LOCUS       NM_053576                856 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus peroxiredoxin 6 (Prdx6), mRNA.
ACCESSION   NM_053576
VERSION     NM_053576.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 856)
  AUTHORS   Xiong,J., Zhou,R. and Deng,X.
  TITLE     PRDX6 alleviated heart failure by inhibiting doxorubicin-induced
            ferroptosis through the JAK2/STAT1 pathway inactivation
  JOURNAL   In Vitro Cell Dev Biol Anim 60 (4), 354-364 (2024)
   PUBMED   38530594
  REMARK    GeneRIF: PRDX6 alleviated heart failure by inhibiting
            doxorubicin-induced ferroptosis through the JAK2/STAT1 pathway
            inactivation.
REFERENCE   2  (bases 1 to 856)
  AUTHORS   Shen,W., Yang,L., Yang,Y., Wang,P., Tao,X., Shen,Y., Wang,S. and
            Shen,Y.
  TITLE     PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARalpha
            Activation in Rats Fed High-Fat Diet
  JOURNAL   Antioxid Redox Signal 38 (16-18), 1184-1200 (2023)
   PUBMED   36401357
  REMARK    GeneRIF: PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent
            PPARalpha Activation in Rats Fed High-Fat Diet.
REFERENCE   3  (bases 1 to 856)
  AUTHORS   Li,H., Wu,Z., Zhong,R., Zhang,Q., Chen,Q. and Shen,Y.
  TITLE     PRDX6 knockout restrains the malignant progression of intrahepatic
            cholangiocarcinoma
  JOURNAL   Med Oncol 39 (12), 250 (2022)
   PUBMED   36209344
  REMARK    GeneRIF: PRDX6 knockout restrains the malignant progression of
            intrahepatic cholangiocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 856)
  AUTHORS   Hong,T., Zhou,Y., Peng,L., Wu,X., Li,Y., Li,Y. and Zhao,Y.
  TITLE     Knocking Down Peroxiredoxin 6 Aggravates Cerebral
            Ischemia-Reperfusion Injury by Enhancing Mitophagy
  JOURNAL   Neuroscience 482, 30-42 (2022)
   PUBMED   34863856
  REMARK    GeneRIF: Knocking Down Peroxiredoxin 6 Aggravates Cerebral
            Ischemia-Reperfusion Injury by Enhancing Mitophagy.
REFERENCE   5  (bases 1 to 856)
  AUTHORS   Tang,B., Ni,W., Zhou,J., Ling,Y., Niu,D., Lu,X., Chen,T.,
            Ramalingam,M. and Hu,J.
  TITLE     Peroxiredoxin 6 secreted by Schwann-like cells protects neuron
            against ischemic stroke in rats via PTEN/PI3K/AKT pathway
  JOURNAL   Tissue Cell 73, 101635 (2021)
   PUBMED   34482185
  REMARK    GeneRIF: Peroxiredoxin 6 secreted by Schwann-like cells protects
            neuron against ischemic stroke in rats via PTEN/PI3K/AKT pathway.
REFERENCE   6  (bases 1 to 856)
  AUTHORS   Chen,J.W., Dodia,C., Feinstein,S.I., Jain,M.K. and Fisher,A.B.
  TITLE     1-Cys peroxiredoxin, a bifunctional enzyme with glutathione
            peroxidase and phospholipase A2 activities
  JOURNAL   J Biol Chem 275 (37), 28421-28427 (2000)
   PUBMED   10893423
REFERENCE   7  (bases 1 to 856)
  AUTHORS   Andreeva,S.G., Merkulova,M.I., Shuvaeva,T.M., Novoselov,V.I.,
            Peshenko,I.V., Novoselov,S.V., Fesenko,E.E. and Lipkin,V.M.
  TITLE     [Study of structure of secretory 28 kDa protein from the rat
            olfactory epithelium]
  JOURNAL   Bioorg Khim 24 (11), 816-821 (1998)
   PUBMED   10079938
REFERENCE   8  (bases 1 to 856)
  AUTHORS   Choi,H.J., Kang,S.W., Yang,C.H., Rhee,S.G. and Ryu,S.E.
  TITLE     Crystal structure of a novel human peroxidase enzyme at 2.0 A
            resolution
  JOURNAL   Nat Struct Biol 5 (5), 400-406 (1998)
   PUBMED   9587003
REFERENCE   9  (bases 1 to 856)
  AUTHORS   Kim,T.S., Sundaresh,C.S., Feinstein,S.I., Dodia,C., Skach,W.R.,
            Jain,M.K., Nagase,T., Seki,N., Ishikawa,K., Nomura,N. and
            Fisher,A.B.
  TITLE     Identification of a human cDNA clone for lysosomal type
            Ca2+-independent phospholipase A2 and properties of the expressed
            protein
  JOURNAL   J Biol Chem 272 (4), 2542-2550 (1997)
   PUBMED   8999971
  REMARK    Erratum:[J Biol Chem 1997 Apr 18;272(16):10981]
REFERENCE   10 (bases 1 to 856)
  AUTHORS   Peshenko,I.V., Novoselov,V.I., Evdokimov,V.A., Nikolaev,Yu.V.,
            Shuvaeva,T.M., Lipkin,V.M. and Fesenko,E.E.
  TITLE     Novel 28-kDa secretory protein from rat olfactory epithelium
  JOURNAL   FEBS Lett 381 (1-2), 12-14 (1996)
   PUBMED   8641418
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF014009.1.
            
            On Jun 10, 2007 this sequence version replaced NM_053576.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF014009.1, Y17295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..856
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..856
                     /gene="Prdx6"
                     /gene_synonym="LPCAT-5"
                     /note="peroxiredoxin 6"
                     /db_xref="GeneID:94167"
                     /db_xref="RGD:71005"
     exon            1..115
                     /gene="Prdx6"
                     /gene_synonym="LPCAT-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..695
                     /gene="Prdx6"
                     /gene_synonym="LPCAT-5"
                     /EC_number="3.1.1.4"
                     /EC_number="2.3.1.23"
                     /EC_number="1.11.1.27"
                     /note="NSGPx; aiPLA2; 1-Cys PRX; antioxidant protein 2;
                     non-selenium glutathione peroxidase; acidic
                     calcium-independent phospholipase A2; 1-Cys peroxiredoxin;
                     thiol-specific antioxidant protein; glutathione-dependent
                     peroxiredoxin; LPC acyltransferase 5; lyso-PC
                     acyltransferase 5; lysophosphatidylcholine acyltransferase
                     5"
                     /codon_start=1
                     /product="peroxiredoxin-6"
                     /protein_id="NP_446028.1"
                     /db_xref="GeneID:94167"
                     /db_xref="RGD:71005"
                     /translation="MPGGLLLGDEAPNFEANTTIGHIRFHDFLGDSWGILFSHPRDFT
                     PVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHFAWSKDINAYNGAAPTEKLPFPI
                     IDDKDRDLAILLGMLDPAEKDEKGMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEI
                     LRVVDSLQLTASNPVATPVDWKKGESVMVLPTLPEEEAKQLFPKGVFTKELPSGKKYL
                     RYTPQP"
     exon            116..272
                     /gene="Prdx6"
                     /gene_synonym="LPCAT-5"
                     /inference="alignment:Splign:2.1.0"
     exon            273..419
                     /gene="Prdx6"
                     /gene_synonym="LPCAT-5"
                     /inference="alignment:Splign:2.1.0"
     exon            420..566
                     /gene="Prdx6"
                     /gene_synonym="LPCAT-5"
                     /inference="alignment:Splign:2.1.0"
     exon            567..856
                     /gene="Prdx6"
                     /gene_synonym="LPCAT-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagcgtcac cactgccgcc atgcccggag ggctgcttct cggggacgaa gcccccaact
       61 ttgaggccaa taccaccatc ggccacatcc gcttccacga tttcctagga gattcatggg
      121 gcattctctt ttcccaccca cgggacttta ccccagtgtg caccacagaa cttggcagag
      181 ctgcaaagct ggcgccagag tttgccaaga ggaatgttaa gttgattgct ctttcaatag
      241 actctgttga ggaccatttt gcctggagca aggacatcaa tgcttacaat ggtgcagcac
      301 ccacagaaaa gctaccattt cccatcatcg acgataagga cagggacctt gccatcctgt
      361 tgggcatgtt ggatccagca gagaaggatg aaaaaggcat gcccgtgaca gcccgtgtgg
      421 tattcatttt tggccctgac aagaaactaa aactgtccat cctctaccca gccaccacgg
      481 gcagaaactt tgatgagatt ctcagagtgg ttgactccct ccagctgaca gcatcaaatc
      541 cagttgccac tccagttgac tggaagaagg gagagagtgt gatggtcctt cccaccctcc
      601 ctgaagagga agccaaacaa cttttcccta aaggagtctt caccaaagag ctcccatctg
      661 gcaagaaata cctccgttat acgccccagc cttaagtctg cgggaactgg ggctgcaact
      721 gctcgcccag cactgggacc tgaggatgac agctgacagc tgcagttccg tagaaagatt
      781 gtggcgtggt cacagccgaa gtcgcgtagg tcgctcgcta tactactggc tcattaaatg
      841 gaaatggcac caaaac
//
