.
REFERENCE   9  (residues 1 to 1275)
  AUTHORS   Alazami,A.M., Al-Mayouf,S.M., Wyngaard,C.A. and Meyer,B.
  TITLE     Novel PRG4 mutations underlie CACP in Saudi families
  JOURNAL   Hum Mutat 27 (2), 213 (2006)
   PUBMED   16429407
REFERENCE   10 (residues 1 to 1275)
  AUTHORS   Rhee,D.K., Marcelino,J., Baker,M., Gong,Y., Smits,P., Lefebvre,V.,
            Jay,G.D., Stewart,M., Wang,H., Warman,M.L. and Carpten,J.D.
  TITLE     The secreted glycoprotein lubricin protects cartilage surfaces and
            inhibits synovial cell overgrowth
  JOURNAL   J Clin Invest 115 (3), 622-631 (2005)
   PUBMED   15719068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Mar 11, 2021 this sequence version replaced NP_001099432.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760400, SAMEA5760475
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1275
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     Protein         1..1275
                     /product="proteoglycan 4 precursor"
                     /note="proteoglycan 4, (megakaryocyte stimulating factor,
                     articular superficial zone protein, camptodactyly,
                     arthropathy, coxa vara, pericarditis syndrome); lubricin"
                     /calculated_mol_wt=135337
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2717
     Region          26..68
                     /region_name="SO"
                     /note="Somatomedin B -like domains; smart00201"
                     /db_xref="CDD:197571"
     Region          69..106
                     /region_name="Somatomedin_B"
                     /note="Somatomedin B domain; pfam01033"
                     /db_xref="CDD:460034"
     Region          <315..724
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1013..1274
                     /region_name="HX"
                     /note="Hemopexin-like repeats.; Hemopexin is a
                     heme-binding protein that transports heme to the liver.
                     Hemopexin-like repeats occur in vitronectin and some
                     matrix metalloproteinases family (matrixins). The HX
                     repeats of some matrixins bind tissue inhibitor of...;
                     cd00094"
                     /db_xref="CDD:238046"
     Site            order(1022,1024,1066,1068,1114,1116,1222,1224)
                     /site_type="metal-binding"
                     /note="Metal binding sites [ion binding]"
                     /db_xref="CDD:238046"
     CDS             1..1275
                     /gene="Prg4"
                     /coded_by="NM_001105962.4:116..3943"
                     /db_xref="GeneID:289104"
                     /db_xref="RGD:1308976"
ORIGIN      
        1 mgwkilpicl smllpvfliq qvssqdissc agrcgegysr datcncdync qhymeccpdf
       61 krvcttelsc kgrcfesfar grecdcdsqc kqygkccady nsfceevhnp tspppktapp
      121 ppgasrtiks ttkrspkspk kktkkvvese eiteehsvse nqesssssss ssstirkiks
      181 sknsanrelq knpkvkdnkk ntpkkkpnpe ppvvdeagsg ldngepkltp ppdpptphnk
      241 vtaspkttaa kpvtpkpsla pnsetskeas stsnkettve tkettetnkq ssaskkektt
      301 saketrsaen tsakdvepts ttpknsaptt tkkpvtttke pvptttkgpe ptskepaptt
      361 pkepeltipk epapttkkpa pttpkepapt tpkepepttp kesapttpke papttpkepa
      421 pttpkepapt tpkepapttp kepapttkkp epttpkepap ttpkepaptt pkepapntpk
      481 epapttpkep apttpkepes ttpkepaptt pkepapttpk epapttpkep apttpkepap
      541 ttpkepaptt pkepapttpk epapttpkep vpttpkepas ttpkepaptt pkepapttpk
      601 epapttpkep apttpkepap ttpkepaltt pkepaptpke pepttpkepa pttpkepapt
      661 tpkepapttk kpeltipkep vpttpkepap ttpkepaptt tkkpelstpk eptstnpkep
      721 eptlpkepel tlpeepepsn petsdeliae laeaptpkal ennpkeptvp tetpevskpe
      781 mttakektte kdttqttttv tpktttetti ipeettepra stttritsta qdttspqmtt
      841 lkattlaakv tapteeiqsk peettlttpa legsdasktt lkpqkptkap kkpastkkpt
      901 kapkkptstk kpktpkgrkp kttpsplkts tmseqnttpl evmlptttvp kqtpnsetae
      961 vnpahedadg gegekplipr ppvlsptavp gtdllverln pginihpmfs detnicngkp
     1021 vdglttlrng tlvafrghyf wmlnpfrpps pprritevwg ipspidtvft rcncegktff
     1081 fkdsqywrft ndvmdagypk livkgfgglt gkivaalsia kykdrpesvy ffkrggniqq
     1141 ytykqepvrk ctgrqpainy svygqaaqvr rrrferavgp fqthtfrihy svpikasyqd
     1201 kgflhnevkv stlwrgfpnv vtsaitlpni rkpdgydyya fskdqyynid vptrtarait
     1261 trsgqtlsrv wyncp
//
