LOCUS       NM_001139492            2955 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protein phosphatase 2, regulatory subunit B'',
            beta (Ppp2r3b), mRNA.
ACCESSION   NM_001139492 XM_001059486
VERSION     NM_001139492.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2955)
  AUTHORS   Nishi,A., Matamales,M., Musante,V., Valjent,E., Kuroiwa,M.,
            Kitahara,Y., Rebholz,H., Greengard,P., Girault,J.A. and Nairn,A.C.
  TITLE     Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation
            of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution
  JOURNAL   J Biol Chem 292 (4), 1462-1476 (2017)
   PUBMED   27998980
REFERENCE   2  (bases 1 to 2955)
  AUTHORS   Zhang,C.E., Tian,Q., Wei,W., Peng,J.H., Liu,G.P., Zhou,X.W.,
            Wang,Q., Wang,D.W. and Wang,J.Z.
  TITLE     Homocysteine induces tau phosphorylation by inactivating protein
            phosphatase 2A in rat hippocampus
  JOURNAL   Neurobiol Aging 29 (11), 1654-1665 (2008)
   PUBMED   17537547
  REMARK    GeneRIF: These results suggest that homocysteine may be an upstream
            effector to induce AD-like tau hyperphosphorylation through
            inactivating PP2A.
REFERENCE   3  (bases 1 to 2955)
  AUTHORS   Wang,L., Zheng,A., Yi,L., Xu,C., Ding,M. and Deng,H.
  TITLE     Identification of potential nuclear reprogramming and
            differentiation factors by a novel selection method for cloning
            chromatin-binding proteins
  JOURNAL   Biochem Biophys Res Commun 325 (1), 302-307 (2004)
   PUBMED   15522233
REFERENCE   4  (bases 1 to 2955)
  AUTHORS   Voorhoeve,P.M., Hijmans,E.M. and Bernards,R.
  TITLE     Functional interaction between a novel protein phosphatase 2A
            regulatory subunit, PR59, and the retinoblastoma-related p107
            protein
  JOURNAL   Oncogene 18 (2), 515-524 (1999)
   PUBMED   9927208
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 30, 2023 this sequence version replaced NM_001139492.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161890.1, SRR26643285.37744.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-744               JAXUCZ010000014.1  109996-110739       c
            745-936             JAXUCZ010000014.1  109722-109913       c
            937-1043            JAXUCZ010000014.1  108695-108801       c
            1044-1146           JAXUCZ010000014.1  108282-108384       c
            1147-1221           JAXUCZ010000014.1  107895-107969       c
            1222-1308           JAXUCZ010000014.1  107639-107725       c
            1309-1468           JAXUCZ010000014.1  106603-106762       c
            1469-1517           JAXUCZ010000014.1  106222-106270       c
            1518-1607           JAXUCZ010000014.1  106035-106124       c
            1608-1783           JAXUCZ010000014.1  105518-105693       c
            1784-1902           JAXUCZ010000014.1  105225-105343       c
            1903-2009           JAXUCZ010000014.1  104807-104913       c
            2010-2955           JAXUCZ010000014.1  103496-104441       c
FEATURES             Location/Qualifiers
     source          1..2955
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2955
                     /gene="Ppp2r3b"
                     /note="protein phosphatase 2, regulatory subunit B'',
                     beta"
                     /db_xref="GeneID:682033"
                     /db_xref="RGD:1588134"
     exon            1..744
                     /gene="Ppp2r3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..2076
                     /gene="Ppp2r3b"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A
                     regulatory subunit B'' subunit beta"
                     /protein_id="NP_001132964.1"
                     /db_xref="GeneID:682033"
                     /db_xref="RGD:1588134"
                     /translation="MAPRKPPPSPLRPCLQMKVDELFLRWLSDPGTQRALRAGLRRIQ
                     GPAVILDHTVTPNPATALDSATKAIAAPAKIAPPDPAVTPNPAAIASSTAITKFSASR
                     KRNRHRAVPPRGEEPGPKAPLPGRGIPAFYFPRGRPGQGPDVDDVIADVERAFARLPS
                     GRAGLQDMGVVAKACCCPLYWKAPLFLAAGGGAQGGFVSARDIIGLWKPILLTCHDEA
                     ARFERLLGGPGDGGLSPEDLAPLVQDVADSHPGLSFLREAEPLRRDYVTTVTQRVFYA
                     VNRSWSGRISCQEIRRSCFLQAVSQLEAEPNPGRATPSFFSYPHFCVIVSKFQALDAD
                     GDGLIDRHDLRRHADGAISSRMIDRIFSGAVTRARPSPEGGKMGLADFVWFLLSEEDK
                     TTPTSTEYWFRCMDLDGDGVLSAPELSFFYEEQAQNLAARGAEPPPFADLTRQALDLV
                     QPRCPGQITLGDLKRCGLAGEFFDAFFNADKFLEHERREPAGPVRAPDADPTLSDWDR
                     FAAAEYDFLLAEEAQDDDAWEEGSESPPSSPDPYDFADDTLDPL"
     exon            745..936
                     /gene="Ppp2r3b"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1043
                     /gene="Ppp2r3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1146
                     /gene="Ppp2r3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1221
                     /gene="Ppp2r3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1308
                     /gene="Ppp2r3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1468
                     /gene="Ppp2r3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1517
                     /gene="Ppp2r3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1607
                     /gene="Ppp2r3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1783
                     /gene="Ppp2r3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1902
                     /gene="Ppp2r3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2009
                     /gene="Ppp2r3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2955
                     /gene="Ppp2r3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagctctg cccttgtttc cacagaaatc tgttcttcct gatccccgcg acgccatcat
       61 tcctagccgg gagtgcctag ctaagcgtcc cccgcagggg gagcatcggg cgcgtccatc
      121 gccggttccc gagtacgtcc gtctgtcccg gttccgacct ctccccaagg tcctccatcc
      181 ccagaagcca ccgccgccgc cgttgaagac gtttcactcc tgtcttcctg atttttcccg
      241 tcgcactctg tgacgcctcc acgccgcgcc ggtattgccc cgtgttcttg aatcccgcag
      301 tcgcgccagt aacgccatca ctcctcgacg gaagtcccgg gccccgtgtc agcggcgggc
      361 gttttgaagc cggggaagcg tgagtccatt cgtcctggtg cggaccccgc gttcgccatg
      421 gcgccccgga agccgccgcc gtcgccgctc cggccttgcc tgcagatgaa ggttgacgag
      481 ctcttcctgc gctggctcag cgatcccggc acacaacgcg cactgcgagc aggactgcgg
      541 cgcatccaag gacctgcggt gatcctcgac cacacagtga cccccaaccc cgccacggcc
      601 ctcgattccg ccaccaaagc cattgctgct ccagccaaaa ttgctccgcc cgaccccgcg
      661 gtgaccccca accccgccgc cattgcctct tccaccgcca ttactaaatt ttccgcctca
      721 cgaaaaagga acaggcacag agcggtccct cccagaggag aggagcctgg gccgaaggcc
      781 ccactcccag gccgaggaat tcccgccttc tacttcccgc gcgggcgccc gggacaggga
      841 cccgatgtgg acgacgtaat cgcggatgtg gagcgcgcat tcgccaggct gccgagcggg
      901 agggcggggc tgcaggatat gggcgttgtt gccaaggcct gctgctgccc actctactgg
      961 aaggccccac tgttccttgc tgcaggaggt ggagcacagg gcggctttgt gagcgcacgt
     1021 gacatcatag gcctgtggaa gccgatcctg ctgacctgcc atgacgaagc agcccgcttc
     1081 gaacgcctcc ttggtggacc aggggacggt ggcctcagcc cagaggacct tgcacccctc
     1141 gtgcaggatg ttgcggactc acatcctggc ctgagcttcc tgcgggaggc agagccgctc
     1201 cgccgggatt atgtcaccac ggtgacacag cgtgtgttct acgctgtgaa ccggtcttgg
     1261 tctgggcgga tctcttgcca ggagattaga cgaagctgct tcctgcaggc cgtgtcccag
     1321 ctggaggcgg aacccaaccc cggccgtgcc acaccatcat tcttctccta tccccacttt
     1381 tgcgtcattg tcagcaaatt tcaggccctg gatgctgatg gcgacggcct gattgatagg
     1441 cacgacctcc ggcggcatgc ggatggcgcc atctcctcta ggatgatcga caggatcttc
     1501 tcaggcgcag tgacccgagc acggccatcc cccgagggtg ggaagatggg gctcgcggac
     1561 ttcgtgtggt tcctgctgtc ggaggaggac aagaccacgc ccaccagcac tgagtactgg
     1621 ttccgctgca tggacctgga tggggacggc gtcctttccg ccccagagct cagcttcttc
     1681 tacgaggaac aggcgcagaa cctggcagcc cggggggcgg agcctccgcc cttcgctgac
     1741 ctcacccggc aggcccttga cttggtgcag ccacgctgcc ctggccagat cacgctgggc
     1801 gacctgaagc gctgcggcct ggcgggcgag ttctttgatg cctttttcaa tgctgacaaa
     1861 ttcctggagc acgaacggcg ggagccagcg gggcctgtga gggccccgga tgccgacccc
     1921 accctctccg actgggatag gttcgctgca gcggagtacg acttcctgct tgctgaggag
     1981 gcacaggatg atgacgcgtg ggaggagggg tctgagtccc cgcccagctc cccggatccc
     2041 tacgacttcg cagatgacac cctagatccg ctgtgacgtg cgtgggcagg gtcgtgggac
     2101 atactgtgca ccctgcccgg ggtcacacag gatcacgcaa ctgaggacta cctcctcggc
     2161 ggcggtgagt tcaatcgact gaggacaacc tcgacactcc catgacatcc tgtgacccca
     2221 cgtgacctcg caccccactg tgcgcagaac cgtcgtctgt aatttttgaa taaagagttc
     2281 aacgtttcca tggcctgcag tcagtgtctc tcccgggacc ctcggtgggc ggggcccggt
     2341 ttgttgattg gcaccagggc ggggtaggtc acagcgaaga ctttcgtcct ggaaggattg
     2401 accgccgggc tggcaggggt tgcgggtgac atcaccaggg tcacgggtga ttggttgatg
     2461 ggcagcgtgc tctggactct ttctttttta aatgtatatt atatattgta ttctgtatta
     2521 tatattatat attgtttaat tgttatatat tatgtatttt atatttatat atgtgtgtat
     2581 atatatacat acatacatac atacatacat acatacatac atacatacat acggtcaacc
     2641 aattgtccca ttggactttt cttcttttta ctttttgtag ttcaaaaatg agatcgacca
     2701 gttgtccttt tgttaaaagt cacatattaa cactgcctgc agactttttg taattaaaga
     2761 aattaatata tatgtatatg taaattatat gtatatataa tttttaaaaa aagtatgagg
     2821 ttgaccagtt gtcccttttg ttctaagcag agcaaaagca tgaatctact aatgtgattg
     2881 taaacataag gctgggtaaa aacttaaacc ttcgaacgac tgaagaataa aactaaaact
     2941 gactggaaaa aaaaa
//
