LOCUS       NM_022540               1417 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus peroxiredoxin 3 (Prdx3), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_022540
VERSION     NM_022540.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1417)
  AUTHORS   Arkat,S., Poovitha,S., Vijayakumar,A., Dhat,R., Sitasawad,S.L. and
            Mahapatra,N.R.
  TITLE     Regulation of peroxiredoxin-3 gene expression under basal and
            hyperglycemic conditions: Key roles for transcription factors Sp1,
            CREB and NF-kappaB
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (5), 166691 (2023)
   PUBMED   36933848
  REMARK    GeneRIF: Regulation of peroxiredoxin-3 gene expression under basal
            and hyperglycemic conditions: Key roles for transcription factors
            Sp1, CREB and NF-kappaB.
REFERENCE   2  (bases 1 to 1417)
  AUTHORS   Li,H., Wang,Z., Xie,X., Luo,M., Shen,H., Li,X., Li,H., Wang,Z.,
            Li,X. and Chen,G.
  TITLE     Peroxiredoxin-3 plays a neuroprotective role in early brain injury
            after experimental subarachnoid hemorrhage in rats
  JOURNAL   Brain Res Bull 193, 95-105 (2023)
   PUBMED   36566946
  REMARK    GeneRIF: Peroxiredoxin-3 plays a neuroprotective role in early
            brain injury after experimental subarachnoid hemorrhage in rats.
REFERENCE   3  (bases 1 to 1417)
  AUTHORS   Tian,Y., Lv,W., Lu,C., Zhao,X., Zhang,C. and Song,H.
  TITLE     LATS2 promotes cardiomyocyte H9C2 cells apoptosis via the
            Prx3-Mfn2-mitophagy pathways
  JOURNAL   J Recept Signal Transduct Res 39 (5-6), 470-478 (2019)
   PUBMED   31829064
  REMARK    GeneRIF: The overexpression of LATS2 induces mitochondrial stress
            by repressing protective mitophagy in a manner dependent on
            Prx3-Mfn2 pathways, thus reducing the survival of H9C2 cells.
REFERENCE   4  (bases 1 to 1417)
  AUTHORS   Hu,W., Dang,X.B., Wang,G., Li,S. and Zhang,Y.L.
  TITLE     Peroxiredoxin-3 attenuates traumatic neuronal injury through
            preservation of mitochondrial function
  JOURNAL   Neurochem Int 114, 120-126 (2018)
   PUBMED   29427714
  REMARK    GeneRIF: PRDX3 protects against traumatic neuronal injury insult by
            preserving mitochondrial function and mitochondrial biogenesis.
REFERENCE   5  (bases 1 to 1417)
  AUTHORS   Chen,J., Shi,S., Cai,X., Li,H., Wang,L., Li,H. and Xu,C.
  TITLE     DR1 activation reduces the proliferation of vascular smooth muscle
            cells by JNK/c-Jun dependent increasing of Prx3
  JOURNAL   Mol Cell Biochem 440 (1-2), 157-165 (2018)
   PUBMED   28828729
  REMARK    GeneRIF: DR1 activation inhibits VSMCs proliferation primarily by
            JNK/c-Jun dependent increasing of Prx3, suggesting DR1 a potential
            target for the prevention of vascular proliferation disease.
REFERENCE   6  (bases 1 to 1417)
  AUTHORS   Knoops,B., Clippe,A., Bogard,C., Arsalane,K., Wattiez,R.,
            Hermans,C., Duconseille,E., Falmagne,P. and Bernard,A.
  TITLE     Cloning and characterization of AOEB166, a novel mammalian
            antioxidant enzyme of the peroxiredoxin family
  JOURNAL   J Biol Chem 274 (43), 30451-30458 (1999)
   PUBMED   10521424
REFERENCE   7  (bases 1 to 1417)
  AUTHORS   Yamashita,H., Avraham,S., Jiang,S., London,R., Van Veldhoven,P.P.,
            Subramani,S., Rogers,R.A. and Avraham,H.
  TITLE     Characterization of human and murine PMP20 peroxisomal proteins
            that exhibit antioxidant activity in vitro
  JOURNAL   J Biol Chem 274 (42), 29897-29904 (1999)
   PUBMED   10514471
REFERENCE   8  (bases 1 to 1417)
  AUTHORS   Matsumoto,A., Okado,A., Fujii,T., Fujii,J., Egashira,M., Niikawa,N.
            and Taniguchi,N.
  TITLE     Cloning of the peroxiredoxin gene family in rats and
            characterization of the fourth member
  JOURNAL   FEBS Lett 443 (3), 246-250 (1999)
   PUBMED   10025941
REFERENCE   9  (bases 1 to 1417)
  AUTHORS   Tsuji,K., Copeland,N.G., Jenkins,N.A. and Obinata,M.
  TITLE     Mammalian antioxidant protein complements alkylhydroperoxide
            reductase (ahpC) mutation in Escherichia coli
  JOURNAL   Biochem J 307 (Pt 2) (Pt 2), 377-381 (1995)
   PUBMED   7733872
REFERENCE   10 (bases 1 to 1417)
  AUTHORS   Nemoto,Y., Yamamoto,T., Takada,S., Matsui,Y. and Obinata,M.
  TITLE     Antisense RNA of the latent period gene (MER5) inhibits the
            differentiation of murine erythroleukemia cells
  JOURNAL   Gene 91 (2), 261-265 (1990)
   PUBMED   2210385
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022540.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF106944.1, FQ219655.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN09345331 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000001.1  270000049-270000111 c
            64-199              JAXUCZ010000001.1  269998448-269998583 c
            200-341             JAXUCZ010000001.1  269996475-269996616 c
            342-477             JAXUCZ010000001.1  269995369-269995504 c
            478-581             JAXUCZ010000001.1  269993322-269993425 c
            582-747             JAXUCZ010000001.1  269988823-269988988 c
            748-1417            JAXUCZ010000001.1  269987691-269988360 c
FEATURES             Location/Qualifiers
     source          1..1417
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..1417
                     /gene="Prdx3"
                     /gene_synonym="Prx3"
                     /note="peroxiredoxin 3"
                     /db_xref="GeneID:64371"
                     /db_xref="RGD:620040"
     exon            1..63
                     /gene="Prdx3"
                     /gene_synonym="Prx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..801
                     /gene="Prdx3"
                     /gene_synonym="Prx3"
                     /EC_number="1.11.1.24"
                     /note="thioredoxin-dependent peroxide reductase,
                     mitochondrial; PRX-3; PRx III; thioredoxin-dependent
                     peroxiredoxin 3"
                     /codon_start=1
                     /product="thioredoxin-dependent peroxide reductase,
                     mitochondrial precursor"
                     /protein_id="NP_071985.2"
                     /db_xref="GeneID:64371"
                     /db_xref="RGD:620040"
                     /translation="MAAAAGRLLWSSVARPASTIFRSISASTVLRPVASRRTCLTDML
                     WSACPQAKFAFSTSSSFHTPAVTQHAPHFKGTAVVNGEFKELSLDDFKGKYLVLFFYP
                     LDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIT
                     LLSDLTKQISRDYGVLLESAGIALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVK
                     AFQFVETHGEVCPANWTPESPTIKPSPTASKEYFEKVHQ"
     exon            64..199
                     /gene="Prdx3"
                     /gene_synonym="Prx3"
                     /inference="alignment:Splign:2.1.0"
     exon            200..341
                     /gene="Prdx3"
                     /gene_synonym="Prx3"
                     /inference="alignment:Splign:2.1.0"
     exon            342..477
                     /gene="Prdx3"
                     /gene_synonym="Prx3"
                     /inference="alignment:Splign:2.1.0"
     exon            478..581
                     /gene="Prdx3"
                     /gene_synonym="Prx3"
                     /inference="alignment:Splign:2.1.0"
     exon            582..747
                     /gene="Prdx3"
                     /gene_synonym="Prx3"
                     /inference="alignment:Splign:2.1.0"
     exon            748..1417
                     /gene="Prdx3"
                     /gene_synonym="Prx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctatcgtggc tcttgcgttc tctgaagatg gcggcagctg cgggaaggtt gctctggtcc
       61 tcggtggctc ggcctgcgag cactattttc cggagtattt ctgcctcaac agttcttagg
      121 cctgttgctt ctagaagaac ctgcttgaca gacatgctgt ggtctgcctg tccccaagca
      181 aagtttgcct ttagcaccag ttcttcattc cacacccctg ctgtcaccca gcatgcgccc
      241 cattttaaag gtactgctgt tgtcaatgga gagttcaaag agctgagtct cgacgacttt
      301 aaggggaaat acttggtgct tttcttctac cctttggatt tcacatttgt gtgtcctaca
      361 gaaattgttg ctttcagtga caaagccaat gagtttcatg acgtaaactg tgaagtagtt
      421 gctgtttctg tggattccca cttcagtcat cttgcctgga tcaacacgcc aagaaagaat
      481 ggtggtttgg gccacatgaa catcacgctg ttgtcggact taactaagca gatatcccga
      541 gactacggag tactgttgga aagtgctggc attgcgctca gaggtctctt cattattgac
      601 cctaatggtg tcatcaagca cctgagtgtc aatgaccttc cggtgggccg aagtgtggaa
      661 gaaacactcc gtttggtaaa ggcgttccag tttgtggaga cccatggaga agtctgccca
      721 gccaactgga caccagagtc ccctacgatc aagccaagtc caacagcttc aaaagagtac
      781 tttgagaagg tccatcaata ataggtcatc ctatgtctgc tgtttacctg aagcttctca
      841 tgccaaaaga gagccccagc tggaatcctg aagattattt atagaatggc aaaacctcac
      901 catgcttgtg tttataagta ctgctccatg ggctttgtaa ttttaagaca ggttcaggtt
      961 aaaggtggcc agctccttcc atagctgtcc ttactaggga cttcttgatg gctaccaatt
     1021 ctctacaagt gcttggtccc catttcttag atcatgtctt cagagggtta agatttctta
     1081 gcctgccctg aagcttggtc tacagtgaag tagcacatag caccagtact tagtgaaatg
     1141 aagtagcaca tagcgccagc acttagtgaa atgaagtagc atatagtgcc agcacttagt
     1201 gaaagcttct gatcaaggtc ctgaaatttc ctcttggatt tttgttaatt atgctgaatt
     1261 tcccattatt ttttagtgta gtcattaact cacagtgtcc ttgtgtgttc taaggtattg
     1321 atgagttata atcatgaagg actatgtttc taaaacacta tgtcattttc ttttcttcaa
     1381 gtgctggatg taaagaataa aaataaacat taagata
//
