LOCUS       NM_001135718            5438 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus
            phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange
            factor 1 (Prex1), mRNA.
ACCESSION   NM_001135718 XM_230873
VERSION     NM_001135718.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5438)
  AUTHORS   Thamilselvan,V., Gamage,S., Harajli,A., Chundru,S.A. and Kowluru,A.
  TITLE     P-Rex1 Mediates Glucose-Stimulated Rac1 Activation and Insulin
            Secretion in Pancreatic beta-Cells
  JOURNAL   Cell Physiol Biochem 54 (6), 1218-1230 (2020)
   PUBMED   33347743
  REMARK    GeneRIF: P-Rex1 Mediates Glucose-Stimulated Rac1 Activation and
            Insulin Secretion in Pancreatic beta-Cells.
REFERENCE   2  (bases 1 to 5438)
  AUTHORS   Satoh,T.
  TITLE     Rho GTPases in insulin-stimulated glucose uptake
  JOURNAL   Small GTPases 5, e28102 (2014)
   PUBMED   24613967
  REMARK    Review article
REFERENCE   3  (bases 1 to 5438)
  AUTHORS   Lawson,C.D., Donald,S., Anderson,K.E., Patton,D.T. and Welch,H.C.
  TITLE     P-Rex1 and Vav1 cooperate in the regulation of
            formyl-methionyl-leucyl-phenylalanine-dependent neutrophil
            responses
  JOURNAL   J Immunol 186 (3), 1467-1476 (2011)
   PUBMED   21178006
REFERENCE   4  (bases 1 to 5438)
  AUTHORS   Schneider,M.R., Dahlhoff,M., Horst,D., Hirschi,B., Trulzsch,K.,
            Muller-Hocker,J., Vogelmann,R., Allgauer,M., Gerhard,M.,
            Steininger,S., Wolf,E. and Kolligs,F.T.
  TITLE     A key role for E-cadherin in intestinal homeostasis and Paneth cell
            maturation
  JOURNAL   PLoS One 5 (12), e14325 (2010)
   PUBMED   21179475
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5438)
  AUTHORS   Qin,J., Xie,Y., Wang,B., Hoshino,M., Wolff,D.W., Zhao,J.,
            Scofield,M.A., Dowd,F.J., Lin,M.F. and Tu,Y.
  TITLE     Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes
            prostate cancer metastasis
  JOURNAL   Oncogene 28 (16), 1853-1863 (2009)
   PUBMED   19305425
REFERENCE   6  (bases 1 to 5438)
  AUTHORS   Waters,J.E., Astle,M.V., Ooms,L.M., Balamatsias,D., Gurung,R. and
            Mitchell,C.A.
  TITLE     P-Rex1 - a multidomain protein that regulates neurite
            differentiation
  JOURNAL   J Cell Sci 121 (Pt 17), 2892-2903 (2008)
   PUBMED   18697831
  REMARK    GeneRIF: This study has identified P-Rex1 as a Rac3-guanine
            nucleotide exchange factor in neuronal cells that localises to, and
            regulates, actin cytoskeletal dynamics at the axonal growth cone to
            in turn regulate neurite differentiation.
REFERENCE   7  (bases 1 to 5438)
  AUTHORS   Yoshizawa,M., Kawauchi,T., Sone,M., Nishimura,Y.V., Terao,M.,
            Chihama,K., Nabeshima,Y. and Hoshino,M.
  TITLE     Involvement of a Rac activator,P-Rex1, in neurotrophin-derived
            signaling and neuronal migration
  JOURNAL   J Neurosci 25 (17), 4406-4419 (2005)
   PUBMED   15858067
REFERENCE   8  (bases 1 to 5438)
  AUTHORS   Welch,H.C., Coadwell,W.J., Ellson,C.D., Ferguson,G.J.,
            Andrews,S.R., Erdjument-Bromage,H., Tempst,P., Hawkins,P.T. and
            Stephens,L.R.
  TITLE     P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated
            guanine-nucleotide exchange factor for Rac
  JOURNAL   Cell 108 (6), 809-821 (2002)
   PUBMED   11955434
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Feb 3, 2021 this sequence version replaced NM_001135718.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.15742.1,
                                           SRR26643297.14407.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               JAXUCZ010000003.1  175875456-175875764 c
            310-381             JAXUCZ010000003.1  175809486-175809557 c
            382-504             JAXUCZ010000003.1  175807185-175807307 c
            505-609             JAXUCZ010000003.1  175799938-175800042 c
            610-711             JAXUCZ010000003.1  175795396-175795497 c
            712-873             JAXUCZ010000003.1  175783436-175783597 c
            874-1007            JAXUCZ010000003.1  175780228-175780361 c
            1008-1126           JAXUCZ010000003.1  175774858-175774976 c
            1127-1276           JAXUCZ010000003.1  175773317-175773466 c
            1277-1424           JAXUCZ010000003.1  175771397-175771544 c
            1425-1525           JAXUCZ010000003.1  175762042-175762142 c
            1526-1629           JAXUCZ010000003.1  175760948-175761051 c
            1630-1679           JAXUCZ010000003.1  175760794-175760843 c
            1680-1755           JAXUCZ010000003.1  175758926-175759001 c
            1756-1828           JAXUCZ010000003.1  175755634-175755706 c
            1829-1971           JAXUCZ010000003.1  175753081-175753223 c
            1972-2064           JAXUCZ010000003.1  175751682-175751774 c
            2065-2213           JAXUCZ010000003.1  175751093-175751241 c
            2214-2299           JAXUCZ010000003.1  175749452-175749537 c
            2300-2436           JAXUCZ010000003.1  175748516-175748652 c
            2437-2533           JAXUCZ010000003.1  175747951-175748047 c
            2534-2721           JAXUCZ010000003.1  175745988-175746175 c
            2722-2883           JAXUCZ010000003.1  175745467-175745628 c
            2884-3094           JAXUCZ010000003.1  175744678-175744888 c
            3095-3371           JAXUCZ010000003.1  175744010-175744286 c
            3372-3578           JAXUCZ010000003.1  175741570-175741776 c
            3579-3667           JAXUCZ010000003.1  175740407-175740495 c
            3668-3750           JAXUCZ010000003.1  175738703-175738785 c
            3751-3841           JAXUCZ010000003.1  175738499-175738589 c
            3842-3970           JAXUCZ010000003.1  175735743-175735871 c
            3971-4012           JAXUCZ010000003.1  175734296-175734337 c
            4013-4233           JAXUCZ010000003.1  175733172-175733392 c
            4234-4333           JAXUCZ010000003.1  175731798-175731897 c
            4334-4477           JAXUCZ010000003.1  175730946-175731089 c
            4478-4592           JAXUCZ010000003.1  175730741-175730855 c
            4593-4659           JAXUCZ010000003.1  175729367-175729433 c
            4660-4832           JAXUCZ010000003.1  175728167-175728339 c
            4833-4935           JAXUCZ010000003.1  175727846-175727948 c
            4936-5003           JAXUCZ010000003.1  175727561-175727628 c
            5004-5438           JAXUCZ010000003.1  175726012-175726446 c
FEATURES             Location/Qualifiers
     source          1..5438
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..5438
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /note="phosphatidylinositol-3,4,5-trisphosphate-dependent
                     Rac exchange factor 1"
                     /db_xref="GeneID:311647"
                     /db_xref="RGD:1306534"
     exon            1..309
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..5046
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /codon_start=1
                     /product="phosphatidylinositol
                     3,4,5-trisphosphate-dependent Rac exchanger 1 protein"
                     /protein_id="NP_001129190.1"
                     /db_xref="GeneID:311647"
                     /db_xref="RGD:1306534"
                     /translation="MEAPGSGSGDGGGDPGGDGAHPDARGPSSGPCAAARDSERQLRL
                     RLCVLNEILATERDYVGTLRFLQSAFLQRIRQNVADSVDKGLTEENVKILFSNIEDIL
                     EVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKV
                     PAARAFLLNCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELSKRTPGKHPDHSAV
                     QSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKI
                     SAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVE
                     NVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDALIREREQRESL
                     KLGMERDAYVMIAEKGEKLYHMMMSKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIG
                     EISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSK
                     GVRLYCRLHSLYAPVIKDRDYHLKTYKSVVPGSKLVDWLLAQGDCQTREEAVALGVGL
                     CNNGFMHHVLEKSEFKDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLIP
                     PQEDDYGFDLEEKNKAVVVKSVQRGSLAEMAGLQAGRKIYSINEDLVFLRPFSEVETI
                     LNQSFCSRRPLRLLVATKAKETIKIPDHPEALSFQIRGTAPPCVFAVGRGSEAVAAGL
                     CAGQCILKVNGNSVANDGALEVLEHFQAFRSRREEALGLYQWVYHSHEDAQQARASQG
                     APDEDPQEDDSVLPLLSLGPQLSLHEDSAVVSLTLDNVHLEHGVVYEYVSTAGAKCHV
                     LEKIVEPRGCFRLAAKILEAFAEDDSLFVQNCGRLMAMGSAIITMSHYEFHNICDTKL
                     ESIGQRIACYQEFAAQLKSRVSPPFKQAPLEDHPLCGLDFCPTNCHINFMEVSYPKTT
                     PSVGRSFSIRFGRKPSLIGLDPEQGHLNPMAYTQHCITTMAAPSWKCAPAVDGDSQSQ
                     GLIDSIFVSASGALSQQERGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQIN
                     RLLSTITEPTSAAPCDPPLVEETSSSPPASEESEVDRTDHGGIKKVCFKVSEDEQEDS
                     GHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDETGSGDELPCDIRIPSDKQDK
                     LHGCLEHLFNQVDSIHALLKGPVMSRAFEETRHFPMEHSWQEFKQKEECTVRGRNLIQ
                     ISIQEDPWNLPSSIRTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAVFCQALVA
                     AVCTFSEQLLAALDYRYNNNGEYEESSRDASRKWLEQVAATGVLLHWQSLLAPATVKE
                     ERTMLEDIWVTLSELDNVTFSFKQLDENSVANTNVFYHIEGSRQALKVVFYLDGFHFS
                     RLPSRLEGGASLRLHTVLFTKALENVEGPSPPGSQAAEDLQQEINAQSLEKVQQYYRR
                     LRAFYLERSNLPTDATTTAVKIDQLIRPINALDELYRLMKSFVHPKAGAGGSLGAGLV
                     PVSSELCYRLGACQITMCGTGMQRSTLSVSLEQAAILARSHGLLPKCVMQATDIMRKQ
                     GPRVEILAKNLRIKDPMPQGAPRLYRLCQPPVDGDL"
     exon            310..381
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            382..504
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            505..609
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            610..711
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            712..873
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1007
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1126
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1276
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1424
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1525
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1629
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1679
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1755
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1828
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1971
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2064
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2213
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2299
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2436
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2533
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2721
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2883
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3094
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3371
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            3372..3578
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3667
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3750
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            3751..3841
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            3842..3970
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            3971..4012
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            4013..4233
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            4234..4333
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            4334..4477
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            4478..4592
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            4593..4659
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            4660..4832
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            4833..4935
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            4936..5003
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
     exon            5004..5438
                     /gene="Prex1"
                     /gene_synonym="RGD1306534"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccgcctgcc ccgggcccgc tgagcggcgc ctgtccggga tgcggagccc ggacgcctga
       61 gccgcggcgc gacctcggcg cgggaagttc gggcgccgcg cggcgatgga ggcgcccggc
      121 agcggtagtg gcgatggcgg cggggaccca ggcggggacg gtgcgcatcc cgatgctcgc
      181 ggtcccagct ccgggccatg cgcggccgcc cgcgactcgg agcgccagct gcgcctccgt
      241 ctgtgcgtac tcaacgagat cctggccacc gagcgcgact acgtgggcac cttgcgtttc
      301 ctgcagtcgg cgttcctaca gcggatccgg cagaatgtgg ccgactctgt ggacaagggc
      361 ctcacggaag agaatgtcaa gatcctcttc tccaacattg aggacatctt ggaggtccat
      421 aaggattttt tggctgccct ggaatactgc ctacatccgg agccccagtc tcagcacgaa
      481 cttgggaatg ttttcttgaa atttaaggac aagttctgtg tgtatgagga gtactgcagt
      541 aaccacgaga aggccctgcg tctgttggtg gagctcaaca aggtccctgc cgctcgcgcc
      601 ttcctcctga actgcatgct tctgggaggc cggaagacca cggacatccc tctggagggc
      661 tacctgctgt cccccatcca gaggatctgc aagtacccac tcctgctcaa ggagttatct
      721 aagaggaccc cgggcaaaca ccctgaccat tccgcggtac agagcgccct gcaagccatg
      781 aagaccgtct gctccaacat caatgagacc aagaggcaga tggagaagct ggaggccctg
      841 gagcagctgc agtctcacat cgaaggctgg gagggctcga acctcacaga catctgcacc
      901 cagcttctcc ttcagggcac tctgctgaag atctctgcag gcaacatcca agagagagcc
      961 ttcttcctct tcgacaactt gctcgtctac tgcaagcgga aatctagggt cactgggagc
     1021 aagaaatcta ccaagaggac caagtccatc aacggctccc tgtacatctt caggggtcgg
     1081 atcaacactg aggtcatgga agtggagaat gtggaagacg ggacagccga ttaccacagc
     1141 aatggctaca ccgtcaccaa tggctggaag atccacaata cagccaaaaa caagtggttt
     1201 gtgtgtatgg ccaagacagc agaggagaag cagaagtggc tggacgccct gatccgagag
     1261 cgggagcagc gagagagcct gaagctgggc atggagcgcg acgcatacgt catgattgcg
     1321 gagaaggggg agaagctgta tcacatgatg atgagcaaga aggtgaactt gatcaaggac
     1381 cgccgacgga agctgagcac cgtccccaag tgcttccttg gcaatgagtt tgtcgcctgg
     1441 ctcctggaaa ttggtgagat cagcaagaca gaagaagggg tcaacttggg ccaggccctg
     1501 ttggagaatg gcatcatcca ccacgtctcc gacaagcatc agttcaagaa cgagcaggtg
     1561 atgtatcgct tccgctacga cgatggcacc tacaaagccc gcagcgagct ggaggacatc
     1621 atgtccaagg gcgtgagact ctattgccgg cttcacagcc tgtacgcccc cgtgatcaag
     1681 gaccgtgatt accacctgaa gacctacaag tccgtggtcc ccgggagcaa gctggtcgac
     1741 tggctcctgg cacaggggga ctgccagaca cgggaggagg cggtggcgct gggtgtgggc
     1801 ctgtgcaaca acggtttcat gcaccatgtt ctggagaaga gcgaattcaa ggacgagtct
     1861 cagtacttcc gcttccatgc ggacgaggag atggaaggga ccagcagcaa gaacaaacag
     1921 cttcgcaacg acttcaagct agtggagaac atcctggcca agcggctgct gatcccgccg
     1981 caggaggatg actatggctt cgatcttgag gagaagaaca aggcagtggt ggtgaagtcc
     2041 gtgcagaggg gttcgctggc tgagatggct ggcctgcagg cggggaggaa gatttactcc
     2101 atcaacgagg acctggtgtt cctacggccc ttctctgagg tggagaccat ccttaaccag
     2161 tccttctgct cccgccgccc gctgcgcctc ctggtggcca ccaaggccaa agagaccatc
     2221 aaaatccctg accacccaga ggccctgtcc ttccagattc gaggaacagc cccgccgtgt
     2281 gtctttgccg tgggcagagg ttctgaggct gtggctgccg ggctctgcgc aggccaatgc
     2341 atcctgaaag tcaacggcaa cagcgtggca aatgatggcg cccttgaagt tctggagcac
     2401 ttccaggctt tccgcagccg cagggaggag gccctgggcc tttaccagtg ggtctaccac
     2461 agccacgagg acgcccagca ggcgagagcc agccagggtg ccccggatga ggacccccag
     2521 gaggatgact cagtcctgcc cctgctgtcc ctgggtcccc agctgagcct gcacgaggac
     2581 agcgctgtgg tcagcctgac gctggacaat gttcacttgg agcacggtgt ggtttatgaa
     2641 tacgtgagca cagcaggagc caagtgtcac gtgctggaaa agatcgtgga gccccgaggc
     2701 tgtttccgcc tggctgccaa gatccttgag gcctttgccg aggacgacag cctcttcgtg
     2761 cagaactgtg ggcggctcat ggccatgggc agcgctatca tcaccatgtc ccactacgag
     2821 ttccacaaca tctgtgacac caagctggag agcattggcc agagaatcgc ctgctaccag
     2881 gagtttgcag cccagctgaa gagcagggtc agccccccct tcaagcaggc acccctggag
     2941 gaccacccgc tgtgtggcct ggacttctgc cctaccaact gccacatcaa cttcatggag
     3001 gtgtcctacc ccaagaccac cccttcagtg ggcaggtcct tcagcatccg ctttgggcgc
     3061 aaaccctccc tcatcggcct tgacccagaa caaggccacc tgaaccccat ggcttacacc
     3121 cagcactgta tcaccaccat ggctgccccg tcctggaagt gcgcgcctgc tgtagatggg
     3181 gactctcaaa gccaaggtct cattgacagt atcttcgtgt cagccagtgg tgccctgagc
     3241 cagcaagaac ggggcctgag ctttctgctc aagcaggagg accgggagat ccaggacgcg
     3301 tatctgcagc tcttcactaa gctggatgtg gccctcaagg agatgaagca gtatgtcacc
     3361 cagatcaaca ggctgctgtc aaccatcaca gagcccacgt cagctgcacc ctgtgaccca
     3421 cccttggtgg aggagacctc atcttcccca ccggccagtg aagagagcga agtggacagg
     3481 actgaccatg gcggcatcaa gaaggtgtgc ttcaaggtgt cagaggacga gcaggaagac
     3541 tcgggccacg acaccatgag ctaccgagac tcctatagtg agtgtaacag caatcgtgac
     3601 tctgtcctgt cctacaccag cgtgagaagc aacagttcgt acctgggcag tgatgagaca
     3661 ggctcagggg atgagctgcc ctgtgacata cgcatcccat ccgacaagca ggacaaactt
     3721 cacggctgcc tggaacatct ctttaaccag gtggattcca tccatgccct gctcaagggg
     3781 cctgtgatga gcagggcgtt tgaggagacc aggcatttcc ccatggagca cagctggcaa
     3841 gagttcaaac agaaagaaga atgcacagtc cgaggccgga acttgatcca gatcagcatc
     3901 caggaggacc cttggaacct acccagctcc atcaggaccc tggtagacaa catccagcga
     3961 tatgtggaag atgggaagaa ccagctgctt ctggccctgc tgaaatgcac agacacggag
     4021 ctgcagctgc gcagggatgc tgtcttctgt caggccctgg tggccgccgt gtgcaccttc
     4081 tcggagcagc tgctggccgc cctcgactac cgctacaaca acaacggcga gtatgaagag
     4141 agcagcagag acgccagccg caagtggctg gagcaggtgg cagccaccgg tgtcctgctg
     4201 cactggcagt ccctgctggc accagccacc gtgaaagagg aacggaccat gctggaggac
     4261 atctgggtga cactgtcgga gctggacaat gtcaccttct cctttaagca gctggatgag
     4321 aattctgtgg ccaacaccaa cgtcttctac cacattgagg gcagcaggca ggcactgaag
     4381 gtagtcttct acctcgatgg cttccacttc tccaggctgc cctctcgcct ggagggtggg
     4441 gccagcctca ggctgcacac cgtgctattc acaaaagctc tggagaatgt ggaagggccg
     4501 tcgcccccag gaagccaggc tgcagaagat ctgcagcagg agatcaatgc gcagtccctg
     4561 gagaaggttc agcagtacta tagaaggctc agggccttct acctggagcg gtccaacctc
     4621 cccacagatg ctaccaccac agctgtgaag atcgaccagc tgatccgtcc catcaacgcc
     4681 ctggacgagc tctaccgcct catgaagtcc ttcgtgcacc cgaaagctgg tgctggtggg
     4741 agcctaggtg ccggcctcgt ccccgtctcc tctgagctct gctaccgtct gggggcgtgt
     4801 cagatcacca tgtgtggcac cggcatgcag cggagcaccc tgagcgtgtc cttggaacaa
     4861 gcagccatct tggctcggag ccacgggctg ctgcccaagt gtgttatgca ggccacagac
     4921 atcatgcgca agcagggccc ccgagtggag atcctggcaa aaaacctccg catcaaagac
     4981 ccaatgcccc aaggtgcacc acgcctctac cgcctctgcc agcctccggt ggatggagac
     5041 ctctgaacac cgacctgctc catgctcagc cactgcctct gcagctgcca tgtgggagga
     5101 cacggagggg ctgcaaggtg acccgaggct tctgccatag ctgtgtcaag acctacccag
     5161 ctgaccctgc cgccaccgtc caggtcaagc ctctgcgagc atacactgtc tctggaccgg
     5221 cagatcacgg ttgggctggc agattctcca tacttaacgc ctgaaacctg agggctgctt
     5281 ggggccccag agctcatgaa tgtagcccgg cctggatgcc tgcactcacc caggtcccct
     5341 acacagggaa aggtcacagg gtccggcggg tgaaggcctg cagaccccgc tcctcagatg
     5401 gcaaagctgc actttgaacc tgggttcctc ccagggtc
//
