LOCUS       NM_031729               1973 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein phosphatase 5, catalytic subunit (Ppp5c),
            mRNA.
ACCESSION   NM_031729
VERSION     NM_031729.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1973)
  AUTHORS   Manilall,A., Mokotedi,L., Gunter,S., Le Roux,R., Fourie,S.,
            Flanagan,C.A. and Millen,A.M.E.
  TITLE     Increased protein phosphatase 5 expression in inflammation-induced
            left ventricular dysfunction in rats
  JOURNAL   BMC Cardiovasc Disord 22 (1), 539 (2022)
   PUBMED   36494772
  REMARK    GeneRIF: Increased protein phosphatase 5 expression in
            inflammation-induced left ventricular dysfunction in rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1973)
  AUTHORS   Storman,E.M., Liu,N.J. and Gintzler,A.R.
  TITLE     Relevance of c-Src and protein phosphatase 2A to aromatase
            activity: Evidence of an acute self-regulating oestrogenic
            signalling complex in rat central nervous system
  JOURNAL   J Neuroendocrinol 34 (4), e13089 (2022)
   PUBMED   35043508
  REMARK    GeneRIF: Relevance of c-Src and protein phosphatase 2A to aromatase
            activity: Evidence of an acute self-regulating oestrogenic
            signalling complex in rat central nervous system.
REFERENCE   3  (bases 1 to 1973)
  AUTHORS   Sager,R.A., Woodford,M.R., Backe,S.J., Makedon,A.M.,
            Baker-Williams,A.J., DiGregorio,B.T., Loiselle,D.R., Haystead,T.A.,
            Zachara,N.E., Prodromou,C., Bourboulia,D., Schmidt,L.S.,
            Linehan,W.M., Bratslavsky,G. and Mollapour,M.
  TITLE     Post-translational Regulation of FNIP1 Creates a Rheostat for the
            Molecular Chaperone Hsp90
  JOURNAL   Cell Rep 26 (5), 1344-1356 (2019)
   PUBMED   30699359
REFERENCE   4  (bases 1 to 1973)
  AUTHORS   Woodford,M.R., Sager,R.A., Marris,E., Dunn,D.M., Blanden,A.R.,
            Murphy,R.L., Rensing,N., Shapiro,O., Panaretou,B., Prodromou,C.,
            Loh,S.N., Gutmann,D.H., Bourboulia,D., Bratslavsky,G., Wong,M. and
            Mollapour,M.
  TITLE     Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates
            folding of kinase and non-kinase clients
  JOURNAL   EMBO J 36 (24), 3650-3665 (2017)
   PUBMED   29127155
REFERENCE   5  (bases 1 to 1973)
  AUTHORS   Hong,T.J., Kim,S., Wi,A.R., Lee,P., Kang,M., Jeong,J.H. and
            Hahn,J.S.
  TITLE     Dynamic nucleotide-dependent interactions of cysteine- and
            histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1
            and melusin with cochaperones PP5 and Sgt1
  JOURNAL   J Biol Chem 288 (1), 215-222 (2013)
   PUBMED   23184943
REFERENCE   6  (bases 1 to 1973)
  AUTHORS   Chen,M.S., Silverstein,A.M., Pratt,W.B. and Chinkers,M.
  TITLE     The tetratricopeptide repeat domain of protein phosphatase 5
            mediates binding to glucocorticoid receptor heterocomplexes and
            acts as a dominant negative mutant
  JOURNAL   J Biol Chem 271 (50), 32315-32320 (1996)
   PUBMED   8943293
REFERENCE   7  (bases 1 to 1973)
  AUTHORS   Fukuda,H., Shima,H., Vesonder,R.F., Tokuda,H., Nishino,H.,
            Katoh,S., Tamura,S., Sugimura,T. and Nagao,M.
  TITLE     Inhibition of protein serine/threonine phosphatases by fumonisin
            B1, a mycotoxin
  JOURNAL   Biochem Biophys Res Commun 220 (1), 160-165 (1996)
   PUBMED   8602837
REFERENCE   8  (bases 1 to 1973)
  AUTHORS   Chinkers,M.
  TITLE     Targeting of a distinctive protein-serine phosphatase to the
            protein kinase-like domain of the atrial natriuretic peptide
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 91 (23), 11075-11079 (1994)
   PUBMED   7972012
REFERENCE   9  (bases 1 to 1973)
  AUTHORS   Becker,W., Kentrup,H., Klumpp,S., Schultz,J.E. and Joost,H.G.
  TITLE     Molecular cloning of a protein serine/threonine phosphatase
            containing a putative regulatory tetratricopeptide repeat domain
  JOURNAL   J Biol Chem 269 (36), 22586-22592 (1994)
   PUBMED   8077208
REFERENCE   10 (bases 1 to 1973)
  AUTHORS   Deana,A.D. and Pinna,L.A.
  TITLE     Identification of pseudo 'phosphothreonyl-specific' protein
            phosphatase T with a fraction of polycation-stimulated protein
            phosphatase 2A
  JOURNAL   Biochim Biophys Acta 968 (2), 179-185 (1988)
   PUBMED   2829978
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X77237.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X77237.1, BC078786.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1973
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1973
                     /gene="Ppp5c"
                     /note="protein phosphatase 5, catalytic subunit"
                     /db_xref="GeneID:65179"
                     /db_xref="RGD:68415"
     exon            1..133
                     /gene="Ppp5c"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1512
                     /gene="Ppp5c"
                     /EC_number="3.1.3.16"
                     /note="PP5; PPT; protein phosphatase T"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 5"
                     /protein_id="NP_113917.1"
                     /db_xref="GeneID:65179"
                     /db_xref="RGD:68415"
                     /translation="MAMAEGERTECAEPPRDEPPAEGTLKRAEELKTQANDYFKAKDY
                     ENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRR
                     AASNMALGKFRAALRDYETVVKVKPNDKDAKMKYQECSKIVKQKAFERAIAGDEHRRS
                     VVDSLDIESMTIEDEYSGPKLEDGKVTITFMKDLMQWYKDQKKLHRKCAYQILVQVKE
                     VLCKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRG
                     SFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEV
                     FEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQ
                     NGRSVSKRGVSCQFGPDVTKAFLEENQLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPN
                     YCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYANTLLQLGMM"
     exon            134..375
                     /gene="Ppp5c"
                     /inference="alignment:Splign:2.1.0"
     exon            376..523
                     /gene="Ppp5c"
                     /inference="alignment:Splign:2.1.0"
     exon            524..645
                     /gene="Ppp5c"
                     /inference="alignment:Splign:2.1.0"
     exon            646..711
                     /gene="Ppp5c"
                     /inference="alignment:Splign:2.1.0"
     exon            712..810
                     /gene="Ppp5c"
                     /inference="alignment:Splign:2.1.0"
     exon            811..916
                     /gene="Ppp5c"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1059
                     /gene="Ppp5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1147
                     /gene="Ppp5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1188
                     /gene="Ppp5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1367
                     /gene="Ppp5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1449
                     /gene="Ppp5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1973
                     /gene="Ppp5c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgctttgcg gcatggcgat ggcggagggc gagcggactg agtgtgctga gcccccccgg
       61 gacgaacccc cggccgaagg cactctgaag cgggcagagg agctcaagac acaggccaac
      121 gactacttca aagccaagga ctacgagaac gctatcaagt tctacagtca ggccatcgag
      181 ttgaacccca gcaatgccat ctactatggc aaccgcagcc tggcctacct gcgcaccgag
      241 tgctatggct atgcactggg cgatgccaca cgggctatcg agcttgacaa gaagtacatc
      301 aaaggttact accgccgggc ggctagcaac atggcactgg gcaagttccg ggctgccctg
      361 cgtgactacg agacggtggt gaaggtgaag cctaatgaca aggatgccaa gatgaagtac
      421 caggagtgca gcaagattgt gaagcagaag gcctttgaga gggccattgc aggcgacgag
      481 cacagacgct ctgtcgtgga ctctctggac atcgaaagca tgaccattga agatgaatac
      541 agtgggccca agcttgagga tggcaaagtg acaatcacct tcatgaaaga cctcatgcag
      601 tggtacaagg atcagaagaa actgcaccgg aagtgcgcct accagatcct agtgcaggtg
      661 aaggaagtcc tctgcaagct gagcacgctg gtggagacaa cgctgaaaga gacagagaag
      721 attacagtgt gtggggacac ccatggccag ttttatgacc tcctcaacat atttgagctc
      781 aacggtttac cctcagagac caacccctat atatttaacg gcgactttgt ggaccgtggt
      841 tccttctccg ttgaagtgat cctcaccctc tttggcttca agctcctgta tccagatcat
      901 tttcatctac ttcgaggcaa ccacgagacg gacaacatga accagatcta tggcttcgag
      961 ggcgaggtga aggccaagta cacagcccaa atgtatgagc tcttcagcga ggtgttcgag
     1021 tggcttccgc tggcacagtg tatcaatggc aaagtgctga tcatgcatgg aggcctattc
     1081 agcgaagatg gtgtcactct ggatgacatc cggaagattg agcggaatcg gcagccccca
     1141 gactcaggtc ccatgtgtga cctgctgtgg tcagatcccc agccacagaa tgggcgctcc
     1201 gtcagcaagc gtggtgtgag ttgtcagttt gggcccgatg tcaccaaggc cttcctggag
     1261 gagaatcaac tggactacat catccgcagc catgaagtca aagctgaggg ctacgaggtg
     1321 gcccatggtg gccgctgtgt caccgtcttc tctgccccca attattgtga ccagatggga
     1381 aacaaagcct cctacatcca cctccagggt tccgacctgc ggccccagtt ccaccaattc
     1441 acagcagtgc ctcaccccaa cgtcaagccc atggcatacg ccaacacgct gctgcagcta
     1501 ggaatgatgt gaggcagtct acagcagtaa ccagggcctg cacagctgga gggccccgcc
     1561 ttcggcctgc tgccccgccc cagggcagcg ttggaccccc ttttactttg taaagtttgt
     1621 atttattccc ctttaggttg cagagggggt gggggcagcg tggggcagca gacgacaggc
     1681 tcctggtcag agaaaggagg agttgaaatt gggggtaggg cacagcctgg gcatttggag
     1741 gaaggccaac ctgggtaggg gtagggccga gaggaggtcc tgccccctcg cctgcatggc
     1801 tcctcccctg gtaaagcaat aggaccctgc cataggaaga ccccaaaaga gggtcatcag
     1861 ggaggcctcc tcctggtagc ctcagggtgg ggcgaggctg gggcccaccc cccagctatt
     1921 ttatgttctg taattaaata tgttaaaata aaataaagtc attattgtaa gtc
//
