LOCUS       NM_017330               1964 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus perforin 1 (Prf1), mRNA.
ACCESSION   NM_017330
VERSION     NM_017330.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1964)
  AUTHORS   Cosgrove,C., Berger,C.T., Kroy,D.C., Cheney,P.C., Ghebremichael,M.,
            Aneja,J., Tomlinson,M., Kim,A.Y., Lauer,G.M. and Alter,G.
  TITLE     Chronic HCV infection affects the NK cell phenotype in the blood
            more than in the liver
  JOURNAL   PLoS One 9 (8), e105950 (2014)
   PUBMED   25148254
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1964)
  AUTHORS   Zhang,C., Yan,M.Y., Lu,P., Chen,P., Yang,M., Ye,X.W., Xu,M.,
            Yang,Z.H. and Zhang,X.Y.
  TITLE     Hypomethylation of perforin regulatory elements in CD4+ T cells
            from rat spleens contributes to the development of autoimmune
            emphysema
  JOURNAL   Respirology 19 (3), 376-381 (2014)
   PUBMED   24506670
  REMARK    GeneRIF: Hypomethylation of perforin regulatory elements in CD4+ T
            cells may result in the lung septal cell apoptosis associated with
            the development of experimental autoimmune emphysema
REFERENCE   3  (bases 1 to 1964)
  AUTHORS   Traore,D.A., Brennan,A.J., Law,R.H., Dogovski,C., Perugini,M.A.,
            Lukoyanova,N., Leung,E.W., Norton,R.S., Lopez,J.A., Browne,K.A.,
            Yagita,H., Lloyd,G.J., Ciccone,A., Verschoor,S., Trapani,J.A.,
            Whisstock,J.C. and Voskoboinik,I.
  TITLE     Defining the interaction of perforin with calcium and the
            phospholipid membrane
  JOURNAL   Biochem J 456 (3), 323-335 (2013)
   PUBMED   24070258
  REMARK    GeneRIF: Defining the interaction of perforin with calcium and the
            phospholipid membrane.
REFERENCE   4  (bases 1 to 1964)
  AUTHORS   Zhu,M., Yuan,H., Guo,W., Li,X., Jin,L., Brunk,U.T., Han,J., Zhao,M.
            and Lu,Y.
  TITLE     Dietary mustard seeds (Sinapis alba Linn) suppress
            1,2-dimethylhydrazine-induced immuno-imbalance and colonic
            carcinogenesis in rats
  JOURNAL   Nutr Cancer 64 (3), 464-472 (2012)
   PUBMED   22420317
REFERENCE   5  (bases 1 to 1964)
  AUTHORS   Kremer,M., Suezer,Y., Volz,A., Frenz,T., Majzoub,M.,
            Hanschmann,K.M., Lehmann,M.H., Kalinke,U. and Sutter,G.
  TITLE     Critical role of perforin-dependent CD8+ T cell immunity for rapid
            protective vaccination in a murine model for human smallpox
  JOURNAL   PLoS Pathog 8 (3), e1002557 (2012)
   PUBMED   22396645
REFERENCE   6  (bases 1 to 1964)
  AUTHORS   Goransdotter Ericson,K., Fadeel,B., Nilsson-Ardnor,S.,
            Soderhall,C., Samuelsson,A., Janka,G., Schneider,M., Gurgey,A.,
            Yalman,N., Revesz,T., Egeler,R., Jahnukainen,K.,
            Storm-Mathiesen,I., Haraldsson,A., Poole,J., de Saint Basile,G.,
            Nordenskjold,M. and Henter,J.
  TITLE     Spectrum of perforin gene mutations in familial hemophagocytic
            lymphohistiocytosis
  JOURNAL   Am J Hum Genet 68 (3), 590-597 (2001)
   PUBMED   11179007
REFERENCE   7  (bases 1 to 1964)
  AUTHORS   Ikezumi,Y., Kawachi,H., Toyabe,S., Uchiyama,M. and Shimizu,F.
  TITLE     An anti-CD5 monoclonal antibody ameliorates proteinuria and
            glomerular lesions in rat mesangioproliferative glomerulonephritis
  JOURNAL   Kidney Int 58 (1), 100-114 (2000)
   PUBMED   10886554
REFERENCE   8  (bases 1 to 1964)
  AUTHORS   Stenger,S., Hanson,D.A., Teitelbaum,R., Dewan,P., Niazi,K.R.,
            Froelich,C.J., Ganz,T., Thoma-Uszynski,S., Melian,A., Bogdan,C.,
            Porcelli,S.A., Bloom,B.R., Krensky,A.M. and Modlin,R.L.
  TITLE     An antimicrobial activity of cytolytic T cells mediated by
            granulysin
  JOURNAL   Science 282 (5386), 121-125 (1998)
   PUBMED   9756476
REFERENCE   9  (bases 1 to 1964)
  AUTHORS   Kagi,D., Ledermann,B., Burki,K., Seiler,P., Odermatt,B.,
            Olsen,K.J., Podack,E.R., Zinkernagel,R.M. and Hengartner,H.
  TITLE     Cytotoxicity mediated by T cells and natural killer cells is
            greatly impaired in perforin-deficient mice
  JOURNAL   Nature 369 (6475), 31-37 (1994)
   PUBMED   8164737
REFERENCE   10 (bases 1 to 1964)
  AUTHORS   Ishikawa,H., Shinkai,Y., Yagita,H., Yue,C.C., Henkart,P.A.,
            Sawada,S., Young,H.A., Reynolds,C.W. and Okumura,K.
  TITLE     Molecular cloning of rat cytolysin
  JOURNAL   J Immunol 143 (9), 3069-3073 (1989)
   PUBMED   2809217
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089808.1.
            
            On Feb 13, 2005 this sequence version replaced NM_017330.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089808.1, CO572485.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1964
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..1964
                     /gene="Prf1"
                     /gene_synonym="Cyta; RATCYTA"
                     /note="perforin 1"
                     /db_xref="GeneID:50669"
                     /db_xref="RGD:708463"
     exon            1..16
                     /gene="Prf1"
                     /gene_synonym="Cyta; RATCYTA"
                     /inference="alignment:Splign:2.1.0"
     exon            17..588
                     /gene="Prf1"
                     /gene_synonym="Cyta; RATCYTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1717
                     /gene="Prf1"
                     /gene_synonym="Cyta; RATCYTA"
                     /note="cytolysin; P1; lymphocyte pore-forming protein;
                     perforin 1 (pore forming protein)"
                     /codon_start=1
                     /product="perforin-1 precursor"
                     /protein_id="NP_059026.2"
                     /db_xref="GeneID:50669"
                     /db_xref="RGD:708463"
                     /translation="MAAYLFLLGLFLLLPRPVPAPCYTATRSECKQKHKFVPGVWAAG
                     EGVDVTTLRRSSSFPVNTGKFLRPDRTCTLCKNALMNDAIQRLPVAIAHWRPHGSHCQ
                     RNVATTKVSSTEGVAREAAANINNDWRAGLDVNPKPEANVHVSVAGSHSKIANFAAEK
                     AHQDQYNFNTDTVECRMYSFRLAQKPPLHPDFRKALKNLPHNFNSSTEHAYRRLISSY
                     GTHFITAVDLGGRVSVLTALRTCQLTLDGLTADEVGDCLSVEAQVSIGAQASVSSEYK
                     ACEEKKKQHKIATSFHQTYRERHVEVLGGPLDSSNDLLFGNQATPEHFSTWIASLPTR
                     PDVVDYSLEPLHILLEDSDPKREALRQAISHYVMSRARWRDCNRPCRAGQHKSSRDSC
                     QCVCQDSKVTNQDCCPRQRGLAKLMVRNFQAKGLWGDYITSTDAYLKVFFGGQEIRTG
                     VVWNNNHPSWSDKMDFGNVLLSTGGPLRVQVWDADNGWDDDLLGTCDKSPKSGFHEVN
                     CPLNHGSIKFIYQANCLPHLTGETCLEYAPQGLLGDPPGNRSGAVW"
     exon            589..1943
                     /gene="Prf1"
                     /gene_synonym="Cyta; RATCYTA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgtggga cttcagcttt ctggagttta tgactactgt gcccgcagca tcatggccgc
       61 gtacctgttc ctcctgggcc ttttcctgct gctgccacga cctgtccctg ctccctgcta
      121 cactgccact cggtcagaat gcaagcagaa gcacaaattc gtgcctggtg tgtgggcggc
      181 tggggaaggt gtggatgtga ccaccctccg ccgctccagc tccttcccag tgaacacagg
      241 gaagttcctg aggcctgacc gcacctgcac cctctgtaaa aacgccctga tgaatgacgc
      301 tatacagcgc ctacccgtgg caatcgccca ctggcggcct cacggctcac actgccagcg
      361 taatgtggcc acaaccaagg tcagctccac ggagggtgtg gcgcgggagg cggctgctaa
      421 tatcaataac gactggcgtg cggggctgga tgtgaaccct aaaccggaag caaacgtgca
      481 tgtgtccgtg gctggctccc attccaagat agccaatttt gcagccgaga aggcccatca
      541 ggaccaatac aactttaata ctgacacagt ggagtgtcgc atgtacagtt ttcgcctggc
      601 acaaaagcct ccactccacc ctgacttcag aaaggcactc aagaaccttc cccacaactt
      661 taacagctcc acagagcatg cttaccgtag actcatctct tcctatggga ctcattttat
      721 tacggctgtg gacctaggtg gccgcgtctc ggtcctcacg gctctgcgta cctgtcagct
      781 gaccctggat gggctcacag ctgatgaggt aggagactgc ttgagcgtgg aagcccaggt
      841 cagcatcggt gcccaagcca gtgtctcaag cgaatacaaa gcttgcgagg agaagaagaa
      901 acaacacaaa atcgccacct ctttccacca gacctaccgt gagcgtcatg tcgaagtgct
      961 cggtggcccc cttgactcct cgaatgacct gctcttcggg aaccaagcta cccctgagca
     1021 cttctctacc tggatagcct cattgcccac caggcctgat gtggtggact acagcctgga
     1081 gcccctgcac atactactgg aagactcgga cccgaagcga gaggcactga gacaggctat
     1141 cagccattat gtgatgagca gggctcgctg gcgagactgt aaccggccct gcagggcagg
     1201 ccagcataag agtagtcgtg attcatgcca gtgtgtgtgc caggattcga aggtcaccaa
     1261 ccaggactgc tgcccacgcc agaggggctt ggccaagttg atggtaagga atttccaggc
     1321 caagggtctg tggggggact acatcacatc tacggatgct tatctgaagg tcttctttgg
     1381 tggccaggag atcaggaccg gtgtagtgtg gaacaataac catccctcgt ggagtgacaa
     1441 gatggacttt gggaatgtgc tcctgtccac agggggaccc ctcagggtgc aggtctggga
     1501 tgctgacaat ggctgggatg atgaccttct tggtacttgt gacaagtctc ccaagtctgg
     1561 tttccatgag gtgaattgtc ccctgaacca cggcagtata aaattcatct accaggccaa
     1621 ttgcttgccc catctcactg gagagacctg cctggagtat gccccccagg ggcttctagg
     1681 agatccacca ggaaaccgca gtggggctgt gtggtaaaaa caaacaaaaa agacataaaa
     1741 aacaaaaaaa aaaaaacaaa acaaaaaaca aaacaaaaca aaaaaaccca aaaaacaaac
     1801 aaaaaccatg cctgagagtt gggtgtagta gcacatgcct tcaatcccag cttttgggag
     1861 gcaaacacag gtggagctct aggagttcga ggccagcctg gtctacatag tgagacctat
     1921 ctcaataaaa gcaaacaaca aaaaaaaaaa aaaaaaaaaa aaaa
//
