LOCUS       NM_001106613            4848 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein phosphatase 4, regulatory subunit 2
            (Ppp4r2), mRNA.
ACCESSION   NM_001106613 XM_001075424 XM_216225
VERSION     NM_001106613.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4848)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   2  (bases 1 to 4848)
  AUTHORS   Bosio,Y., Berto,G., Camera,P., Bianchi,F., Ambrogio,C., Claus,P.
            and Di Cunto,F.
  TITLE     PPP4R2 regulates neuronal cell differentiation and survival,
            functionally cooperating with SMN
  JOURNAL   Eur J Cell Biol 91 (8), 662-674 (2012)
   PUBMED   22559936
  REMARK    GeneRIF: PPP4R2 is required for differentiation of neuronal cells.
REFERENCE   3  (bases 1 to 4848)
  AUTHORS   Yoon,Y.S., Lee,M.W., Ryu,D., Kim,J.H., Ma,H., Seo,W.Y., Kim,Y.N.,
            Kim,S.S., Lee,C.H., Hunter,T., Choi,C.S., Montminy,M.R. and
            Koo,S.H.
  TITLE     Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic
            subunit (PP4C) is a key regulator of hepatic gluconeogenesis
  JOURNAL   Proc Natl Acad Sci U S A 107 (41), 17704-17709 (2010)
   PUBMED   20876121
REFERENCE   4  (bases 1 to 4848)
  AUTHORS   Lee,D.H., Pan,Y., Kanner,S., Sung,P., Borowiec,J.A. and
            Chowdhury,D.
  TITLE     A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA
            repair via homologous recombination
  JOURNAL   Nat Struct Mol Biol 17 (3), 365-372 (2010)
   PUBMED   20154705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Feb 11, 2021 this sequence version replaced NM_001106613.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1346569.1,
                                           SRR26643429.17397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               JAXUCZ010000004.1  135010919-135011174
            257-338             JAXUCZ010000004.1  135011972-135012053
            339-509             JAXUCZ010000004.1  135033624-135033794
            510-603             JAXUCZ010000004.1  135043171-135043264
            604-641             JAXUCZ010000004.1  135045059-135045096
            642-716             JAXUCZ010000004.1  135046444-135046518
            717-860             JAXUCZ010000004.1  135046876-135047019
            861-1147            JAXUCZ010000004.1  135047693-135047979
            1148-4848           JAXUCZ010000004.1  135048144-135051844
FEATURES             Location/Qualifiers
     source          1..4848
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..4848
                     /gene="Ppp4r2"
                     /note="protein phosphatase 4, regulatory subunit 2"
                     /db_xref="GeneID:297486"
                     /db_xref="RGD:1307312"
     exon            1..256
                     /gene="Ppp4r2"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..1464
                     /gene="Ppp4r2"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 4
                     regulatory subunit 2"
                     /protein_id="NP_001100083.3"
                     /db_xref="GeneID:297486"
                     /db_xref="RGD:1307312"
                     /translation="MDVERLQEALKDFEKRGKKEVCPVLDQFLCHVAKTGETMIQWSQ
                     FKGYFIFKLEKVMDDFRTSAPEPRGPPNPNVEYIPFDEMKERILKIVTGFNGIPFTIQ
                     RLCELLTDPRRNYTGTDKFLRGVEKNVMVVSCVCPSSEKNNSNSLNRMNGVMFPGNSP
                     NYTDRSNINGPGTPRPLNRPKLSLSAPLTTNGLPESTDSRDSDLQLSEEKGHSDSSAS
                     DSEVSSPSSGKNKHPDEDTVESEEREVKRLKFDDEGDVRETASQAVSSEVSSVRAEET
                     ETASSPPEKDRENRTRQHCTEEEEEEEEEEEEESFMTPREMVPERKNQEKESDDALTV
                     NEETSEESHQTEGSGASPSQTDSASERSDSAGASRGGSDCRETQESGGPPARKTGECV
                     SGSAMENDEATEVTDEPVEQE"
     exon            257..338
                     /gene="Ppp4r2"
                     /inference="alignment:Splign:2.1.0"
     exon            339..509
                     /gene="Ppp4r2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..603
                     /gene="Ppp4r2"
                     /inference="alignment:Splign:2.1.0"
     exon            604..641
                     /gene="Ppp4r2"
                     /inference="alignment:Splign:2.1.0"
     exon            642..716
                     /gene="Ppp4r2"
                     /inference="alignment:Splign:2.1.0"
     exon            717..860
                     /gene="Ppp4r2"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1147
                     /gene="Ppp4r2"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..4848
                     /gene="Ppp4r2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttggagggct ggtggtagcg gctcggggag gttctcgctc tgtccgtctc gctccgtctc
       61 tcgctttccc ccggctccct tcgggacccc cctccccgat cgccggcgtg tggcggagtg
      121 tgtgcgaggg cgggggcggg cgtcgggggg gcgggggcgg gcgccgcggc ccccgggacg
      181 gcggccgagg gaggcgccgg cggcgaggga ctccgcggcg ccatggacgt cgagaggctg
      241 caggaggcgc tgaaagattt tgagaagaga gggaaaaagg aagtttgtcc tgtactggat
      301 cagtttctct gtcatgtagc caaaactgga gaaacaatga ttcagtggtc ccaatttaaa
      361 ggctatttca ttttcaaact ggagaaagtg atggatgatt ttagaacttc agctcctgaa
      421 ccaagaggtc ctcccaatcc taatgttgaa tatattccct ttgatgaaat gaaggaaaga
      481 atactgaaaa ttgtcactgg atttaatggt atccctttta ctattcaacg actatgtgaa
      541 ttgctaacag atccaagaag aaattataca ggaactgaca aatttctcag aggagtagaa
      601 aagaatgtca tggttgttag ctgcgtttgt ccttcttcag agaagaacaa ttctaatagt
      661 ttaaacagaa tgaatggtgt tatgtttcct ggaaactccc caaactatac tgacaggtct
      721 aatataaatg ggcctggaac acccaggcca cttaatcgac caaagctttc tttgtcagcc
      781 cccttaacaa caaatggttt gcctgagagc acagatagca gagattcaga cctacagcta
      841 agtgaagaga aaggacacag tgattcttca gcatctgatt cagaagtttc ctctccaagc
      901 tctggtaaaa acaaacatcc agatgaagat actgtggaat ctgaggaacg tgaggtgaaa
      961 agactgaagt ttgacgatga aggtgatgtc cgagagacag ctagccaagc ggtgtccagt
     1021 gaagtctctt cagttagagc agaggaaacg gaaacagcat catccccccc tgagaaggac
     1081 agagaaaatc gaaccaggca gcactgtaca gaagaggagg aagaggagga ggaagaggag
     1141 gaagaagagt catttatgac accaagagaa atggttccag aaagaaaaaa tcaagaaaag
     1201 gaatctgatg atgccttaac tgtgaacgaa gagacttcag aggagagcca tcagacggag
     1261 ggctctggtg cgtctccatc tcagacagac tccgcttcag aaaggagtga cagtgccggg
     1321 gcctccaggg gtggctctga ctgccgggag acacaggagt caggagggcc ccctgccagg
     1381 aaaactggag agtgtgtgtc agggtcagcc atggagaatg atgaagccac agaagtcaca
     1441 gatgaaccag tggaacaaga ataactactt aaaaacactt agaggcagta ttttacatac
     1501 agttctggtt ttacactgta taaaactttt aagtaataaa taaagtggac ctttagtttt
     1561 acaagagaaa caggctgtaa aataaagaac cttaagaata aaccctgaaa gagttgtacg
     1621 tgggaagagc tgtgaatact ggctcctctg ggtcccgctt attgctgatt ttcttgtttt
     1681 gtttggtttt ttgtttgttt ttttcctggt gtactcaaat cagtggtttg tgtatagatt
     1741 tttttttttt aatttagaat taaaggtttt aaactggaag ataattataa ttttgaaaac
     1801 tttaaagatg atctcatttg gtttatacat acacaaggaa gatttttgtc ttgtctctag
     1861 cagtttcata ttttggtcat agtttaaaca tgttaacatg tgaattatag ggtttcatgt
     1921 ggtttcaggt ttttattgtt ggactgtaca atgggacttt aagtcctata tacatatgta
     1981 gattatcctg ggggaatgtt atatttttct gtttctataa gagatgaata cagtggatac
     2041 ttttttattg gtaataactg agttcacttc tttcagaaga cattttcttt ctcttctgag
     2101 taattgagac aaaaatctgg cccctgtgaa accctgggaa tctttaagtc tattgaaata
     2161 ccaggttaaa cacattccaa gagatctgtg caaactgaat tcttttgtat acttctaagg
     2221 tgcctgagaa aaagacttca ttatttatga gacagcgtgc tctatcttgg gagttgcgct
     2281 ccagcattag cttactgtgt agaatgagcg cttaggagct gacatgaaac catctcagaa
     2341 gagcccacag gcccataacc cttgattgct tttctgcaca ttgtcaccgt tccatctgtc
     2401 cttctgaatc accctgtgtg cgcatggcac tggtgtgaag cgtcactgta agaattcata
     2461 gtccttcagt aatgtacctg agctaagatt agatgactga agctttaggg tacacagaaa
     2521 ccaccatgat ttgtataaca ttttgaagtg aattactatt tttgaacatg cttcttcaac
     2581 agccagtgtt atatttttca gatcaacaca aagcacaatg gttattactc taaactcaac
     2641 attttcaaat tcacatactt aaagtcatgc aagctgcaac ttccctgtca gaattactgg
     2701 ctgccaaatt tatacctgtt tcttcagctg tactttttga tatttagaat ttttaaattt
     2761 ctgtaaagta gattttgtag actgtaatgt gttcactgcc tttgtgaagc ggtatataat
     2821 tgtataattt cgtgtgtaac cgaatgcttg gctttcaata cagtattcat ataaagcaat
     2881 aaatattaat gttatgaaat attcgagtac atttttatca aaatacaaaa aaatcctttt
     2941 tttagtttga gacatctgag gtacacagat ggacttacta gctgatgcaa acagtttctc
     3001 acactgtatc ctaagctttg ggcgatttgg aggggaacca caaggtttgg attttgactg
     3061 cttagacatt actttggcta aaaagatatt tggctccgtt tgttcataaa gtaatatact
     3121 actgactgat gaccttcagg ttcacagcag ctggatttta tgaatctaat aaaatgaatg
     3181 ttgatttact gcacccaaga ggggtgaaaa tcaaatgtaa cttaaaaggg ttttggcaaa
     3241 agggttaaaa tgaagcaagt tttaagtgtg acattcattt gtaatggctt gttactctat
     3301 ttagttgagg gattgccagt aagagcagat tttaaacatt ataggtttag aattttcgag
     3361 attttcctta gggtatttat gagattgttg tcaataaacc tgttctctaa gctcctgtga
     3421 cctttgatag tctttcttta tggtgccacg gaccattcac aaacatcagt tcactgctgg
     3481 ttaaaaggtg aagatttagc atcatgaata gaggactgtg gttttatttg taaacttgca
     3541 attgctatct ttgcaagggg aaatgtattt ctttattaaa taaagtacaa ttaataatgg
     3601 tgactgtacc aaaatgacat cactcaattc tatgagaggt ctgcatttta atctatagtt
     3661 taatagcttt aatatttatt agctactcct atgttgatca tagatgaaag ttgttgctgt
     3721 ttatgcagat acatgtaggg tactggtgaa aggtctctag ggcagttgca atattcacat
     3781 tgtgaaacca tgttcaggct gtggatgcat tggccccttg gaagtccatt tccacaagtc
     3841 ttgttagatg cacttacagg aaatgcaaga aaagcatcag ttctaacaac tcagtcatat
     3901 gtgaatgatg aaaaggcaag ttttaggcac atttccttaa tgtacccagc aaagtcctat
     3961 gagaagatcc aagggagggg caaggctttg gaggctgaag tagctggctc tttgtcttga
     4021 acagatccta acctgtttct ccattcccaa tcctaaggca agaactggcc aatgccagtg
     4081 agacagtata catatgacat ggttttgtca cttctcttta aaaagtgaaa ctgtttttga
     4141 aaactgtctt cagttctgaa aatgtagcag aaaagacata gtggaaatat attttgagtg
     4201 ttagataact ttaatccact tactgttcgt cacaagtaca gcctttccca tgtggaactc
     4261 cagagcggtg gagttacagc tctggctttg gaaagctgtt ccaggaatcc tgcatcggaa
     4321 agtcttaaag cattgagatc cctgtgtttt attttggcag tgtagatagg catgtattta
     4381 tgcatttgta aaatcgattt ttcaaataat gtatgtaatg tactagcttg aatggtgctg
     4441 ggcagagcct gaagctgctg caattttgaa tgtgaagcct gtaccgaggg tggaaatgta
     4501 actgcagagc caaagcaaac tactctgggt agtgtttcaa actgtctctt gagcaggagt
     4561 ttcttagatc tattggtttt gacaaaatga agatcagttc ttaagatttg ttctaataag
     4621 atgaatggat gcaaaaacac cttgtaattt catggaatta tgaaaactat cgtgatgggg
     4681 ttattgacct aacgaggatg ctagtatgca ctggccatga ttcatatatc tcacatttaa
     4741 aaaatagtcc ggacaccaga attctctttc aatttggagc ctagatcaat cactttgcca
     4801 aataaatgta ttattttcat aatgcaataa agtatgaact agaatgtt
//
