LOCUS       NM_057114                909 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus peroxiredoxin 1 (Prdx1), mRNA.
ACCESSION   NM_057114
VERSION     NM_057114.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 909)
  AUTHORS   Wu,N., Du,X., Peng,Z., Zhang,Z., Cui,L., Li,D., Wang,R. and Ma,M.
  TITLE     Silencing of peroxiredoxin 1 expression ameliorates ulcerative
            colitis in a rat model
  JOURNAL   J Int Med Res 49 (3), 300060520986313 (2021)
   PUBMED   33682513
  REMARK    GeneRIF: Silencing of peroxiredoxin 1 expression ameliorates
            ulcerative colitis in a rat model.
REFERENCE   2  (bases 1 to 909)
  AUTHORS   Stancill,J.S., Happ,J.T., Broniowska,K.A., Hogg,N. and Corbett,J.A.
  TITLE     Peroxiredoxin 1 plays a primary role in protecting pancreatic
            beta-cells from hydrogen peroxide and peroxynitrite
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 318 (5), R1004-R1013 (2020)
   PUBMED   32292063
  REMARK    GeneRIF: Pancreatic beta-cells use cytoplasmic Prdx1 as a primary
            defense mechanism against both ROS and RNS.
REFERENCE   3  (bases 1 to 909)
  AUTHORS   Guo,W., Liu,X., Li,J., Shen,Y., Zhou,Z., Wang,M., Xie,Y., Feng,X.,
            Wang,L. and Wu,X.
  TITLE     Prdx1 alleviates cardiomyocyte apoptosis through ROS-activated MAPK
            pathway during myocardial ischemia/reperfusion injury
  JOURNAL   Int J Biol Macromol 112, 608-615 (2018)
   PUBMED   29410271
  REMARK    GeneRIF: Prdx1 inhibited MAPK pathway induced cells apoptosis, and
            reactive oxygen species is the upstream regulator of
            hypoxia/reoxygenation induced apoptosis.
REFERENCE   4  (bases 1 to 909)
  AUTHORS   Sepa-Kishi,D.M., Katsnelson,G., Bikopoulos,G., Iqbal,A. and
            Ceddia,R.B.
  TITLE     Cold acclimation reduces hepatic protein Kinase B and AMP-activated
            protein kinase phosphorylation and increases gluconeogenesis in
            Rats
  JOURNAL   Physiol Rep 6 (5) (2018)
   PUBMED   29504286
REFERENCE   5  (bases 1 to 909)
  AUTHORS   Zhu,Z., Zheng,X., Li,D., Wang,T., Xu,R., Piao,H. and Liu,K.
  TITLE     Prx1 promotes the proliferation and migration of vascular smooth
            muscle cells in a TLR4-dependent manner
  JOURNAL   Mol Med Rep 15 (1), 345-351 (2017)
   PUBMED   27922677
  REMARK    GeneRIF: TLR4 silencing inhibits the peroxiredocin 1 -induced
            proliferation of vascular smooth muscle cells.
REFERENCE   6  (bases 1 to 909)
  AUTHORS   Ishii,T., Kawane,T., Taketani,S. and Bannai,S.
  TITLE     Inhibition of the thiol-specific antioxidant activity of rat liver
            MSP23 protein by hemin
  JOURNAL   Biochem Biophys Res Commun 216 (3), 970-975 (1995)
   PUBMED   7488219
REFERENCE   7  (bases 1 to 909)
  AUTHORS   Immenschuh,S., Iwahara,S., Satoh,H., Nell,C., Katz,N. and
            Muller-Eberhard,U.
  TITLE     Expression of the mRNA of heme-binding protein 23 is coordinated
            with that of heme oxygenase-1 by heme and heavy metals in primary
            rat hepatocytes and hepatoma cells
  JOURNAL   Biochemistry 34 (41), 13407-13411 (1995)
   PUBMED   7577927
REFERENCE   8  (bases 1 to 909)
  AUTHORS   Iwahara,S., Satoh,H., Song,D.X., Webb,J., Burlingame,A.L., Nagae,Y.
            and Muller-Eberhard,U.
  TITLE     Purification, characterization, and cloning of a heme-binding
            protein (23 kDa) in rat liver cytosol
  JOURNAL   Biochemistry 34 (41), 13398-13406 (1995)
   PUBMED   7577926
REFERENCE   9  (bases 1 to 909)
  AUTHORS   Ishii,T., Yamada,M., Sato,H., Matsue,M., Taketani,S., Nakayama,K.,
            Sugita,Y. and Bannai,S.
  TITLE     Cloning and characterization of a 23-kDa stress-induced mouse
            peritoneal macrophage protein
  JOURNAL   J Biol Chem 268 (25), 18633-18636 (1993)
   PUBMED   8360158
REFERENCE   10 (bases 1 to 909)
  AUTHORS   Shau,H., Gupta,R.K. and Golub,S.H.
  TITLE     Identification of a natural killer enhancing factor (NKEF) from
            human erythroid cells
  JOURNAL   Cell Immunol 147 (1), 1-11 (1993)
   PUBMED   8462106
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jun 27, 2022 this sequence version replaced NM_057114.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ219859.1, BC088118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                JAXUCZ010000005.1  135383906-135383965
            61-177              JAXUCZ010000005.1  135385810-135385926
            178-331             JAXUCZ010000005.1  135390625-135390778
            332-454             JAXUCZ010000005.1  135391195-135391317
            455-585             JAXUCZ010000005.1  135392830-135392960
            586-909             JAXUCZ010000005.1  135399181-135399504
FEATURES             Location/Qualifiers
     source          1..909
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..909
                     /gene="Prdx1"
                     /gene_synonym="Hbp23"
                     /note="peroxiredoxin 1"
                     /db_xref="GeneID:117254"
                     /db_xref="RGD:620039"
     exon            1..60
                     /gene="Prdx1"
                     /gene_synonym="Hbp23"
                     /inference="alignment:Splign:2.1.0"
     exon            61..177
                     /gene="Prdx1"
                     /gene_synonym="Hbp23"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..671
                     /gene="Prdx1"
                     /gene_synonym="Hbp23"
                     /EC_number="1.11.1.24"
                     /note="thioredoxin peroxidase 2; heme-binding 23 kDa
                     protein; thioredoxin-dependent peroxide reductase 2;
                     thioredoxin-dependent peroxiredoxin 1"
                     /codon_start=1
                     /product="peroxiredoxin-1"
                     /protein_id="NP_476455.1"
                     /db_xref="GeneID:117254"
                     /db_xref="RGD:620039"
                     /translation="MSSGNAKIGHPAPSFKATAVMPDGQFKDISLSDYKGKYVVFFFY
                     PLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWINTPKKQGGLGPMNI
                     PLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITINDLPVGRSVDEILRLV
                     QAFQFTDKHGEVCPAGWKPGSDTIKPDVNKSKEYFSKQK"
     exon            178..331
                     /gene="Prdx1"
                     /gene_synonym="Hbp23"
                     /inference="alignment:Splign:2.1.0"
     exon            332..454
                     /gene="Prdx1"
                     /gene_synonym="Hbp23"
                     /inference="alignment:Splign:2.1.0"
     exon            455..585
                     /gene="Prdx1"
                     /gene_synonym="Hbp23"
                     /inference="alignment:Splign:2.1.0"
     exon            586..909
                     /gene="Prdx1"
                     /gene_synonym="Hbp23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcacgtctt cctgtgttct cacggttggt tctgtttgtg agacctgtag ctcgactctg
       61 ctgatagcaa gatgtcttca ggaaatgcaa aaattgggca tcctgctccc agcttcaaag
      121 ccacggctgt tatgcccgat ggacaattca aagatatcag cctaagtgat tacaaaggaa
      181 aatatgttgt attctttttt taccctcttg actttacttt tgtgtgtccc acggagatca
      241 ttgctttcag tgatagagca gaagaattta agaaactcaa ctgccaagtg attggagctt
      301 ctgtggattc tcacttctgt catctggcat ggattaacac acccaagaaa caaggaggat
      361 tgggacccat gaacattccc ttggtatcag atcccaagcg caccattgct caggattatg
      421 gagtcttaaa agctgatgaa ggtatctctt tcaggggcct ctttattatt gatgataaag
      481 gtatccttcg ccagataaca ataaatgatc ttcctgttgg ccgctctgtg gatgagattc
      541 tgagactagt ccaggccttc cagttcactg acaaacatgg tgaagtgtgc ccagctggct
      601 ggaaacctgg cagtgatacc atcaagcctg atgtcaataa gagtaaagag tatttctcta
      661 agcagaagtg agcactggac cagttttctg gcagacagct ttgagcagcc agaagaaatt
      721 tgtactctac acatgacgtg gtgtgattcc agataagcct ttcctacaag ggctaggggt
      781 ggttagcctt tcttccacta ttggtaaggg gcagaccatc ttatatcagt cacagaaacc
      841 aacctgttaa ttttctctct ctctctcttt tttttttttt aagtatctat taaacgtgaa
      901 ttctgtgaa
//
