LOCUS       NM_001013957            1124 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus polyglutamine binding protein 1 (Pqbp1), mRNA.
ACCESSION   NM_001013957 XM_217596
VERSION     NM_001013957.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1124)
  AUTHORS   Yoh,S.M., Schneider,M., Seifried,J., Soonthornvacharin,S.,
            Akleh,R.E., Olivieri,K.C., De Jesus,P.D., Ruan,C., de Castro,E.,
            Ruiz,P.A., Germanaud,D., des Portes,V., Garcia-Sastre,A., Konig,R.
            and Chanda,S.K.
  TITLE     PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to
            HIV-1
  JOURNAL   Cell 161 (6), 1293-1305 (2015)
   PUBMED   26046437
REFERENCE   2  (bases 1 to 1124)
  AUTHORS   Ikeuchi,Y., de la Torre-Ubieta,L., Matsuda,T., Steen,H., Okazawa,H.
            and Bonni,A.
  TITLE     The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling
            link that orchestrates ciliary morphogenesis in postmitotic neurons
  JOURNAL   Cell Rep 4 (5), 879-889 (2013)
   PUBMED   23994472
REFERENCE   3  (bases 1 to 1124)
  AUTHORS   Wang,Q., Moore,M.J., Adelmant,G., Marto,J.A. and Silver,P.A.
  TITLE     PQBP1, a factor linked to intellectual disability, affects
            alternative splicing associated with neurite outgrowth
  JOURNAL   Genes Dev 27 (6), 615-626 (2013)
   PUBMED   23512658
REFERENCE   4  (bases 1 to 1124)
  AUTHORS   Kunde,S.A., Musante,L., Grimme,A., Fischer,U., Muller,E.,
            Wanker,E.E. and Kalscheuer,V.M.
  TITLE     The X-chromosome-linked intellectual disability protein PQBP1 is a
            component of neuronal RNA granules and regulates the appearance of
            stress granules
  JOURNAL   Hum Mol Genet 20 (24), 4916-4931 (2011)
   PUBMED   21933836
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            [WARNING] On Oct 17, 2024 this sequence was replaced by
            NM_001013957.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001013957.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059163.1, SRR21887620.658745.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000021.1  17275838-17275950
            114-206             JAXUCZ010000021.1  17276050-17276142
            207-318             JAXUCZ010000021.1  17278482-17278593
            319-431             JAXUCZ010000021.1  17278768-17278880
            432-710             JAXUCZ010000021.1  17278987-17279265
            711-774             JAXUCZ010000021.1  17279450-17279513
            775-1124            JAXUCZ010000021.1  17279669-17280018
FEATURES             Location/Qualifiers
     source          1..1124
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..1124
                     /gene="Pqbp1"
                     /note="polyglutamine binding protein 1"
                     /db_xref="GeneID:302557"
                     /db_xref="RGD:1549750"
     exon            1..113
                     /gene="Pqbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            114..206
                     /gene="Pqbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..931
                     /gene="Pqbp1"
                     /note="PQBP-1; polyglutamine tract-binding protein 1"
                     /codon_start=1
                     /product="polyglutamine-binding protein 1"
                     /protein_id="NP_001013979.2"
                     /db_xref="GeneID:302557"
                     /db_xref="RGD:1549750"
                     /translation="MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATR
                     IEGLPPSWYKVFDPSCGLPYYWNVETDLVSWLSPHDPNFVVSKSAKKLRNSNADAEDK
                     SERNLEKVDRNHEKSDRSHEKPDRSHEKADRNHEKSDRERERNYDKVDRERDRDRERE
                     RAFDKADREDGKDRRHHRREDLAPYPKNKKATSRKDEELDPMDPSSYSDAPRGTWSTG
                     LPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRSKQQD"
     exon            207..318
                     /gene="Pqbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..431
                     /gene="Pqbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..710
                     /gene="Pqbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..774
                     /gene="Pqbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..1124
                     /gene="Pqbp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcctgggt ccgtagagtt ctggtgagac tagatctggc catactgcta cgttatctct
       61 ttcatctctt agcacgcatt tttgttctgc tttttcagct gctggtgcag ttgtttctag
      121 atccagtcag caacccacta tgcctctccc tgttgcgctg cagacccgct tggcaaagag
      181 gggcatcctc aaacatctgg agccagagcc agaggaagag attattgctg aggattacga
      241 tgatgatcct gttgactatg aggccaccag gatagaaggt ctgccaccaa gctggtacaa
      301 ggtgtttgac ccttcttgtg gactccctta ctattggaat gtggagacag acctcgtgtc
      361 ctggctctca ccacatgatc ccaactttgt ggttagcaaa tctgccaaga aactcaggaa
      421 cagtaatgca gatgctgagg acaagtcgga gcggaatctt gaaaaggttg acagaaatca
      481 tgagaagtca gatcgtagtc acgagaagcc agacagaagc catgagaagg cagaccgaaa
      541 ccacgagaag tctgaccgag aacgagagcg gaactatgac aaggtagaca gagagagaga
      601 tcgggatagg gaacgagaac gggcatttga caaggcagac cgggaagatg gcaaagaccg
      661 gcgccaccat cgcagagagg acctggctcc ttaccccaag aacaagaaag cgacgagccg
      721 gaaagatgaa gaattagacc ccatggaccc cagctcatac tcagatgcac cccggggcac
      781 atggtcaaca ggactaccca agaggaatga ggccaagact ggggctgaca cgacagcggc
      841 tgggcctctc ttccagcagc gcccataccc ttcccctggg gctgtgctcc gcgccaatgc
      901 agaagcctcc cgcagcaaac agcaggactg aatttgtgtt ccctgtagct ttggcagtca
      961 tttctgtgtt gctttcttgc ggctctggag taggacccat ggcttcagac gtgctgaata
     1021 attagtccac cagtgagcta cactcccagc ccccttggtg ttgttttatg aacaacaagc
     1081 ccttgttggt gttgtttaat aaaagctttt tggggaacca tctc
//
