LOCUS       NM_053610                837 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus peroxiredoxin 5 (Prdx5), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_053610
VERSION     NM_053610.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 837)
  AUTHORS   Wang,M.J., Huang,H.Y., Chiu,T.L., Chang,H.F. and Wu,H.R.
  TITLE     Peroxiredoxin 5 Silencing Sensitizes Dopaminergic Neuronal Cells to
            Rotenone via DNA Damage-Triggered ATM/p53/PUMA Signaling-Mediated
            Apoptosis
  JOURNAL   Cells 9 (1), 22 (2019)
   PUBMED   31861721
  REMARK    GeneRIF: Peroxiredoxin 5 Silencing Sensitizes Dopaminergic Neuronal
            Cells to Rotenone via DNA Damage-Triggered ATM/p53/PUMA
            Signaling-Mediated Apoptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 837)
  AUTHORS   Bakovic,J., Yu,B.Y.K., Silva,D., Chew,S.P., Kim,S., Ahn,S.H.,
            Palmer,L., Aloum,L., Stanzani,G., Malanchuk,O., Duchen,M.R.,
            Singer,M., Filonenko,V., Lee,T.H., Skehel,M. and Gout,I.
  TITLE     A key metabolic integrator, coenzyme A, modulates the activity of
            peroxiredoxin 5 via covalent modification
  JOURNAL   Mol Cell Biochem 461 (1-2), 91-102 (2019)
   PUBMED   31375973
  REMARK    GeneRIF: the role of a key metabolic integrator coenzyme A (CoA) in
            modulating the activity of Prdx5 was investigated.
REFERENCE   3  (bases 1 to 837)
  AUTHORS   Hu,H., Tian,M., Li,P., Bao,Y., Guan,X., Lian,Z., Yin,Y., Ding,C.
            and Yu,S.
  TITLE     Brucella infection regulates peroxiredoxin-5 protein expression to
            facilitate intracellular survival by reducing the production of
            nitric oxide and reactive oxygen species
  JOURNAL   Biochem Biophys Res Commun 516 (1), 82-88 (2019)
   PUBMED   31196623
REFERENCE   4  (bases 1 to 837)
  AUTHORS   Choi,H.I., Ma,S.K., Bae,E.H., Lee,J. and Kim,S.W.
  TITLE     Peroxiredoxin 5 Protects TGF-beta Induced Fibrosis by Inhibiting
            Stat3 Activation in Rat Kidney Interstitial Fibroblast Cells
  JOURNAL   PLoS One 11 (2), e0149266 (2016)
   PUBMED   26872211
  REMARK    GeneRIF: Prdx5 protects TGF-beta induced fibrosis.  Prdx5
            negatively modulates TGF-beta induced Stat3 activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 837)
  AUTHORS   Sabharwal,S.S., Waypa,G.B., Marks,J.D. and Schumacker,P.T.
  TITLE     Peroxiredoxin-5 targeted to the mitochondrial intermembrane space
            attenuates hypoxia-induced reactive oxygen species signalling
  JOURNAL   Biochem J 456 (3), 337-346 (2013)
   PUBMED   24044889
  REMARK    GeneRIF: IMS-PRDX5 expression also attenuates the increase in
            cytosolic [Ca(2+)] in PASMCs during hypoxia.
REFERENCE   6  (bases 1 to 837)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   7  (bases 1 to 837)
  AUTHORS   Seo,M.S., Kang,S.W., Kim,K., Baines,I.C., Lee,T.H. and Rhee,S.G.
  TITLE     Identification of a new type of mammalian peroxiredoxin that forms
            an intramolecular disulfide as a reaction intermediate
  JOURNAL   J Biol Chem 275 (27), 20346-20354 (2000)
   PUBMED   10751410
REFERENCE   8  (bases 1 to 837)
  AUTHORS   Knoops,B., Clippe,A., Bogard,C., Arsalane,K., Wattiez,R.,
            Hermans,C., Duconseille,E., Falmagne,P. and Bernard,A.
  TITLE     Cloning and characterization of AOEB166, a novel mammalian
            antioxidant enzyme of the peroxiredoxin family
  JOURNAL   J Biol Chem 274 (43), 30451-30458 (1999)
   PUBMED   10521424
REFERENCE   9  (bases 1 to 837)
  AUTHORS   Yamashita,H., Avraham,S., Jiang,S., London,R., Van Veldhoven,P.P.,
            Subramani,S., Rogers,R.A. and Avraham,H.
  TITLE     Characterization of human and murine PMP20 peroxisomal proteins
            that exhibit antioxidant activity in vitro
  JOURNAL   J Biol Chem 274 (42), 29897-29904 (1999)
   PUBMED   10514471
REFERENCE   10 (bases 1 to 837)
  AUTHORS   Kropotov,A., Sedova,V., Ivanov,V., Sazeeva,N., Tomilin,A.,
            Krutilina,R., Oei,S.L., Griesenbeck,J., Buchlow,G. and Tomilin,N.
  TITLE     A novel human DNA-binding protein with sequence similarity to a
            subfamily of redox proteins which is able to repress
            RNA-polymerase-III-driven transcription of the Alu-family
            retroposons in vitro
  JOURNAL   Eur J Biochem 260 (2), 336-346 (1999)
   PUBMED   10095767
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF110732.1.
            
            [WARNING] On Oct 7, 2024 this sequence was replaced by NM_053610.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF110732.1, FQ217688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132299, SAMD00132306
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..837
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..837
                     /gene="Prdx5"
                     /gene_synonym="Aoeb166"
                     /note="peroxiredoxin 5"
                     /db_xref="GeneID:113898"
                     /db_xref="RGD:71007"
     exon            1..207
                     /gene="Prdx5"
                     /gene_synonym="Aoeb166"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..681
                     /gene="Prdx5"
                     /gene_synonym="Aoeb166"
                     /EC_number="1.11.1.24"
                     /note="peroxisomal and mitochondrial; peroxiredoxin-5,
                     mitochondrial; PLP; prx-V; thioredoxin reductase;
                     antioxidant enzyme B166; thioredoxin peroxidase PMP20;
                     peroxisomal antioxidant enzyme; peroxiredoxin V;
                     thioredoxin-dependent peroxiredoxin 5"
                     /codon_start=1
                     /product="peroxiredoxin-5, mitochondrial precursor"
                     /protein_id="NP_446062.1"
                     /db_xref="GeneID:113898"
                     /db_xref="RGD:71007"
                     /translation="MVQLRFCVLGSIAGSVLRASATWTCVAGRAGRKGAGWECGGARS
                     FSSAAVTMAPIKVGDTIPSVEVFEGEPGKKVNLAELFKDKKGVLFGVPGAFTPGCSKT
                     HLPGFVEQAGALKAKGAQVVACLSVNDAFVTAEWGRAHQAEGKVQLLADPTGAFGKET
                     DLLLDDSLVSLFGNRRLKRFSMVIDKGVVKALNVEPDGTGLTCSLAPNILSQL"
     exon            208..342
                     /gene="Prdx5"
                     /gene_synonym="Aoeb166"
                     /inference="alignment:Splign:2.1.0"
     exon            343..474
                     /gene="Prdx5"
                     /gene_synonym="Aoeb166"
                     /inference="alignment:Splign:2.1.0"
     exon            475..513
                     /gene="Prdx5"
                     /gene_synonym="Aoeb166"
                     /inference="alignment:Splign:2.1.0"
     exon            514..575
                     /gene="Prdx5"
                     /gene_synonym="Aoeb166"
                     /inference="alignment:Splign:2.1.0"
     exon            576..816
                     /gene="Prdx5"
                     /gene_synonym="Aoeb166"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaatcatc tgcgggtggg ctgcggcggc ggggcgggca tggtccagct gaggttttgc
       61 gtcctaggca gcatagccgg atcggtgctc cgtgcatcgg ctacttggac gtgcgtggca
      121 ggcagagcag gccggaaagg agcaggttgg gagtgtggtg gggcccgcag cttcagcagt
      181 gccgcggtga ctatggcccc gatcaaggtg ggagacacca ttccctcagt ggaggtattt
      241 gaaggggaac ctggaaagaa ggtgaacttg gcagagctgt tcaaggacaa gaaaggtgtt
      301 ttgtttggag tccctggggc atttacacct ggctgttcca agacccatct gcctgggttt
      361 gtggagcaag ccggagctct gaaggccaag ggagcacaag tggtggcctg tctgagtgtt
      421 aatgatgcct tcgtgactgc agagtggggt cgagcccacc aggcagaagg caaggttcag
      481 ctcctggctg accccactgg agcttttgga aaggagacag atttactact agatgattct
      541 ttggtgtctc tctttgggaa tcgtcggcta aaaaggttct ccatggtgat agacaagggc
      601 gtagtaaagg cactgaacgt ggagccggat ggcacaggcc tcacctgcag cctggccccc
      661 aacatcctct cacaactctg aggccctgac cagaatgtcc tctgactctc ccatctcctc
      721 cacccagctc tgggccaaag gcccagtacc tccttacctg agggccactg gaatggaacc
      781 ttgacaatat ttctgcaata aacagtttaa tttgtgaaaa aaaaaaaaaa aaaaaaa
//
