LOCUS       NM_017042               2265 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Rattus norvegicus protein phosphatase 3 catalytic subunit beta
            (Ppp3cb), mRNA.
ACCESSION   NM_017042
VERSION     NM_017042.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2265)
  AUTHORS   Ke,C., Huang,Y., Mao,Z., Ke,Z., Wang,Z., Li,R., Long,S., Guo,Y.,
            Wang,F., Qian,M., Zhao,R., Zheng,J. and Xie,S.
  TITLE     Calcineurin suppresses rat H9c2 cardiomyocyteprotective autophagy
            under chronic intermittent hypoxia by downregulating the AMPK
            pathway
  JOURNAL   Exp Cell Res 433 (2), 113850 (2023)
   PUBMED   37926341
  REMARK    GeneRIF: Calcineurin suppresses rat H9c2 cardiomyocyteprotective
            autophagy under chronic intermittent hypoxia by downregulating the
            AMPK pathway.
REFERENCE   2  (bases 1 to 2265)
  AUTHORS   Genis-Mendoza,A., Gallegos-Silva,I., Tovilla-Zarate,C.A.,
            Lopez-Narvaez,L., Gonzalez-Castro,T.B., Hernandez-Diaz,Y.,
            Lopez-Casamichana,M., Nicolini,H. and Morales-Mulia,S.
  TITLE     Comparative Analysis of Gene Expression Profiles Involved in
            Calcium Signaling Pathways Using the NLVH Animal Model of
            Schizophrenia
  JOURNAL   J Mol Neurosci 64 (1), 111-116 (2018)
   PUBMED   29214423
REFERENCE   3  (bases 1 to 2265)
  AUTHORS   Li,S.J., Wang,J., Ma,L., Lu,C., Wang,J., Wu,J.W. and Wang,Z.X.
  TITLE     Cooperative autoinhibition and multi-level activation mechanisms of
            calcineurin
  JOURNAL   Cell Res 26 (3), 336-349 (2016)
   PUBMED   26794871
REFERENCE   4  (bases 1 to 2265)
  AUTHORS   Cottrell,J.R., Li,B., Kyung,J.W., Ashford,C.J., Mann,J.J.,
            Horvath,T.L., Ryan,T.A., Kim,S.H. and Gerber,D.J.
  TITLE     Calcineurin Agamma is a Functional Phosphatase That Modulates
            Synaptic Vesicle Endocytosis
  JOURNAL   J Biol Chem 291 (4), 1948-1956 (2016)
   PUBMED   26627835
REFERENCE   5  (bases 1 to 2265)
  AUTHORS   Wu,J., Zheng,C., Wang,X., Yun,S., Zhao,Y., Liu,L., Lu,Y., Ye,Y.,
            Zhu,X., Zhang,C., Shi,S. and Liu,Z.
  TITLE     MicroRNA-30 family members regulate calcium/calcineurin signaling
            in podocytes
  JOURNAL   J Clin Invest 125 (11), 4091-4106 (2015)
   PUBMED   26436650
REFERENCE   6  (bases 1 to 2265)
  AUTHORS   Kissinger,C.R., Parge,H.E., Knighton,D.R., Lewis,C.T.,
            Pelletier,L.A., Tempczyk,A., Kalish,V.J., Tucker,K.D.,
            Showalter,R.E., Moomaw,E.W. et al.
  TITLE     Crystal structures of human calcineurin and the human
            FKBP12-FK506-calcineurin complex
  JOURNAL   Nature 378 (6557), 641-644 (1995)
   PUBMED   8524402
REFERENCE   7  (bases 1 to 2265)
  AUTHORS   Kuno,T., Mukai,H., Ito,A., Chang,C.D., Kishima,K., Saito,N. and
            Tanaka,C.
  TITLE     Distinct cellular expression of calcineurin A alpha and A beta in
            rat brain
  JOURNAL   J Neurochem 58 (5), 1643-1651 (1992)
   PUBMED   1313851
REFERENCE   8  (bases 1 to 2265)
  AUTHORS   Wadzinski,B.E., Heasley,L.E. and Johnson,G.L.
  TITLE     Multiplicity of protein serine-threonine phosphatases in PC12
            pheochromocytoma and FTO-2B hepatoma cells
  JOURNAL   J Biol Chem 265 (35), 21504-21508 (1990)
   PUBMED   2174876
REFERENCE   9  (bases 1 to 2265)
  AUTHORS   Kuno,T., Takeda,T., Hirai,M., Ito,A., Mukai,H. and Tanaka,C.
  TITLE     Evidence for a second isoform of the catalytic subunit of
            calmodulin-dependent protein phosphatase (calcineurin A)
  JOURNAL   Biochem Biophys Res Commun 165 (3), 1352-1358 (1989)
   PUBMED   2558657
REFERENCE   10 (bases 1 to 2265)
  AUTHORS   Guerini,D. and Klee,C.B.
  TITLE     Cloning of human calcineurin A: evidence for two isozymes and
            identification of a polyproline structural domain
  JOURNAL   Proc Natl Acad Sci U S A 86 (23), 9183-9187 (1989)
   PUBMED   2556704
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D90036.1.
            
            On Sep 4, 2012 this sequence version replaced NM_017042.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D90036.1, M31809.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2265              D90036.1           1-2265
FEATURES             Location/Qualifiers
     source          1..2265
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..2265
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /note="protein phosphatase 3 catalytic subunit beta"
                     /db_xref="GeneID:24675"
                     /db_xref="RGD:3383"
     exon            1..124
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1617
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase 3, catalytic subunit, beta
                     isozyme; CAM-PRP catalytic subunit; Calcineurin subunit A
                     beta; protein phosphatase-2Bb; CaN Abeta; CNA beta"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2B
                     catalytic subunit beta isoform"
                     /protein_id="NP_058738.1"
                     /db_xref="GeneID:24675"
                     /db_xref="RGD:3383"
                     /translation="MAAPEPARAAPPPPPPPPPPLGADRVVKAVPFPPTHRLTSEEVF
                     DMDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHG
                     QFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNH
                     ECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTL
                     DDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCE
                     FLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYE
                     NNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGED
                     QFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
                     RQTLQSATVEAIEAEKAIRGSSPPHRICSFEEAKGLDRINERMPPRKDAVQQDGFNSL
                     NTAHTTENHGTGNHSAQ"
     exon            125..325
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /inference="alignment:Splign:2.1.0"
     exon            326..450
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /inference="alignment:Splign:2.1.0"
     exon            451..562
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..708
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..848
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..926
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1021
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1147
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1225
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1310
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1408
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1438
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..2265
                     /gene="Ppp3cb"
                     /gene_synonym="Calna2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgcccggc ccggcaccta gccgagcccc gggcccagca tggccgcccc ggagccggcc
       61 cgggccgcgc cgccccctcc cccgcccccg ccgccccccc tcggggccga ccgcgtcgtc
      121 aaagccgttc cttttccccc aactcaccgg ttgacatctg aagaagtgtt tgatatggat
      181 gggataccca gggttgatgt tctgaagaac catctggtaa aagaaggtcg ggtagatgaa
      241 gaaattgcac taagaattat caatgagggt gctgccatac ttaggcggga gaaaaccatg
      301 atagaagtag aagctccaat tacagtgtgt ggtgacatcc atggccaatt ttttgatctg
      361 atgaaacttt ttgaagtagg aggatcacct gctaatacac gatacctttt tcttggtgat
      421 tatgtggaca gaggttattt tagtatagag tgtgtcttgt atttatgggt cttgaagatt
      481 ctatacccaa gcacattatt ccttctgaga ggcaaccatg aatgcagaca cctcactgag
      541 tattttacct ttaagcagga atgtaaaatt aagtattcag aaagggtcta tgaagcttgt
      601 atggaggctt ttgacagctt gccccttgct gcacttctaa accaacaatt tctttgtgtt
      661 catggtggac tttcaccaga gatacacaca ctggatgata ttaggagatt agatagattt
      721 aaagagccac ctgcatttgg accaatgtgt gacttgctgt ggtctgatcc ttctgaagac
      781 tttggaaatg aaaaatcaca agaacatttt agtcataata cggttcgagg atgttcttat
      841 ttttataact atccagcagt gtgtgaattt ttgcaaaaca ataatttgtt atcgattatt
      901 agagctcatg aagctcaaga tgcaggctat agaatgtaca gaaaaagtca aactacaggg
      961 tttccttcat taataacaat tttttcggca cctaattact tagatgtcta caataataaa
     1021 gctgctgtac taaagtatga gaacaatgtg atgaacatcc gccagtttaa ctgttctcca
     1081 catccttact ggttgcccaa ttttatggat gtctttacat ggtctttacc atttgttgga
     1141 gaaaaagtca cagagatgtt ggtaaatgtt ctcagtattt gctctgatga tgaactaatg
     1201 acagaagggg aagaccagtt tgatgtaggt tcagctgcag cccggaaaga aatcataaga
     1261 aacaagatcc gagcaattgg caagatggca agagtcttct ctgttctcag ggaggagagt
     1321 gaaagcgtgc tgacactcaa gggcctgact cccacaggga tgttgcctag tggagtgttg
     1381 gctggaggac ggcagacctt gcaaagtgcc acagttgagg ctattgaggc tgaaaaagca
     1441 atacgaggat cctctccacc acatagaatc tgcagttttg aagaggcaaa gggtttggat
     1501 aggatcaatg agagaatgcc accccggaaa gatgctgtgc agcaagatgg tttcaattcc
     1561 ctgaacaccg cacataccac tgagaaccac gggactggca accatagtgc ccagtgacca
     1621 gcggcttccc agggatggac agatcactaa ggagccggag gggtcggccg agctgatgat
     1681 aaatgtcata atctctctga agaaacaaac cattgtgctt tttgagaccc ttgccccctt
     1741 cccggatgga ggcttgaggg ccttgggact tgtgctgtcc ataagattgg ggaatcgctg
     1801 ccacagcgga gagcagtgag caaggggctt ggggcaaatt ccagtggagg aagcccaaac
     1861 ctccatttat gcttgtggtt cacacattta cgtttacaaa tgagatttcc tttgttttct
     1921 ccctcagtag aattagattt ttttcaacca tgactttaaa tgcaatcttt agagttaatg
     1981 tggaacctcc ctcaccccca ccccatgaaa tgtctttaag aggatggatt agcatggtct
     2041 taaaatatat ttctgaggtt actagatgta ttttgaattg tagacaaaat ctgagaaacc
     2101 cagttggtgt ttatataaaa acgctgacct caggtcatag ttcttaaatg tggctaattc
     2161 tgtaacatag tcttggtatt tttcaattat gaatgcataa actatttcta agaagactct
     2221 tacttgaaca agatccaaaa aaccaattta gatccttttt gcccc
//
