LOCUS       NP_001101361             486 aa            linear   ROD 26-FEB-2024
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            alpha isoform [Rattus norvegicus].
ACCESSION   NP_001101361 XP_001066948 XP_232413
VERSION     NP_001101361.1
DBSOURCE    REFSEQ: accession NM_001107891.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 486)
  AUTHORS   Porter IM, Schleicher K, Porter M and Swedlow JR.
  TITLE     Bod1 regulates protein phosphatase 2A at mitotic kinetochores
  JOURNAL   Nat Commun 4, 2677 (2013)
   PUBMED   24157919
REFERENCE   2  (residues 1 to 486)
  AUTHORS   Pitman MR, Barr RK, Gliddon BL, Magarey AM, Moretti PA and Pitson
            SM.
  TITLE     A critical role for the protein phosphatase 2A B'alpha regulatory
            subunit in dephosphorylation of sphingosine kinase 1
  JOURNAL   Int J Biochem Cell Biol 43 (3), 342-347 (2011)
   PUBMED   21075214
REFERENCE   3  (residues 1 to 486)
  AUTHORS   Terentyev D, Belevych AE, Terentyeva R, Martin MM, Malana GE, Kuhn
            DE, Abdellatif M, Feldman DS, Elton TS and Gyorke S.
  TITLE     miR-1 overexpression enhances Ca(2+) release and promotes cardiac
            arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and
            causing CaMKII-dependent hyperphosphorylation of RyR2
  JOURNAL   Circ Res 104 (4), 514-521 (2009)
   PUBMED   19131648
REFERENCE   4  (residues 1 to 486)
  AUTHORS   Cunha SR and Mohler PJ.
  TITLE     Obscurin targets ankyrin-B and protein phosphatase 2A to the
            cardiac M-line
  JOURNAL   J Biol Chem 283 (46), 31968-31980 (2008)
   PUBMED   18782775
REFERENCE   5  (residues 1 to 486)
  AUTHORS   Tsao CC, Nica AF, Kurinna SM, Jiffar T, Mumby M and Ruvolo PP.
  TITLE     Mitochondrial protein phosphatase 2A regulates cell death induced
            by simulated ischemia in kidney NRK-52E cells
  JOURNAL   Cell Cycle 6 (19), 2377-2385 (2007)
   PUBMED   17700073
  REMARK    GeneRIF: These findings suggest that activation of a PP2A isoform
            that contains the B56 alpha regulatory subunit is required for
            ischemia-induced cell death in kidney epithelial proximal tubule
            cells.
REFERENCE   6  (residues 1 to 486)
  AUTHORS   Bhasin N, Cunha SR, Mudannayake M, Gigena MS, Rogers TB and Mohler
            PJ.
  TITLE     Molecular basis for PP2A regulatory subunit B56alpha targeting in
            cardiomyocytes
  JOURNAL   Am J Physiol Heart Circ Physiol 293 (1), H109-H119 (2007)
   PUBMED   17416611
REFERENCE   7  (residues 1 to 486)
  AUTHORS   Li HH, Cai X, Shouse GP, Piluso LG and Liu X.
  TITLE     A specific PP2A regulatory subunit, B56gamma, mediates DNA
            damage-induced dephosphorylation of p53 at Thr55
  JOURNAL   EMBO J 26 (2), 402-411 (2007)
   PUBMED   17245430
REFERENCE   8  (residues 1 to 486)
  AUTHORS   Yu P, Yang Z, Jones JE, Wang Z, Owens SA, Mueller SC, Felder RA and
            Jose PA.
  TITLE     D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells
  JOURNAL   Kidney Int 66 (6), 2167-2180 (2004)
   PUBMED   15569306
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_232413.2, XP_001066948.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     Protein         1..486
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit alpha isoform"
                     /calculated_mol_wt=56206
     Region          64..442
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..486
                     /gene="Ppp2r5a"
                     /coded_by="NM_001107891.1:178..1638"
                     /db_xref="GeneID:312754"
                     /db_xref="RGD:1308022"
ORIGIN      
        1 msspsppapv acaaisasek vdgftrksvr kaqrqkrsqg ssqfrsqgsq aelhplpqlk
       61 datsneqqel fcqklqqccv lfdfmdsvsd lkskeikrat lnelveyvst nrgvivesay
      121 sdivkmisan ifrtlppsdn pdfdpeedep tleaswphiq lvyefflrfl espdfqpsia
      181 kryidqkfvq qllelfdsed prerdflktv lhriygkflg mrafirkqtn niflrfiyet
      241 ehfngvaell eilgsiingf alplkaehkq flmkvlipmh takglalfha qlaycvvqfl
      301 ekdttltepv irgllkfwpk tcsqkevmfl geieeildvi eptqfkkiee plfkqiskcv
      361 ssshfqvaer alyfwnneyi lslieenidk ilpimfasly kiskehwnqt ivalvynvlk
      421 tlmemngklf ddltssykae rqrekkkele reelwkklee lklkkalekq nnaynmhsil
      481 sntsaq
//
