LOCUS       NP_001380724            1598 aa            linear   ROD 30-MAR-2024
DEFINITION  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2
            protein [Rattus norvegicus].
ACCESSION   NP_001380724 XP_006237815
VERSION     NP_001380724.1
DBSOURCE    REFSEQ: accession NM_001393795.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1598)
  AUTHORS   Feng,F., Wu,X., Shi,X., Gao,Q., Wu,Y., Yu,Y., Cheng,Q., Li,B.,
            Yi,B., Liu,C., Hao,Q., Zhang,L., Gao,C. and Jiang,X.
  TITLE     Comprehensive analysis of genomic alterations of Chinese hilar
            cholangiocarcinoma patients
  JOURNAL   Int J Clin Oncol 26 (4), 717-727 (2021)
   PUBMED   33387086
REFERENCE   2  (residues 1 to 1598)
  AUTHORS   Liu,L., Zeng,P., Yang,S. and Yuan,Z.
  TITLE     Leveraging methylation to identify the potential causal genes
            associated with survival in lung adenocarcinoma and lung squamous
            cell carcinoma
  JOURNAL   Oncol Lett 20 (1), 193-200 (2020)
   PUBMED   32537022
REFERENCE   3  (residues 1 to 1598)
  AUTHORS   Liao,Z., Zheng,Q., Wei,T., Zhang,Y., Ma,J., Zhao,Z., Sun,H. and
            Nan,K.
  TITLE     MicroRNA-561 Affects Proliferation and Cell Cycle Transition
            Through PTEN/AKT Signaling Pathway by Targeting P-REX2a in NSCLC
  JOURNAL   Oncol Res 28 (2), 147-159 (2020)
   PUBMED   31711559
REFERENCE   4  (residues 1 to 1598)
  AUTHORS   Yu,J., Ou,Z., Lei,Y., Chen,L., Su,Q. and Zhang,K.
  TITLE     LncRNA MYCNOS facilitates proliferation and invasion in
            hepatocellular carcinoma by regulating miR-340
  JOURNAL   Hum Cell 33 (1), 148-158 (2020)
   PUBMED   31776854
REFERENCE   5  (residues 1 to 1598)
  AUTHORS   Li,C.H., Yen,C.H., Chen,Y.F., Lee,K.J., Fang,C.C., Zhang,X.,
            Lai,C.C., Huang,S.F., Lin,H.K. and Arthur Chen,Y.M.
  TITLE     Characterization of the GNMT-HectH9-PREX2 tripartite relationship
            in the pathogenesis of hepatocellular carcinoma
  JOURNAL   Int J Cancer 140 (10), 2284-2297 (2017)
   PUBMED   28205209
REFERENCE   6  (residues 1 to 1598)
  AUTHORS   Liao,Z., Wang,X., Zeng,Y. and Zou,Q.
  TITLE     Identification of DEP domain-containing proteins by a machine
            learning method and experimental analysis of their expression in
            human HCC tissues
  JOURNAL   Sci Rep 6, 39655 (2016)
   PUBMED   28000796
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 1598)
  AUTHORS   Lan,X., Xiao,F., Ding,Q., Liu,J., Liu,J., Li,J., Zhang,J. and
            Tian,D.A.
  TITLE     The effect of CXCL9 on the invasion ability of hepatocellular
            carcinoma through up-regulation of PREX2
  JOURNAL   J Mol Histol 45 (6), 689-696 (2014)
   PUBMED   25151370
REFERENCE   8  (residues 1 to 1598)
  AUTHORS   Hodakoski,C., Hopkins,B.D., Barrows,D., Mense,S.M., Keniry,M.,
            Anderson,K.E., Kern,P.A., Hawkins,P.T., Stephens,L.R. and
            Parsons,R.
  TITLE     Regulation of PTEN inhibition by the pleckstrin homology domain of
            P-REX2 during insulin signaling and glucose homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 111 (1), 155-160 (2014)
   PUBMED   24367090
REFERENCE   9  (residues 1 to 1598)
  AUTHORS   Donald,S., Humby,T., Fyfe,I., Segonds-Pichon,A., Walker,S.A.,
            Andrews,S.R., Coadwell,W.J., Emson,P., Wilkinson,L.S. and
            Welch,H.C.
  TITLE     P-Rex2 regulates Purkinje cell dendrite morphology and motor
            coordination
  JOURNAL   Proc Natl Acad Sci U S A 105 (11), 4483-4488 (2008)
   PUBMED   18334636
REFERENCE   10 (residues 1 to 1598)
  AUTHORS   Donald,S., Hill,K., Lecureuil,C., Barnouin,R., Krugmann,S., John
            Coadwell,W., Andrews,S.R., Walker,S.A., Hawkins,P.T., Stephens,L.R.
            and Welch,H.C.
  TITLE     P-Rex2, a new guanine-nucleotide exchange factor for Rac
  JOURNAL   FEBS Lett 572 (1-3), 172-176 (2004)
   PUBMED   15304343
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 11, 2021 this sequence version replaced XP_006237815.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.26122.1,
                                           SRR26643289.14634.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1598
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     Protein         1..1598
                     /product="phosphatidylinositol
                     3,4,5-trisphosphate-dependent Rac exchanger 2 protein"
                     /note="DEP domain containing 2"
                     /calculated_mol_wt=181606
     Region          19..204
                     /region_name="RhoGEF"
                     /note="RhoGEF domain; pfam00621"
                     /db_xref="CDD:459876"
     Region          210..356
                     /region_name="PH_Collybistin_ASEF"
                     /note="Collybistin/APC-stimulated guanine nucleotide
                     exchange factor pleckstrin homology (PH) domain; cd01224"
                     /db_xref="CDD:269931"
     Region          374..454
                     /region_name="DEP_1_P-Rex"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1
                     found in P-Rex-like proteins. The P-Rex family is the
                     guanine-nucleotide exchange factor (GEF) for the small
                     GTPase Rac that contains an N-terminal RhoGEF domain, two
                     DEP and PDZ domains. Rac-GEF...; cd04439"
                     /db_xref="CDD:239886"
     Region          466..558
                     /region_name="DEP_2_P-Rex"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2
                     found in P-Rex-like proteins. The P-Rex family is the
                     guanine-nucleotide exchange factor (GEF) for the small
                     GTPase Rac that contains an N-terminal RhoGEF domain, two
                     DEP and PDZ domains. Rac-GEF...; cd04440"
                     /db_xref="CDD:239887"
     Region          587..>636
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Region          668..743
                     /region_name="PDZ_RGS12-like"
                     /note="PDZ domain of regulator of G-protein signaling 12
                     (RGS12), and related domains; cd06710"
                     /db_xref="CDD:467194"
     Site            order(678..684,692,695,724,728,731..732)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467194"
     CDS             1..1598
                     /gene="Prex2"
                     /gene_synonym="Depdc2"
                     /coded_by="NM_001393795.1:457..5253"
                     /db_xref="GeneID:312912"
                     /db_xref="RGD:1307865"
ORIGIN      
        1 msdesardad kqlrlrvcvl selqkterdy vgtleflvsa flhrmnqcaa akldknvtee
       61 tvkmlfsnie eilavhkefl kvveeclhpe pnaqqevgtc flnfkdkfri ydeycsnhek
      121 aqklllelnk irtirtflln cmllggrknt dvplegylvt piqrickypl llkellkrtp
      181 rkhsdytavm ealqamkavc snineakrqm eklevleewq ahiegwegsn itdtctemlm
      241 cgvlmkissg niqervfflf dnllvyckrk hrrlknskas tdghryvfrg rintevmeve
      301 nvddgtadfh ssghivvngw kihntaknkw fvcmakspee khewfeailk ererrkglkl
      361 gmeqdtwvmi seqgeklykm mckqgnlikd rkrklttfpk cflgsefvsw lleigeihrp
      421 eegvhlgqal lengiihhvt dkhqfkpeqm lyrfryddgt fyprsemqdv iskgvrlycr
      481 lhslftpvvr dkdyhlrtyk svvmanklid wliaqgdcrt reeamifavg lcdngfmhhv
      541 leksefkdep llfrffadee megsnmkhrl mkhdlkvven viakslliks negsygfgle
      601 dknkvpiikl vekgsnaema gmevgkkifa ingdlvflrp fpevdcflks clnsrkplrv
      661 lvstkpretv kipdsadglg fqirgfgpsv vhavgrgtva aaaglhpgqc iikvnginvs
      721 kethasviah vtacrkykrp mkqdsiqwvy dslesaqedi qkshskppgd eagdvfdckv
      781 edvmdkfntl aiidgkkehv sltvdnvhle ygvvyeydst agtkcnvvek mvepkgffsl
      841 takilealak sdehfvqnct slnslnevia tdlqskftsm cservehvch rissygrfsr
      901 vlknrawptf kqakakmspl hssdfcptnc hvnvmevsyp kasaslgsaf gvqldsrkhn
      961 shdkenrsad pgklspmvyi qhtittmaap sglslghkdg hglryllkee dletqdiyhk
     1021 llgklqtalk evemcvcqid dllssitysp klerktteyv iptdsdnekg ernskrvcfn
     1081 vagdeqedsg hdtvsnrdsy sdcnsnrnsi asftsicssq cssyfhsdem dsgdelptsi
     1141 rishdkqdki htcleqlfiq ldsitnllkg ravvrafeqt kyltpgrglq efqqemeakl
     1201 scprrlrlhl kqdpwnlpsg vralaqsfrk yveevkcril lalleysdse tqlrrdmvfc
     1261 qslvatvcaf seqlmaalnq mfdnskenem etweasrrwl dqianagvlf hfqsllspnl
     1321 kdeqamledt lvalfdlekv sfffkpseee plvanvplty qvegsrqalk vvfymdsyhf
     1381 eqlpqrlkng ggfkihpvlf sqalesmegy cyrdnisvee fqaqintasl ekvkqynqkl
     1441 rafyldksns ppnatskaay ieklmrplna ldelyrlvts firskriaac vntpcsasgv
     1501 gllsvsselc drlgachiim cssgvhrctl svtleqaitl arshglppry imqatdvmrk
     1561 qgarvqntak nlgvrdrtpq saprlyklce ppppvgde
//
