LOCUS       NM_053512                964 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus peroxiredoxin 4 (Prdx4), mRNA.
ACCESSION   NM_053512
VERSION     NM_053512.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 964)
  AUTHORS   Tam,K.C., Ali,E., Hua,J., Chataway,T. and Barritt,G.J.
  TITLE     Evidence for the interaction of peroxiredoxin-4 with the
            store-operated calcium channel activator STIM1 in liver cells
  JOURNAL   Cell Calcium 74, 14-28 (2018)
   PUBMED   29804005
  REMARK    GeneRIF: In the rough endoplasmic reticulum, Prx-4 interacts with
            and is located with STIM1 in liver microsomes.
REFERENCE   2  (bases 1 to 964)
  AUTHORS   Rao,Z., Wang,S. and Wang,J.
  TITLE     Peroxiredoxin 4 inhibits IL-1beta-induced chondrocyte apoptosis via
            PI3K/AKT signaling
  JOURNAL   Biomed Pharmacother 90, 414-420 (2017)
   PUBMED   28391163
  REMARK    GeneRIF: The regulatory effects of PRDX4 on IL-1beta-induced
            chondrocyte apoptosis.
REFERENCE   3  (bases 1 to 964)
  AUTHORS   Yao,W., Zhao,H., Shi,R., Li,X., Li,Y., Ke,C. and Liu,J.
  TITLE     Recombinant protein transduction domain-Cu/Zn superoxide dismutase
            alleviates bone cancer pain via peroxiredoxin 4 modulation and
            antioxidation
  JOURNAL   Biochem Biophys Res Commun 486 (4), 1143-1148 (2017)
   PUBMED   28391978
  REMARK    GeneRIF: Our data suggested that reactive oxygen species, at least
            in part, play a role in cancer metastatic pain development and
            persistency which can be attenuated by the adminstration of
            recombinant PTD-Cu/Zn SOD via the peroxiredoxin 4 modulation from
            oxidative stress.
REFERENCE   4  (bases 1 to 964)
  AUTHORS   Avezov,E., Cross,B.C., Kaminski Schierle,G.S., Winters,M.,
            Harding,H.P., Melo,E.P., Kaminski,C.F. and Ron,D.
  TITLE     Lifetime imaging of a fluorescent protein sensor reveals surprising
            stability of ER thiol redox
  JOURNAL   J Cell Biol 201 (2), 337-349 (2013)
   PUBMED   23589496
REFERENCE   5  (bases 1 to 964)
  AUTHORS   Zito,E., Hansen,H.G., Yeo,G.S., Fujii,J. and Ron,D.
  TITLE     Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic
            acid depletion and noncanonical scurvy in mice
  JOURNAL   Mol Cell 48 (1), 39-51 (2012)
   PUBMED   22981861
REFERENCE   6  (bases 1 to 964)
  AUTHORS   Iuchi,Y., Okada,F., Tsunoda,S., Kibe,N., Shirasawa,N., Ikawa,M.,
            Okabe,M., Ikeda,Y. and Fujii,J.
  TITLE     Peroxiredoxin 4 knockout results in elevated spermatogenic cell
            death via oxidative stress
  JOURNAL   Biochem J 419 (1), 149-158 (2009)
   PUBMED   19105792
REFERENCE   7  (bases 1 to 964)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   8  (bases 1 to 964)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 964)
  AUTHORS   Wong,C.M., Chun,A.C., Kok,K.H., Zhou,Y., Fung,P.C., Kung,H.F.,
            Jeang,K.T. and Jin,D.Y.
  TITLE     Characterization of human and mouse peroxiredoxin IV: evidence for
            inhibition by Prx-IV of epidermal growth factor- and p53-induced
            reactive oxygen species
  JOURNAL   Antioxid Redox Signal 2 (3), 507-518 (2000)
   PUBMED   11229364
REFERENCE   10 (bases 1 to 964)
  AUTHORS   Matsumoto,A., Okado,A., Fujii,T., Fujii,J., Egashira,M., Niikawa,N.
            and Taniguchi,N.
  TITLE     Cloning of the peroxiredoxin gene family in rats and
            characterization of the fourth member
  JOURNAL   FEBS Lett 443 (3), 246-250 (1999)
   PUBMED   10025941
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF106945.1.
            
            On Aug 30, 2012 this sequence version replaced NM_053512.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF106945.1, FQ223273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-964               AF106945.1         2-965
FEATURES             Location/Qualifiers
     source          1..964
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..964
                     /gene="Prdx4"
                     /note="peroxiredoxin 4"
                     /db_xref="GeneID:85274"
                     /db_xref="RGD:620043"
     exon            1..274
                     /gene="Prdx4"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..849
                     /gene="Prdx4"
                     /EC_number="1.11.1.24"
                     /note="prx-IV; peroxiredoxin IV; antioxidant enzyme
                     AOE372; thioredoxin peroxidase AO372;
                     thioredoxin-dependent peroxide reductase A0372;
                     thioredoxin-dependent peroxiredoxin 4"
                     /codon_start=1
                     /product="peroxiredoxin-4 precursor"
                     /protein_id="NP_445964.1"
                     /db_xref="GeneID:85274"
                     /db_xref="RGD:620043"
                     /translation="METWSKLLDGTTPSRRWRKLVLLLPPLLLFLLQTEALQGLESDD
                     RFRTRENECHFYAGGQVYPGEVSRVSVADHSLHLSKAKISKPAPYWEGTAVINGEFKE
                     LKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRIEEFKSINTEVVACSVDSQFTHLA
                     WINTPRRQGGLGPIRIPLLSDLNHQISKDYGVYLEDSGHTLRGLFIIDDKGVLRQITL
                     NDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN"
     exon            275..392
                     /gene="Prdx4"
                     /inference="alignment:Splign:2.1.0"
     exon            393..509
                     /gene="Prdx4"
                     /inference="alignment:Splign:2.1.0"
     exon            510..632
                     /gene="Prdx4"
                     /inference="alignment:Splign:2.1.0"
     exon            633..763
                     /gene="Prdx4"
                     /inference="alignment:Splign:2.1.0"
     exon            764..798
                     /gene="Prdx4"
                     /inference="alignment:Splign:2.1.0"
     exon            799..910
                     /gene="Prdx4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaggtgtt ttcgtgctcg cttggtcatg gaaacgtggt ccaagctgct ggacgggacc
       61 acgccgtccc gtcgctggcg aaagctggta ttgctcctgc cgcctctgct gctgttcctg
      121 ttacagactg aagctttgca gggcttggag agtgatgatc ggttccggac ccgcgaaaat
      181 gagtgccact tctacgctgg tggacaagtg taccccggag aggtgtcccg ggtttcggtc
      241 gcagatcact ccctgcacct aagcaaagcc aagatttcca agccagcacc ttattgggaa
      301 ggaacagctg tgataaacgg agaattcaag gagctcaaat tgaccgacta tcgtgggaaa
      361 tacttggttt ttttcttcta cccactggat ttcacctttg tgtgtccaac tgaaatcatc
      421 gcttttgggg atcgaattga agaattcaaa tctataaata ctgaagtggt agcatgctct
      481 gttgattctc agtttactca cttggcctgg atcaataccc ctcgaagaca aggaggactg
      541 gggccaataa ggattccact tctttcagac ctgaaccatc agatctcaaa ggactacggt
      601 gtataccttg aggactctgg acatactctt agagggctct ttattatcga tgacaaagga
      661 gtcctaagac agattactct gaatgacctt cctgtgggta gatcagtgga tgagacactg
      721 cgtttggttc aagccttcca gtacactgac aagcatggag aagtctgccc tgctggctgg
      781 aaacctggta gtgaaacaat aatcccagat ccagctggaa aactgaagta tttcgacaag
      841 ctaaactgaa aagtacttca gttatgatgc ttagaccttc tcaataaagg tcattgtgtt
      901 aattaccata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      961 aaaa
//
