LOCUS       NM_022502               2263 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus palmitoyl-protein thioesterase 1 (Ppt1), mRNA.
ACCESSION   NM_022502
VERSION     NM_022502.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2263)
  AUTHORS   Liu,Y., Zhao,W., Gu,G., Lu,L., Feng,J., Guo,Q. and Ding,Z.
  TITLE     Palmitoyl-protein thioesterase 1 (PPT1): an obesity-induced rat
            testicular marker of reduced fertility
  JOURNAL   Mol Reprod Dev 81 (1), 55-65 (2014)
   PUBMED   24302477
  REMARK    GeneRIF: PPT1 expression may provide a testicular marker of reduced
            fertility in obese males, as increases in its expression may be
            detrimental to Sertoli-cell function during spermatogenesis.
REFERENCE   2  (bases 1 to 2263)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2263)
  AUTHORS   Lyly,A., von Schantz,C., Heine,C., Schmiedt,M.L., Sipila,T.,
            Jalanko,A. and Kyttala,A.
  TITLE     Novel interactions of CLN5 support molecular networking between
            Neuronal Ceroid Lipofuscinosis proteins
  JOURNAL   BMC Cell Biol 10, 83 (2009)
   PUBMED   19941651
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2263)
  AUTHORS   Rusyn,E., Mousallem,T., Persaud-Sawin,D.A., Miller,S. and
            Boustany,R.M.
  TITLE     CLN3p impacts galactosylceramide transport, raft morphology, and
            lipid content
  JOURNAL   Pediatr Res 63 (6), 625-631 (2008)
   PUBMED   18317235
REFERENCE   5  (bases 1 to 2263)
  AUTHORS   Zhang,Z., Lee,Y.C., Kim,S.J., Choi,M.S., Tsai,P.C., Saha,A.,
            Wei,H., Xu,Y., Xiao,Y.J., Zhang,P., Heffer,A. and Mukherjee,A.B.
  TITLE     Production of lysophosphatidylcholine by cPLA2 in the brain of mice
            lacking PPT1 is a signal for phagocyte infiltration
  JOURNAL   Hum Mol Genet 16 (7), 837-847 (2007)
   PUBMED   17341491
REFERENCE   6  (bases 1 to 2263)
  AUTHORS   Hellsten,E., Vesa,J., Olkkonen,V.M., Jalanko,A. and Peltonen,L.
  TITLE     Human palmitoyl protein thioesterase: evidence for lysosomal
            targeting of the enzyme and disturbed cellular routing in infantile
            neuronal ceroid lipofuscinosis
  JOURNAL   EMBO J 15 (19), 5240-5245 (1996)
   PUBMED   8895569
REFERENCE   7  (bases 1 to 2263)
  AUTHORS   Lu,J.Y., Verkruyse,L.A. and Hofmann,S.L.
  TITLE     Lipid thioesters derived from acylated proteins accumulate in
            infantile neuronal ceroid lipofuscinosis: correction of the defect
            in lymphoblasts by recombinant palmitoyl-protein thioesterase
  JOURNAL   Proc Natl Acad Sci U S A 93 (19), 10046-10050 (1996)
   PUBMED   8816748
REFERENCE   8  (bases 1 to 2263)
  AUTHORS   Vesa,J., Hellsten,E., Verkruyse,L.A., Camp,L.A., Rapola,J.,
            Santavuori,P., Hofmann,S.L. and Peltonen,L.
  TITLE     Mutations in the palmitoyl protein thioesterase gene causing
            infantile neuronal ceroid lipofuscinosis
  JOURNAL   Nature 376 (6541), 584-587 (1995)
   PUBMED   7637805
REFERENCE   9  (bases 1 to 2263)
  AUTHORS   Camp,L.A., Verkruyse,L.A., Afendis,S.J., Slaughter,C.A. and
            Hofmann,S.L.
  TITLE     Molecular cloning and expression of palmitoyl-protein thioesterase
  JOURNAL   J Biol Chem 269 (37), 23212-23219 (1994)
   PUBMED   7916016
REFERENCE   10 (bases 1 to 2263)
  AUTHORS   Camp,L.A. and Hofmann,S.L.
  TITLE     Purification and properties of a palmitoyl-protein thioesterase
            that cleaves palmitate from H-Ras
  JOURNAL   J Biol Chem 268 (30), 22566-22574 (1993)
   PUBMED   7901201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 7, 2023 this sequence version replaced NM_022502.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213911.1, FQ213474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000005.1  140406318-140406455
            139-248             JAXUCZ010000005.1  140411863-140411972
            249-376             JAXUCZ010000005.1  140412288-140412415
            377-447             JAXUCZ010000005.1  140413728-140413798
            448-550             JAXUCZ010000005.1  140416504-140416606
            551-641             JAXUCZ010000005.1  140421829-140421919
            642-740             JAXUCZ010000005.1  140422607-140422705
            741-812             JAXUCZ010000005.1  140424083-140424154
            813-2263            JAXUCZ010000005.1  140425751-140427201
FEATURES             Location/Qualifiers
     source          1..2263
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2263
                     /gene="Ppt1"
                     /gene_synonym="Ppt"
                     /note="palmitoyl-protein thioesterase 1"
                     /db_xref="GeneID:29411"
                     /db_xref="RGD:61994"
     exon            1..138
                     /gene="Ppt1"
                     /gene_synonym="Ppt"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..935
                     /gene="Ppt1"
                     /gene_synonym="Ppt"
                     /EC_number="3.1.2.22"
                     /note="PPT-1; palmitoyl-protein hydrolase 1"
                     /codon_start=1
                     /product="palmitoyl-protein thioesterase 1 precursor"
                     /protein_id="NP_071947.1"
                     /db_xref="GeneID:29411"
                     /db_xref="RGD:61994"
                     /translation="MASPGYRRLLAAALLPWCCAAWALGHLDPPSPPPLVIWHGMGDS
                     CCNPMSMGSIKKMVEKEIPGIYVLSLEIGKNMVEDVENSFFLNVNLQVGMACQILEKD
                     PKLQHGYNAIGFSQGGQFLRAVAQRCPTPPMMTLISVGGQHQGVFGLPRCPGESSHIC
                     DFIRKSLNAGAYSKVVQERLVQAQYWHDPIKEEVYRNCSIFLADINQERHINESYKEN
                     LMALKKFVMVKFFNDSIVDPVDSEWFGFYRSGQAKETIPLQETTLYTEDRLGLKKMDK
                     AGKLVFLAKEGDHLQISKEWFTAHIIPFLK"
     exon            139..248
                     /gene="Ppt1"
                     /gene_synonym="Ppt"
                     /inference="alignment:Splign:2.1.0"
     exon            249..376
                     /gene="Ppt1"
                     /gene_synonym="Ppt"
                     /inference="alignment:Splign:2.1.0"
     exon            377..447
                     /gene="Ppt1"
                     /gene_synonym="Ppt"
                     /inference="alignment:Splign:2.1.0"
     exon            448..550
                     /gene="Ppt1"
                     /gene_synonym="Ppt"
                     /inference="alignment:Splign:2.1.0"
     exon            551..641
                     /gene="Ppt1"
                     /gene_synonym="Ppt"
                     /inference="alignment:Splign:2.1.0"
     exon            642..740
                     /gene="Ppt1"
                     /gene_synonym="Ppt"
                     /inference="alignment:Splign:2.1.0"
     exon            741..812
                     /gene="Ppt1"
                     /gene_synonym="Ppt"
                     /inference="alignment:Splign:2.1.0"
     exon            813..2263
                     /gene="Ppt1"
                     /gene_synonym="Ppt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtgattgc taagatggcg tcgcccggtt accggaggct gctagctgcg gctctgcttc
       61 cttggtgttg cgccgcctgg gccctgggac atctggaccc accttctcca ccaccgctgg
      121 tgatctggca tgggatgggg gacagctgct gtaaccccat gagcatgggt agcattaaaa
      181 agatggttga aaaggaaata ccagggattt acgtcctgtc tctggagatt gggaagaaca
      241 tggtggagga tgtggagaac agcttcttct tgaatgtcaa cctccaagtc ggaatggcat
      301 gtcagattct ggaaaaggat cctaagttgc aacacggata caatgctatt ggcttctccc
      361 agggaggcca gttcctgagg gcagtggctc agagatgccc aacacctccc atgatgaccc
      421 tgatctcagt tgggggacaa catcaaggtg tctttggact ccctcgatgc ccaggagaga
      481 gttctcatat ctgtgacttc atcaggaagt cacttaacgc tggtgcttac tccaaagttg
      541 tgcaagaacg cctggtgcaa gcacagtact ggcatgaccc catcaaggag gaagtgtacc
      601 gaaactgcag catcttcttg gcagacataa atcaagagag gcatatcaat gagtcctaca
      661 aggagaacct gatggccctc aagaagtttg tgatggtgaa attctttaac gattccatcg
      721 tggaccctgt agactctgag tggtttggat tttacagaag tggccaagct aaggaaacca
      781 ttcccctcca ggagaccact ctctacacag aggaccgcct ggggctaaag aaaatggaca
      841 aagcaggaaa gctagtgttt ctggctaagg aaggagacca ccttcaaata tctaaagagt
      901 ggtttacagc ccacatcata ccttttctta agtgaagccc ttgcactttg cagcagagtt
      961 tatgacacca cagctcttcc aaactccagt ttgcaaccag tccttctctc gtgttatcat
     1021 ctaacatgcc ctgcttggaa agatctaaga tctgaatctt atcctttgcc gcctgctatc
     1081 accatatggt gttgaattca agtttaatta gctagtaacc gtgcagactg ctttacaacc
     1141 atgtgatatg gtcaagctct cttttacgga aggggagtct gctattgcag atcagcaatt
     1201 gtgcctaagt gaagtgaagt gaagcagaga gacaagctct gagggtaaaa cccatacaaa
     1261 tttggagcaa ataaaagcct catggtatcc agtcctgaga tgttcacaca agcaatttct
     1321 caacattgct gtgggggcca tgcatgtttc tacatcattt cttaaagctg ttttcctatt
     1381 ttagtgttgc cctctagtgg cacctagcag tcactccaca agcctaccaa catgccccct
     1441 cagagctcac cttctatcct taatcttcag tcaccaaaag ggggatccac cagcagggtt
     1501 gcttaggaga ggaaatgtcc tttttctttt cttccctttt ttgagacagg gtttcactca
     1561 ctttttaacc ctagctggcc tgcaattcac tatgtagagc agactggcct tgaactcagt
     1621 cacagaaatc acctgcccct ctgccttctg agtgctggga ttaaaggcat gcacccccac
     1681 cccctacagc aatgtgtgtc ttagacacca tggatagtgc gggagtggag aagtgaaaac
     1741 taggtggctg gtcttgccac tgcactcttg gctaactgtc cttaatatta caagtagcgt
     1801 aaatgtcact tacactactg caaacaatgg gaggaacagt ctgaaaagat ggaccttgac
     1861 gatcctaccc tacgtcctat ttgccagcat gcgtccaact gctactgact gggttcaaga
     1921 aaatgactaa agagtaaaaa tcaacacata ttaaactgat gatgattctg acagttaaag
     1981 aaaaacaaca ctgatccacc atttcctaca tttgaacatg gactccttag cccccatcct
     2041 gaaaagatcc cagcatgttc tagatgattc ctatagagac tggtttggag aaatgactgt
     2101 tttcgtcaaa gtaccattag ccctgcagaa tccacccact gctggttttt ccttttcctt
     2161 tctcaaacct agtgaaataa aaggatgagg gttatgggga ggaagtggga ggatctgaaa
     2221 atagctttga ggttgtctta aaaaaataaa gaatagtttc tta
//
