LOCUS       NM_053385               1446 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus proline and arginine rich end leucine rich repeat
            protein (Prelp), mRNA.
ACCESSION   NM_053385 XM_001061571
VERSION     NM_053385.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1446)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 1446)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 1446)
  AUTHORS   Bengtsson,E., Lindblom,K., Tillgren,V. and Aspberg,A.
  TITLE     The leucine-rich repeat protein PRELP binds fibroblast cell-surface
            proteoglycans and enhances focal adhesion formation
  JOURNAL   Biochem J 473 (9), 1153-1164 (2016)
   PUBMED   26920026
  REMARK    GeneRIF: These findings provide support for a role of the
            N-terminal region of PRELP as an important regulator of cell
            adhesion and behaviour, which may be of importance in pathological
            conditions.
REFERENCE   4  (bases 1 to 1446)
  AUTHORS   Chiasserini,D., van Weering,J.R., Piersma,S.R., Pham,T.V.,
            Malekzadeh,A., Teunissen,C.E., de Wit,H. and Jimenez,C.R.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   5  (bases 1 to 1446)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   6  (bases 1 to 1446)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   7  (bases 1 to 1446)
  AUTHORS   Lui,J.C., Andrade,A.C., Forcinito,P., Hegde,A., Chen,W., Baron,J.
            and Nilsson,O.
  TITLE     Spatial and temporal regulation of gene expression in the mammalian
            growth plate
  JOURNAL   Bone 46 (5), 1380-1390 (2010)
   PUBMED   20096814
  REMARK    GeneRIF: Prelp were present exclusively in the proliferative zone
            of in growth plate cartilage of 1-week-old rats.
REFERENCE   8  (bases 1 to 1446)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   9  (bases 1 to 1446)
  AUTHORS   Tarunina,M., Alger,L., Chu,G., Munger,K., Gudkov,A. and Jat,P.S.
  TITLE     Functional genetic screen for genes involved in senescence: role of
            Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in
            senescence and cell survival
  JOURNAL   Mol Cell Biol 24 (24), 10792-10801 (2004)
   PUBMED   15572682
REFERENCE   10 (bases 1 to 1446)
  AUTHORS   Bengtsson,E., Aspberg,A., Heinegard,D., Sommarin,Y. and
            Spillmann,D.
  TITLE     The amino-terminal part of PRELP binds to heparin and heparan
            sulfate
  JOURNAL   J Biol Chem 275 (52), 40695-40702 (2000)
   PUBMED   11007795
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF163569.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001061571.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF163569.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1446
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1446
                     /gene="Prelp"
                     /note="proline and arginine rich end leucine rich repeat
                     protein"
                     /db_xref="GeneID:84400"
                     /db_xref="RGD:620226"
     exon            1..77
                     /gene="Prelp"
                     /inference="alignment:Splign:2.1.0"
     exon            78..1051
                     /gene="Prelp"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1227
                     /gene="Prelp"
                     /note="prolargin; proline-arginine-rich end leucine-rich
                     repeat protein; proline arginine-rich end leucine-rich
                     repeat protein-like"
                     /codon_start=1
                     /product="prolargin precursor"
                     /protein_id="NP_445837.1"
                     /db_xref="GeneID:84400"
                     /db_xref="RGD:620226"
                     /translation="MRASFFWFLPLLLILASVAQGQPRPKPGIRRKPKPRPTPSFPQP
                     HEPAEPTDLPPPLPPGPPSVFPDCPRECYCPPDFPSALYCDSRNLRKVPIIPPRIHYL
                     YLQNNFITELPVESFKNATGLRWINLDNNRIRKVDQRVLEKLPGLAFLYMDKNQLEEV
                     PSALPRNLEQLRLSQNLISRIPPGVFSKLENLLLLDLQHNRLSDGVFKADTFQGLKNL
                     MQLNLAHNILRRMPPKVPPAIHQLYLDSNKIETIPSGYFKDFPNLAFIRMNYNKLSDR
                     GLPKNSFNISNLLVLHLSHNKISNVPAISNKLEHLYLNNNSIEKINGTQICPSNLVAF
                     HDFSSDLENVPHLRYLRLDGNFLKPPIPLDLMMCFRLLQSVVI"
     exon            1052..1421
                     /gene="Prelp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctaacgcag cttcaccaaa gggtggggag gaacagagga gtgctccagc gtccagagga
       61 gaggcaggtg tgtgcaggta catcacctgg atcatgaggg catccttctt ctggttcctt
      121 ccacttctcc tcatcttggc ctcagtggcc caaggccagc caagaccaaa acctgggatt
      181 aggcgtaaac ccaagccaag gcccacaccc agctttcctc agccccacga gccagcagag
      241 cccacagacc tgcctccacc ccttcctcct ggccctccat ctgtcttccc tgactgtcca
      301 cgggaatgct actgcccgcc tgacttccca tcagccctct actgtgacag ccgaaacctt
      361 cgcaaggtcc caatcatccc accccgaatt cactaccttt atctgcagaa caacttcatc
      421 accgagctcc ccgtagaatc tttcaaaaat gccacaggcc tcaggtggat caacctggac
      481 aacaaccgca ttcgcaaggt ggaccagaga gtgctggaga agctccctgg cctggcattc
      541 ctctacatgg acaagaacca gctggaagag gtgccatcag ctctgccccg gaacctggaa
      601 cagctgaggc taagccagaa cctcatctcc aggatcccgc ccggagtatt cagcaagctt
      661 gagaaccttc tgcttctgga tctgcagcac aataggctga gcgacggagt cttcaaagcc
      721 gacaccttcc agggcctcaa gaacctcatg caactcaatc tggcccacaa catcctgaga
      781 aggatgcccc ccaaggtgcc cccggccatt caccagctct acctggacag caataagatc
      841 gagaccattc ccagcggata cttcaaggac ttccccaacc ttgccttcat ccgcatgaac
      901 tacaacaagc tgtcggatcg agggctcccc aagaactcct tcaacatctc caacttgctg
      961 gtgctccact tgtcacacaa caagatcagc aatgtgccgg ccatcagcaa caagctggaa
     1021 cacctgtacc tcaacaacaa tagcatagag aagatcaatg ggacccagat ttgccccagc
     1081 aacctagtgg ccttccatga cttctcctcg gatctggaaa acgtgccaca cctgcgctac
     1141 ctgcggctgg atgggaattt cctgaagcca cccatcccgt tggacctcat gatgtgcttc
     1201 cgcctcctgc agtctgtggt tatctaggct gtgcccagag ctggacctcc tctgacagca
     1261 cttgaaggct ggtggcccaa gctcactgtt tttatctgtc tccctctctt gctcccagcc
     1321 ctgccttttg tcccctggcg tggatggtaa ataccacata acctgctcca gctctaaagc
     1381 aagagtcccc acccagtcca aagacaccct gccagccaaa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaa
//
