LOCUS       NM_031619                858 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus proteoglycan 2, pro eosinophil major basic
            protein (Prg2), mRNA.
ACCESSION   NM_031619
VERSION     NM_031619.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 858)
  AUTHORS   Juiz,N.A., Torrejon,I., Burgos,M., Torres,A.M.F., Duffy,T.,
            Cayo,N.M., Tabasco,A., Salvo,M., Longhi,S.A. and Schijman,A.G.
  TITLE     Alterations in Placental Gene Expression of Pregnant Women with
            Chronic Chagas Disease
  JOURNAL   Am J Pathol 188 (6), 1345-1353 (2018)
   PUBMED   29545200
REFERENCE   2  (bases 1 to 858)
  AUTHORS   Seebauer,C.T., Brunner,S., Glockzin,G., Piso,P., Ruemmele,P.,
            Schlitt,H.J., Geissler,E.K., Fichtner-Feigl,S. and Kesselring,R.
  TITLE     Peritoneal carcinomatosis of colorectal cancer is characterized by
            structural and functional reorganization of the tumor
            microenvironment inducing senescence and proliferation arrest in
            cancer cells
  JOURNAL   Oncoimmunology 5 (12), e1242543 (2016)
   PUBMED   28439450
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 858)
  AUTHORS   Schwantes,E.A., Manthei,D.M., Denlinger,L.C., Evans,M.D.,
            Gern,J.E., Jarjour,N.N. and Mathur,S.K.
  TITLE     Interferon gene expression in sputum cells correlates with the
            Asthma Index Score during virus-induced exacerbations
  JOURNAL   Clin Exp Allergy 44 (6), 813-821 (2014)
   PUBMED   24450586
REFERENCE   4  (bases 1 to 858)
  AUTHORS   Cadman,E.T., Thysse,K.A., Bearder,S., Cheung,A.Y., Johnston,A.C.,
            Lee,J.J. and Lawrence,R.A.
  TITLE     Eosinophils are important for protection, immunoregulation and
            pathology during infection with nematode microfilariae
  JOURNAL   PLoS Pathog 10 (3), e1003988 (2014)
   PUBMED   24626328
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 858)
  AUTHORS   Kim,C.K., Callaway,Z., Kim,D.W. and Kita,H.
  TITLE     Eosinophil degranulation is more important than eosinophilia in
            identifying asthma in chronic cough
  JOURNAL   J Asthma 48 (10), 994-1000 (2011)
   PUBMED   22022864
REFERENCE   6  (bases 1 to 858)
  AUTHORS   Specht,S., Saeftel,M., Arndt,M., Endl,E., Dubben,B., Lee,N.A.,
            Lee,J.J. and Hoerauf,A.
  TITLE     Lack of eosinophil peroxidase or major basic protein impairs
            defense against murine filarial infection
  JOURNAL   Infect Immun 74 (9), 5236-5243 (2006)
   PUBMED   16926417
REFERENCE   7  (bases 1 to 858)
  AUTHORS   Swaminathan,G.J., Weaver,A.J., Loegering,D.A., Checkel,J.L.,
            Leonidas,D.D., Gleich,G.J. and Acharya,K.R.
  TITLE     Crystal structure of the eosinophil major basic protein at 1.8 A.
            An atypical lectin with a paradigm shift in specificity
  JOURNAL   J Biol Chem 276 (28), 26197-26203 (2001)
   PUBMED   11319227
REFERENCE   8  (bases 1 to 858)
  AUTHORS   Denzler,K.L., Farmer,S.C., Crosby,J.R., Borchers,M., Cieslewicz,G.,
            Larson,K.A., Cormier-Regard,S., Lee,N.A. and Lee,J.J.
  TITLE     Eosinophil major basic protein-1 does not contribute to
            allergen-induced airway pathologies in mouse models of asthma
  JOURNAL   J Immunol 165 (10), 5509-5517 (2000)
   PUBMED   11067904
REFERENCE   9  (bases 1 to 858)
  AUTHORS   Nittoh,T., Watanabe,M., Okoyama,H., Misawa,S., Isobe,Y.,
            Hayashi,H., Mue,S. and Ohuchi,K.
  TITLE     Corrigendum to 'Cloning of cDNA for rat eosinophil major basic
            protein' [Biochim. Biophys. Acta 1264 (1995) 261-264]
  JOURNAL   Biochim Biophys Acta 1306 (1), 115-116 (1996)
   PUBMED   8611616
REFERENCE   10 (bases 1 to 858)
  AUTHORS   Nittoh,T., Watanabe,M., Okayama,H., Misawa,S., Isobe,Y.,
            Hayashi,H., Mue,S. and Ohuchi,K.
  TITLE     Cloning of cDNA for rat eosinophil major basic protein
  JOURNAL   Biochim Biophys Acta 1264 (3), 261-264 (1995)
   PUBMED   8547309
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D50568.1, CB703061.1 and CA509460.1.
            
            On Jun 13, 2010 this sequence version replaced NM_031619.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D50568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                D50568.1           1-38
            39-376              CB703061.1         34-371
            377-838             D50568.1           377-838
            839-858             CA509460.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..858
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..858
                     /gene="Prg2"
                     /note="proteoglycan 2, pro eosinophil major basic protein"
                     /db_xref="GeneID:58826"
                     /db_xref="RGD:69336"
     exon            1..27
                     /gene="Prg2"
                     /inference="alignment:Splign:2.1.0"
     exon            28..102
                     /gene="Prg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..728
                     /gene="Prg2"
                     /note="bone marrow proteoglycan; BMPG; eosinophil major
                     basic protein; proteoglycan 2, bone marrow"
                     /codon_start=1
                     /product="bone marrow proteoglycan precursor"
                     /protein_id="NP_113807.2"
                     /db_xref="GeneID:58826"
                     /db_xref="RGD:69336"
                     /translation="MKFPLLLALLVGGAFALHLSSEASDSKSPLVDESLPREAEISRP
                     EVEECPPGEQLMSLEEEEEEEEEEGSGSEGALGNEGAVSGQDVTDENLQCPKEEDTTS
                     LMGDSGFKTGRYLLVRRPECFNKAQLVCRSCYRGTLASIHSFSVNFRIQSFVRGINQG
                     QVWIGGRIVGWGRCKRFRWIDGSSWNFAYWAAGQPRRGGGRCVTLCTRGGHWRRSGCG
                     KRRPFICAY"
     exon            103..425
                     /gene="Prg2"
                     /inference="alignment:Splign:2.1.0"
     exon            426..557
                     /gene="Prg2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..669
                     /gene="Prg2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..843
                     /gene="Prg2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      819..824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prg2"
     polyA_site      843
                     /gene="Prg2"
ORIGIN      
        1 cagacttgac aagacccagg agggcctgtc ctcatcaagc caagatgaaa ttccctctac
       61 ttctggctct tctagtcggg ggagcatttg ctcttcatct aagctctgaa gcttctgact
      121 ccaaaagccc actggtggat gagagcttgc ctcgggaagc agagatatca agaccggaag
      181 tagaagaatg ccctcctggg gaacagctaa tgtccctgga ggaggaggag gaggaagagg
      241 aggaagaagg ttctggaagt gaaggtgctc ttggaaatga aggagctgtc tcaggtcagg
      301 atgtgacaga tgagaacctt cagtgcccca aggaggaaga cacaacgagt ctgatgggtg
      361 actctggatt caagaccggt cgctacctcc tagtcaggag gcctgagtgc tttaacaaag
      421 ctcagttggt ctgccggagc tgctaccggg gcacccttgc ctccatccac agtttcagtg
      481 ttaacttccg aatccagtcc tttgtcaggg gaatcaacca gggtcaagtc tggattggag
      541 gcaggattgt gggctggggt cgctgcaaac gcttccgatg gattgatgga agctcttgga
      601 attttgcata ctgggctgct gggcagcctc gtcgcggcgg tggcagatgt gtgaccctgt
      661 gtacccgagg aggccactgg cgccgatctg gctgtggcaa gagacgcccc ttcatctgtg
      721 catattaagc tggtcccagc tgggagttca aattcatcct ctcctgggta gctgcctctt
      781 ctttcctgcg agatgtccct cgtctttcac caccctaaaa taaagccgct ttacttaaac
      841 agaaaaaaaa aaaaaaaa
//
