LOCUS       NM_012626                486 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus pancreatic polypeptide (Ppy), mRNA.
ACCESSION   NM_012626
VERSION     NM_012626.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Wang,S., Zhang,J., Zhao,A., Hipkens,S., Magnuson,M.A. and Gu,G.
  TITLE     Loss of Myt1 function partially compromises endocrine islet cell
            differentiation and pancreatic physiological function in the mouse
  JOURNAL   Mech Dev 124 (11-12), 898-910 (2007)
   PUBMED   17928203
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Browning,K.N., Coleman,F.H. and Travagli,R.A.
  TITLE     Effects of pancreatic polypeptide on pancreas-projecting rat dorsal
            motor nucleus of the vagus neurons
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 289 (2), G209-G219 (2005)
   PUBMED   15817809
  REMARK    GeneRIF: pancreas-projecting rat dorsal motor nucleus of the vagus
            neurons are heterogeneous with respect to their response to PP,
            which may underlie functional differences in the vagal modulation
            of pancreatic functions
REFERENCE   3  (bases 1 to 486)
  AUTHORS   Kovacs,P., Voigt,B. and Kloting,I.
  TITLE     Novel quantitative trait loci for blood pressure and related traits
            on rat chromosomes 1, 10, and 18
  JOURNAL   Biochem Biophys Res Commun 235 (2), 343-348 (1997)
   PUBMED   9199194
REFERENCE   4  (bases 1 to 486)
  AUTHORS   Gregor,P., Millham,M.L., Feng,Y., DeCarr,L.B., McCaleb,M.L. and
            Cornfield,L.J.
  TITLE     Cloning and characterization of a novel receptor to pancreatic
            polypeptide, a member of the neuropeptide Y receptor family
  JOURNAL   FEBS Lett 381 (1-2), 58-62 (1996)
   PUBMED   8641440
REFERENCE   5  (bases 1 to 486)
  AUTHORS   Lundell,I., Blomqvist,A.G., Berglund,M.M., Schober,D.A.,
            Johnson,D., Statnick,M.A., Gadski,R.A., Gehlert,D.R. and
            Larhammar,D.
  TITLE     Cloning of a human receptor of the NPY receptor family with high
            affinity for pancreatic polypeptide and peptide YY
  JOURNAL   J Biol Chem 270 (49), 29123-29128 (1995)
   PUBMED   7493937
REFERENCE   6  (bases 1 to 486)
  AUTHORS   Bard,J.A., Walker,M.W., Branchek,T.A. and Weinshank,R.L.
  TITLE     Cloning and functional expression of a human Y4 subtype receptor
            for pancreatic polypeptide, neuropeptide Y, and peptide YY
  JOURNAL   J Biol Chem 270 (45), 26762-26765 (1995)
   PUBMED   7592911
REFERENCE   7  (bases 1 to 486)
  AUTHORS   Deng,A.Y. and Rapp,J.P.
  TITLE     Locus for the inducible, but not a constitutive, nitric oxide
            synthase cosegregates with blood pressure in the Dahl
            salt-sensitive rat
  JOURNAL   J Clin Invest 95 (5), 2170-2177 (1995)
   PUBMED   7537756
REFERENCE   8  (bases 1 to 486)
  AUTHORS   Kopin,A.S., Toder,A.E. and Leiter,A.B.
  TITLE     Different splice site utilization generates diversity between the
            rat and human pancreatic polypeptide precursors
  JOURNAL   Arch Biochem Biophys 267 (2), 742-748 (1988)
   PUBMED   3214179
REFERENCE   9  (bases 1 to 486)
  AUTHORS   Yonekura,H., Nata,K., Watanabe,T., Kurashina,Y., Yamamoto,H. and
            Okamoto,H.
  TITLE     Mosaic evolution of prepropancreatic polypeptide. II. Structural
            conservation and divergence in pancreatic polypeptide gene
  JOURNAL   J Biol Chem 263 (6), 2990-2997 (1988)
   PUBMED   3343236
REFERENCE   10 (bases 1 to 486)
  AUTHORS   Yamamoto,H., Nata,K. and Okamoto,H.
  TITLE     Mosaic evolution of prepropancreatic polypeptide
  JOURNAL   J Biol Chem 261 (14), 6156-6159 (1986)
   PUBMED   3009446
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M13588.1 and BP484139.1.
            
            On Oct 3, 2006 this sequence version replaced NM_012626.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M13588.1, BP484139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676811 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-446               M13588.1           1-446
            447-454             BP484139.1         430-437
            455-486             M13588.1           453-484
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..486
                     /gene="Ppy"
                     /note="pancreatic polypeptide"
                     /db_xref="GeneID:24677"
                     /db_xref="RGD:3385"
     exon            1..54
                     /gene="Ppy"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..351
                     /gene="Ppy"
                     /note="pancreatic prohormone; PP; pancreatic polypeptide
                     prohormone"
                     /codon_start=1
                     /product="pancreatic polypeptide prohormone precursor"
                     /protein_id="NP_036758.1"
                     /db_xref="GeneID:24677"
                     /db_xref="RGD:3385"
                     /translation="MAVAYYCLSLFLLSTWVALLLQPLQGAWGAPLEPMYPGDYATHE
                     QRAQYETQLRRYINTLTRPRYGKRDEDTAGLPGRQLPPCTSLLVGLMPCAAARS"
     exon            55..245
                     /gene="Ppy"
                     /inference="alignment:Splign:2.1.0"
     exon            246..357
                     /gene="Ppy"
                     /inference="alignment:Splign:2.1.0"
     exon            358..486
                     /gene="Ppy"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccagcag aaggtaggtg tctgggtcca atacccactc gctcaggaca caggatggcc
       61 gtcgcatact actgcctctc cctgtttctc ctatccactt gggtggctct gctgctacag
      121 cccctgcagg gtgcctgggg agccccactg gagccaatgt acccggggga ctatgctacg
      181 catgaacaga gggctcaata cgaaactcag ctccgaagat acatcaacac actgaccagg
      241 cctaggtatg ggaagagaga tgaggacaca gctgggcttc ctggaaggca gctcccacca
      301 tgcaccagcc ttctggtggg tttgatgccc tgcgctgctg cccggagctg aaggcaggga
      361 tctcagccca atggatttgt agcctccctt ctgtctctct cctacccatg gctgtaggac
      421 ggtacaggcc cagctcttgc aacaacctgc tcccttgcaa actaaataaa gcaaaggaaa
      481 aattat
//
