LOCUS       NM_021701                739 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus protein phosphatase 3, regulatory subunit B, beta
            (Ppp3r2), mRNA.
ACCESSION   NM_021701
VERSION     NM_021701.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 739)
  AUTHORS   Bales,J.W., Ma,X., Yan,H.Q., Jenkins,L.W. and Dixon,C.E.
  TITLE     Regional calcineurin subunit B isoform expression in rat
            hippocampus following a traumatic brain injury
  JOURNAL   Brain Res 1358, 211-220 (2010)
   PUBMED   20713027
REFERENCE   2  (bases 1 to 739)
  AUTHORS   MacDonnell,S.M., Kubo,H., Harris,D.M., Chen,X., Berretta,R.,
            Barbe,M.F., Kolwicz,S., Reger,P.O., Eckhart,A., Renna,B.F.,
            Koch,W.J., Houser,S.R. and Libonati,J.R.
  TITLE     Calcineurin inhibition normalizes beta-adrenergic responsiveness in
            the spontaneously hypertensive rat
  JOURNAL   Am J Physiol Heart Circ Physiol 293 (5), H3122-H3129 (2007)
   PUBMED   17827263
  REMARK    GeneRIF: In conclusion, CsA normalized the blunted beta-AR
            responsiveness associated with hypertension.
REFERENCE   3  (bases 1 to 739)
  AUTHORS   Saeki,M., Irie,Y., Ni,L., Itsuki,Y., Terao,Y., Kawabata,S. and
            Kamisaki,Y.
  TITLE     Calcineurin potentiates the activation of procaspase-3 by
            accelerating its proteolytic maturation
  JOURNAL   J Biol Chem 282 (16), 11786-11794 (2007)
   PUBMED   17324936
  REMARK    GeneRIF: calcineurin B potentiates the activation of procaspase-3
            by accelerating its proteolytic maturation
REFERENCE   4  (bases 1 to 739)
  AUTHORS   Loane,D.J., Hicks,G.A., Perrino,B.A. and Marrion,N.V.
  TITLE     Inhibition of BK channel activity by association with calcineurin
            in rat brain
  JOURNAL   Eur J Neurosci 24 (2), 433-441 (2006)
   PUBMED   16903851
  REMARK    GeneRIF: These data suggest that BK(Ca) channel activity is
            inhibited by calcineurin, an effect mediated by the association of
            the calcineurin B subunit with the carboxyl terminus of the
            channel.
REFERENCE   5  (bases 1 to 739)
  AUTHORS   Wilkins,B.J. and Molkentin,J.D.
  TITLE     Calcium-calcineurin signaling in the regulation of cardiac
            hypertrophy
  JOURNAL   Biochem Biophys Res Commun 322 (4), 1178-1191 (2004)
   PUBMED   15336966
  REMARK    Review article
REFERENCE   6  (bases 1 to 739)
  AUTHORS   Abe,T., Takagi,N., Nakano,M., Furuya,M. and Takeo,S.
  TITLE     Altered Bad localization and interaction between Bad and Bcl-xL in
            the hippocampus after transient global ischemia
  JOURNAL   Brain Res 1009 (1-2), 159-168 (2004)
   PUBMED   15120593
REFERENCE   7  (bases 1 to 739)
  AUTHORS   Sugimoto,M., Matsui,H., Etoh,S., Shimizu,T., Nishio,H., Moia,L.J.,
            Tokuda,M., Itano,T., Takenaka,I. and Hatase,O.
  TITLE     Isolation and sequence of rat testis cDNA for a calcium binding
            polypeptide similar to the regulatory subunit of calcineurin
  JOURNAL   Biochem Biophys Res Commun 180 (3), 1476-1482 (1991)
   PUBMED   1659420
REFERENCE   8  (bases 1 to 739)
  AUTHORS   Mukai,H., Chang,C.D., Tanaka,H., Ito,A., Kuno,T. and Tanaka,C.
  TITLE     cDNA cloning of a novel testis-specific calcineurin B-like protein
  JOURNAL   Biochem Biophys Res Commun 179 (3), 1325-1330 (1991)
   PUBMED   1718268
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D10393.1.
            
            On Aug 30, 2012 this sequence version replaced NM_021701.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10393.1, BF563790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-739               D10393.1           4-742
FEATURES             Location/Qualifiers
     source          1..739
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..739
                     /gene="Ppp3r2"
                     /gene_synonym="Cblp"
                     /note="protein phosphatase 3, regulatory subunit B, beta"
                     /db_xref="GeneID:29749"
                     /db_xref="RGD:69232"
     exon            1..527
                     /gene="Ppp3r2"
                     /gene_synonym="Cblp"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..549
                     /gene="Ppp3r2"
                     /gene_synonym="Cblp"
                     /EC_number="3.1.3.16"
                     /note="calcineurin B, type II; protein phosphatase 2B
                     regulatory subunit 2; calcineurin B-like protein"
                     /codon_start=1
                     /product="calcineurin subunit B type 2"
                     /protein_id="NP_067733.1"
                     /db_xref="GeneID:29749"
                     /db_xref="RGD:69232"
                     /translation="MGNEASYHSEMGTHFDHDEIKRLGRSFKKMDLDKSGSLSVDEFM
                     SLPELQQNPLVGRVIDIFDTDGNGEVDFREFIVGTSQFSVKGDEEQKLRFAFRIYDMD
                     NDGFISNGELFQVLKMMVGNNLKDWQLQQLVDKSILVLDKDGDGRISFEEFRDVVRTM
                     EIHKKLVVFVDHGQED"
     exon            528..739
                     /gene="Ppp3r2"
                     /gene_synonym="Cblp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccccact gcctcgccat gggaaatgag gccagttacc attctgagat gggcacccac
       61 ttcgaccacg acgagattaa aaggctgggc agaagcttca agaagatgga cttggacaaa
      121 tcgggctccc tgagcgtaga cgagttcatg tcgctgcctg agctgcagca gaatccactg
      181 gtgggccgag tgatcgacat ctttgacaca gacggcaacg gggaagtgga cttccgcgag
      241 ttcatcgtgg gcacctccca gttcagcgtc aagggtgacg aagagcagaa gctaaggttc
      301 gccttcagaa tctatgacat ggataatgat ggcttcatct ccaacgggga gctcttccag
      361 gtgcttaaga tgatggtggg aaacaacctc aaggactggc agctgcagca gctggtggac
      421 aaaagcatct tggtcctgga taaggatggt gatggccgga tatcctttga agagttccgt
      481 gatgtggtca gaaccatgga gatccacaag aaattggtcg tgtttgtaga tcacggtcaa
      541 gaagactaaa agcttaaaaa taagagaggt gtacatctgt gcctttcttt ctcgaggttg
      601 tgtacatggg agaagacaac aattctcatg gagtattagg aactcctttc gtttacctgt
      661 ggcattcaga ctttttaaca aacagattgt taacttcctg ttgtaacaac tagcagaaat
      721 atatttatct ttgcctagc
//
