LOCUS       NM_001108903            2688 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus PR/SET domain 9 (Prdm9), mRNA.
ACCESSION   NM_001108903 XM_001056338 XM_344847
VERSION     NM_001108903.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2688)
  AUTHORS   Gasic,S., Mihola,O. and Trachtulec,Z.
  TITLE     Prdm9 deficiency of rat oocytes causes synapsis among
            non-homologous chromosomes and aneuploidy
  JOURNAL   Mamm Genome 33 (4), 590-605 (2022)
   PUBMED   35596034
  REMARK    GeneRIF: Prdm9 deficiency of rat oocytes causes synapsis among
            non-homologous chromosomes and aneuploidy.
REFERENCE   2  (bases 1 to 2688)
  AUTHORS   Diagouraga,B., Clement,J.A.J., Duret,L., Kadlec,J., de Massy,B. and
            Baudat,F.
  TITLE     PRDM9 Methyltransferase Activity Is Essential for Meiotic DNA
            Double-Strand Break Formation at Its Binding Sites
  JOURNAL   Mol Cell 69 (5), 853-865 (2018)
   PUBMED   29478809
REFERENCE   3  (bases 1 to 2688)
  AUTHORS   Altemose,N., Noor,N., Bitoun,E., Tumian,A., Imbeault,M.,
            Chapman,J.R., Aricescu,A.R. and Myers,S.R.
  TITLE     A map of human PRDM9 binding provides evidence for novel behaviors
            of PRDM9 and other zinc-finger proteins in meiosis
  JOURNAL   Elife 6, e28383 (2017)
   PUBMED   29072575
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2688)
  AUTHORS   Parvanov,E.D., Tian,H., Billings,T., Saxl,R.L., Spruce,C.,
            Aithal,R., Krejci,L., Paigen,K. and Petkov,P.M.
  TITLE     PRDM9 interactions with other proteins provide a link between
            recombination hotspots and the chromosomal axis in meiosis
  JOURNAL   Mol Biol Cell 28 (3), 488-499 (2017)
   PUBMED   27932493
REFERENCE   5  (bases 1 to 2688)
  AUTHORS   Li,X., Li,C., Li,X., Cui,P., Li,Q., Guo,Q., Han,H., Liu,S. and
            Sun,G.
  TITLE     Involvement of Histone Lysine Methylation in p21 Gene Expression in
            Rat Kidney In Vivo and Rat Mesangial Cells In Vitro under Diabetic
            Conditions
  JOURNAL   J Diabetes Res 2016, 3853242 (2016)
   PUBMED   27652271
  REMARK    GeneRIF: SET7/9 Recruitment to p21 Gene Promoter Was Increased
            under Diabetic Conditions
REFERENCE   6  (bases 1 to 2688)
  AUTHORS   Berg,I.L., Neumann,R., Sarbajna,S., Odenthal-Hesse,L., Butler,N.J.
            and Jeffreys,A.J.
  TITLE     Variants of the protein PRDM9 differentially regulate a set of
            human meiotic recombination hotspots highly active in African
            populations
  JOURNAL   Proc Natl Acad Sci U S A 108 (30), 12378-12383 (2011)
   PUBMED   21750151
REFERENCE   7  (bases 1 to 2688)
  AUTHORS   Baudat,F., Buard,J., Grey,C., Fledel-Alon,A., Ober,C.,
            Przeworski,M., Coop,G. and de Massy,B.
  TITLE     PRDM9 is a major determinant of meiotic recombination hotspots in
            humans and mice
  JOURNAL   Science 327 (5967), 836-840 (2010)
   PUBMED   20044539
  REMARK    Erratum:[Science. 2010 May 7;328(5979):690]
REFERENCE   8  (bases 1 to 2688)
  AUTHORS   Parvanov,E.D., Petkov,P.M. and Paigen,K.
  TITLE     Prdm9 controls activation of mammalian recombination hotspots
  JOURNAL   Science 327 (5967), 835 (2010)
   PUBMED   20044538
REFERENCE   9  (bases 1 to 2688)
  AUTHORS   Mihola,O., Trachtulec,Z., Vlcek,C., Schimenti,J.C. and Forejt,J.
  TITLE     A mouse speciation gene encodes a meiotic histone H3
            methyltransferase
  JOURNAL   Science 323 (5912), 373-375 (2009)
   PUBMED   19074312
REFERENCE   10 (bases 1 to 2688)
  AUTHORS   Hayashi,K., Yoshida,K. and Matsui,Y.
  TITLE     A histone H3 methyltransferase controls epigenetic events required
            for meiotic prophase
  JOURNAL   Nature 438 (7066), 374-378 (2005)
   PUBMED   16292313
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 23, 2009 this sequence version replaced NM_001108903.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.727.1,
                                           SRR26643293.1116.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               JAXUCZ010000001.1  65198633-65198737   c
            106-216             JAXUCZ010000001.1  65197651-65197761   c
            217-340             JAXUCZ010000001.1  65197231-65197354   c
            341-448             JAXUCZ010000001.1  65196797-65196904   c
            449-498             JAXUCZ010000001.1  65195971-65196020   c
            499-655             JAXUCZ010000001.1  65194027-65194183   c
            656-757             JAXUCZ010000001.1  65192887-65192988   c
            758-1029            JAXUCZ010000001.1  65192409-65192680   c
            1030-1097           JAXUCZ010000001.1  65191979-65192046   c
            1098-1291           JAXUCZ010000001.1  65190669-65190862   c
            1292-2688           JAXUCZ010000001.1  65178666-65180062   c
FEATURES             Location/Qualifiers
     source          1..2688
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2688
                     /gene="Prdm9"
                     /gene_synonym="Prdm7"
                     /note="PR/SET domain 9"
                     /db_xref="GeneID:365155"
                     /db_xref="RGD:1305247"
     exon            1..105
                     /gene="Prdm9"
                     /gene_synonym="Prdm7"
                     /inference="alignment:Splign:2.1.0"
     exon            106..216
                     /gene="Prdm9"
                     /gene_synonym="Prdm7"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..2526
                     /gene="Prdm9"
                     /gene_synonym="Prdm7"
                     /EC_number="2.1.1.354"
                     /EC_number="2.1.1.355"
                     /EC_number="2.1.1.361"
                     /EC_number="2.1.1.362"
                     /EC_number="2.1.1.359"
                     /note="PR domain-containing protein 9; PR domain zinc
                     finger protein 9; PR domain containing 7; PR domain
                     containing 9; PR domain 9; protein-lysine
                     N-methyltransferase PRDM9; [histone H4]-lysine20
                     N-methyltransferase PRDM9; [histone H3]-lysine4
                     N-trimethyltransferase PRDM9; [histone H3]-lysine9
                     N-trimethyltransferase PRDM9; [histone H3]-lysine36
                     N-trimethyltransferase PRDM9; [histone
                     H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase PRDM9"
                     /protein_id="NP_001102373.2"
                     /db_xref="GeneID:365155"
                     /db_xref="RGD:1305247"
                     /translation="MSRTMNTNKPEENSTEGDAGKLEWKPKVKDEFKDISIYFSKEEW
                     AEMGEWEKIRYRNVKRNYKMLISIGLRAPRPAFMCYQRQAIKPQINDNEDSDEEWTPK
                     QQVSSPWVPFRVKHSKQQKETPRMPLSDKSSVKEVFGIENLLNTSGSEHAQKPVCSPE
                     EGNTSGQHFGKKLKLRRKNVEVNRYRLRERKDLAYEEVSEPQDDDYLYCEKCQNFFID
                     SCPNHGPPVFVKDSVVDRGHPNHSVLSLPPGLRIGPSGIPEAGLGVWNEASDLPVGLH
                     FGPYKGQITEDEEAANSGYSWLITKGRNCYEYVDGQDESQANWMRYVNCARDDEEQNL
                     VAFQYHRKIFYRTCRVIRPGRELLVWYGDEYGQELGIKWGSKMKKGFTAGRELRTEIH
                     PCFLCSLAFSSQKFLTQHVEWNHRTEIFPGASARINPKPGDPCPDQLQEHFDSQNKND
                     KASNEVKRKSKPRHKWTRQRISTAFSSTLKEQMRSEESKRTVEEELRTGQTTNIEDTA
                     KSFIASETSRIERQCGQCFSDKSNVSEHQRTHTGEKPYICRECGRGFSQKSDLIKHQR
                     THTEEKPYICRECGRGFTQKSDLIKHQRTHTEEKPYICRECGRGFTQKSDLIKHQRTH
                     TGEKPYICRECGRGFTQKSDLIKHQRTHTEEKPYICRECGRGFTQKSSLIRHQRTHTG
                     EKPYICRECGLGFTQKSNLIRHLRTHTGEKPYICRECGLGFTRKSNLIQHQRTHTGEK
                     PYICRECGQGLTWKSSLIQHQRTHTGEKPYICRECGRGFTWKSSLIQHQRTHTVEK"
     exon            217..340
                     /gene="Prdm9"
                     /gene_synonym="Prdm7"
                     /inference="alignment:Splign:2.1.0"
     exon            341..448
                     /gene="Prdm9"
                     /gene_synonym="Prdm7"
                     /inference="alignment:Splign:2.1.0"
     exon            449..498
                     /gene="Prdm9"
                     /gene_synonym="Prdm7"
                     /inference="alignment:Splign:2.1.0"
     exon            499..655
                     /gene="Prdm9"
                     /gene_synonym="Prdm7"
                     /inference="alignment:Splign:2.1.0"
     exon            656..757
                     /gene="Prdm9"
                     /gene_synonym="Prdm7"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1029
                     /gene="Prdm9"
                     /gene_synonym="Prdm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1097
                     /gene="Prdm9"
                     /gene_synonym="Prdm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1291
                     /gene="Prdm9"
                     /gene_synonym="Prdm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..2688
                     /gene="Prdm9"
                     /gene_synonym="Prdm7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctcagaa ggacgaacgg cggcggtggc tgcagagcca caggattctg gaccatgagt
       61 acaggcgaaa ccttcaagac cagcgagact ttctaggctc agcccgacca taggaccctg
      121 atcttctcca gggaaatgtc ccgcaccatg aacaccaaca agccggaaga gaatagtact
      181 gaaggagatg cagggaaact cgagtggaaa cccaaggtca aagatgagtt caaagacatt
      241 tccatatact tctccaaaga agaatgggca gagatgggag agtgggagaa aattcgctat
      301 agaaatgtga aaaggaacta taaaatgctg atttctatag gtctcagagc ccctagacca
      361 gctttcatgt gttaccaaag gcaggcaatc aagccccaga taaatgacaa tgaggattct
      421 gatgaggaat ggacaccaaa gcagcaagtc agttctcctt gggtgccttt ccgggtgaag
      481 cacagtaaac aacagaagga aacacccaga atgccattaa gtgataaatc tagtgtgaag
      541 gaagtatttg gaatagaaaa tttgctgaac acaagtggct cagagcatgc ccagaaacca
      601 gtgtgctccc ctgaagaagg gaatacctcc ggacagcact ttggaaaaaa actgaaactc
      661 aggagaaaga atgttgaagt gaataggtac aggctgcgag agagaaagga ccttgcatat
      721 gaagaggtca gcgagcccca ggatgatgac tacctctatt gtgagaagtg ccagaatttc
      781 ttcatcgaca gttgtcccaa ccatgggcct cctgtatttg taaaagacag tgtggtggac
      841 agggggcatc ccaaccactc agtcctcagt ctgccccctg ggctgagaat tggtccatca
      901 ggcatccctg aagctggact tggagtatgg aatgaagcat ctgatctacc agtgggtctg
      961 cactttggtc cctataaggg ccagattaca gaggatgaag aggcagccaa cagtggatac
     1021 tcctggctga tcaccaaggg aagaaactgc tatgagtatg tggatgggca ggatgagtcc
     1081 caagccaact ggatgaggta tgtgaactgt gcccgggatg acgaagagca gaacctggtg
     1141 gcctttcaat atcacaggaa aatcttctat cggacctgcc gggtcatcag gccaggtcgc
     1201 gagcttctgg tctggtatgg ggatgagtat ggccaagagc tgggcatcaa gtggggaagc
     1261 aagatgaaga aaggattcac agcaggaaga gaactaagga cagagattca tccttgtttt
     1321 ttgtgctctt tggccttctc aagtcagaaa ttcctcactc aacatgtaga atggaatcat
     1381 cgcacagaaa tcttcccagg agcatctgca aggataaatc ctaagccagg agatccctgt
     1441 ccagatcagc ttcaggaaca ttttgattca cagaacaaga atgacaaagc cagcaatgaa
     1501 gtcaaaagaa aatccaaacc caggcataaa tggacaagac agaggatttc aacagccttt
     1561 tccagtactc tcaaagaaca aatgagatct gaggaaagta agagaactgt agaagaagag
     1621 cttagaacag gccagacaac aaatatagag gacacagcca aatcatttat tgcatcagaa
     1681 acctcaagaa ttgaaaggca atgtgggcaa tgtttcagtg ataagtcaaa tgtcagtgag
     1741 caccagagga cacacacagg ggagaagccc tacatttgca gggagtgtgg gcggggcttt
     1801 tcacagaagt cagacctcat caagcaccag aggacacaca cagaggagaa gccctacatt
     1861 tgcagggagt gtgggcgggg ctttacacag aagtcagacc tcatcaagca ccagaggaca
     1921 cacacagagg agaagcccta catttgcagg gagtgtgggc ggggctttac acagaagtca
     1981 gacctcatca agcaccagag gacacacaca ggggagaagc cctacatttg cagggagtgt
     2041 gggcggggct ttacacagaa gtcagacctc atcaagcacc agaggacaca cacagaggag
     2101 aagccctaca tttgcaggga gtgtgggcgg ggctttacac agaagtcaag cctcatccgg
     2161 caccagagga cacacacagg ggagaagccc tacatttgca gggagtgtgg gctgggcttt
     2221 acacagaagt caaacctcat ccggcacctg aggacacaca caggggagaa gccctacatt
     2281 tgcagggagt gtgggctggg ctttacacgg aagtcaaacc tcatccagca ccagaggaca
     2341 cacacagggg agaagcccta catttgcagg gagtgtgggc agggccttac atggaagtca
     2401 agcctcatcc agcaccagag gacacacaca ggggagaagc cctacatttg cagggagtgt
     2461 gggcggggct ttacatggaa gtcaagcctc atccagcacc agaggacaca cacagtggag
     2521 aagtaatatc ttttcaaaaa gaatgagaaa gccaatagca ataaaaccgc atctcaacaa
     2581 ttacagaaag accactaaac atcttcccac ctgttctact aaaacttctg agaagtctga
     2641 ttttcaaaac tagagtataa aatgattaaa aaggaaaatt aaatcccc
//
