LOCUS       NM_001012202            5212 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus protein phosphatase 2, regulatory subunit B'',
            alpha (Ppp2r3a), mRNA.
ACCESSION   NM_001012202 XM_343456
VERSION     NM_001012202.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5212)
  AUTHORS   Wu,C.Y., Liang,Y., Li,X.F. and Song,G.B.
  TITLE     The potential mechanism of PPP2R3A in myocardial cells and its
            interacting proteins
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (24), 7913-7925 (2021)
   PUBMED   34982454
  REMARK    GeneRIF: The potential mechanism of PPP2R3A in myocardial cells and
            its interacting proteins.
REFERENCE   2  (bases 1 to 5212)
  AUTHORS   Xiao,G., Lian,G., Wang,T., Chen,W., Zhuang,W., Luo,L., Wang,H. and
            Xie,L.
  TITLE     Zinc-mediated activation of CREB pathway in proliferation of
            pulmonary artery smooth muscle cells in pulmonary hypertension
  JOURNAL   Cell Commun Signal 19 (1), 103 (2021)
   PUBMED   34635097
  REMARK    GeneRIF: Zinc-mediated activation of CREB pathway in proliferation
            of pulmonary artery smooth muscle cells in pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5212)
  AUTHORS   Yger,M. and Girault,J.A.
  TITLE     DARPP-32, Jack of All Trades em leader Master of Which?
  JOURNAL   Front Behav Neurosci 5, 56 (2011)
   PUBMED   21927600
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5212)
  AUTHORS   Xing,Y., Xu,Y., Chen,Y., Jeffrey,P.D., Chao,Y., Lin,Z., Li,Z.,
            Strack,S., Stock,J.B. and Shi,Y.
  TITLE     Structure of protein phosphatase 2A core enzyme bound to
            tumor-inducing toxins
  JOURNAL   Cell 127 (2), 341-353 (2006)
   PUBMED   17055435
REFERENCE   5  (bases 1 to 5212)
  AUTHORS   Creyghton,M.P., Roel,G., Eichhorn,P.J., Vredeveld,L.C., Destree,O.
            and Bernards,R.
  TITLE     PR130 is a modulator of the Wnt-signaling cascade that counters
            repression of the antagonist Naked cuticle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5397-5402 (2006)
   PUBMED   16567647
REFERENCE   6  (bases 1 to 5212)
  AUTHORS   Creyghton,M.P., Roel,G., Eichhorn,P.J., Hijmans,E.M., Maurer,I.,
            Destree,O. and Bernards,R.
  TITLE     PR72, a novel regulator of Wnt signaling required for Naked cuticle
            function
  JOURNAL   Genes Dev 19 (3), 376-386 (2005)
   PUBMED   15687260
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Sep 13, 2008 this sequence version replaced NM_001012202.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.33116.1,
                                           SRR26643294.34204.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2294              JAXUCZ010000008.1  110675189-110677482 c
            2295-2561           JAXUCZ010000008.1  110656991-110657257 c
            2562-2665           JAXUCZ010000008.1  110648962-110649065 c
            2666-2768           JAXUCZ010000008.1  110642630-110642732 c
            2769-2843           JAXUCZ010000008.1  110634543-110634617 c
            2844-2930           JAXUCZ010000008.1  110619052-110619138 c
            2931-3087           JAXUCZ010000008.1  110616772-110616928 c
            3088-3136           JAXUCZ010000008.1  110613597-110613645 c
            3137-3226           JAXUCZ010000008.1  110612419-110612508 c
            3227-3402           JAXUCZ010000008.1  110603066-110603241 c
            3403-3521           JAXUCZ010000008.1  110602476-110602594 c
            3522-3628           JAXUCZ010000008.1  110601265-110601371 c
            3629-5212           JAXUCZ010000008.1  110583724-110585307 c
FEATURES             Location/Qualifiers
     source          1..5212
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..5212
                     /gene="Ppp2r3a"
                     /note="protein phosphatase 2, regulatory subunit B'',
                     alpha"
                     /db_xref="GeneID:363122"
                     /db_xref="RGD:1306958"
     exon            1..2294
                     /gene="Ppp2r3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..3755
                     /gene="Ppp2r3a"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase 2 (formerly 2A), regulatory
                     subunit B'', alpha; DNA for thyroid hormone receptor
                     binding site (258bp)"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A
                     regulatory subunit B'' subunit alpha"
                     /protein_id="NP_001012202.2"
                     /db_xref="GeneID:363122"
                     /db_xref="RGD:1306958"
                     /translation="MAATYRLVVSTVNHYSSVVIDRRFEQAIHYCTGTCHTFTHGIDC
                     IVVHHSVCADLLHIPVSQFKDVDLNSVFLSHENGLSSAEDYPHQALTGIPRSKRASTF
                     QNTCNLKDIAGEAISFASGKIKEFSLEKLRNSNHAAYKKGRKVKSDSFNRRSVDLDLL
                     CGHYSNDGTSPSFGLLRSSSVEEKSLSHRNSLDTSLTSMLFQNLSEEDLVTQILEKHK
                     IDHFSSGTDIKMCLDILLKCSEDLKKCTDIIKQCIKKKSGGSINEGSGSDAMSNSETV
                     YMNVMARLAYYLRKLPFEFVQSGSNETVDLTELVNNVPNLQLTPFSPLYGTEQPPKYE
                     DIVHLSALDSRQFQTVELQDDMHNFKQTDTVKTPPNNTNSLCSLEVNDPGTLKPVQLQ
                     SPSLTINHLENVSSGNLMETLYIEEESDGKKSLLDKGQKADNGQGQEPLKVNEHKEFS
                     DHDTYLKKCPAPVQNEISKIFEKPMVVRPPKEESELAVPPTELRAQRHFMNPNSQEEI
                     DKLLMDLESFSQKMETSLGEPLAKGKSINSLNSHSHLTGQIHKDLEPKPIVSSATEKV
                     SPSCLTRIIENNGHKIEEEDRALLLRILESIEDFAQELVECKSSRGSLSQEKEMMQIL
                     QETLTASSQPTPSVSRSPVGEKPKDSTSVVLIQQTPEVIKIQNKPEKKPATPCPPAAT
                     LPSSPQPASPVPCVSDVVNTPLSINIPQFYFPEGLPDTCSNHEQILGRIEAAFKDIED
                     QKADIHEMGRIAKACGCPLYWKAPMFRAAGGEKTGFVTAQSFMAMWKKLLSDHHDDAS
                     RFIWLLAKPSCSHLQQEDFIPLLQDVVDTHPGLTFLKDAPEFHSRYITTVVQRIFYTV
                     NRSWSGKITSTEIRKSNFLQTLALLEEEEDINQITDYFSYEHFYVIYCKFWELDGDHD
                     LYISQADLSRYNDQASSNRIIERIFSGAVTRGKTVQREGRMSYADFVWFLISEEDKRN
                     PTSIEYWFRCMDVDGDGVLSMYELEYFYEEQCERMEAMGIEPLPFHDLLCQMLDLVKP
                     ANDGRITLRDLKRCRMAHIFYDTFFNLEKYLDHEQRDPFAVQKDVENEGPEPSDWDRF
                     AAEEYEALVTEESAQVQLQEGSFEDYESDEPVSPSELGNKGNKILTSSLSEKCGKLQS
                     VDEE"
     exon            2295..2561
                     /gene="Ppp2r3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2665
                     /gene="Ppp2r3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2768
                     /gene="Ppp2r3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2843
                     /gene="Ppp2r3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..2930
                     /gene="Ppp2r3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3087
                     /gene="Ppp2r3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3136
                     /gene="Ppp2r3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3226
                     /gene="Ppp2r3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3402
                     /gene="Ppp2r3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3521
                     /gene="Ppp2r3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3522..3628
                     /gene="Ppp2r3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..5212
                     /gene="Ppp2r3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagagtta aaagaagata ttcttccata gaaataatcg tatagtatca tgttactaaa
       61 gtgtaccata tctaagttat tagacttgct gtataagcat acctgtgcag cagctactgt
      121 atagtgagag ctaccaaacc tcaaatttaa acatttccct tcatggaaaa gttactatat
      181 tttgtaagaa accactgaac attgtcatta aatatttttt tcagcaaagt atcatttagg
      241 aaaattttct tgaagcaaac tctatcaagt tctaagtcct agcattgagt gaatttgata
      301 ttatggcagc aacttacaga ctcgtggtta gcactgtgaa ccattatagc agtgtagtga
      361 tagaccggcg ttttgaacaa gccatacatt attgcactgg aacctgccat accttcacac
      421 atggaataga ctgcattgta gtgcatcata gtgtttgtgc agaccttttg cacatccctg
      481 tgtctcagtt caaagatgtg gatctgaact ctgtgttttt gtctcatgaa aatggccttt
      541 cctcagctga agactatccc catcaggccc tcacaggaat acccaggtcc aagagagcat
      601 ccacatttca gaatacctgt aacttaaagg acattgcagg agaagcaatc agctttgcca
      661 gtgggaaaat aaaagaattt tcccttgaaa aactcagaaa ttcaaatcat gcagcttaca
      721 aaaaaggaag aaaagttaaa tctgactcat ttaataggcg atcagttgat ttggatttac
      781 tctgtggcca ttatagtaac gatgggacct ccccatcctt tggcttactc cggagttcct
      841 cagttgagga aaaatcttta tctcatagaa actcactaga tacaagccta acttccatgc
      901 tttttcagaa cttgtctgaa gaagatctag ttacgcagat tttggaaaaa cataaaatag
      961 atcatttttc ttctgggaca gacataaaaa tgtgcttgga catcttactg aaatgctctg
     1021 aagatttgaa aaaatgtaca gacatcataa aacaatgcat aaagaaaaag tcaggaggaa
     1081 gcatcaacga aggaagtggc agtgacgcaa tgtctaactc tgaaaccgtc tatatgaatg
     1141 taatggccag gttagcttac tacctgagaa agttaccatt tgaatttgtg cagtctggga
     1201 gtaatgagac tgtagatttg acagagcttg tcaataatgt acctaactta caactgactc
     1261 cattctcccc attatatggg actgaacagc cccctaaata tgaagatatc gtccacctct
     1321 cagcccttga ctccagacag tttcagactg ttgaattgca agatgacatg cataatttta
     1381 aacaaacaga tactgtaaaa acccctccaa acaacacaaa ttccttgtgt agcttggagg
     1441 taaacgatcc tggaactcta aaacctgtgc agcttcaatc accgtcatta accataaacc
     1501 atttagagaa tgtttcttct ggtaacttaa tggaaactct ttatattgaa gaagagtcag
     1561 atggaaagaa gtcattatta gataaaggac aaaaagcaga taatggacaa ggtcaggaac
     1621 cattaaaggt aaatgaacat aaagaatttt cagaccatga tacttatctt aaaaaatgtc
     1681 ctgccccagt gcaaaatgaa atcagtaaga tatttgaaaa gccaatggta gttcgtccac
     1741 ctaaggaaga atctgaatta gcagttcctc ctacagaact cagagcccag aggcacttta
     1801 tgaatcctaa cagtcaagaa gagatcgaca aattgttaat ggatttggaa tcattctcac
     1861 agaagatgga gacctctcta ggagaaccac ttgccaaggg taaaagcatc aattctctaa
     1921 atagtcatag tcatttgact ggtcagatcc acaaagatct tgagcctaaa cctatagtct
     1981 cttcagctac ggagaaagtc tcaccttctt gtctaacaag gattattgaa aacaacggac
     2041 acaaaataga ggaagaggac cgagccctct tacttcgaat tctggaaagc attgaagact
     2101 ttgctcaaga actagttgaa tgcaagtcaa gcagagggag cctatcacaa gaaaaggaaa
     2161 tgatgcaaat tctgcaggaa actttgacag cttcctccca gcccactcca tcagtcagta
     2221 ggagccctgt tggtgagaaa cccaaagata gtacttcagt tgttttgatt caacagacac
     2281 cagaagtgat caagattcaa aataaaccag aaaaaaaacc tgcaacacca tgtccacctg
     2341 cagccaccct tccaagtagt ccccagcctg cctcccctgt tccttgtgtg agcgatgtcg
     2401 tgaatacacc actgtccata aacattccac agttctactt tcccgaagga ctcccagaca
     2461 cctgcagcaa ccacgaacag atcctaggca gaattgaagc tgctttcaag gatattgaag
     2521 atcaaaaagc agatattcat gaaatgggga gaattgcaaa ggcctgcggc tgtccactct
     2581 attggaaagc ccccatgttc agggctgcag gaggagagaa gactggattt gtgacagcac
     2641 agtcattcat ggccatgtgg aaaaagttgc taagtgacca tcatgatgat gcctccaggt
     2701 tcatctggct tctggcaaag cccagctgca gccatctcca acaagaggat tttatccctc
     2761 tacttcagga tgtggtagat acacaccctg gcctcacctt cctgaaagat gctcctgaat
     2821 tccattcccg ctacatcacc acggttgttc agagaatatt ctacacagtc aacagatctt
     2881 ggagtggaaa aattacttca acagagataa ggaaaagcaa ctttttgcaa actctggccc
     2941 ttttggagga agaggaagat ataaaccaaa tcacagatta cttctcttat gaacatttct
     3001 atgtcattta ttgtaaattc tgggaactag atggtgatca tgacctatac atcagccaag
     3061 ctgatctctc tcgatacaat gaccaggctt catcaaatag aattattgaa agaatatttt
     3121 ctggagcagt aacaagaggg aaaactgtac aaagagaggg aagaatgagc tatgcagatt
     3181 ttgtttggtt tttgatttct gaggaagaca aacggaaccc taccagcatt gagtattggt
     3241 tccgctgcat ggatgtggat ggagatggtg tactttccat gtatgaacta gagtatttct
     3301 atgaagagca gtgtgaacgg atggaagcca tgggcatcga gcccttgccg tttcatgatc
     3361 tgttgtgcca gatgctagac ttggtgaagc cagctaatga tggcagaata actctgcgag
     3421 atttgaagag gtgcagaatg gctcacatct tctacgacac tttctttaac ctggagaagt
     3481 acttggacca tgaacaaaga gatccttttg cagtccagaa ggatgttgaa aatgagggcc
     3541 ccgagccctc tgactgggac aggtttgctg ctgaggagta cgaggctctg gtgactgagg
     3601 aatctgccca ggttcagctc caggaaggct catttgaaga ctatgaatca gatgagcctg
     3661 tgtctccctc tgaacttgga aacaagggca ataaaatcct aacttcaagc ctttcagaga
     3721 aatgtggaaa gctccagtca gtggatgaag agtagttgcc ataatctaca cggaaaggat
     3781 ggtgtggaga gacgttctag ttgtacactg ctttgtaaag agtttggttc ctccgagtgc
     3841 actagaaact aaaatgctct aagtagttca gcacaggaga ccccaccagt ttgttgcaaa
     3901 cgtgcagcgc tcttccttgg aagtaccatg ctgtcatcag tcaccttcca aagtctgcag
     3961 tcagcactct acaccccttg gtgtatggag gctctcttgg aaataaggcc acacacagtt
     4021 ctctgcacag aagcagaagc tgcctcagta ctggccagct tccctggggt acctcaggct
     4081 cctacagaac ctttaagaaa acttcacttg cagaaaactt gagtcaaaaa ttctggaact
     4141 tgaaaaaggg cctctggaac tggctttatc ctgtaacaaa agcactgcca agcatctcag
     4201 aaactactta tgtactggag gagttcgggg ccttcaactt acctggctta acgtaacttc
     4261 accatggcct gccgagctgc taagtcactt acattctcag gtaaccaacc actgggccct
     4321 gccagccctg ctggcagctc tggcagcctc tgcatctgac tgtggacctt gtacaaaaac
     4381 ctcataaaat ttttttctga aaatgaagac aagtacagaa tttggcacta cttacatttg
     4441 cagacacttt ttagattatg tattaatcta caagttaatg acctatcttc atttctagca
     4501 gaaggcttac ttgaagactt aaggaatgta acataccatg gaaacttctc actatacata
     4561 ctccatccct ctcttaaata ctaaattagg tcaaaaataa aaggcacaaa ctaaagagca
     4621 gtatacctta cttcctgtgg aaaataccag gtatatttca tccacctcat tattatcaac
     4681 cttggaagaa aaacagtggc tctcacccac agtagaaagc cttttttact atagtggtga
     4741 atccagaatc ctacactttc caacaggcca caatgcagct aacccctaca acatgcttat
     4801 tgttacccat tatactttag gaaaaaaaaa aaaaaaacta aaaagggtgg acatttctaa
     4861 aatcaaagca gctttctact gtcccttttt ttgtttcaat tttaaatggt cagagtagcc
     4921 ttccttttct ctccatccta gttcttttcc taatagaaag gccaagcagt gaagtaaacc
     4981 ttgggtgatg ggaagtcaca catggaagaa atgagaattt tagacatata atatcaacta
     5041 atactagaaa tttgcaagct gcaaccccac ctgtcccaag atcctccagt tccctaagac
     5101 tcaactaatc tcccttataa ccattataga aactgagaac tattacaact aggagttaac
     5161 ccagataatt aaagcctagc agtgactaaa ttgacaaaaa aaaaaaaaaa aa
//
