LOCUS       NM_001010951            4408 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus prolyl endopeptidase-like (Prepl), mRNA.
ACCESSION   NM_001010951 XM_216634
VERSION     NM_001010951.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4408)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 4408)
  AUTHORS   Regal,L., Martensson,E., Maystadt,I., Voermans,N., Lederer,D.,
            Burlina,A., Juan Fita,M.J., Hoogeboom,A.J.M., Olsson Engman,M.,
            Hollemans,T., Schouten,M., Meulemans,S., Jonson,T., Francois,I.,
            Gil Ortega,D., Kamsteeg,E.J. and Creemers,J.W.M.
  TITLE     PREPL deficiency: delineation of the phenotype and development of a
            functional blood assay
  JOURNAL   Genet Med 20 (1), 109-118 (2018)
   PUBMED   28726805
REFERENCE   3  (bases 1 to 4408)
  AUTHORS   Regal,L., Shen,X.M., Selcen,D., Verhille,C., Meulemans,S.,
            Creemers,J.W. and Engel,A.G.
  TITLE     PREPL deficiency with or without cystinuria causes a novel
            myasthenic syndrome
  JOURNAL   Neurology 82 (14), 1254-1260 (2014)
   PUBMED   24610330
REFERENCE   4  (bases 1 to 4408)
  AUTHORS   Morawski,M., Nuytens,K., Juhasz,T., Zeitschel,U., Seeger,G.,
            Waelkens,E., Regal,L., Schulz,I., Arendt,T., Szeltner,Z.,
            Creemers,J. and Rossner,S.
  TITLE     Cellular and ultra structural evidence for cytoskeletal
            localization of prolyl endopeptidase-like protein in neurons
  JOURNAL   Neuroscience 242, 128-139 (2013)
   PUBMED   23485813
REFERENCE   5  (bases 1 to 4408)
  AUTHORS   Radhakrishnan,K., Baltes,J., Creemers,J.W. and Schu,P.
  TITLE     Trans-Golgi network morphology and sorting is regulated by
            prolyl-oligopeptidase-like protein PREPL and the AP-1 complex
            subunit mu1A
  JOURNAL   J Cell Sci 126 (Pt 5), 1155-1163 (2013)
   PUBMED   23321636
REFERENCE   6  (bases 1 to 4408)
  AUTHORS   Lone,A.M., Bachovchin,D.A., Westwood,D.B., Speers,A.E.,
            Spicer,T.P., Fernandez-Vega,V., Chase,P., Hodder,P.S., Rosen,H.,
            Cravatt,B.F. and Saghatelian,A.
  TITLE     A substrate-free activity-based protein profiling screen for the
            discovery of selective PREPL inhibitors
  JOURNAL   J Am Chem Soc 133 (30), 11665-11674 (2011)
   PUBMED   21692504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Apr 8, 2021 this sequence version replaced NM_001010951.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.26067.1,
                                           SRR26643298.34047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               JAXUCZ010000006.1  15333395-15333523
            130-252             JAXUCZ010000006.1  15343508-15343630
            253-319             JAXUCZ010000006.1  15344848-15344914
            320-526             JAXUCZ010000006.1  15345609-15345815
            527-662             JAXUCZ010000006.1  15347463-15347598
            663-879             JAXUCZ010000006.1  15349225-15349441
            880-1065            JAXUCZ010000006.1  15349890-15350075
            1066-1263           JAXUCZ010000006.1  15353265-15353462
            1264-1439           JAXUCZ010000006.1  15354752-15354927
            1440-1656           JAXUCZ010000006.1  15356282-15356498
            1657-1806           JAXUCZ010000006.1  15358972-15359121
            1807-1930           JAXUCZ010000006.1  15359483-15359606
            1931-2004           JAXUCZ010000006.1  15360097-15360170
            2005-4408           JAXUCZ010000006.1  15360422-15362825
FEATURES             Location/Qualifiers
     source          1..4408
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..4408
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /note="prolyl endopeptidase-like"
                     /db_xref="GeneID:298771"
                     /db_xref="RGD:1310143"
     exon            1..129
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /inference="alignment:Splign:2.1.0"
     exon            130..252
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2094
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /EC_number="3.4.21.-"
                     /codon_start=1
                     /product="prolyl endopeptidase-like"
                     /protein_id="NP_001010951.1"
                     /db_xref="GeneID:298771"
                     /db_xref="RGD:1310143"
                     /translation="MDAFEKVRTRLETQPQEEYEIVNAEIKHGGFVYYQEGCCLVRSK
                     DEEADSDNYEVLFNLEELKLEQPFIDCIRVAPDEKYVAAKIRAEDSETSTCIVVKLSD
                     QPAMEASFPNVSSFEWVKDEEDEDVLFYTFQRNLRCHDVYRATFGDNKRNERFYTEKD
                     PSYFVFLYLTKDSRFLTLNIMNKTTSEVWLIDGLSPWDPPMLIQKRIHGMLYYVEHRD
                     DELYILTNVGEPTEFKLMRTAADAPAIMNWDLFFTMKRNTKVVDLDMFKDHCVLFLKH
                     SNLLYVNVIGLADDSVRSLKLPPWACGFIMDTNSDPKNCPFQLCSPIRPPKYYTYKFA
                     EGKLFEETGHEDPITKTSRVLRIEAKSKDGKLVPMTVFHKTDSEDLQRKPLLVHVYGA
                     YGMDLKMNFRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLEACI
                     KTLHSQGFSQPSLTTLSAFSAGGVLVGALCNSKPELLRAVTLEAPFLDVLNTMMDTTL
                     PLTLEELEEWGNPSSDEKHKNYIKRYCPCQNMKPQHYPSVHITAYENDERVPLKGIVN
                     YTEKLKEAVAEHSKGAGEGYQPPNIVLDIQPGGNHVIEDSHKKITTQMKFLYDELGLD
                     STDAFEALKKYLKV"
     exon            253..319
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /inference="alignment:Splign:2.1.0"
     exon            320..526
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /inference="alignment:Splign:2.1.0"
     exon            527..662
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /inference="alignment:Splign:2.1.0"
     exon            663..879
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1065
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1263
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1439
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1656
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1806
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1930
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2004
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..4408
                     /gene="Prepl"
                     /gene_synonym="RGD1310143"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcttgctg ggtgctgaag gcaggcttcg ggtggacaag tctgaggtta ctgcagctcc
       61 ttcctgagag cttcgggttc tcgtatttgt cttctctacc tttgctcgtc cagctgtctt
      121 tcaatttgcg atcttctgcc tgttaagcca gagagtgaaa attccatttc tgaagacatg
      181 gatgcatttg aaaaagtgag gacaaggcta gaaacacagc cacaggaaga gtacgaaatc
      241 gtcaatgcgg agattaaaca tggcggcttt gtctattatc aagaaggttg ctgcttggtc
      301 cgttccaaag acgaagaagc tgacagtgat aattatgaag ttttattcaa cctggaagaa
      361 cttaaactgg agcagccctt catcgattgc atccgagttg ctcctgatga gaagtacgtg
      421 gctgctaaga taagggcgga ggattctgaa acctccacct gcatagtggt gaagctcagc
      481 gatcagcctg ccatggaagc ctctttcccc aacgtgtcca gctttgaatg ggtgaaggat
      541 gaagaagatg aagatgtctt attctacacc ttccagagga accttcgctg tcacgatgtg
      601 taccgagcca cgtttggtga caacaaacgc aatgagcggt tctacacaga gaaagacccc
      661 agctattttg ttttcctcta tcttacaaaa gacagtcgtt tcctcaccct gaatatcatg
      721 aacaagacga cttccgaggt gtggctcatc gatggcctga gcccgtggga cccaccaatg
      781 ctcattcaga agagaatcca tgggatgctt tactatgttg agcatcgaga tgacgaattg
      841 tacatcctga ctaatgttgg agaacctaca gaattcaagc tgatgcggac tgcagctgac
      901 gcccctgcta ttatgaattg ggatttattt ttcacaatga agagaaacac caaggttgta
      961 gacttggaca tgtttaagga ccactgcgtt ctgttcctga aacacagcaa tctcctctat
     1021 gttaatgtga ttggtctggc tgacgactcc gtccgctctc taaagctgcc tccttgggcc
     1081 tgtggattca taatggatac aaattctgac ccgaagaact gccccttcca gctttgctcc
     1141 ccaataagac ccccaaaata ttacacatac aaatttgcag agggcaaact gtttgaggaa
     1201 actggtcacg aagatccaat cacaaagacc agtcgagttt tacgcataga agccaaaagc
     1261 aaggatggaa agctagtgcc catgacggtt tttcacaaga cggattctga ggacttgcag
     1321 aggaagcctc tcttggtgca cgtatatgga gcttacggaa tggatctgaa gatgaacttc
     1381 aggcctgaaa ggcgggtctt ggtggatgat gggtggatct tagcatattg ccatgttagg
     1441 ggtggtggcg agctgggtct ccagtggcat gctgatggcc gtctaactaa aaagctcaat
     1501 ggcctggctg acttagaggc ttgcattaag acgcttcaca gccagggctt ttctcagccc
     1561 agcctaacaa cgctgagcgc tttcagtgct ggaggtgtgc ttgtgggagc actgtgtaac
     1621 tctaagccag agctcctgag agcagtgacc ctggaggccc ctttcttgga tgttctcaac
     1681 accatgatgg acaccacact tccgctgaca ctggaagagt tggaagaatg ggggaaccct
     1741 tcgtccgatg agaaacacaa gaactacata aagcgctact gtccatgcca gaatatgaag
     1801 ccacagcatt acccttcagt tcatatcaca gcgtatgaaa acgacgagcg agtgccgctg
     1861 aaaggaatcg tgaactacac cgagaagctt aaggaggccg tcgcagagca cagcaaggga
     1921 gcaggggaag gctatcagcc ccccaacatt gttttagata ttcagcctgg agggaaccat
     1981 gtgattgagg attctcacaa aaagatcaca acccagatga aattcctgta tgatgaactt
     2041 ggacttgaca gcactgatgc tttcgaggct ctgaagaagt acctaaaagt ctgaaacgcc
     2101 gctgccttca gccgggactg gaaacaatgg aaatagtgat cagtcttatt tccacttggt
     2161 ttagcgaaag tgaggttttt ttaagttatt atataaagtt ttagaagttg tttctttgtg
     2221 taattttgct tcgtgtccat attgctccta ctcttcccac cagcacacac accctagatg
     2281 aatctgggca agtgtctcca gccatgctcc ttctgatgta gagaagggag ccagaggacg
     2341 aggcaggaaa acgccaggcc tctcaatcag tctttttttt tttttttttc agagctgggg
     2401 accaaaccca gggccttgcg cttgctaggc aagcgctcta ccactgagct aaatccccaa
     2461 cccctcaatc agtcttttaa cagaatttta caattcagtg gccttcctct ctgctagtga
     2521 atagttttcg gctccgtggc tgtaagtcag tcatcttgca gtttccacaa ccccactcta
     2581 aagcaaagag tagcatcttt atacataaat gctttagcat tttgggggta atcttttaaa
     2641 cattttattg tccttccaaa catttgagaa tcttacctaa aacaatgcat tcgtgctaca
     2701 gaaatatcta agaactgatg ccattcctga ggcccttgca tgtgtgatgg caagcatacc
     2761 agacgcaggg tggccacctc ttacagagct gcctagcacg agctatacag aaggtccagc
     2821 acgctggagt agcatgcacg gttggaaata aaacatttgt ctctgaaagc tttctggtga
     2881 tggaggagag tcttcatgct gtgttccaag atgagcccct ctcccttctc cagagaaacg
     2941 gcatgggtat caacatcact gcctttggag gctggattgg tacttaatct tattctcagt
     3001 tttgtaggaa catctgaaat agtttcctgt agatttagca cagttgatga ttctccaaaa
     3061 ttcagaacca caaggaagac tttatctatg ccatccagct ccctggtgta cacaacagag
     3121 tgattgtcgt ccctcaaaag gcaaaaccag cctctgctga gaagcagctc tctggcatgg
     3181 agtagactca gatcctgata tagcctcagt gctgagctcg gctgggtttt ttggacctgt
     3241 ttttttaaaa agaatattca cacaaatgtt ttactttaag acttatcccc accccattcc
     3301 cccagaaaaa ccttgctttc tttgcccttt aaaataactg ccccattgta aagcgtctgt
     3361 aaatagtgtg tcctcaagtc agatgcctgg aagcaaaaag ccaccaccac aggggacctg
     3421 gacttggttc tctctgtagg acactgcgaa gggcactgtg gtgagaggtc ctgggtccag
     3481 cagacatgga tgtcagatca ctggtgatag atgtaaccct gcacactgca gtgcaagtca
     3541 gcaagtctgt gttcgctttc tctgtgctgg gccgtaaaag gtagctttca tgtccttaag
     3601 atgtgggttt actttacagc tgcacaaacc tacctaacga tgctgctttc ccgctccttt
     3661 tctcataagc actttctgtc acctcgtccc cacaggtgac actgtccggc acacaacacc
     3721 ctgtgaccgg gttcacctgc cttctgtccc cttccttgta agcatcacct gtctcggacg
     3781 ttctcaaacc ccttcccttc tacattattt agttaagata gattatcaga cagataattg
     3841 ctgtgtctaa gcgtatgtac attcaataca taatgccaaa tgatttgtag ctgttgccaa
     3901 atcaacagta atgttcctca tgacactctt gccagccttg tctctggggt ggggctgttg
     3961 tcgtctttgg tattgtggtt ctttcccggg agatgtctaa caatgcgtat ttaatgacta
     4021 tctcgtggat gtttagagat gttcattcta tcatcaggca cgaagtgttc ctggtttgtg
     4081 tctgtgagcg tctgcggccg ctcactctca gtagcttaga taacgcatgt agagcagttt
     4141 ggtgccactc gctcacacga ggggcccagg acactgctct cttctccttt cctgtgaact
     4201 cgttctctgt aaccgtgagc ttgtcccttt ctcttctcct ttctctcagt cctcgtttga
     4261 tgtatcttga cgcttcagtt aacatcgtaa agacttgtgg gatttggtgg acttgtcagt
     4321 gcttatcacc gtttgaaaat gcatttctct catatactgc tttcgtattg aattctattt
     4381 tgtctgctat taaatatttc caagccca
//
