LOCUS       NM_001106281            2369 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus prolylcarboxypeptidase (Prcp), mRNA.
ACCESSION   NM_001106281 XM_001063114 XM_214993
VERSION     NM_001106281.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2369)
  AUTHORS   Danyukova T, Ariunbat K, Thelen M, Brocke-Ahmadinejad N, Mole SE
            and Storch S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   2  (bases 1 to 2369)
  AUTHORS   Liu J, Hakucho A and Fujimiya T.
  TITLE     Angiotensinase C mRNA and Protein Downregulations Are Involved in
            Ethanol-Deteriorated Left Ventricular Systolic Dysfunction in
            Spontaneously Hypertensive Rats
  JOURNAL   Biomed Res Int 2015, 409350 (2015)
   PUBMED   26509155
  REMARK    GeneRIF: chronic ethanol regimen is sufficient to promote the
            enhanced RAS activity-induced decrease in the production of cardiac
            collagen via downregulated angiotensinase C, leading to the further
            deterioration of LV systolic dysfunction in SHRs
REFERENCE   3  (bases 1 to 2369)
  AUTHORS   Marangoni RA, Santos RA and Piccolo C.
  TITLE     Deficient prolylcarboxypeptidase gene and protein expression in
            left ventricles of spontaneously hypertensive rats (SHR)
  JOURNAL   Peptides 61, 69-74 (2014)
   PUBMED   25218829
  REMARK    GeneRIF: it appears unlikely that PRCP function is regulated by the
            renin-angiotensin system or by afterload conditions.
REFERENCE   4  (bases 1 to 2369)
  AUTHORS   Villarejo AB, Prieto I, Segarra AB, Banegas I, Wangensteen R, Vives
            F, de Gasparo M and Ramirez-Sanchez M.
  TITLE     Relationship of angiotensinase and vasopressinase activities
            between hypothalamus, heart, and plasma in L-NAME-treated WKY and
            SHR
  JOURNAL   Horm Metab Res 46 (8), 561-567 (2014)
   PUBMED   24627106
  REMARK    GeneRIF: eNOS inhibition in spontaneously hypertensive rats induces
            or enhances an inverse reciprocal interaction between hypothalamus
            and left ventricle involving the renin-angiotensin system and
            vasopressin.
REFERENCE   5  (bases 1 to 2369)
  AUTHORS   Adams GN, Stavrou EX, Fang C, Merkulova A, Alaiti MA, Nakajima K,
            Morooka T, Merkulov S, Larusch GA, Simon DI, Jain MK and Schmaier
            AH.
  TITLE     Prolylcarboxypeptidase promotes angiogenesis and vascular repair
  JOURNAL   Blood 122 (8), 1522-1531 (2013)
   PUBMED   23744584
REFERENCE   6  (bases 1 to 2369)
  AUTHORS   Adams GN, LaRusch GA, Stavrou E, Zhou Y, Nieman MT, Jacobs GH, Cui
            Y, Lu Y, Jain MK, Mahdi F, Shariat-Madar Z, Okada Y, D'Alecy LG and
            Schmaier AH.
  TITLE     Murine prolylcarboxypeptidase depletion induces vascular
            dysfunction with hypertension and faster arterial thrombosis
  JOURNAL   Blood 117 (14), 3929-3937 (2011)
   PUBMED   21297000
REFERENCE   7  (bases 1 to 2369)
  AUTHORS   Wallingford N, Perroud B, Gao Q, Coppola A, Gyengesi E, Liu ZW, Gao
            XB, Diament A, Haus KA, Shariat-Madar Z, Mahdi F, Wardlaw SL,
            Schmaier AH, Warden CH and Diano S.
  TITLE     Prolylcarboxypeptidase regulates food intake by inactivating
            alpha-MSH in rodents
  JOURNAL   J Clin Invest 119 (8), 2291-2303 (2009)
   PUBMED   19620781
  REMARK    GeneRIF: PRCP is an important component of melanocortin signaling
            and weight maintenance via control of active alpha-MSH1-13 levels.
REFERENCE   8  (bases 1 to 2369)
  AUTHORS   Qin XP, Zeng SY, Tian HH, Deng SX, Ren JF, Zheng YB, Li D, Li YJ,
            Liao DF and Chen SY.
  TITLE     Involvement of prolylcarboxypeptidase in the effect of rutaecarpine
            on the regression of mesenteric artery hypertrophy in renovascular
            hypertensive rats
  JOURNAL   Clin Exp Pharmacol Physiol 36 (3), 319-324 (2009)
   PUBMED   19018804
  REMARK    GeneRIF: Suggest that in renovascular hypertension the repression
            of increases in systolic blood pressure and reversal of mesenteric
            artery remodelling by rutaecarpine may be related to increased
            expression of PRCP.
REFERENCE   9  (bases 1 to 2369)
  AUTHORS   Mallela J, Yang J and Shariat-Madar Z.
  TITLE     Prolylcarboxypeptidase: a cardioprotective enzyme
  JOURNAL   Int J Biochem Cell Biol 41 (3), 477-481 (2009)
   PUBMED   18396440
  REMARK    Review article
REFERENCE   10 (bases 1 to 2369)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000041.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001106281.4.
            
            On Feb 10, 2021 this sequence version replaced NM_001106281.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487231.125212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132267, SAMD00132269
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               JACYVU010000041.1  7556972-7557192
            222-362             JACYVU010000041.1  7589492-7589632
            363-464             JACYVU010000041.1  7591974-7592075
            465-646             JACYVU010000041.1  7595681-7595862
            647-804             JACYVU010000041.1  7596535-7596692
            805-974             JACYVU010000041.1  7597907-7598076
            975-1139            JACYVU010000041.1  7602724-7602888
            1140-1327           JACYVU010000041.1  7603584-7603771
            1328-2369           JACYVU010000041.1  7608335-7609376
FEATURES             Location/Qualifiers
     source          1..2369
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2369
                     /gene="Prcp"
                     /note="prolylcarboxypeptidase"
                     /db_xref="GeneID:293118"
                     /db_xref="RGD:1307842"
     exon            1..221
                     /gene="Prcp"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1544
                     /gene="Prcp"
                     /EC_number="3.4.16.2"
                     /note="lysosomal Pro-X carboxypeptidase;
                     prolylcarboxypeptidase (angiotensinase C)"
                     /codon_start=1
                     /product="lysosomal Pro-X carboxypeptidase precursor"
                     /protein_id="NP_001099751.2"
                     /db_xref="GeneID:293118"
                     /db_xref="RGD:1307842"
                     /translation="MGCWALLLLPFLSLGAATTIRPRLKTLGSPHLSTNTPDPAVPSS
                     YSVHYFQQKVDHFGFSDTRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGF
                     MWDVAEELKAMLVFAEHRYYGKSLPFGRDSFKDSQHLNFLTSEQALADFAELIRHLKE
                     TIPGTEGQPVIAIGGSYGGMLAAWFRMKYPHIVVGALAASAPIWQLDGMAPCGEFMKI
                     VTKDFSQSGPHCSESIRRSWSVINRLSDTGSGLQWLRDTLHLCSPLTSEKMPTLKGWI
                     AETWVNLAMVNYPYACNFLQPLPAWPIKEVCRYLRNPNVSDTVLLQNIFQALNVYYNY
                     SGQTKCLNISQTTTSSLGSTGWSFQACTEMVMPFCTNGIDDMFEPYLWDLETYSNDCF
                     NQWGVKPRPHWMTTMYGGKNISSHSNIIFSNGDLDPWSGGGVTKDITDTLVAINIPEG
                     AHHLDLRAHNAFDPSSVLLSRLLEVKHMKKWIADFYSNSTWKS"
     exon            222..362
                     /gene="Prcp"
                     /inference="alignment:Splign:2.1.0"
     exon            363..464
                     /gene="Prcp"
                     /inference="alignment:Splign:2.1.0"
     exon            465..646
                     /gene="Prcp"
                     /inference="alignment:Splign:2.1.0"
     exon            647..804
                     /gene="Prcp"
                     /inference="alignment:Splign:2.1.0"
     exon            805..974
                     /gene="Prcp"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1139
                     /gene="Prcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1327
                     /gene="Prcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..2369
                     /gene="Prcp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcttttct gcgggtggct ctctttcttt agccgcccac actgtggctg ctgtcctgag
       61 ccatgggctg ctgggctctc ctgctcctgc cttttctatc actcggggcc gccacaacca
      121 tccggcctag gctaaagacc ctcggcagcc cgcacttgtc aactaacaca cccgaccctg
      181 ctgtacccag tagctactca gttcattact tccaacagaa ggttgaccac tttgggtttt
      241 ctgacacaag aacttttaag cagcggtacc tagtagctga taaacactgg cagagaaatg
      301 gtggatctat acttttctac actggaaatg aaggggacat tgtctggttt tgtaataata
      361 cggggttcat gtgggatgtg gccgaggagc tgaaagctat gctggtgttt gctgagcatc
      421 gatactatgg gaagtccctt cccttcggtc gggactcctt caaggattcc caacatttga
      481 atttcctgac atcagaacag gctctggctg attttgcaga gttaatcagg cacttgaaag
      541 aaacaatccc aggaactgaa ggtcagcctg tcatcgccat tgggggctct tatggtggca
      601 tgctcgcagc ctggttcagg atgaaatatc ctcacatagt tgtcggagct ctggcagctt
      661 ccgcccctat ctggcagctt gatggtatgg ccccctgtgg agagtttatg aagattgtaa
      721 ctaaagactt cagccaaagt ggtccacatt gttcagaaag tatccgtaga tcctggagtg
      781 tcattaatcg actctcagat accggcagtg gtctccagtg gctcagggac actcttcacc
      841 tgtgtagtcc cttgacttct gagaagatgc caacgttgaa aggatggata gctgaaacct
      901 gggtgaacct ggccatggtg aactacccgt atgcatgcaa ctttttgcag cctttgcctg
      961 cttggcccat caaggaggtg tgccgatact tgaggaatcc caatgtgtcc gatacagtgc
     1021 tgctgcagaa tattttccag gctctgaatg tgtattataa ttattcgggc caaacaaaat
     1081 gcctgaatat ttcacaaaca accacaagca gtctgggctc tacgggctgg agctttcagg
     1141 cctgcacaga aatggtcatg cccttttgta ctaatggtat tgatgacatg tttgaaccct
     1201 atctgtggga cttggagacg tattccaatg actgttttaa ccaatgggga gtgaaaccac
     1261 ggcctcattg gatgactacc atgtatggtg gcaaaaacat cagttcacac tccaacatca
     1321 ttttcagcaa tggtgaccta gacccgtggt caggaggtgg agtcaccaaa gacatcacag
     1381 acaccctggt ggctatcaac atccctgagg gggcccatca tttagatctt cgagcccaca
     1441 atgccttcga tccttcctct gtgctgttat ctcgcttatt ggaagttaaa cacatgaaga
     1501 aatggattgc agatttctat agcaattcta cttggaagtc ctgagccact tttaaaaaat
     1561 attttttttt tgttttcttc ttatatgttc cctccaccca catacccatc cacttttttt
     1621 ttttttatat gtaactatgt tctctcatta gtcattgtgt ttgttgggcc aaagttgaga
     1681 cacaagagag cgacatgggt gggcacagac atcccaccta ggtgactcct cctgtctcac
     1741 ggtctttgtg tcatcatggc agctcacagg ccatcagaac tggcgtggtt cctcactgcc
     1801 tttcaccaga gggagaaccc ttctctcacc agcggggagg actccttggc tttgaggctg
     1861 aagtctctct ggtccattgt aagcccctat tcgtgccaca aaagggaagg cagaagcttg
     1921 attaaaaacg ctgcagctgc cctctggtag gatgtgggat gccagtccag gaaacggggc
     1981 agcttccttt gagctcagag tgactctgaa ctgggcagcc ataaagagcc aggcagacct
     2041 acctgtgagt tgctccagtc tccctccagc tgttgggagg tcagtgtgcc tgggctggct
     2101 gcttttggaa agtccttttt ctctttccca cttggcagct ctccttagtt ctgggatatt
     2161 tgccaccggt ggtactgcca ggaaggaatc tggccttctc ctgctctctt tgtttccaag
     2221 ttcaattttt tgcggtgatc tggctaaatt ctgccaattt aggaaaagtg cttttttttt
     2281 tttttttttt ttttttttac tttaaaaact ggacaaattc tgttaataaa aatcctttaa
     2341 aaatagacaa atcttctatt gaaaaagta
//
