LOCUS       NM_017041               2334 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Rattus norvegicus protein phosphatase 3 catalytic subunit alpha
            (Ppp3ca), mRNA.
ACCESSION   NM_017041
VERSION     NM_017041.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2334)
  AUTHORS   Ke,C., Huang,Y., Mao,Z., Ke,Z., Wang,Z., Li,R., Long,S., Guo,Y.,
            Wang,F., Qian,M., Zhao,R., Zheng,J. and Xie,S.
  TITLE     Calcineurin suppresses rat H9c2 cardiomyocyteprotective autophagy
            under chronic intermittent hypoxia by downregulating the AMPK
            pathway
  JOURNAL   Exp Cell Res 433 (2), 113850 (2023)
   PUBMED   37926341
  REMARK    GeneRIF: Calcineurin suppresses rat H9c2 cardiomyocyteprotective
            autophagy under chronic intermittent hypoxia by downregulating the
            AMPK pathway.
REFERENCE   2  (bases 1 to 2334)
  AUTHORS   Maltsev,A.V., Bal,N.V. and Balaban,P.M.
  TITLE     Serine/Threonine Phosphatases in LTP: Two B or Not to Be the
            Protein Synthesis Blocker-Induced Impairment of Early Phase
  JOURNAL   Int J Mol Sci 22 (9), 4857 (2021)
   PUBMED   34064311
  REMARK    GeneRIF: Serine/Threonine Phosphatases in LTP: Two B or Not to Be
            the Protein Synthesis Blocker-Induced Impairment of Early Phase.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2334)
  AUTHORS   Chen,C.H., Lin,J.W., Huang,C.Y., Yeh,Y.L., Shen,C.Y.,
            Badrealam,K.F., Ho,T.J., Padma,V.V., Kuo,W.W. and Huang,C.Y.
  TITLE     The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy
  JOURNAL   J Cell Physiol 235 (4), 3539-3547 (2020)
   PUBMED   31584202
  REMARK    GeneRIF: The combined inhibition of the CaMKIIdelta and calcineurin
            signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
REFERENCE   4  (bases 1 to 2334)
  AUTHORS   Su,Q., Liu,M., Jiang,M., Wang,Y., Ma,X., Li,S. and Xie,J.
  TITLE     Involvement of calcineurin/NFATc4 pathway in a single-prolonged
            stress-based rat model of post-traumatic stress disorder
  JOURNAL   Mol Biol Rep 46 (6), 6197-6204 (2019)
   PUBMED   31486013
  REMARK    GeneRIF: Our results show that CaN/NFATc4 pathway were involved in
            the development of PTSD model, which suggested that the changes of
            CaN/NFATc4 pathway may be one of the pathological molecular
            mechanism in the dysfunction of hippocampus in PTSD.
REFERENCE   5  (bases 1 to 2334)
  AUTHORS   Liu,J., Liu,W., Li,H., Deng,Q., Yang,M., Li,X. and Liang,Z.
  TITLE     Identification of key genes and pathways associated with
            cholangiocarcinoma development based on weighted gene correlation
            network analysis
  JOURNAL   PeerJ 7, e7968 (2019)
   PUBMED   31687280
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2334)
  AUTHORS   Chang,C.D., Takeda,T., Mukai,H., Shuntoh,H., Kuno,T. and Tanaka,C.
  TITLE     Molecular cloning and characterization of the promoter region of
            the calcineurin A alpha gene
  JOURNAL   Biochem J 288 (Pt 3) (Pt 3), 801-805 (1992)
   PUBMED   1335233
  REMARK    Erratum:[Biochem J 1993 May 1;291(Pt 3):951]
REFERENCE   7  (bases 1 to 2334)
  AUTHORS   Perrino,B.A., Fong,Y.L., Brickey,D.A., Saitoh,Y., Ushio,Y.,
            Fukunaga,K., Miyamoto,E. and Soderling,T.R.
  TITLE     Characterization of the phosphatase activity of a
            baculovirus-expressed calcineurin A isoform
  JOURNAL   J Biol Chem 267 (22), 15965-15969 (1992)
   PUBMED   1322410
REFERENCE   8  (bases 1 to 2334)
  AUTHORS   Kuno,T., Mukai,H., Ito,A., Chang,C.D., Kishima,K., Saito,N. and
            Tanaka,C.
  TITLE     Distinct cellular expression of calcineurin A alpha and A beta in
            rat brain
  JOURNAL   J Neurochem 58 (5), 1643-1651 (1992)
   PUBMED   1313851
REFERENCE   9  (bases 1 to 2334)
  AUTHORS   Wadzinski,B.E., Heasley,L.E. and Johnson,G.L.
  TITLE     Multiplicity of protein serine-threonine phosphatases in PC12
            pheochromocytoma and FTO-2B hepatoma cells
  JOURNAL   J Biol Chem 265 (35), 21504-21508 (1990)
   PUBMED   2174876
REFERENCE   10 (bases 1 to 2334)
  AUTHORS   Ito,A., Hashimoto,T., Hirai,M., Takeda,T., Shuntoh,H., Kuno,T. and
            Tanaka,C.
  TITLE     The complete primary structure of calcineurin A, a calmodulin
            binding protein homologous with protein phosphatases 1 and 2A
  JOURNAL   Biochem Biophys Res Commun 163 (3), 1492-1497 (1989)
   PUBMED   2551293
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017041.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D90035.1, M29275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               JAXUCZ010000002.1  227839607-227839870
            265-465             JAXUCZ010000002.1  227969173-227969373
            466-590             JAXUCZ010000002.1  228041392-228041516
            591-702             JAXUCZ010000002.1  228049014-228049125
            703-848             JAXUCZ010000002.1  228050488-228050633
            849-988             JAXUCZ010000002.1  228054037-228054176
            989-1066            JAXUCZ010000002.1  228061286-228061363
            1067-1161           JAXUCZ010000002.1  228063715-228063809
            1162-1287           JAXUCZ010000002.1  228076415-228076540
            1288-1362           JAXUCZ010000002.1  228078545-228078619
            1363-1447           JAXUCZ010000002.1  228097385-228097469
            1448-1545           JAXUCZ010000002.1  228105438-228105535
            1546-1575           JAXUCZ010000002.1  228108568-228108597
            1576-2334           JAXUCZ010000002.1  228111678-228112436
FEATURES             Location/Qualifiers
     source          1..2334
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..2334
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /note="protein phosphatase 3 catalytic subunit alpha"
                     /db_xref="GeneID:24674"
                     /db_xref="RGD:3382"
     exon            1..264
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1772
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /EC_number="3.1.3.16"
                     /note="CAM-PRP catalytic subunit; Calcineurin subunit A
                     alpha; protein phosphatase-2Ba; protein phosphatase 3,
                     catalytic subunit, alpha isozyme; CNA alpha; calcineurin A
                     alpha"
                     /codon_start=1
                     /product="protein phosphatase 3 catalytic subunit alpha"
                     /protein_id="NP_058737.1"
                     /db_xref="GeneID:24674"
                     /db_xref="RGD:3382"
                     /translation="MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVD
                     ILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLF
                     EVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYF
                     TFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRF
                     KEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCDFLQHNNLLS
                     ILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQF
                     NCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAAAR
                     KEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVE
                     AIEADEAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAMPSDANLNSINKALASETN
                     GTDSNGSNSSNIQ"
     exon            265..465
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..590
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..702
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..848
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..988
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1066
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1161
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1287
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1362
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1447
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1545
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1575
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..2334
                     /gene="Ppp3ca"
                     /gene_synonym="Calna1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggaggag tgaaggcggc ggcggcggag gagggacgcg cggagccggc agtaactttc
       61 gagccagccc agagcccgga gctccagccg agcggtttgc agcgcggcgg cggcggcgct
      121 gagtgtctgg cccgccggtg cggtcggggt gtgcagtcgg acgggaccag cagcgcgtcg
      181 ctgtcccccc ctcccggtga ctggagatgt ccgagcccaa ggcgattgat cccaagttgt
      241 cgactaccga cagggtggtg aaagccgttc catttccgcc aagtcaccgg ctgacagcaa
      301 aggaagtgtt tgataacgat gggaagcctc gtgtggatat cttaaaagca catctcatga
      361 aggaaggcag gctggaagaa agtgtcgcgt tgagaataat aacagagggt gcttcgattc
      421 tccgacagga aaaaaacttg ctggatattg atgccccagt cacagtttgc ggggacatcc
      481 atggacaatt ctttgacttg atgaagctct ttgaagtggg aggatctcct gccaacactc
      541 gctacctctt cttaggggac tatgttgaca gagggtactt cagtatcgaa tgtgtgctgt
      601 atttgtgggc cttgaaaatt ctttacccca aaacactgtt tttacttcgt ggaaaccatg
      661 aatgtaggca cctaacagag tatttcacgt ttaaacaaga atgtaaaata aagtattcag
      721 aacgcgttta tgacgcctgt atggatgcct tcgactgcct tcccctggct gcgctgatga
      781 accaacaatt cctgtgtgta cacggtggtt tgtctccaga gattaacact ctagatgaca
      841 tcagaaaatt agaccgattc aaagaaccac ctgcttatgg gcctatgtgt gacatcttgt
      901 ggtcagaccc cctggaggac tttggaaatg agaagactca ggaacatttc actcacaaca
      961 cagtcagggg ttgttcgtac ttctacagtt acccggctgt atgtgacttc ctgcagcaca
     1021 ataatttgtt gtccatactc cgagcccacg aagcccagga cgcagggtac cgcatgtaca
     1081 ggaaaagcca aacaactggc ttcccgtctc taattacgat cttctcggca ccaaattact
     1141 tagatgtgta caataataaa gctgcagtgt tgaagtacga gaacaacgtg atgaacatca
     1201 ggcagttcaa ctgctccccc catccgtact ggctcccaaa tttcatggat gttttcacct
     1261 ggtcgctgcc atttgttggg gagaaagtga ctgagatgct ggtaaacgtc ctgaacatct
     1321 gctcagatga tgaactgggg tcagaagaag atggatttga cggagccacg gctgcagccc
     1381 ggaaggaggt catcaggaac aagatccgag caataggcaa aatggccaga gtattctcag
     1441 ttctcagaga agagagtgag agcgttctaa ctctgaaggg cctgaccccg actggcatgc
     1501 tccccagcgg agtgctctct ggcgggaaac aaactctgca aagcgctact gttgaggcca
     1561 ttgaggctga tgaagccatc aaaggattct caccacaaca taagattacc agcttcgagg
     1621 aggccaaggg cttagaccga attaacgaga ggatgccgcc tcgcagagac gccatgcctt
     1681 ccgacgccaa ccttaactcc atcaacaagg ctctcgcctc agagactaac ggcacagaca
     1741 gcaacggcag taatagcagc aatattcagt gaccacttcc tgttcacttt tttttttttt
     1801 gagctgcagg gcatgatggg tttgctgcat ctcagcagtt ggatgttctt gcctctgacg
     1861 gtagcttgtt tgctctgggg gggccaggaa ttggattcag tttacactat catgaaaaaa
     1921 aaaaagaggg agagagagag agataataaa actatatttt ggtgagggtg gtgattaaac
     1981 acctcttttg ggtatgcctt taaaaatgct tctaggaaaa aaaaagtttt aaaaagaaag
     2041 ctaatgctag tctatacttc aatgttaggg gaatgaacac gttttcctag cgcactgggg
     2101 acttttagat aggttaatga aaggcctttt attctgttac tggacacgaa aactttgtct
     2161 aatttcttat actctattgt acgtttacag tcgcagcact aaaaatggat gacatcaaac
     2221 atttttaaac agaaaaaaaa gatgtacaaa ctaaataagg actatttatt gataatgttt
     2281 tgctactctt gtcagacaat ggctataaac tgaattaggc agtcttaaaa aaaa
//
