LOCUS       NM_133312               2554 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus PR/SET domain 4 (Prdm4), mRNA.
ACCESSION   NM_133312
VERSION     NM_133312.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2554)
  AUTHORS   Tunbak,H., Georgiou,C., Guan,C., Richardson,W.D. and Chittka,A.
  TITLE     Zinc fingers 1, 2, 5 and 6 of transcriptional regulator, PRDM4, are
            required for its nuclear localisation
  JOURNAL   Biochem Biophys Res Commun 474 (2), 388-394 (2016)
   PUBMED   27125459
  REMARK    GeneRIF: We investigated the potential mechanism of nuclear
            shuttling of PRDM4 via the importin alpha/beta-mediated pathway and
            find that PRDM4 nuclear targeting is independent of
            alpha/beta-mediated nuclear import.
REFERENCE   2  (bases 1 to 2554)
  AUTHORS   Bogani,D., Morgan,M.A., Nelson,A.C., Costello,I., McGouran,J.F.,
            Kessler,B.M., Robertson,E.J. and Bikoff,E.K.
  TITLE     The PR/SET domain zinc finger protein Prdm4 regulates gene
            expression in embryonic stem cells but plays a nonessential role in
            the developing mouse embryo
  JOURNAL   Mol Cell Biol 33 (19), 3936-3950 (2013)
   PUBMED   23918801
REFERENCE   3  (bases 1 to 2554)
  AUTHORS   Chittka,A., Nitarska,J., Grazini,U. and Richardson,W.D.
  TITLE     Transcription factor positive regulatory domain 4 (PRDM4) recruits
            protein arginine methyltransferase 5 (PRMT5) to mediate histone
            arginine methylation and control neural stem cell proliferation and
            differentiation
  JOURNAL   J Biol Chem 287 (51), 42995-43006 (2012)
   PUBMED   23048031
  REMARK    GeneRIF: SC1 and PRMT5 are components of an epigenetic regulatory
            complex that maintains the 'stem-like' cellular state of the neural
            stem cells.
REFERENCE   4  (bases 1 to 2554)
  AUTHORS   Chittka,A., Arevalo,J.C., Rodriguez-Guzman,M., Perez,P., Chao,M.V.
            and Sendtner,M.
  TITLE     The p75NTR-interacting protein SC1 inhibits cell cycle progression
            by transcriptional repression of cyclin E
  JOURNAL   J Cell Biol 164 (7), 985-996 (2004)
   PUBMED   15051733
REFERENCE   5  (bases 1 to 2554)
  AUTHORS   Chittka,A. and Chao,M.V.
  TITLE     Identification of a zinc finger protein whose subcellular
            distribution is regulated by serum and nerve growth factor
  JOURNAL   Proc Natl Acad Sci U S A 96 (19), 10705-10710 (1999)
   PUBMED   10485890
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133312.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF176023.1, SRR26360194.890365.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000007.1  19846401-19846533
            134-319             JAXUCZ010000007.1  19848874-19849059
            320-1114            JAXUCZ010000007.1  19851225-19852019
            1115-1264           JAXUCZ010000007.1  19853746-19853895
            1265-1383           JAXUCZ010000007.1  19854983-19855101
            1384-1469           JAXUCZ010000007.1  19856519-19856604
            1470-1597           JAXUCZ010000007.1  19857676-19857803
            1598-1912           JAXUCZ010000007.1  19858355-19858669
            1913-2081           JAXUCZ010000007.1  19860199-19860367
            2082-2554           JAXUCZ010000007.1  19866702-19867174
FEATURES             Location/Qualifiers
     source          1..2554
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2554
                     /gene="Prdm4"
                     /gene_synonym="SC-1"
                     /note="PR/SET domain 4"
                     /db_xref="GeneID:170820"
                     /db_xref="RGD:619929"
     CDS             1..2397
                     /gene="Prdm4"
                     /gene_synonym="SC-1"
                     /note="PR domain-containing protein 4; PR domain
                     containing 4; PR domain 4"
                     /codon_start=1
                     /product="PR domain zinc finger protein 4"
                     /protein_id="NP_579846.2"
                     /db_xref="GeneID:170820"
                     /db_xref="RGD:619929"
                     /translation="MNDMNLSPVGMEQLSSSSVSNALPVSGSHLGLAASPSHSAIPAP
                     GLPVAIPNLGPSLSSLPSALSLMLPMGIGDRGVMCGLPERNYTLPPPPYPHLESSYFR
                     TILPGILSYLADRPPPQYIHPNSINVDGNTALSITNNPSALDPYQANGNVGLELGIVS
                     IDSRSVNTHGAQSLHPNDGHEVALDTTITMENVSRVTSPISTDGMAEELTMDGVTGEH
                     SQIPNGSRSHEPLSVDSVSNNLTADTVGHGGVIPIHGNGLELPVVMETDHIANRVNGI
                     SDSVLSDSIHTVAMSTNSVSVALSTSHNLASLESVSLQEVGLSLEPVAVSSITQEVAM
                     GTGHVDVSSDSLSFVPSSLQMEDSNSNKENMATLFTIWCTLCDRAYPSDCPDHGPVTF
                     VPDTPIESRARLSLPKQLVLRQSIVGTDVGVWTAETIPVRTCFGPLIGQQSHSMEVAE
                     WTDKAVSHVWKIYHNGVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGKIYF
                     CTSQDIPPENELLFYYSRDYAQQIGVPEHPDVHLCNCGKECSSYSEFKAHLTSHIHNH
                     LPSQGHSSSHGPSHSKERKWKCSMCPQAFISPSKLHVHFMGHMGMKPHKCDFCSKAFS
                     DPSNLRTHLKIHTGQKNYRCTLCDKSFTQKAHLESHMVIHTGEKNLKCDYCDKLFMRR
                     QDLKQHVLIHTQERQIKCPKCDKLFLRTNHLKKHLNSHEGRRDYVCEKCTKAYLTKYH
                     LTRHLKACKEPASSSSAQDDEDEDGDSGEDGLPGSMTTEGCRMSSAVYSADESLSAHK
                     "
     exon            1..133
                     /gene="Prdm4"
                     /gene_synonym="SC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            134..319
                     /gene="Prdm4"
                     /gene_synonym="SC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..1114
                     /gene="Prdm4"
                     /gene_synonym="SC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1264
                     /gene="Prdm4"
                     /gene_synonym="SC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1383
                     /gene="Prdm4"
                     /gene_synonym="SC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1469
                     /gene="Prdm4"
                     /gene_synonym="SC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1597
                     /gene="Prdm4"
                     /gene_synonym="SC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1912
                     /gene="Prdm4"
                     /gene_synonym="SC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2081
                     /gene="Prdm4"
                     /gene_synonym="SC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2554
                     /gene="Prdm4"
                     /gene_synonym="SC-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaatgaca tgaacttgag cccagtgggg atggagcagc tgtcttcatc ctctgtgagc
       61 aatgccctgc cagtctcagg aagtcacctg ggtctggctg cctctccctc tcacagtgcc
      121 atccctgccc caggacttcc agtggcaatt ccaaacctcg gtccctccct gagctctctg
      181 ccttctgcct tgtctctgat gctccccatg ggcattggag atcgaggagt aatgtgtggg
      241 ttacctgaaa gaaactatac cctacctcca ccaccttacc ctcacctaga gagcagttac
      301 ttcagaacca ttctacctgg cattttatct tatttagctg acagaccacc tcctcagtat
      361 atccacccca actctataaa tgttgatgga aatacagcat tatctatcac caacaaccct
      421 tcggcactag atccctatca ggccaatgga aatgttggat tagaactagg cattgtttca
      481 atagactctc gctctgtaaa cactcatggt gcccaaagtc ttcatcctaa tgatggccac
      541 gaagtagcat tggacacaac aatcactatg gagaatgtct ctagggttac cagcccaatc
      601 tccacagacg gaatggcaga ggaacttaca atggatggag ttacaggaga acattcccag
      661 atcccaaatg gctccagaag tcatgaaccc ctctctgtgg attctgtgag caacaacctt
      721 acagctgaca ctgtaggaca tggtggtgtg atacccattc atgggaatgg tctggagctt
      781 ccagtggtca tggagacaga ccacattgca aaccgggtca atgggatatc tgacagcgtc
      841 ctcagtgatt ccatccacac cgtggccatg agcaccaact ctgtaagcgt ggcactttct
      901 acctcacaca acctcgcctc cctagaatct gtttccctcc aggaagttgg ccttagccta
      961 gagcctgtgg ctgtctcttc catcacccag gaagttgcca tggggacagg tcatgtagat
     1021 gtatcctcag acagcttgtc ttttgtacca tcttcactgc aaatggaaga ctccaattca
     1081 aacaaggaaa acatggcaac cttgtttaca atttggtgca cgctttgtga ccgagcctac
     1141 ccctcagatt gccctgatca tggaccagtg acttttgttc ctgatacacc aatagagagc
     1201 agagcaagac tatccctccc gaagcagctt gttctccgcc agtccattgt ggggacagat
     1261 gttggcgtgt ggactgcaga gaccattccc gtgcggactt gcttcgggcc tctaattggc
     1321 cagcagagtc actccatgga agtggcggag tggacagaca aggccgttag ccacgtctgg
     1381 aagatatacc acaatggcgt cctagaattc tgcatcatta caaccgatga gaatgagtgt
     1441 aattggatga tgtttgtgcg caaagccagg aaccgtgaag aacagaattt ggtggcttat
     1501 ccccatgatg gaaaaatcta tttctgtacc tcacaagaca tccctcctga aaacgagctg
     1561 cttttctatt atagccggga ttatgctcaa cagataggtg ttcctgaaca ccccgatgtg
     1621 cacctctgta actgtggcaa ggagtgcagt tcctattcag agttcaaagc tcacctgacc
     1681 agccatatcc acaatcatct ccctagccag ggccacagca gcagccatgg gccaagccac
     1741 agcaaggaaa ggaagtggaa gtgctccatg tgcccccagg cctttatttc tccttctaaa
     1801 ctccacgttc actttatggg tcatatgggc atgaagcccc acaagtgtga tttttgtagc
     1861 aaggctttta gtgatccaag caacctacgg acacacctca aaatacatac aggtcagaag
     1921 aattacaggt gtactttgtg tgacaagtct ttcacgcaga aggctcactt ggaatctcac
     1981 atggtcatcc acacgggtga gaagaatctc aagtgtgatt actgtgacaa gctattcatg
     2041 cggagacagg acctcaagca gcatgtgctc atccacacac aagaacgcca gatcaagtgt
     2101 ccgaagtgtg ataaactgtt cctgagaaca aaccacttga agaagcatct caactctcac
     2161 gagggaagac gagactatgt ctgtgagaaa tgcacaaagg cttacctaac caagtaccac
     2221 ctcacccgcc acctgaaggc ctgcaaggag cccgcctcca gctcctccgc ccaggacgat
     2281 gaggacgagg atggggactc gggggaagac ggtctcccag gctccatgac gacagagggc
     2341 tgcaggatga gcagtgctgt ttactcagca gatgagtctc tctccgcaca taaataagag
     2401 gaaaaagcaa ctgctttgga tggcacatac actggggaaa cataaccagc ccactgtagt
     2461 ggttttatag gaaatgcttt ctgatcccta acccgctgtt aagagtggac tgagtggggg
     2521 tagctaaagc acttacagag gtctgcccaa atgg
//
