LOCUS       NM_017309               2979 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus protein phosphatase 3, regulatory subunit B,
            alpha (Ppp3r1), mRNA.
ACCESSION   NM_017309
VERSION     NM_017309.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2979)
  AUTHORS   Huang,Y., Chen,S.R. and Pan,H.L.
  TITLE     Calcineurin Regulates Synaptic Plasticity and Nociceptive
            Transmission at the Spinal Cord Level
  JOURNAL   Neuroscientist 28 (6), 628-638 (2022)
   PUBMED   34791930
  REMARK    GeneRIF: Calcineurin Regulates Synaptic Plasticity and Nociceptive
            Transmission at the Spinal Cord Level.
            Review article
REFERENCE   2  (bases 1 to 2979)
  AUTHORS   Agg,B., Baranyai,T., Makkos,A., Veto,B., Farago,N., Zvara,A.,
            Giricz,Z., Veres,D.V., Csermely,P., Aranyi,T., Puskas,L.G.,
            Varga,Z.V. and Ferdinandy,P.
  TITLE     MicroRNA interactome analysis predicts post-transcriptional
            regulation of ADRB2 and PPP3R1 in the hypercholesterolemic
            myocardium
  JOURNAL   Sci Rep 8 (1), 10134 (2018)
   PUBMED   29973623
  REMARK    GeneRIF: Ppp3r1 mRNA and protein are decreased in the
            hypercholesterolemic heart.
            Erratum:[Sci Rep. 2018 Aug 9;8(1):12159. doi:
            10.1038/s41598-018-30163-9.. PMID: 30089810]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2979)
  AUTHORS   Sheftic,S.R., Page,R. and Peti,W.
  TITLE     Investigating the human Calcineurin Interaction Network using the
            piLxVP SLiM
  JOURNAL   Sci Rep 6, 38920 (2016)
   PUBMED   27974827
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2979)
  AUTHORS   Li,S.J., Wang,J., Ma,L., Lu,C., Wang,J., Wu,J.W. and Wang,Z.X.
  TITLE     Cooperative autoinhibition and multi-level activation mechanisms of
            calcineurin
  JOURNAL   Cell Res 26 (3), 336-349 (2016)
   PUBMED   26794871
REFERENCE   5  (bases 1 to 2979)
  AUTHORS   Biesemann,C., Gronborg,M., Luquet,E., Wichert,S.P., Bernard,V.,
            Bungers,S.R., Cooper,B., Varoqueaux,F., Li,L., Byrne,J.A.,
            Urlaub,H., Jahn,O., Brose,N. and Herzog,E.
  TITLE     Proteomic screening of glutamatergic mouse brain synaptosomes
            isolated by fluorescence activated sorting
  JOURNAL   EMBO J 33 (2), 157-170 (2014)
   PUBMED   24413018
REFERENCE   6  (bases 1 to 2979)
  AUTHORS   Huai,Q., Kim,H.Y., Liu,Y., Zhao,Y., Mondragon,A., Liu,J.O. and
            Ke,H.
  TITLE     Crystal structure of calcineurin-cyclophilin-cyclosporin shows
            common but distinct recognition of immunophilin-drug complexes
  JOURNAL   Proc Natl Acad Sci U S A 99 (19), 12037-12042 (2002)
   PUBMED   12218175
REFERENCE   7  (bases 1 to 2979)
  AUTHORS   Perrino,B.A., Wilson,A.J., Ellison,P. and Clapp,L.H.
  TITLE     Substrate selectivity and sensitivity to inhibition by FK506 and
            cyclosporin A of calcineurin heterodimers composed of the alpha or
            beta catalytic subunit
  JOURNAL   Eur J Biochem 269 (14), 3540-3548 (2002)
   PUBMED   12135494
  REMARK    GeneRIF: The enzymatic properties of CaN heterodimers comprised of
            the regulatory B subunit (CnB) with either the alpha or beta
            catalytic subunit were compared using in vitro phosphatase assays.
REFERENCE   8  (bases 1 to 2979)
  AUTHORS   Zeng,H., Chattarji,S., Barbarosie,M., Rondi-Reig,L., Philpot,B.D.,
            Miyakawa,T., Bear,M.F. and Tonegawa,S.
  TITLE     Forebrain-specific calcineurin knockout selectively impairs
            bidirectional synaptic plasticity and working/episodic-like memory
  JOURNAL   Cell 107 (5), 617-629 (2001)
   PUBMED   11733061
REFERENCE   9  (bases 1 to 2979)
  AUTHORS   Graef,I.A., Chen,F., Chen,L., Kuo,A. and Crabtree,G.R.
  TITLE     Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the
            developing vasculature
  JOURNAL   Cell 105 (7), 863-875 (2001)
   PUBMED   11439183
REFERENCE   10 (bases 1 to 2979)
  AUTHORS   Chang,C.D., Mukai,H., Kuno,T. and Tanaka,C.
  TITLE     cDNA cloning of an alternatively spliced isoform of the regulatory
            subunit of Ca2+/calmodulin-dependent protein phosphatase
            (calcineurin B alpha 2)
  JOURNAL   Biochim Biophys Acta 1217 (2), 174-180 (1994)
   PUBMED   8110831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 15, 2021 this sequence version replaced NM_017309.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212066.1, BC088855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               JAXUCZ010000014.1  95769846-95770094
            250-289             JAXUCZ010000014.1  95789195-95789234
            290-466             JAXUCZ010000014.1  95802307-95802483
            467-526             JAXUCZ010000014.1  95803813-95803872
            527-711             JAXUCZ010000014.1  95804231-95804415
            712-2979            JAXUCZ010000014.1  95805748-95808015
FEATURES             Location/Qualifiers
     source          1..2979
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..2979
                     /gene="Ppp3r1"
                     /note="protein phosphatase 3, regulatory subunit B, alpha"
                     /db_xref="GeneID:29748"
                     /db_xref="RGD:69230"
     exon            1..249
                     /gene="Ppp3r1"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..759
                     /gene="Ppp3r1"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase 2B regulatory subunit 1"
                     /codon_start=1
                     /product="calcineurin subunit B type 1"
                     /protein_id="NP_059005.1"
                     /db_xref="GeneID:29748"
                     /db_xref="RGD:69230"
                     /translation="MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFM
                     SLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMD
                     KDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGL
                     DIHKKMVVDV"
     exon            250..289
                     /gene="Ppp3r1"
                     /inference="alignment:Splign:2.1.0"
     exon            290..466
                     /gene="Ppp3r1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..526
                     /gene="Ppp3r1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..711
                     /gene="Ppp3r1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..2979
                     /gene="Ppp3r1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctctgcg cgccctgttt cgtgccttga ggttgcggtc agcgcgagcc gctgcagcga
       61 ttcggggccg cccgtgagcg tgaggctgca accctctcct cccgccgacg catctccaac
      121 cgagactccg cccgcctcac tccgggccca ggccccgttg caccccgccc ggcaccggac
      181 agcaaagccg ccgtcgccgc gtcccaagga acctacagcc gccgccagcg ccgcccgcct
      241 agcaagatgg gaaatgaggc gagttaccct ttggaaatgt gctcacactt cgatgctgat
      301 gagattaaaa ggctaggaaa gagattcaag aagcttgact tggacaactc tggttctttg
      361 agcgtggagg agttcatgtc tctgcctgag ttacaacaga accctttagt acagcgggtc
      421 atagatatat tcgacacaga cgggaatgga gaagtggact tcaaagaatt cattgaagga
      481 gtctctcagt tcagtgtcaa aggcgataag gaacagaagt tgaggttcgc tttccgtatc
      541 tacgacatgg ataaagacgg ctatatttcc aatggagagc tcttccaggt gttgaagatg
      601 atggtgggca acaacctgaa agatacgcag ttacagcaga ttgtagacaa aaccataata
      661 aacgcagata aggacgggga cgggagaata tcctttgagg agttctgtgc tgttgtaggt
      721 ggcctagata tccacaaaaa gatggtggtg gatgtgtgac tctttgaaga ctctaccacc
      781 cagcactttt gctttcttct ccatctctga agatctgctc aagacgtcca gcaatgctct
      841 ctgtgtgtgt aaatggaagt atttttctct gtgaagccac attttccaac atgagcctca
      901 tgaagccaac gaagtgttat tgaactccta ccctctcaat aactcagtgt agcactttca
      961 agtttgaggg gcagcagcag gaaaagagca tatcagtatg gtggagaaag ggaaggggtg
     1021 gctctttaat ttatttttct tcatctttta taacaagaaa gtatctatat atacatatgt
     1081 aaatatttat atatagatat atgtagcttt ctatatattt agtaggttgg ctttaattta
     1141 atatacttga ttcagaaaca aaatgttaga gtacaaaagt gccaagcaga acatatacca
     1201 tccttacttt tatttcacac ggttttatat gtagatagag gattgtacaa ttcgcgccag
     1261 gtattaggcc agctagtttc ctttctctgt gctttctcct ttgagagatt gacaaagcat
     1321 ttgttaatgc cctattattt accttaatta cacttttgta acgagtctgt aactttattt
     1381 atatctctga gtatctttcc agggactgtg tcttactgcc gagcagcgtt taatccatct
     1441 ctgttggagg tctagttcag tgctgttgcc aagagtgggt tcttgtgtcc atagaactgc
     1501 ataccctgtg gctgcttcag gctgatactt tttaagtagt cgctgttaat tttattaagc
     1561 gtccctgaga aaaaatgtaa ttagcagttg tgattttatc aaggtcagaa gttttctgag
     1621 gcagtcatga cttttttaaa cgttattatt tagtgaagaa aatccaaagc agtcatgcaa
     1681 tggcttaaaa catccttgtt tcgttgtaca caaggaaaca cttgtcacta aactacaaat
     1741 cctgggttta ttcatgcatt tcaaaaaaag ttaaccggaa aaaaagtcaa ctgatactta
     1801 aagagcacat atttctgtaa aatcccattt gtggttaaaa tgggggagta tcctgctaat
     1861 ctatatgccg ttggagagca gattttgccc acatttacat ttttaaaatt tctttgccag
     1921 atagaaggca agatagcaca tgatggattt tgttgttttg cctgcacaac tagcaatggc
     1981 tgatgatgta atagatttgt gtgacgtaaa agtacgtcat ggtctaccac atgacgttat
     2041 cccttccctt ctctgcaaag gtactggaag agagacattc tggatagttt tatatggcag
     2101 tcttccctat acagtttttc tatataaatt ggttttgtaa tcatgagtgg taaagggcgg
     2161 gtcgaatcga ggtgagggaa tattaaatag agtacacctg cctgccaccg ctgtcccctc
     2221 aactgagtgc tgcacaccat gggctctgtc tgtgagagaa aaatcccggt gcttggtgtc
     2281 tttgcatgac atggagtttt gcatgtagat caatttaaaa tgtacctctt gtttacataa
     2341 tttgcataat tttaaaagat gatgttgcca aactttggaa atgttaatac tcaaaatgaa
     2401 aatctccact ccatgtaact actttctccc tctggatcag cacatggctt gcaatcccag
     2461 ccagtggtgt gatctgtccc agtgtcaacc gccatgtgct ctgcttcagg agggactgac
     2521 tagtcttttg tgaatttttt tgtacataat tatttgttac aaatatttta gcaaatgctt
     2581 tctatatctc ttgcttgtgc atatcttggc tggcgttgtg gaaaaaaata gtgcaaacta
     2641 tttccttact ggggaatgaa ggggtttctt ttttagtttg tgtgagggag gtggggaggg
     2701 catggtttat gttgaatgtt taaattttct tctgcatgat acatgtcatg ttgtgaaatc
     2761 tttagagaac ttcatactgt atgagtaaga aaataaaata tttgaaactt ggcttgaatg
     2821 tatttgttag cttgtatttg tagcaggtgt actgctacag ttgataatcc tgtccaggct
     2881 tttagggttt taaaaacttg gataaatgtt ttgttgttct gaaccataga ctacaggtga
     2941 cataagttgt tttatctgga ataaacaagg ctaaatgtt
//
