LOCUS       NM_001170708            2024 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus prolactin regulatory element binding (Preb),
            mRNA.
ACCESSION   NM_001170708 XM_002726713 XM_002729612
VERSION     NM_001170708.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2024)
  AUTHORS   Maeda,M., Katada,T. and Saito,K.
  TITLE     TANGO1 recruits Sec16 to coordinately organize ER exit sites for
            efficient secretion
  JOURNAL   J Cell Biol 216 (6), 1731-1743 (2017)
   PUBMED   28442536
REFERENCE   2  (bases 1 to 2024)
  AUTHORS   Tanabe,T., Maeda,M., Saito,K. and Katada,T.
  TITLE     Dual function of cTAGE5 in collagen export from the endoplasmic
            reticulum
  JOURNAL   Mol Biol Cell 27 (13), 2008-2013 (2016)
   PUBMED   27170179
REFERENCE   3  (bases 1 to 2024)
  AUTHORS   Saito,K., Yamashiro,K., Shimazu,N., Tanabe,T., Kontani,K. and
            Katada,T.
  TITLE     Concentration of Sec12 at ER exit sites via interaction with cTAGE5
            is required for collagen export
  JOURNAL   J Cell Biol 206 (6), 751-762 (2014)
   PUBMED   25202031
REFERENCE   4  (bases 1 to 2024)
  AUTHORS   Nishiuchi,Y., Murao,K., Imachi,H., Nishiuchi,T., Iwama,H. and
            Ishida,T.
  TITLE     Transcriptional factor prolactin regulatory element-binding
            protein-mediated gene transcription of ABCA1 via 3',5'-cyclic
            adenosine-5'-monophosphate
  JOURNAL   Atherosclerosis 212 (2), 418-425 (2010)
   PUBMED   20643408
  REMARK    GeneRIF: PREB regulates the cAMP-mediated transcription of the
            ABCA1 gene in vascular smooth muscle cells
REFERENCE   5  (bases 1 to 2024)
  AUTHORS   Yu,X., Murao,K., Imachi,H., Li,J., Nishiuchi,T., Dobashi,H.,
            Hosomi,N., Masugata,H., Zhang,G.X., Iwama,H. and Ishida,T.
  TITLE     The transcription factor prolactin regulatory element-binding
            protein mediates prolactin transcription induced by
            thyrotropin-releasing hormone in GH3 cells
  JOURNAL   Endocrine 38 (1), 53-59 (2010)
   PUBMED   20960102
  REMARK    GeneRIF: PREB can function as a transcriptional regulator of
            prolactin promoter activity and might be involved in TRH-induced
            PRL gene transcription
REFERENCE   6  (bases 1 to 2024)
  AUTHORS   Murao,K., Imachi,H., Yu,X., Muraoka,T., Hosami,N., Dobashi,H. and
            Ishida,T.
  TITLE     The transcriptional factor PREB mediates MCP-1 transcription
            induced by cytokines in human vascular endothelial cells
  JOURNAL   Atherosclerosis 207 (1), 45-50 (2009)
   PUBMED   19426980
  REMARK    GeneRIF: The transcriptional factor PREB mediates MCP-1
            transcription induced by cytokines in human vascular endothelial
            cells.
REFERENCE   7  (bases 1 to 2024)
  AUTHORS   Ohtsuka,S., Murao,K., Imachi,H., Cao,W.M., Yu,X., Li,J., Iwama,H.,
            Wong,N.C., Bancroft,C. and Ishida,T.
  TITLE     Prolactin regulatory element binding protein as a potential
            transcriptional factor for the insulin gene in response to glucose
            stimulation
  JOURNAL   Diabetologia 49 (7), 1599-1607 (2006)
   PUBMED   16752178
  REMARK    GeneRIF: PREB may contribute to the regulation of insulin gene
            transcription and insulin secretion in response to glucose
            stimulation.
REFERENCE   8  (bases 1 to 2024)
  AUTHORS   Bergman,M.R., Cheng,S., Honbo,N., Piacentini,L., Karliner,J.S. and
            Lovett,D.H.
  TITLE     A functional activating protein 1 (AP-1) site regulates matrix
            metalloproteinase 2 (MMP-2) transcription by cardiac cells through
            interactions with JunB-Fra1 and JunB-FosB heterodimers
  JOURNAL   Biochem J 369 (Pt 3), 485-496 (2003)
   PUBMED   12371906
REFERENCE   9  (bases 1 to 2024)
  AUTHORS   Weissman,J.T., Plutner,H. and Balch,W.E.
  TITLE     The mammalian guanine nucleotide exchange factor mSec12 is
            essential for activation of the Sar1 GTPase directing endoplasmic
            reticulum export
  JOURNAL   Traffic 2 (7), 465-475 (2001)
   PUBMED   11422940
REFERENCE   10 (bases 1 to 2024)
  AUTHORS   Fliss,M.S., Hinkle,P.M. and Bancroft,C.
  TITLE     Expression cloning and characterization of PREB (prolactin
            regulatory element binding), a novel WD motif DNA-binding protein
            with a capacity to regulate prolactin promoter activity
  JOURNAL   Mol Endocrinol 13 (4), 644-657 (1999)
   PUBMED   10194769
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078936.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_002726713.1, XM_002729612.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078936.1, AF061817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2024
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..2024
                     /gene="Preb"
                     /gene_synonym="mSec12"
                     /note="prolactin regulatory element binding"
                     /db_xref="GeneID:58842"
                     /db_xref="RGD:61929"
     exon            1..305
                     /gene="Preb"
                     /gene_synonym="mSec12"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1424
                     /gene="Preb"
                     /gene_synonym="mSec12"
                     /note="prolactin regulatory element-binding protein;
                     mammalian guanine nucleotide exchange factor mSec12;
                     mammalian guanine nucleotide exchange factor Sec12"
                     /codon_start=1
                     /product="guanine nucleotide-exchange factor SEC12"
                     /protein_id="NP_001164179.1"
                     /db_xref="GeneID:58842"
                     /db_xref="RGD:61929"
                     /translation="MGRRRGVELYRAPFPLYALRIDPKTGLLIAAGGGGAAKTGIKNG
                     VHFLQLEQISGCLSASLLHSHDTETRATMNLALAGDILAAGQDAQCQLLRFQIHQQKG
                     SKAEKSGSKEQGPRQRKGAAPAEKKSGAEVHPEGVELKVKNLEAVQTDFSTEPLQKVV
                     CFNHDNTLLATGGSDGHVRVWKVPSLEKVLEFKAHEGEIGDLALGPDGKLVTVGWDFK
                     ASVWQKDQLVTQLQWQENGPTSSNTPYRYQACRFGQVPDQPGGLRLFTVQIPHKRLRQ
                     PPPCYLTAWDSSTFLPLQTRSCGHEVISCLTVSESGTFLGLGTVTGSVAIYIAFSLQR
                     LYYVKEAHGIVVTDVTFLPEKGCGPKLLGPHETALFSVAVDSRCQLHLLPSRRSVPVW
                     LLLLLCVGLIIVTILLLQSAFPGFL"
     exon            306..495
                     /gene="Preb"
                     /gene_synonym="mSec12"
                     /inference="alignment:Splign:2.1.0"
     exon            496..716
                     /gene="Preb"
                     /gene_synonym="mSec12"
                     /inference="alignment:Splign:2.1.0"
     exon            717..797
                     /gene="Preb"
                     /gene_synonym="mSec12"
                     /inference="alignment:Splign:2.1.0"
     exon            798..922
                     /gene="Preb"
                     /gene_synonym="mSec12"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1096
                     /gene="Preb"
                     /gene_synonym="mSec12"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1169
                     /gene="Preb"
                     /gene_synonym="mSec12"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1329
                     /gene="Preb"
                     /gene_synonym="mSec12"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1992
                     /gene="Preb"
                     /gene_synonym="mSec12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcgagcg cagatcggct acctgcggtg attagagtgg tggcaaatcc acagtgctga
       61 gaggggtcgc cagtcttccg ggaaactgta gcaccaagtt ccgcagcttt tggaggcggg
      121 gcgcggcatg tcttgggttc ctccgggctg gcagtgaacg tgcgggcagg atgggccggc
      181 gccggggtgt ggagctgtac cgggccccgt tcccgttgta cgcgcttcgg atagacccca
      241 agactggact gctcatcgct gcgggcggag gaggagctgc caagaccggc ataaagaatg
      301 gcgtgcattt tctgcagcta gagcagatca gcgggtgcct gagcgcctcc ttgctgcact
      361 ctcatgacac ggagacaagg gccactatga atttggcgct ggctggtgac atccttgctg
      421 ctggacagga tgcccagtgt cagcttcttc gtttccagat ccatcaacag aagggcagta
      481 aagcagagaa gtcaggttcc aaggagcagg ggcctcggca gaggaagggg gcagctccag
      541 cagagaagaa atcgggagcg gaagttcacc cggaaggggt tgagctcaaa gtaaagaatt
      601 tggaggcagt acagacagac ttcagcactg aaccgctgca gaaagttgtg tgcttcaacc
      661 atgataacac cctgcttgcc accggaggat ctgacggtca tgttcgtgtc tggaaggtac
      721 ctagcctaga gaaagttctg gagtttaaag cccacgaagg ggagattgga gatttggctt
      781 tgggtcctga tggcaagttg gttactgtgg gctgggactt taaggcctcc gtgtggcaga
      841 aggatcaact ggtgacacag ctacagtggc aagagaatgg acccacctct tctaacacac
      901 cgtaccgcta ccaggcctgc aggtttgggc aggttccaga tcagcctggt gggctgcgac
      961 tcttcacagt gcagataccc cacaagcgcc tacgacagcc cccaccctgc tacctcacag
     1021 cctgggacag ttccaccttc ttgcctcttc agaccaggtc ctgtggccat gaagtcattt
     1081 cctgcctcac tgtcagtgaa tcgggtacct tcctaggcct aggcacggtc actggctctg
     1141 tcgccatcta catagctttc tctctccagc gcctgtatta tgtgaaggag gcccatggca
     1201 ttgtggtgac agatgtgacc tttctacctg agaagggttg cggtccaaag ctccttgggc
     1261 cccatgaaac ggccctgttc tctgtggctg tggatagtcg ttgccagttg cacctgctgc
     1321 cctcacgtcg gagtgttccc gtatggctcc tgctcctgct atgtgttggc cttattatcg
     1381 tgaccatcct gctgctccag agtgccttcc cggggtttct ttaacatcct gaccaatggg
     1441 agtcatcctt ggacagtact accttctgga gcagagtcat tgaggcccat gactgaagct
     1501 gcatctgatg aaatggatgg gtactgccgg tccctgctaa agcctgccgg ccagtggcct
     1561 ccctatcact ctgggtcttg ggagccctgc tttcacctgt ggatccattt aggacagtgt
     1621 ggtctgaagc tcaggccaca ctgcctgcct cgttccctct gcctcccagg gctccagagc
     1681 cgagctcttc ctaggaacat gtgaagatgc caaagagccc agaggcattg ccatccttct
     1741 cgcagagact gtttttcctc ctccccttcc agtctgcgca caaggtcctc agctttgtcg
     1801 agacaaagtc tgtggaagag gcaaaaggaa gacccaggta gcggtgatct gtaggtagca
     1861 cccagccagt caggccagac gcacagggag ttcctgggtg acctactgca gcctgaggaa
     1921 agggaaagtg aacctcagtt tattaggcag gaagagttga tatttaataa agaaagaaag
     1981 attgaaccga gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
