LOCUS       NM_181379               2709 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus protein phosphatase 2, regulatory subunit B',
            beta (Ppp2r5b), mRNA.
ACCESSION   NM_181379 XM_008760143
VERSION     NM_181379.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2709)
  AUTHORS   Van Kanegan,M.J. and Strack,S.
  TITLE     The protein phosphatase 2A regulatory subunits B'beta and B'delta
            mediate sustained TrkA neurotrophin receptor autophosphorylation
            and neuronal differentiation
  JOURNAL   Mol Cell Biol 29 (3), 662-674 (2009)
   PUBMED   19029245
REFERENCE   2  (bases 1 to 2709)
  AUTHORS   Van Kanegan,M.J., Adams,D.G., Wadzinski,B.E. and Strack,S.
  TITLE     Distinct protein phosphatase 2A heterotrimers modulate growth
            factor signaling to extracellular signal-regulated kinases and Akt
  JOURNAL   J Biol Chem 280 (43), 36029-36036 (2005)
   PUBMED   16129692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Mar 9, 2021 this sequence version replaced
            XM_008760143.1, NM_181379.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2785595.1,
                                           SRR26360194.232489.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760476,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               JAXUCZ010000001.1  212964350-212964662 c
            314-773             JAXUCZ010000001.1  212963466-212963925 c
            774-970             JAXUCZ010000001.1  212962596-212962792 c
            971-1072            JAXUCZ010000001.1  212961486-212961587 c
            1073-1165           JAXUCZ010000001.1  212961249-212961341 c
            1166-1296           JAXUCZ010000001.1  212960997-212961127 c
            1297-1356           JAXUCZ010000001.1  212959879-212959938 c
            1357-1465           JAXUCZ010000001.1  212959670-212959778 c
            1466-1519           JAXUCZ010000001.1  212959251-212959304 c
            1520-1570           JAXUCZ010000001.1  212959135-212959185 c
            1571-1690           JAXUCZ010000001.1  212958905-212959024 c
            1691-1818           JAXUCZ010000001.1  212957962-212958089 c
            1819-1920           JAXUCZ010000001.1  212957680-212957781 c
            1921-2709           JAXUCZ010000001.1  212956533-212957321 c
FEATURES             Location/Qualifiers
     source          1..2709
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2709
                     /gene="Ppp2r5b"
                     /note="protein phosphatase 2, regulatory subunit B', beta"
                     /db_xref="GeneID:309179"
                     /db_xref="RGD:727786"
     exon            1..313
                     /gene="Ppp2r5b"
                     /inference="alignment:Splign:2.1.0"
     exon            314..773
                     /gene="Ppp2r5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             575..2068
                     /gene="Ppp2r5b"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit beta isoform"
                     /protein_id="NP_852044.1"
                     /db_xref="GeneID:309179"
                     /db_xref="RGD:727786"
                     /translation="METKLPPASTPTSPSSPGLSPVPPPDKVDGFSRRSLRRARPRRS
                     HSSSQFRYQSNQQELTPLPLLKDVPASELHELLSRKLAQCGVMFDFLDCVADLKGKEV
                     KRAALNELVECVGSTRGVLIEPVYPDIIRMISVNIFRTLPPSENPEFDPEEDEPNLEP
                     SWPHLQLVYEFFLRFLESPDFQPSVAKRYVDQKFVLMLLELFDSEDPREREYLKTILH
                     RVYGKFLGLRAYIRKQCNHIFLRFIYELEHFNGVAELLEILGSIINGFALPLKTEHKQ
                     FLVRVLIPLHSVKSLSVFHAQLAYCVVQFLEKDATLTEHVIRGLLKYWPKTCTQKEVM
                     FLGEMEEILDVIEPSQFVKIQEPLFKQVARCVSSPHFQVAERALYFWNNEYILSLIED
                     NCHTVLPAVFGTLYQVSKEHWNQTIVSLIYNVLKTFMEMNGKLFDELTASYKLEKQQE
                     QQKAQERQELWRGLEELRLRRLQGTQGAKEAPVPRPTPQVAASGGQS"
     exon            774..970
                     /gene="Ppp2r5b"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1072
                     /gene="Ppp2r5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1165
                     /gene="Ppp2r5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1296
                     /gene="Ppp2r5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1356
                     /gene="Ppp2r5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1465
                     /gene="Ppp2r5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1519
                     /gene="Ppp2r5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1570
                     /gene="Ppp2r5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1690
                     /gene="Ppp2r5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1818
                     /gene="Ppp2r5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1920
                     /gene="Ppp2r5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2709
                     /gene="Ppp2r5b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcggcggg tgccggtgcg cagcgagccg gggctcccgc tgcgctgcac cgcgcggatc
       61 tgagtccaga gatttctgcc gagggtcgcg tgctgccagg gcccagccca gagcccaccg
      121 agcgcccgac cccttttggg gctgagctgg gggcatgctc cagcaccccc agagcctggg
      181 agcgaaccca ggagcgccgc cgcccagccc cagcgccccg agcggcggaa ccaccgctaa
      241 ggacccttga accgtcgtct cctccaccaa ggcaacctct agggtcggcg accaaagtct
      301 ggatttctga ggaaagagcc agcgtgggaa cccagactgg actcttctgg acctccagga
      361 aagagctgag ccattgcctt tcgactttgc ctgccccccc aggactgggc agttgccaga
      421 ggccctgggg gggtcaggac tgtggtcttc acccccaccc cccaacacgc tgggcaggat
      481 gggtcccagt tagtgtgtgt ggtctcattc agcttactcc agacccacaa ggagcccctt
      541 gggctctgaa agattgactt gctgccctct ggccatggag acgaagctgc cccctgcaag
      601 cacccccaca agcccctcct ccccggggct gtctccagtg ccaccaccag acaaggtgga
      661 tggcttctcc cgccgatccc tccgcagggc ccggccccga cgctcacaca gctcttctca
      721 gttccgctat cagagcaacc agcaagagct cactccactg cccctgctca aagatgtgcc
      781 agcctctgag ttacatgagt tgctaagccg gaaactggcc caatgtgggg tgatgtttga
      841 cttcttggac tgtgtggctg acctcaaggg caaggaggtg aagcgtgcag ccctcaatga
      901 acttgtggaa tgtgtgggga gcacccgggg ggtcctcatt gagcctgtct acccagacat
      961 catccgcatg atatcagtaa atatcttccg gaccctgccg cccagtgaga accctgaatt
     1021 tgaccctgaa gaagatgagc ccaaccttga gccttcgtgg ccacatctac agctggtata
     1081 tgagtttttc ctgcggttct tggagagtcc agatttccag ccctctgtgg ccaagagata
     1141 cgtggatcaa aagtttgttc tgatgctcct ggagctattt gacagcgagg acccccggga
     1201 acgtgagtac ctcaagacca tcttgcatcg ggtatacggc aagttcctgg gtctccgggc
     1261 ctacatccgc aaacagtgca accacatctt cctccggttc atctatgagc tggagcactt
     1321 taatggtgtg gctgagctgt tagagatctt aggaagcatc atcaatggct ttgcgctgcc
     1381 cctgaagact gagcacaaac agttcctggt tcgagtcctc atccccttgc actctgtcaa
     1441 gtcactgtct gtttttcatg ctcagctggc atactgtgtg gtgcagttcc tggagaagga
     1501 tgcgaccttg acagagcatg ttatccgggg gcttctcaaa tactggccta aaacctgcac
     1561 ccagaaggag gtgatgttcc tgggggagat ggaagagatt ctcgatgtga tcgagccctc
     1621 ccagtttgtg aagatccagg agcctctctt caagcaggtg gctcgctgtg tctccagccc
     1681 ccatttccag gttgcagagc gggctctgta tttctggaac aatgagtaca tcctgagcct
     1741 cattgaggac aactgccaca ctgtgctgcc tgcggtattt gggaccctct accaagtgtc
     1801 caaggagcac tggaatcaaa ccatcgtgtc cctgatctac aacgtgctca agactttcat
     1861 ggagatgaat gggaagctgt ttgatgagct tacagcctcc tacaagctag aaaaacagca
     1921 ggagcagcag aaggcccagg agcggcagga actttggcga ggcttggagg aactgcggtt
     1981 acgccggcta caggggaccc aaggggccaa ggaagcccct gtcccaaggc ctacgcccca
     2041 ggtggctgcc agtgggggtc aaagctagat aaatctagaa caggagaagc tagacccaga
     2101 gctatcagcc cctccatccc ttctgcccag gggcccaggg aggcccatgc ctccccgtgg
     2161 ccttgccagc gtggctctag gactccctac cagccccatg ggaacagctt tcatggaggg
     2221 gagaccagaa ggcaagatgg tagtcttggc agcagaactc tcaggccctt gtggcaagat
     2281 tctggcaaga ctagaccagg gcaagtcttc gactgggaag ctgccatcgg ggatcctccc
     2341 ctgccctaca cagctaggct ccaggcggca gctgggcttc tccccctgct cctggcttgg
     2401 gccatggaca ctcagcacct ggcttggcct gccttggtct ggtcagggcc ttcctcatcc
     2461 ccatcatggg ggcacagtct atttattctg cccagctcac cttcaacaag acattgtcca
     2521 gggacatctt cctctcctcc cccttgccct gaacttcctt atcccctttt tatttattgg
     2581 gcagggggag gggtgagggc acaggcaaga agagagtcac attgtcctgg ggtgaggggg
     2641 ggtcacagta atcatggtct gctcccttca cctggctagg gggcagactt aataaagagc
     2701 gaaactcaa
//
