LOCUS       XP_038967290            1276 aa            linear   ROD 22-FEB-2024
DEFINITION  histone-lysine N-methyltransferase PRDM16 isoform X1 [Rattus
            norvegicus].
ACCESSION   XP_038967290
VERSION     XP_038967290.1
DBLINK      BioProject: PRJNA1074393
DBSOURCE    REFSEQ: accession XM_039111362.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_086023) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_036323735.1-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/09/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1276
                     /organism="Rattus norvegicus"
                     /strain="BN/NHsdMcwi"
                     /bio_material="RGD 61498"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /sex="male"
                     /tissue_type="kidney, spleen, liver"
                     /geo_loc_name="USA: Wisconsin, Milwaukee"
                     /lat_lon="43.05 N 88.04 W"
                     /collected_by="Rebecca Schilling, Melinda Dwinell"
     Protein         1..1276
                     /product="histone-lysine N-methyltransferase PRDM16
                     isoform X1"
                     /calculated_mol_wt=140899
     Region          61..222
                     /region_name="PR-SET_PRDM16"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 16 (PRDM16) and similar proteins; cd19213"
                     /db_xref="CDD:380990"
     Site            order(91,94..96,113,157,170..174,176,185..186,210)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380990"
     Site            order(91,94..96,170..174,176,210)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380990"
     Region          232..252
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          282..304
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          284..304
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(289,291,293,295..296,299..300,303,317,319,323..324,
                     327..328,331,345,347,349,351..352,355..356)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          296..320
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          310..332
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          312..332
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          338..359
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          340..358
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          367..389
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          369..389
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          395..417
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          397..417
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          426..444
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          952..974
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          954..974
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(959,961,963,965..966,969..970,973,987,989,993..994,
                     997..998,1002,1016,1018,1020,1022..1023,1026..1027,1030)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          966..990
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          982..>1016
                     /region_name="SUF4-like"
                     /note="N-terminal domain of Oryza sativa transcription
                     factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana
                     SUF4 (AtSUF4), and similar proteins; cd20908"
                     /db_xref="CDD:411020"
     Region          982..1008
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:411020"
     Region          982..1003
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(987,993,1005,1007,1010)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411020"
     Region          1009..1031
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          1011..1031
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..1276
                     /gene="Prdm16"
                     /coded_by="XM_039111362.2:623..4453"
                     /db_xref="GeneID:100366024"
                     /db_xref="RGD:2324431"
ORIGIN      
        1 mrskararkl aksdgdvvnn myepdpdlla sqsaeeeted gilspipmgp pspfptsedf
       61 tpkegspyea pvyipedipi ppdfelress ipgaglgiwa krkmeigerf gpymvapraa
      121 lkeadfgwem ltdtevssqe scikkqiseg lgsekfcvda nqagagswlk yirvacscdd
      181 qnlamcqine qiyykvikdi epgeellvhv kegayslgvm apsldedptf rcdecdelfq
      241 crldlrrhkk yacsssgapl yeglgeelkp eglgggndgq aheckdcerm fpnkysleqh
      301 mivhteerey kcdqcpkafn wksnlirhqm shdsgkrfec encvkvftdp snlqrhirsq
      361 hvgarahacp dcgktfatss glkqhkhihs tvkpficevc hksytqfsnl crhkrmhadc
      421 rtqikckdcg qmfsttssln khrrfcegkn hytpgglftp glpltpspmm dktkpsptln
      481 hgglgfseyf psrphpgslp fsaappafpt ltpgfpgifp pslyprppll pptpllkspl
      541 nhgqdaklhs plgnpalplv savsnssqga taatgpeekf dgrledsyve kvknrspdms
      601 dgsdfedint ttgtdldttt gtgsdldsdl dsdrdkskdk gkpaeskpef ggasvppgam
      661 nsvaevpafy sqhsffpppe eqlltasgaa gdsikaiasi aekyfgpgfm smqekklgsl
      721 pyhsvfpfqf lpnfphslyp ftdralahnl lvkaepkspr dalkvggpsa ecpfdlttkp
      781 keakpalltp kaplvpssge eqpldlsigs rarasqnggs reprknhiyg erkpgvgegl
      841 pkvcpaqlpq qpslhyakps pffmdpiysr vekrkvadpv gvlkekylrp spllfhpqms
      901 aietmtekle sfaamkadsg sslqplphhp fnfrsppptl sdpilrkgke rytcrycgki
      961 fprsanltrh lrthtgeqpy rckycdrsfs issnlqrhvr nihnkekpfk chlcnrcfgq
     1021 qtnldrhlkk hehegapvsq hsgvltnhlg tsassptses dnhalldeke dsyfseirnf
     1081 iansemnqas trmdkrpevq dldgnppcpg sasakqedve eeeeeeleee dddslagksq
     1141 edtvsptpep qgvyedeede eppnltmdfd htrrcveerg ggllaleptp tfgkgldlrr
     1201 aaeeafevkd vlnstldsev lkqtlyrqak nqayammlsl sedtplhaps qssldawlni
     1261 tgpssesgaf npinhl
//
