LOCUS       NM_001077648            6150 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus PR/SET domain 2 (Prdm2), mRNA.
ACCESSION   NM_001077648 XM_001073041 XM_233620
VERSION     NM_001077648.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6150)
  AUTHORS   Barbier,E., Johnstone,A.L., Khomtchouk,B.B., Tapocik,J.D.,
            Pitcairn,C., Rehman,F., Augier,E., Borich,A., Schank,J.R.,
            Rienas,C.A., Van Booven,D.J., Sun,H., Natt,D., Wahlestedt,C. and
            Heilig,M.
  TITLE     Dependence-induced increase of alcohol self-administration and
            compulsive drinking mediated by the histone methyltransferase PRDM2
  JOURNAL   Mol Psychiatry 22 (12), 1746-1758 (2017)
   PUBMED   27573876
  REMARK    GeneRIF: Findings indicate that PRDM2-mediated reprogramming of the
            genome in neurons of the dorsomedial prefrontal cortex is involved
            in increasing alcohol self-administration, compulsive-like drinking
            and stress-induced relapse. This broad spectrum of actions provides
            a strong rationale to explore PRMD2 itself or some of its
            downstream targets as candidate targets for novel alcoholism
            medications.
REFERENCE   2  (bases 1 to 6150)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   3  (bases 1 to 6150)
  AUTHORS   Steele-Perkins,G., Fang,W., Yang,X.H., Van Gele,M., Carling,T.,
            Gu,J., Buyse,I.M., Fletcher,J.A., Liu,J., Bronson,R.,
            Chadwick,R.B., de la Chapelle,A., Zhang,X., Speleman,F. and
            Huang,S.
  TITLE     Tumor formation and inactivation of RIZ1, an Rb-binding member of a
            nuclear protein-methyltransferase superfamily
  JOURNAL   Genes Dev 15 (17), 2250-2262 (2001)
   PUBMED   11544182
REFERENCE   4  (bases 1 to 6150)
  AUTHORS   Abbondanza,C., Medici,N., Nigro,V., Rossi,V., Gallo,L., Piluso,G.,
            Belsito,A., Roscigno,A., Bontempo,P., Puca,A.A., Molinari,A.M.,
            Moncharmont,B. and Puca,G.A.
  TITLE     The retinoblastoma-interacting zinc-finger protein RIZ is a
            downstream effector of estrogen action
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3130-3135 (2000)
   PUBMED   10706618
REFERENCE   5  (bases 1 to 6150)
  AUTHORS   Xie,M., Shao,G., Buyse,I.M. and Huang,S.
  TITLE     Transcriptional repression mediated by the PR domain zinc finger
            gene RIZ
  JOURNAL   J Biol Chem 272 (42), 26360-26366 (1997)
   PUBMED   9334209
REFERENCE   6  (bases 1 to 6150)
  AUTHORS   Muraosa,Y., Takahashi,K., Yoshizawa,M. and Shibahara,S.
  TITLE     cDNA cloning of a novel protein containing two zinc-finger domains
            that may function as a transcription factor for the human
            heme-oxygenase-1 gene
  JOURNAL   Eur J Biochem 235 (3), 471-479 (1996)
   PUBMED   8654390
REFERENCE   7  (bases 1 to 6150)
  AUTHORS   Buyse,I.M., Shao,G. and Huang,S.
  TITLE     The retinoblastoma protein binds to RIZ, a zinc-finger protein that
            shares an epitope with the adenovirus E1A protein
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4467-4471 (1995)
   PUBMED   7538672
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001077648.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                JAXUCZ010000005.1  160815050-160815140 c
            92-165              JAXUCZ010000005.1  160795628-160795701 c
            166-280             JAXUCZ010000005.1  160780798-160780912 c
            281-384             JAXUCZ010000005.1  160779146-160779249 c
            385-537             JAXUCZ010000005.1  160762747-160762899 c
            538-664             JAXUCZ010000005.1  160758167-160758293 c
            665-775             JAXUCZ010000005.1  160739196-160739306 c
            776-5156            JAXUCZ010000005.1  160729875-160734255 c
            5157-5300           JAXUCZ010000005.1  160708565-160708708 c
            5301-6150           JAXUCZ010000005.1  160705462-160706311 c
FEATURES             Location/Qualifiers
     source          1..6150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..6150
                     /gene="Prdm2"
                     /gene_synonym="Riz"
                     /note="PR/SET domain 2"
                     /db_xref="GeneID:313678"
                     /db_xref="RGD:1594531"
     exon            1..91
                     /gene="Prdm2"
                     /gene_synonym="Riz"
                     /inference="alignment:Splign:2.1.0"
     exon            92..165
                     /gene="Prdm2"
                     /gene_synonym="Riz"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..5277
                     /gene="Prdm2"
                     /gene_synonym="Riz"
                     /EC_number="2.1.1.355"
                     /note="retinoblastoma interacting zinc finger protein;
                     zinc finger protein RIZ; PR domain-containing protein 2;
                     retinoblastoma protein-interacting zinc finger protein; PR
                     domain containing 2, with ZNF domain; retinoblastoma
                     protein-binding zinc finger protein; PR domain 2"
                     /codon_start=1
                     /product="PR domain zinc finger protein 2"
                     /protein_id="NP_001071116.2"
                     /db_xref="GeneID:313678"
                     /db_xref="RGD:1594531"
                     /translation="MHQNTESVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVW
                     ATKPILKGKKFGPFVGDKKKRSQVRNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVN
                     WACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARS
                     KRSSPKSRRGKKKSHENKNKGIRTHPTQLKASELDSTFANMRGSAEGPKEEDERPLAS
                     APEQPAPLPEVGNQDAVPQVAIPLPACEPQPEVDGKQEVTDCEVNDVEEEELEEEEEL
                     EEEEEEELGEDGVEEADMPNESSAKEPEIRCEEKPEDLLEEPQSMSNEAREDSPDVTP
                     PPHTPRAREEANGDVLETFMFPCQHCERKFATKQGLERHMHIHISTINHAFKCKYCGK
                     RFGTQINRRRHERRHETGLKRRPSMTLQSSEDPDDGKGENVTSKDESSPPQLGQDCLI
                     LNSEKTSQEVLNSSFVEENGEVKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGV
                     RRKGGLLEEPQPPAEQAPPSQNVYVPSTEPEEEGETDDVYIMDISSNISENLNYYIDG
                     KIQTNSSTSNCDVIEMESNSAHLYGIDCLLTPVTVEITQNIKSTQVSVTDDLLKDSPS
                     STNCESKKRRTASPPVLPKIKTETESDSTAPSCSLSLPLSISTAEVVSFHKEKGVYLS
                     SKLKQLLQTQDKLTLPAGFSAAEIPKLGPVCASAPASMLPVTSSRFKRRTSSPPSSPQ
                     HSPALRDFGKPNDGKAAWTDTVLTSKKPKLESRSDSPAWSLSGRDERETGSPPCFDEY
                     KISKEWAASSTFSSVCNQQPLDLSSGVKQKSEGTGKTPVPWESVLDLSVHKKPCDSEG
                     KEFKENHLAQPAAKKKKPTTCMLQKVLLNEYNGVSLPTETTPEVTRSPSPCKSPDTQP
                     DPELGPDSSCSVPTAESPPEVVGPSSPPLQTASLSSGQLPPLLTPTEPSSPPPCPPVL
                     TVATPPPPLLPTVPLSHPSSDASPQQCPSPFSNTTAQSPLPILSPTVSPSPSPIPPVE
                     PLMSAASPGPPTLSSSSSSSSSFPSSSCSSTSPSPPPLSAVSSVVSSGDNLEASLPAV
                     TFKQEESESEGLKPKEEAPPAGGQSVVQETFSKNFICNVCESPFLSIKDLTKHLSVHA
                     EEWPFKCEFCVQLFKVKTDLSEHRFLLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHP
                     DEVCTHHEFESGTLRPQNFTDPSKANVEHMPSLPEEPLETSREEELNDSSEELYTTIK
                     IMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRNPMGIGVTATNFTTHNIPQTFTTA
                     IRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSG
                     KNAFRRMGQPKRLSFNVELGKMSPNKLKLSALKKKNQLVQKAILQKNRAAKQKADLRD
                     TSEASSHICPYCDREFTYIGSLNKHAAFSCPKKPLSPSKRKVSHSSKKGGHASSSSSD
                     RNSSSHPRRRTADTEIKMQSTQAPLGKTRARSTGPAQASLPSSSFRSRQNVKFAASVK
                     SKKASSSSLRNSSPIRMAKITHVEGKKPKAVAKSHSAQLSSKSSRGLHVRVQKSKAVI
                     QSKTALASKRRTDRFIVKSRERSGGPITRSLQLAAAADLSESRREDSSARHELKDFSY
                     SLRLASRCGSSTASYITRQCRKVKAAAATPFQGPFLKE"
     exon            166..280
                     /gene="Prdm2"
                     /gene_synonym="Riz"
                     /inference="alignment:Splign:2.1.0"
     exon            281..384
                     /gene="Prdm2"
                     /gene_synonym="Riz"
                     /inference="alignment:Splign:2.1.0"
     exon            385..537
                     /gene="Prdm2"
                     /gene_synonym="Riz"
                     /inference="alignment:Splign:2.1.0"
     exon            538..664
                     /gene="Prdm2"
                     /gene_synonym="Riz"
                     /inference="alignment:Splign:2.1.0"
     exon            665..775
                     /gene="Prdm2"
                     /gene_synonym="Riz"
                     /inference="alignment:Splign:2.1.0"
     exon            776..5156
                     /gene="Prdm2"
                     /gene_synonym="Riz"
                     /inference="alignment:Splign:2.1.0"
     exon            5157..5300
                     /gene="Prdm2"
                     /gene_synonym="Riz"
                     /inference="alignment:Splign:2.1.0"
     exon            5301..6150
                     /gene="Prdm2"
                     /gene_synonym="Riz"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaagatgg cggcggcgcg gccgcgggcg ccagggcgac ggcggcggct gaggctctgg
       61 gctcgctgaa gcgttggcac gtcgcgctct gggctcatgt aatcaaagaa gtttctttgt
      121 tgtgtgtatc ttcacagaac acaacaggaa ttgaaaatgc atcagaacac tgagtctgtg
      181 gcagccactg agactctggc tgaggtacct gaacatgtgc ttcgaggact tccagaggaa
      241 gtaagacttt tcccatctgc agtcgacaag actcggattg gtgtctgggc tactaaacca
      301 attttaaaag ggaaaaagtt tgggccattt gttggtgata agaagaagag atcccaggtt
      361 aggaataatg tgtacatgtg ggaggtctac tacccaaatt tggggtggat gtgcattgat
      421 gccaccgatc cggagaaggg caactggcta cgctatgtga actgggcttg ctcaggagaa
      481 gagcagaatt tatttccact ggaaatcaac agagccattt actataaaac cttaaagcca
      541 atcgcgcctg gcgaggagct cctggtctgg tacaatgggg aagacaaccc tgagatagca
      601 gctgcgattg aggaagagcg agccagcgcc cggagcaagc ggagctcccc gaagagccgc
      661 agagggaaga agaaatcaca cgagaacaaa aacaaaggca tcagaaccca ccccacacag
      721 ctgaaggcaa gtgagctgga ctctaccttt gcaaacatga ggggctctgc agaaggtcca
      781 aaagaagagg atgagaggcc tttggcttcg gcacctgagc agccagcccc tctgccggag
      841 gtggggaacc aagatgcagt tccacaggtg gccatccctc tccctgcctg cgagccacag
      901 ccagaggtag atgggaaaca agaagtcaca gactgtgagg tcaatgatgt ggaggaagag
      961 gagctggaag aggaagagga gctggaagag gaggaggagg aggagttggg agaagatggg
     1021 gtagaagaag cagacatgcc gaatgaaagc tctgcgaaag agccggagat ccggtgtgaa
     1081 gaaaagccag aagacttatt agaagagcca cagagcatgt cgaatgaagc tcgtgaagac
     1141 tctccagacg tgacccctcc tccccacact cccagagcta gagaggaggc caacggtgat
     1201 gtacttgaga catttatgtt tccgtgtcag cactgtgaaa gaaaatttgc aacgaagcag
     1261 gggctagagc gtcacatgca catccacatt tctaccatca atcatgcttt caagtgcaag
     1321 tactgtggga aacggtttgg cacacagatt aacaggaggc ggcatgaacg gcgccacgaa
     1381 acggggttga agagaagacc cagcatgact ttacagtcct cagaggatcc agatgatggc
     1441 aagggggaaa atgttacttc taaagatgag tcaagtccac ctcaactcgg gcaagactgt
     1501 ttgatattga actcagagaa aacctcacag gaagtactga attcatcttt tgtggaagaa
     1561 aatggtgaag ttaaagaact tcatccgtgc aaatactgca aaaaggtatt tggaactcac
     1621 accaatatga gacgacatca gcgtagagtt catgagcgcc acctgattcc caaaggtgtc
     1681 aggcgaaaag gaggacttct ggaagagcca cagccaccag cagagcaggc tccaccctcc
     1741 cagaatgtct atgtcccaag cacagagcca gaggaggaag gggaaacaga tgacgtgtac
     1801 atcatggaca tttctagcaa catctctgaa aacctaaatt actatattga cggtaagatt
     1861 cagaccaaca gcagcactag taactgtgat gtgattgaga tggagtctaa ttctgcacac
     1921 ttgtatggca tagactgtct gctcactcca gtgaccgtgg agattactca gaacataaag
     1981 agcactcagg tctctgtgac agatgatctt ctcaaagact ctcccagcag cacaaattgt
     2041 gagtctaaga aacggaggac tgccagtcca cctgtgctcc ccaaaattaa aacggagacg
     2101 gagtctgatt ccacagcacc ctcgtgttcc ttaagtctgc ccctgagcat atccacagcc
     2161 gaggtggtgt ccttccataa agagaagggc gtctatttgt cgtccaagct caagcagctt
     2221 cttcagaccc aggacaagct gacccttcct gcagggtttt cagcagctga gattcctaag
     2281 ttaggtcccg tgtgtgcgtc tgctcctgca tccatgttgc ccgtgacctc tagtaggttt
     2341 aagagacgca ccagctctcc accgagctct ccacagcaca gccctgccct tcgagacttc
     2401 gggaaaccaa atgatgggaa agcagcatgg acagacacag tcctgacttc caagaaaccc
     2461 aagttagaaa gtcgtagtga ctcaccagca tggagtttgt ctgggagaga tgaaagagaa
     2521 accggaagcc ctccttgctt tgatgaatac aaaatatcaa aggaatgggc agccagttct
     2581 actttcagca gtgtgtgcaa ccaacagcca ttggatttat ccagcggggt caaacagaag
     2641 tcagagggca caggcaagac tccagtccca tgggaatctg tattggatct cagtgtgcat
     2701 aaaaagcctt gcgattctga aggcaaggaa ttcaaagaga accatttggc acagccagct
     2761 gcaaagaaga aaaaaccaac cacctgtatg cttcaaaagg ttcttctcaa tgagtataat
     2821 ggtgttagct tacctacaga aaccacacca gaggtgacca ggagcccaag tccttgtaaa
     2881 tccccagata cacagccaga tcctgaactt ggtcctgact caagttgctc agtccccact
     2941 gctgagtctc cacctgaagt tgttggccct tcctcacccc ctctccagac agcctcctta
     3001 tcctccggtc agctgcctcc tctcttaacc cccacagagc cttcttcccc tcccccctgc
     3061 cctcctgtgt taactgttgc cactccacca cctcccctcc ttccaaccgt ccctctctcc
     3121 cacccctctt ctgatgcctc ccctcagcag tgtccctctc cgttctcaaa caccactgct
     3181 cagtctcctc ttcccattct ctccccaaca gtgtctccct ctccctctcc cattcctcct
     3241 gtagagccac ttatgtctgc tgcttcccct ggtcccccaa cactttcttc ctcctcctct
     3301 tcttcctctt ccttcccttc ctcttcctgc tcctccacct ccccctcccc accccctctt
     3361 tcagcagtgt catctgtggt ttcctctggg gacaacctgg aggcatctct gcctgcagta
     3421 actttcaaac aggaggagtc agagagtgaa ggtctgaaac ccaaggaaga ggccccacct
     3481 gcagggggac agagtgtggt ccaagaaaca ttcagcaaaa acttcatttg caatgtctgt
     3541 gaatcgcctt ttctttccat taaagaccta accaaacatt tatccgtcca tgctgaagag
     3601 tggcccttca aatgtgagtt ttgtgtgcag ctgtttaagg ttaagactga tctatcagag
     3661 catcgatttc tgcttcatgg ggttggaaat atctttgtgt gttctgtatg taagaaagaa
     3721 tttgccttct tatgcaatct gcagcagcac cagcgtgatc tccacccaga tgaggtatgc
     3781 acacaccacg agtttgaaag tgggaccctg aggccccaga acttcacaga ccccagcaag
     3841 gccaatgtgg agcatatgcc aagtttgcca gaagagcctt tagaaacttc tagagaggag
     3901 gagttaaatg attcctctga agagctttac acgaccatca aaataatggc ttctggaata
     3961 aagacgaagg atccagatgt tcgacttggt ctcaaccagc actacccgag ctttaaacct
     4021 cctccatttc agtaccacca tcgaaaccct atggggatag gggtgacagc caccaacttc
     4081 accacccaca atattccaca gactttcact actgccatcc gctgcacaaa gtgtgggaag
     4141 ggcgtcgaca atatgcctga gctgcataag catatcttgg cgtgtgcgtc tgcaagtgac
     4201 aagaagaggt acacccctaa gaaaaaccca gtgcccctga aacaaactgt gcagcccaaa
     4261 aatggagtgg tggttctaga caactctggg aaaaatgcct tcagacggat ggggcagccc
     4321 aagagactga gcttcaatgt tgaactgggt aaaatgtctc caaacaagct caagctgagt
     4381 gcgctgaaga agaaaaacca gctggtgcag aaggccatcc ttcagaagaa cagagccgcg
     4441 aagcagaagg cggacctgag ggacacttcc gaggcgtcct cacacatctg cccgtactgt
     4501 gacagggagt tcacatacat tggcagcctg aataagcatg ccgccttcag ctgtcctaaa
     4561 aaacctcttt ctccttccaa aagaaaagtt tcccattcgt ctaagaaagg tggccatgca
     4621 tcatcttcta gcagtgacag aaacagcagc agccaccccc ggaggcggac tgcagatacc
     4681 gagatcaaga tgcagagcac gcaggcaccc ttgggcaaga ccagagctcg gagtacaggc
     4741 cccgcccagg cctcactgcc ctcctcgtcc ttcagatcca gacagaatgt caaatttgca
     4801 gcttcagtga aatccaaaaa agcaagctct tcatccttga ggaattccag tcccataaga
     4861 atggccaaaa ttactcacgt cgagggcaaa aaacccaaag ctgttgccaa gagtcattct
     4921 gctcagctct caagcaaatc ctcccgaggc ctgcatgtca gagtgcagaa gagcaaagct
     4981 gtcatacaga gcaagactgc cctggccagt aagaggagaa cagaccggtt catagtgaaa
     5041 tctagagagc gcagcggggg cccaatcacc cgaagccttc agctggcagc tgctgcggac
     5101 ctgagtgaaa gcaggagaga ggacagcagt gccaggcatg agctgaagga cttcagctac
     5161 agtctccgcc tggcatctcg atgcggctca tcaacagcct cttacatcac cagacaatgc
     5221 agaaaggtca aggccgccgc agcaactccg ttccagggac ccttcctcaa agagtaggca
     5281 ctctgtctgc tccttaacag cacctgaagt gacctggaat cagtgaagcc aaagggacca
     5341 gcagtctgcc ctgcagagag cactgacctc tcccagttgt gagagtgaga gaacgagaga
     5401 gagagagaga gagagagaga gagagagaga gagagagaat gagaatgtgt gtgtgtgtgc
     5461 tggtgcatgt gtgtggtctt caagccaagg tcccagcctc aggagcagga ccttcccatt
     5521 tcccgtcatc ctctggatga tccttggacg tggcccagaa ccgtgctctg tggtgcagcc
     5581 atcctgcccg ggaggggcat ctccttctat gcaatttttt taaagagttc cttggccctg
     5641 ctttgtgctt cttgagctgt ccgtttgcca ccactgggac ttggatctgg ccctgagggg
     5701 tggggaagag ggcctatcta aggataacct ttcagaggtc aagctcccct tcatgccacc
     5761 cctcccccct gccctcaccg accttttccc cacactgtct ctgggaatca atagcagata
     5821 gcatatagat ccatcagggt tgagcctgaa cctcggccct agcactagga aatccccctt
     5881 ttctccctaa gcaactggag ccgccagctt tcaagtcatt tcctcctttg aggttctaga
     5941 gtccgagagt ctgctccgaa gtctctcctg ggaacccggg agccctcgca cccaggacgc
     6001 agactctgtg cccattctta gacctgaggt agaagaagca gtgttttggg acgatagggt
     6061 ggaggcgtgc ctactttgtc tcctctggtg ggacctccta catcattggc atctgaacct
     6121 tgcaagttcg ctgcaaagag aagcaaagga
//
