LOCUS       NM_019367               1719 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus palmitoyl-protein thioesterase 2 (Ppt2), mRNA.
ACCESSION   NM_019367
VERSION     NM_019367.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1719)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   2  (bases 1 to 1719)
  AUTHORS   Gupta,P., Soyombo,A.A., Shelton,J.M., Wilkofsky,I.G.,
            Wisniewski,K.E., Richardson,J.A. and Hofmann,S.L.
  TITLE     Disruption of PPT2 in mice causes an unusual lysosomal storage
            disorder with neurovisceral features
  JOURNAL   Proc Natl Acad Sci U S A 100 (21), 12325-12330 (2003)
   PUBMED   14528005
REFERENCE   3  (bases 1 to 1719)
  AUTHORS   Gupta,P., Soyombo,A.A., Atashband,A., Wisniewski,K.E.,
            Shelton,J.M., Richardson,J.A., Hammer,R.E. and Hofmann,S.L.
  TITLE     Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in
            knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (24), 13566-13571 (2001)
   PUBMED   11717424
REFERENCE   4  (bases 1 to 1719)
  AUTHORS   Aguado,B. and Campbell,R.D.
  TITLE     Characterization of a human MHC class III region gene product with
            S-thioesterase activity
  JOURNAL   Biochem J 341 (Pt 3) (Pt 3), 679-689 (1999)
   PUBMED   10417332
REFERENCE   5  (bases 1 to 1719)
  AUTHORS   Soyombo,A.A. and Hofmann,S.L.
  TITLE     Molecular cloning and expression of palmitoyl-protein thioesterase
            2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase
            with a distinct substrate specificity
  JOURNAL   J Biol Chem 272 (43), 27456-27463 (1997)
   PUBMED   9341199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB736242.1 and BC062023.1.
            
            On Sep 28, 2009 this sequence version replaced NM_019367.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062023.1, AF061971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                CB736242.1         56-93
            39-1719             BC062023.1         1-1681
FEATURES             Location/Qualifiers
     source          1..1719
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1719
                     /gene="Ppt2"
                     /note="palmitoyl-protein thioesterase 2"
                     /db_xref="GeneID:54398"
                     /db_xref="RGD:620375"
     exon            1..133
                     /gene="Ppt2"
                     /inference="alignment:Splign:2.1.0"
     exon            134..324
                     /gene="Ppt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1050
                     /gene="Ppt2"
                     /EC_number="3.1.2.22"
                     /note="lysosomal thioesterase PPT2"
                     /codon_start=1
                     /product="lysosomal thioesterase PPT2 precursor"
                     /protein_id="NP_062240.1"
                     /db_xref="GeneID:54398"
                     /db_xref="RGD:620375"
                     /translation="MPGLWRQRLPSAWALLLLPFLPLLLPAAPAPHRGSYKPVIVVHG
                     LFDSSYSFRHLLDYINETHPGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMEKAP
                     EGVHLICYSQGGLVCRALLSVMDEHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSN
                     LYRICYSPWGQEFSICNYWHDPHHDDLYLNASSFLALINGERDHPNATAWRKNFLRVG
                     RLVLIGGPDDGVITPWQSSFFGFYDANETVLEMEEQPVYLRDSFGLKTLLARGAIVRC
                     PMAGVSHTTWHSNRTLYDACIEPWLS"
     exon            325..478
                     /gene="Ppt2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..574
                     /gene="Ppt2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..682
                     /gene="Ppt2"
                     /inference="alignment:Splign:2.1.0"
     exon            683..766
                     /gene="Ppt2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..851
                     /gene="Ppt2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..906
                     /gene="Ppt2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1704
                     /gene="Ppt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgagcaac cctccccccc gtccgtcatc cccctgcgcg ctctccttgt ccccttttcc
       61 ccccgtaccc cgtggattcc cgactaggta caagtaaaca gctggcggaa cgaagcctcc
      121 agacacaggc caggtgggag catgccgggg ctatggaggc agaggcttcc ttcggcttgg
      181 gctttgcttc tcctgccttt cctgccgctg ctgttgcccg cagcccccgc accccaccgc
      241 gggtcctaca agccagtgat cgtggtgcat gggctctttg acagttcata cagcttccgc
      301 cacctgctgg actacatcaa tgagacacac cccgggactg tggtgacagt gcttgatctc
      361 ttcgatggca gagagagctt gcgacccctg tgggaacagg ttcaagggtt ccgagaggct
      421 gtggtcccca tcatggaaaa ggcccctgag ggggtacacc tcatctgcta ctcccaggga
      481 ggcctggtgt gccgcgcatt gctgtctgtc atggatgagc acaatgtgga ttccttcatc
      541 tccctttctt ctccacagat gggacagtat ggagacacgg actatttgaa gtggctgttc
      601 cctacgtcca tgcggtctaa cctctatcgg atctgctata gcccctgggg ccaggaattt
      661 tccatttgca actactggca cgaccctcac cacgatgact tgtacctcaa cgccagcagc
      721 tttctggccc tcatcaatgg ggagagagac catccgaatg ccactgcatg gcggaagaac
      781 ttccttcgtg tgggccgtct ggtgctgatt gggggtccgg acgatggagt catcactccc
      841 tggcaatcta gcttctttgg tttctatgat gccaacgaga cggtcttgga gatggaggaa
      901 cagccggtgt atcttcgaga ctcttttggg ttgaagactc tcttggcccg gggggccata
      961 gtgagatgcc ccatggctgg ggtctctcac accacctggc actccaatcg cacgctctat
     1021 gacgcttgca ttgagccctg gctctcctga agacgtcctc agggctctcc aggaattccc
     1081 cagcccagag atcaagtggt ggccttctgg cgtgcctgtg accacctcgt cgctcccaca
     1141 ctgccccacc tccccaccag ggctcccaaa ccctcccctc tgctcctctg tgaatgacaa
     1201 gtcctggtcc cctacctcat gtcctcactt ggggacgtct ccatgctctc cctttctgcc
     1261 atggctgagg ttgggaagca agcaccaggt ttttaactgt ggcttcaccg ctgctgctgt
     1321 tgcttctccg ggtctggctg taccggagga gaacccagcc cctgcccacc tcaggggtct
     1381 tccaggccac tcaggacatt tttagcttgt tattcccatg cccctctttt ctgtccctgt
     1441 ggccagcctc cccaccgaga ggggcgcccg tacaaggggg ttctgaggct cccctatggg
     1501 gacagttcca cttttgaagt gtcagtgttg gggaatatct gtggcctgca aggcccatct
     1561 caggtttggg gatcccccag tccctatgat cagtgttggg gtatcccctg ggagcctagg
     1621 ttctttgagg ccccagcccc tcttttaacc acccttgagt gggtggtccc cgtatttata
     1681 gaaataaaag ttccatttcc tcaaaaaaaa aaaaaaaaa
//
