LOCUS       NM_134359               1457 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus protein phosphatase 4, catalytic subunit (Ppp4c),
            mRNA.
ACCESSION   NM_134359 XM_341929
VERSION     NM_134359.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1457)
  AUTHORS   Ma,Y., Hou,J., Huang,D., Zhang,Y., Liu,Z. and Tian,M.
  TITLE     Expression of protein phosphatase 4 in different tissues under
            hypoxia
  JOURNAL   Indian J Pathol Microbiol 66 (3), 577-583 (2023)
   PUBMED   37530343
  REMARK    GeneRIF: Expression of protein phosphatase 4 in different tissues
            under hypoxia.
REFERENCE   2  (bases 1 to 1457)
  AUTHORS   Yan,S.
  TITLE     Integrative analysis of promising molecular biomarkers and pathways
            for coronary artery disease using WGCNA and MetaDE methods
  JOURNAL   Mol Med Rep 18 (3), 2789-2797 (2018)
   PUBMED   30015926
REFERENCE   3  (bases 1 to 1457)
  AUTHORS   Eleftheriadou,O., Boguslavskyi,A., Longman,M.R., Cowan,J.,
            Francois,A., Heads,R.J., Wadzinski,B.E., Ryan,A., Shattock,M.J. and
            Snabaitis,A.K.
  TITLE     Expression and regulation of type 2A protein phosphatases and
            alpha4 signalling in cardiac health and hypertrophy
  JOURNAL   Basic Res Cardiol 112 (4), 37 (2017)
   PUBMED   28526910
REFERENCE   4  (bases 1 to 1457)
  AUTHORS   Panier,S. and Durocher,D.
  TITLE     Push back to respond better: regulatory inhibition of the DNA
            double-strand break response
  JOURNAL   Nat Rev Mol Cell Biol 14 (10), 661-672 (2013)
   PUBMED   24002223
  REMARK    Review article
REFERENCE   5  (bases 1 to 1457)
  AUTHORS   Yoon,Y.S., Lee,M.W., Ryu,D., Kim,J.H., Ma,H., Seo,W.Y., Kim,Y.N.,
            Kim,S.S., Lee,C.H., Hunter,T., Choi,C.S., Montminy,M.R. and
            Koo,S.H.
  TITLE     Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic
            subunit (PP4C) is a key regulator of hepatic gluconeogenesis
  JOURNAL   Proc Natl Acad Sci U S A 107 (41), 17704-17709 (2010)
   PUBMED   20876121
REFERENCE   6  (bases 1 to 1457)
  AUTHORS   Lee,D.H., Pan,Y., Kanner,S., Sung,P., Borowiec,J.A. and
            Chowdhury,D.
  TITLE     A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA
            repair via homologous recombination
  JOURNAL   Nat Struct Mol Biol 17 (3), 365-372 (2010)
   PUBMED   20154705
REFERENCE   7  (bases 1 to 1457)
  AUTHORS   Veluthakal,R., Wadzinski,B.E. and Kowluru,A.
  TITLE     Localization of a nuclear serine/threonine protein phosphatase in
            insulin-secreting INS-1 cells: potential regulation by IL-1beta
  JOURNAL   Apoptosis 11 (8), 1401-1411 (2006)
   PUBMED   16830232
REFERENCE   8  (bases 1 to 1457)
  AUTHORS   Hastie,C.J., Carnegie,G.K., Morrice,N. and Cohen,P.T.
  TITLE     A novel 50 kDa protein forms complexes with protein phosphatase 4
            and is located at centrosomal microtubule organizing centres
  JOURNAL   Biochem J 347 Pt 3 (Pt 3), 845-855 (2000)
   PUBMED   10769191
REFERENCE   9  (bases 1 to 1457)
  AUTHORS   Wadzinski,B.E., Heasley,L.E. and Johnson,G.L.
  TITLE     Multiplicity of protein serine-threonine phosphatases in PC12
            pheochromocytoma and FTO-2B hepatoma cells
  JOURNAL   J Biol Chem 265 (35), 21504-21508 (1990)
   PUBMED   2174876
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091574.1.
            
            On Apr 19, 2005 this sequence version replaced XM_341929.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091574.1, CO575359.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1457
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..1457
                     /gene="Ppp4c"
                     /gene_synonym="Ppx"
                     /note="protein phosphatase 4, catalytic subunit"
                     /db_xref="GeneID:171366"
                     /db_xref="RGD:621225"
     exon            1..279
                     /gene="Ppp4c"
                     /gene_synonym="Ppx"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1105
                     /gene="Ppp4c"
                     /gene_synonym="Ppx"
                     /EC_number="3.1.3.16"
                     /note="pp4; PP4C; protein phosphatase 4 (formerly X),
                     catalytic subunit"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 4 catalytic
                     subunit"
                     /protein_id="NP_599186.1"
                     /db_xref="GeneID:171366"
                     /db_xref="RGD:621225"
                     /translation="MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQR
                     VDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKV
                     RYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKI
                     FCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFG
                     SDVVAQFNAANDIDMTCRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELD
                     EHLQKDFIIFEAAPQETRGIPSKKPVADYFL"
     exon            280..331
                     /gene="Ppp4c"
                     /gene_synonym="Ppx"
                     /inference="alignment:Splign:2.1.0"
     exon            332..382
                     /gene="Ppp4c"
                     /gene_synonym="Ppx"
                     /inference="alignment:Splign:2.1.0"
     exon            383..484
                     /gene="Ppp4c"
                     /gene_synonym="Ppx"
                     /inference="alignment:Splign:2.1.0"
     exon            485..658
                     /gene="Ppp4c"
                     /gene_synonym="Ppx"
                     /inference="alignment:Splign:2.1.0"
     exon            659..785
                     /gene="Ppp4c"
                     /gene_synonym="Ppx"
                     /inference="alignment:Splign:2.1.0"
     exon            786..975
                     /gene="Ppp4c"
                     /gene_synonym="Ppx"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1419
                     /gene="Ppp4c"
                     /gene_synonym="Ppx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcgggac gcggagggtc ctggaccgcc gtgaggggag gggggggcgg tcccagaatc
       61 gagtcccccc tcccgcacgg accctctgat tggcgggctc gccttcgctt ttcccaggag
      121 acccctgtgc ggtccggagg gggcgccagc cccgactctg acccgcgccg gggggtgggc
      181 catggcggaa atcagcgacc tggaccggca gatcgagcag ctgcggcgct gcgaacttat
      241 caaagagagc gaagtcaagg ccctgtgcgc taaggccaga gagatcttgg tagaagagag
      301 caacgtgcag agggtggact cgccagtcac agtatgcggt gacatccacg gacaattcta
      361 tgacctcaag gagctgttca gagtaggtgg cgatgtccct gagaccaact acctcttcat
      421 gggagacttt gtggaccgtg gtttctacag tgttgaaacc ttcctcctcc tgctggctct
      481 taaggttcga tatcctgacc gaatcacttt gatccggggc aatcatgaga gtcgccagat
      541 tacccaggtc tatgggttct atgatgagtg cttacggaaa tatggttcag tgactgtatg
      601 gcgctactgt actgagatct ttgactacct cagcctgtct gccatcattg atggcaagat
      661 cttctgtgtg catggaggtc tttccccttc tatccagacc ttggaccaga tccggacaat
      721 tgaccgaaag caagaggtac cccatgatgg acccatgtgt gacctcctgt ggtctgaccc
      781 tgaagacaca acaggctggg gagtgagccc ccgtggggca ggctacctgt ttggcagtga
      841 tgtggtcgcc cagttcaatg cagccaacga cattgatatg acctgccgtg cccaccaatt
      901 ggtgatggaa ggttacaagt ggcacttcaa tgagacggtg cttactgtgt ggtcagcgcc
      961 taattactgc taccgctgtg ggaatgtggc agccatctta gaactggatg agcacctcca
     1021 gaaagatttc atcatcttcg aggctgcacc ccaagagaca cgtggcatcc cctccaaaaa
     1081 gccagtggct gactatttcc tgtgactcct tggccccagc ccctctggcc cttggaccac
     1141 tgtgactgcc ctctgcccag tcggaggctg ggtatgaggg gctgcctggc tttgcttgcc
     1201 cccagggtgc ggacttgctc tggagaggtt ggagccttag ctcctggctt cctctccttc
     1261 ctcccacttg atccatgaag tttccagtca ttttgttttt cttttttcct ttttcttttt
     1321 tctttctttc tttctttttt tttttttttt ttgttttttg tttttagata aaacattttg
     1381 agaaaaaaag aaaaaaattc taataaaaga agaaaaataa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaaaaaa aaaaaaa
//
