LOCUS       NM_001107891            2596 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus protein phosphatase 2, regulatory subunit B',
            alpha (Ppp2r5a), mRNA.
ACCESSION   NM_001107891 XM_001066948 XM_232413
VERSION     NM_001107891.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2596)
  AUTHORS   Porter IM, Schleicher K, Porter M and Swedlow JR.
  TITLE     Bod1 regulates protein phosphatase 2A at mitotic kinetochores
  JOURNAL   Nat Commun 4, 2677 (2013)
   PUBMED   24157919
REFERENCE   2  (bases 1 to 2596)
  AUTHORS   Pitman MR, Barr RK, Gliddon BL, Magarey AM, Moretti PA and Pitson
            SM.
  TITLE     A critical role for the protein phosphatase 2A B'alpha regulatory
            subunit in dephosphorylation of sphingosine kinase 1
  JOURNAL   Int J Biochem Cell Biol 43 (3), 342-347 (2011)
   PUBMED   21075214
REFERENCE   3  (bases 1 to 2596)
  AUTHORS   Terentyev D, Belevych AE, Terentyeva R, Martin MM, Malana GE, Kuhn
            DE, Abdellatif M, Feldman DS, Elton TS and Gyorke S.
  TITLE     miR-1 overexpression enhances Ca(2+) release and promotes cardiac
            arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and
            causing CaMKII-dependent hyperphosphorylation of RyR2
  JOURNAL   Circ Res 104 (4), 514-521 (2009)
   PUBMED   19131648
REFERENCE   4  (bases 1 to 2596)
  AUTHORS   Cunha SR and Mohler PJ.
  TITLE     Obscurin targets ankyrin-B and protein phosphatase 2A to the
            cardiac M-line
  JOURNAL   J Biol Chem 283 (46), 31968-31980 (2008)
   PUBMED   18782775
REFERENCE   5  (bases 1 to 2596)
  AUTHORS   Tsao CC, Nica AF, Kurinna SM, Jiffar T, Mumby M and Ruvolo PP.
  TITLE     Mitochondrial protein phosphatase 2A regulates cell death induced
            by simulated ischemia in kidney NRK-52E cells
  JOURNAL   Cell Cycle 6 (19), 2377-2385 (2007)
   PUBMED   17700073
  REMARK    GeneRIF: These findings suggest that activation of a PP2A isoform
            that contains the B56 alpha regulatory subunit is required for
            ischemia-induced cell death in kidney epithelial proximal tubule
            cells.
REFERENCE   6  (bases 1 to 2596)
  AUTHORS   Bhasin N, Cunha SR, Mudannayake M, Gigena MS, Rogers TB and Mohler
            PJ.
  TITLE     Molecular basis for PP2A regulatory subunit B56alpha targeting in
            cardiomyocytes
  JOURNAL   Am J Physiol Heart Circ Physiol 293 (1), H109-H119 (2007)
   PUBMED   17416611
REFERENCE   7  (bases 1 to 2596)
  AUTHORS   Li HH, Cai X, Shouse GP, Piluso LG and Liu X.
  TITLE     A specific PP2A regulatory subunit, B56gamma, mediates DNA
            damage-induced dephosphorylation of p53 at Thr55
  JOURNAL   EMBO J 26 (2), 402-411 (2007)
   PUBMED   17245430
REFERENCE   8  (bases 1 to 2596)
  AUTHORS   Yu P, Yang Z, Jones JE, Wang Z, Owens SA, Mueller SC, Felder RA and
            Jose PA.
  TITLE     D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells
  JOURNAL   Kidney Int 66 (6), 2167-2180 (2004)
   PUBMED   15569306
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_232413.4, XM_001066948.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2596
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..2596
                     /gene="Ppp2r5a"
                     /note="protein phosphatase 2, regulatory subunit B',
                     alpha"
                     /db_xref="GeneID:312754"
                     /db_xref="RGD:1308022"
     exon            1..358
                     /gene="Ppp2r5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1638
                     /gene="Ppp2r5a"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit alpha isoform"
                     /protein_id="NP_001101361.1"
                     /db_xref="GeneID:312754"
                     /db_xref="RGD:1308022"
                     /translation="MSSPSPPAPVACAAISASEKVDGFTRKSVRKAQRQKRSQGSSQF
                     RSQGSQAELHPLPQLKDATSNEQQELFCQKLQQCCVLFDFMDSVSDLKSKEIKRATLN
                     ELVEYVSTNRGVIVESAYSDIVKMISANIFRTLPPSDNPDFDPEEDEPTLEASWPHIQ
                     LVYEFFLRFLESPDFQPSIAKRYIDQKFVQQLLELFDSEDPRERDFLKTVLHRIYGKF
                     LGMRAFIRKQTNNIFLRFIYETEHFNGVAELLEILGSIINGFALPLKAEHKQFLMKVL
                     IPMHTAKGLALFHAQLAYCVVQFLEKDTTLTEPVIRGLLKFWPKTCSQKEVMFLGEIE
                     EILDVIEPTQFKKIEEPLFKQISKCVSSSHFQVAERALYFWNNEYILSLIEENIDKIL
                     PIMFASLYKISKEHWNQTIVALVYNVLKTLMEMNGKLFDDLTSSYKAERQREKKKELE
                     REELWKKLEELKLKKALEKQNNAYNMHSILSNTSAQ"
     exon            359..555
                     /gene="Ppp2r5a"
                     /inference="alignment:Splign:2.1.0"
     exon            556..657
                     /gene="Ppp2r5a"
                     /inference="alignment:Splign:2.1.0"
     exon            658..750
                     /gene="Ppp2r5a"
                     /inference="alignment:Splign:2.1.0"
     exon            751..881
                     /gene="Ppp2r5a"
                     /inference="alignment:Splign:2.1.0"
     exon            882..941
                     /gene="Ppp2r5a"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1050
                     /gene="Ppp2r5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1104
                     /gene="Ppp2r5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1155
                     /gene="Ppp2r5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1275
                     /gene="Ppp2r5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1403
                     /gene="Ppp2r5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1505
                     /gene="Ppp2r5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..2596
                     /gene="Ppp2r5a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggcgcgg ggatgcggct gtgaggcgct gtcgggtgag gagcagcttg cggagcgcga
       61 gggcggcgcg gccggggccc gggacgcagg ggcgcaggct cgccgtgccc gtccccgtgc
      121 cccgccgatt tcccgggcca gtcgcctcgg caggcgccga gcgcccgggt cgccgagatg
      181 tcgtcgccgt cgccgcccgc accagttgcc tgcgccgcca tctcggcctc ggagaaagtg
      241 gacggcttca cccggaaatc ggtgcgcaag gcgcagaggc agaagcgctc tcagggctcg
      301 tcgcagttcc gcagccaggg cagccaggcg gagctgcacc ccctgcccca gctcaaagat
      361 gctacatcaa atgaacagca agagcttttc tgccagaagc tacaacagtg ctgtgtactg
      421 tttgatttca tggactctgt ttcagacttg aagagcaaag aaattaaaag agcaacgctc
      481 aatgagctgg ttgagtatgt ttcgactaac cgtggtgtaa ttgttgaatc agcgtattct
      541 gatattgtaa aaatgatcag tgctaacatc ttccggacac ttcctccaag tgataaccca
      601 gactttgacc cggaagagga tgagcccaca cttgaggcct cttggcctca catacagctg
      661 gtgtatgaat tcttcttgag attcttggag agtcctgatt tccagcccag cattgcaaag
      721 cgatacattg accagaagtt tgtacaacag ctcctggagc ttttcgacag tgaagaccca
      781 cgagagcgtg acttcctgaa gaccgtcctg caccggattt acgggaagtt cctgggaatg
      841 agggcgttca tcagaaagca aaccaacaac atcttcctca ggtttatcta tgaaacggag
      901 catttcaatg gagtggctga gctccttgaa atactgggaa gtatcatcaa tggctttgcg
      961 ttgccactga aagcagaaca taagcagttt ctaatgaagg ttcttattcc tatgcatact
     1021 gcaaaaggac tggctctgtt tcatgctcag ctggcctact gtgttgtgca gttcctggag
     1081 aaagacacga cactgacaga gccggtgatc agaggactcc tgaaattttg gccaaaaaca
     1141 tgcagtcaga aagaggtgat gtttttagga gaaattgaag agatcttaga cgtcattgag
     1201 ccaacacaat tcaaaaagat tgaagagccg ctttttaaac agatatccaa gtgtgtctcc
     1261 agttctcact tccaggttgc agagagagca ctgtacttct ggaataacga atacattctc
     1321 agtttgattg aggagaacat cgataagatc ctgcccatca tgtttgccag tttgtataaa
     1381 atttccaaag aacactggaa tcagactatt gtagctctgg tatacaacgt gctgaaaacc
     1441 ctaatggaga tgaacgggaa gctttttgat gaccttacta gttcctacaa ggctgaaaga
     1501 cagagagaga agaagaaaga actggaacgc gaagaattat ggaaaaagtt agaagagttg
     1561 aagctgaaga aggctctaga gaaacagaac aatgcttaca acatgcacag tattctcagc
     1621 aataccagtg cccagtaaaa ggtcagctcc ccctgctggg cggcagtgtt gtacactctt
     1681 ggaatatata aaaacttcaa agccaaacct catcagtata atgtaattag gaggccagtt
     1741 tttcctggca agcgtaagcg aaagagataa ggactaaaca tagccctgtg ctgtgtcacg
     1801 gccacagtat attgtaaact ttgtctaatc atggagtgtc actgtcatct gttgagtgag
     1861 gtgactgtgg gagtggcgtg agtcacacga cttagcccag gtgtgctgca cacacagatc
     1921 aagccggcct ctgcacactt cctttatcat gtgctttcac agtgctgcac accttgggta
     1981 cttctgagga aagaaccttc cttcatgaga taagctgagg tgttgccctt cccttcccct
     2041 ctcctagaga ggcgggtggg gagataaagg cccagcctca ttaaagatac tgccatactc
     2101 tgggttttgc aacatcttgc gtttccaggc ttccgaagca caaagtatta aaagctgggg
     2161 ggaagtaaac caaatgttga ctgttcccaa atcccctgca gcagcagcac ccagagcgtg
     2221 cgcagagcag caccggcggg tggaccctag ctcacctcct tcattcctcc aaggctggag
     2281 gcagggcctt cccagtcctc aacctgcccg tcccaggcct gcctgcaggg tgaaggaggc
     2341 cctgggtccc acagtgtgat gcggactgct agctatcact gcctggcttt gtgtaaggga
     2401 aatgcagtgg gcaaactctg aattgactgc gtagaagcct tgtatgtttt tacctggtcg
     2461 ggtatttttc acacctgttg ttatcagtac cattccaacc tcttgccttg cagttgtatg
     2521 gaaaaccgtt ttataatgaa agatcttcac tggggattga gcagcattta ataaagtcta
     2581 tgtttgtatt ttgcct
//
