LOCUS       NM_001415125            4429 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protein phosphatase 2, regulatory subunit B',
            gamma (Ppp2r5c), transcript variant 1, mRNA.
ACCESSION   NM_001415125 XM_008764959
VERSION     NM_001415125.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4429)
  AUTHORS   Terentyev,D., Belevych,A.E., Terentyeva,R., Martin,M.M.,
            Malana,G.E., Kuhn,D.E., Abdellatif,M., Feldman,D.S., Elton,T.S. and
            Gyorke,S.
  TITLE     miR-1 overexpression enhances Ca(2+) release and promotes cardiac
            arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and
            causing CaMKII-dependent hyperphosphorylation of RyR2
  JOURNAL   Circ Res 104 (4), 514-521 (2009)
   PUBMED   19131648
  REMARK    GeneRIF: miR-1 overexpression enhances Ca(2+) release and promotes
            cardiac arrhythmogenesis by targeting PP2A regulatory subunit
            B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2.
REFERENCE   2  (bases 1 to 4429)
  AUTHORS   Bhasin,N., Cunha,S.R., Mudannayake,M., Gigena,M.S., Rogers,T.B. and
            Mohler,P.J.
  TITLE     Molecular basis for PP2A regulatory subunit B56alpha targeting in
            cardiomyocytes
  JOURNAL   Am J Physiol Heart Circ Physiol 293 (1), H109-H119 (2007)
   PUBMED   17416611
  REMARK    GeneRIF: These new data implicate ankyrin-B as a critical targeting
            component for PP2A in heart and identify a new class of signaling
            proteins targeted by ankyrin polypeptides.
REFERENCE   3  (bases 1 to 4429)
  AUTHORS   Li,H.H., Cai,X., Shouse,G.P., Piluso,L.G. and Liu,X.
  TITLE     A specific PP2A regulatory subunit, B56gamma, mediates DNA
            damage-induced dephosphorylation of p53 at Thr55
  JOURNAL   EMBO J 26 (2), 402-411 (2007)
   PUBMED   17245430
REFERENCE   4  (bases 1 to 4429)
  AUTHORS   Xu,Y., Xing,Y., Chen,Y., Chao,Y., Lin,Z., Fan,E., Yu,J.W.,
            Strack,S., Jeffrey,P.D. and Shi,Y.
  TITLE     Structure of the protein phosphatase 2A holoenzyme
  JOURNAL   Cell 127 (6), 1239-1251 (2006)
   PUBMED   17174897
REFERENCE   5  (bases 1 to 4429)
  AUTHORS   Glaser,N.D., Lukyanenko,Y.O., Wang,Y., Wilson,G.M. and Rogers,T.B.
  TITLE     JNK activation decreases PP2A regulatory subunit B56alpha
            expression and mRNA stability and increases AUF1 expression in
            cardiomyocytes
  JOURNAL   Am J Physiol Heart Circ Physiol 291 (3), H1183-H1192 (2006)
   PUBMED   16603688
  REMARK    GeneRIF: In an established model of sustained JNK activation, a 70%
            decrease in expression of the targeting subunit of PP2A, B56alpha,
            was observed in either neonatal or adult cardiomyocytes.
REFERENCE   6  (bases 1 to 4429)
  AUTHORS   Lin,S.S., Bassik,M.C., Suh,H., Nishino,M., Arroyo,J.D., Hahn,W.C.,
            Korsmeyer,S.J. and Roberts,T.M.
  TITLE     PP2A regulates BCL-2 phosphorylation and proteasome-mediated
            degradation at the endoplasmic reticulum
  JOURNAL   J Biol Chem 281 (32), 23003-23012 (2006)
   PUBMED   16717086
REFERENCE   7  (bases 1 to 4429)
  AUTHORS   Tang,Z., Shu,H., Qi,W., Mahmood,N.A., Mumby,M.C. and Yu,H.
  TITLE     PP2A is required for centromeric localization of Sgo1 and proper
            chromosome segregation
  JOURNAL   Dev Cell 10 (5), 575-585 (2006)
   PUBMED   16580887
REFERENCE   8  (bases 1 to 4429)
  AUTHORS   Lee,S.F., Shah,S., Li,H., Yu,C., Han,W. and Yu,G.
  TITLE     Mammalian APH-1 interacts with presenilin and nicastrin and is
            required for intramembrane proteolysis of amyloid-beta precursor
            protein and Notch
  JOURNAL   J Biol Chem 277 (47), 45013-45019 (2002)
   PUBMED   12297508
REFERENCE   9  (bases 1 to 4429)
  AUTHORS   McCright,B., Rivers,A.M., Audlin,S. and Virshup,D.M.
  TITLE     The B56 family of protein phosphatase 2A (PP2A) regulatory subunits
            encodes differentiation-induced phosphoproteins that target PP2A to
            both nucleus and cytoplasm
  JOURNAL   J Biol Chem 271 (36), 22081-22089 (1996)
   PUBMED   8703017
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Dec 21, 2022 this sequence version replaced XM_008764959.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1369193.1,
                                           SRR26643292.27345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000006.1  135283034-135283198
            166-231             JAXUCZ010000006.1  135283784-135283849
            232-394             JAXUCZ010000006.1  135302311-135302473
            395-594             JAXUCZ010000006.1  135363356-135363555
            595-705             JAXUCZ010000006.1  135381839-135381949
            706-798             JAXUCZ010000006.1  135383219-135383311
            799-929             JAXUCZ010000006.1  135383395-135383525
            930-989             JAXUCZ010000006.1  135388511-135388570
            990-1098            JAXUCZ010000006.1  135390255-135390363
            1099-1152           JAXUCZ010000006.1  135391640-135391693
            1153-1323           JAXUCZ010000006.1  135398550-135398720
            1324-1451           JAXUCZ010000006.1  135403548-135403675
            1452-1553           JAXUCZ010000006.1  135404857-135404958
            1554-1626           JAXUCZ010000006.1  135406854-135406926
            1627-1743           JAXUCZ010000006.1  135410962-135411078
            1744-4429           JAXUCZ010000006.1  135416906-135419591
FEATURES             Location/Qualifiers
     source          1..4429
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..4429
                     /gene="Ppp2r5c"
                     /note="protein phosphatase 2, regulatory subunit B',
                     gamma"
                     /db_xref="GeneID:691318"
                     /db_xref="RGD:1585097"
     exon            1..165
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1875
                     /gene="Ppp2r5c"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform 1"
                     /protein_id="NP_001402054.1"
                     /db_xref="GeneID:691318"
                     /db_xref="RGD:1585097"
                     /translation="MPNKNKKEKEPPKPVKSGKGSKEGQDTAEAEIASRKNSLASVQS
                     STSKIKVPVPQPVPVKKDKRQNSSRFNASNNRELQKLPSLKDVPPADQEKLFIQKLRQ
                     CCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEAVHMFAVNMFRT
                     LPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFV
                     LQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIA
                     ELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDST
                     LTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSP
                     HFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKL
                     FMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYAVYSQASAMSI
                     PVAMETDGPQFEDVQMLKKTVSDETRQAQKDLKKDRPLVRRKSELPQDPHTEKALEAH
                     CRASELLSQDGR"
     exon            166..231
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
     exon            232..394
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
     exon            395..594
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
     exon            595..705
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
     exon            706..798
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
     exon            799..929
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
     exon            930..989
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1098
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1152
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1323
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1451
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1553
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1626
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1743
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..4429
                     /gene="Ppp2r5c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccccggg cggcggctgc agcggcggcg gcggcggccg gggcggcgcg acggccgggc
       61 cgggggcgct tctgctgctg cagcggcagt ggcggcgggc ggcggcaggg gcggcggcgg
      121 cggcggcccg caccagccat gccgaataaa aacaagaagg agaaagaacc accaaaaccg
      181 gtgaaaagtg gaaaaggttc aaaagaagga caagatacag cagaagcaga gatagccagc
      241 cggaaaaaca gcctcgcatc tgtccagtct tcgacatcta aaataaaagt accagtccct
      301 cagcccgtcc ctgtgaagaa agacaaacgg cagaattctt cacgatttaa tgccagcaat
      361 aacagagaac tgcaaaagct cccatcttta aaagatgttc ctcctgcaga tcaagagaag
      421 ctttttatcc agaagctacg tcagtgttgt gtcctctttg actttgtttc tgacccactg
      481 agtgacctga agtggaagga ggtaaagcga gctgcactca gtgagatggt ggaatatatc
      541 acacacaacc ggaacgtaat cacggagccc atttaccccg aggccgtcca catgtttgca
      601 gttaacatgt ttcgaacctt gccaccctcc tccaatccta cgggagcaga attcgaccca
      661 gaagaagatg aaccaacgtt agaagccgcc tggcctcatc tgcagcttgt ttatgaattt
      721 ttcttaagat ttttagagtc tccagatttc cagcccaata tagcaaagaa atatattgat
      781 cagaagtttg tattgcagct tctagagctc tttgacagcg aggatcctcg ggagagagat
      841 tttctaaaaa ctaccctgca cagaatctat gggaagttct taggcctgcg cgcttacatc
      901 aggaaacaga tcaataatat attttatagg tttatctatg agacagagca tcacaatggc
      961 atagcagagt tactggagat cctgggaagt ataattaatg gatttgcctt accactaaag
     1021 gaagagcaca agattttcct gttaaaggtg ttgctgccct tgcacaaagt gaaatccctg
     1081 agtgtctacc atccccagct ggcgtactgt gtcgtgcagt ttttagagaa ggacagcacc
     1141 ctcactgaac cagtggtaat ggcacttctc aaatactggc caaagactca cagtccaaaa
     1201 gaagtaatgt tcttaaatga attagaagaa atcttagatg taattgaacc atcagaattt
     1261 gtgaagatca tggagcctct tttccgacag ttagccaaat gtgtttccag ccctcacttc
     1321 caggtggcag agcgggcgct gtattactgg aacaatgagt acatcatgag tttaatcagt
     1381 gacaatgcag cgaagattct gcccatcatg tttccatcct tataccgcaa ctcaaagacc
     1441 cactggaaca agaccataca cggcttgata tacaacgccc tgaaactctt catggagatg
     1501 aaccaaaaac tcttcgatga ctgcacgcag cagttcaaag cagagaaact caaagagaag
     1561 ctaaaaatga aagagcgaga agaagcgtgg gttaaaatag aaaatctagc caaagcgaat
     1621 ccccagtatg cagtgtatag tcaagccagc gccatgagca tcccggttgc catggagaca
     1681 gatggtcctc agtttgaaga tgtgcagatg ctgaaaaaga cagtgagcga cgagactcgt
     1741 caggcacaga aggatctgaa gaaggaccgt ccccttgtgc gccgcaagtc cgagctgcct
     1801 caggaccccc acaccgagaa agccttggaa gctcactgca gagccagtga gctgctctcc
     1861 caggacgggc gctagcgtct ggagcagcac gccgagctgg gcctgtcagt tctcttctgg
     1921 atgctgtaga aaagacatac tgtttgtgcc ataccagtca gttacactca aaagtcaaag
     1981 cttcctccga cccccgttct gtaggcaata acgcttgtct gcctcagctc gagattagga
     2041 gttcaaacaa tggtggcttc tctggccctg ctggccaagc tgggggctgg gggagttggt
     2101 gacggtgtca tcaccttgtt gtcaccaccc cagcacaccc ctgagtgaga cagagtaaga
     2161 gctataggga agctgtcacc ctggctgtcg tcttctcgca cccagtggac cctgtgttcc
     2221 tctgaagtgg gagttctgtg gtgataccga tgacatttca aggcacgtgt tagaggcatc
     2281 tcccccttta agacttttca acccttgacg ttgttttccc tcttgctctg ccagcagctg
     2341 atggttgtca ggcctcacag agatgactcc ttgctttcac attctagctg cctaccggga
     2401 aagaggccaa cagtcctcag cgctgggacc tttgaaggtg tttctttccc ttgactaaca
     2461 gcacggtcac catgtcccac ttcccttaat gtctaccgaa agccatattt catagtctgt
     2521 ggtagaggcc agggttccac ctaagcgcca aggagagctc tgagaagtgc ttcctcagtc
     2581 caccttgagt agaactgcaa tgttgaaatt atgtgttcat atttttattt gcagaatcag
     2641 tttttcatct acttacacat gatccttcaa caaggctctt gaattgataa agattacagg
     2701 atctaagaat tccacatctg tagaaagtca cagtaaatca agccacaagg cctagtgtag
     2761 actgtggctg cctgcgccgt aatgtgcgct gtgtgggcac ccagtgagcc tttctgttgg
     2821 aaaaagcaca ttaccaggct tgcaaggaaa agagcagtgt ctgtgtttcc actggtcttc
     2881 acgtgctgct acaggcttca cagaattctt gcatggatta agcttctgtt ttagacggaa
     2941 tagcacgagg agaaaaatcc ataaacttag tgctttgtct agtctttttt tttttctctc
     3001 agggtggcca gtattttgac ttatttatcc tgcttaaaag ctgcttgaga tgtgaactgc
     3061 tattctggac agtgactcgt ttcttttgtc tccagcatat atataactta gtgttacgtg
     3121 tcttgatgca caagatatgg taaaaatgtg gcttctttta aaacctgctt cttaatcgtg
     3181 gtctcgggta tccatgaaaa agttgtgaaa tcagacattg ctctgccatg gccacggagc
     3241 ctgcttctgg gtccccttag acggctgccg atgctcatgc cgcacggtgg gggagaaggg
     3301 cgcgtgcaga gagggaaagc ctgcatggct gaccagaaag gcggccccag ttgagggtgg
     3361 acaggtggcc gcttgggtga gaacacttcc tgagaaactt gacaagtatc tatccacttt
     3421 actattatga aatctataat ttaaaaaaaa aagttgagat gccttctcct tttgagggaa
     3481 aaagggtgct ttattgtaca aagcagcgtc tctgtgtttt gatcccccat tgtttgaact
     3541 ctcgtcttta gctggtagag tctcagatat ccctgacacg gggcattctg tgtgcggtga
     3601 ggggttcccg agaggctccg gagccctgcg tgaaagcaag ctctcagtgt acgggtgatt
     3661 gtgcaaagct cagcacggca gagcatcctc tggtccaggt ctcacttctg ctctttattg
     3721 aagacaaaca ttcaccaata aagaaaaaaa aaagagaaag atgttttgag agaaactaat
     3781 tttctttgac aagagtatta cttaattttt tggcctatta aggttcccct agttagtact
     3841 cgattccctg tgctaatcgt tcaactgtat attgttaaga cacactgctg attctgtacc
     3901 aaactggtct caaaaaaaaa aaaaaagtac cacattgaaa ataaatgggt gactgttttt
     3961 cttcacacgg ctctagtttg gcaccttcac tctttccaga atgtgtctgt gcggcagaga
     4021 tatcacagtt caagtgtctt tctagtgtgg ctttggatgg cttcctttga acattgtaca
     4081 tacattgtat ctttgtttta tggtaataag taataaaaaa tgtagacttc gtattttgta
     4141 caaaatgtcc tatgtacaga ataaaaaaaa agttcataga aacagcaaaa actaggttaa
     4201 gtggcacagt tatttttctt taggaaatat ctgtaacttt acgctttagc gaaatgttaa
     4261 gtaccgacat attttttaac attttgtaat tcagaacttt ttttgttttg acattgttta
     4321 tgaagaaaga cttcatgcac ttgccattta atatgctctt ttatctaatt ttaaagaact
     4381 ctttaaaacg gtgtattata cggactaaat aaagaacatg tgaatttta
//
