LOCUS       NM_144746               1734 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus protein phosphatase 2, regulatory subunit B,
            delta (Ppp2r2d), mRNA.
ACCESSION   NM_144746
VERSION     NM_144746.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1734)
  AUTHORS   Van Kanegan,M.J. and Strack,S.
  TITLE     The protein phosphatase 2A regulatory subunits B'beta and B'delta
            mediate sustained TrkA neurotrophin receptor autophosphorylation
            and neuronal differentiation
  JOURNAL   Mol Cell Biol 29 (3), 662-674 (2009)
   PUBMED   19029245
  REMARK    GeneRIF: Select PP2A heterotrimers oppose desensitization of the
            TrkA receptor tyrosine kinase, perhaps through dephosphorylation of
            inhibitory Ser/Thr phosphorylation sites on the receptor itself.
REFERENCE   2  (bases 1 to 1734)
  AUTHORS   Kabashima,T., Kawaguchi,T., Wadzinski,B.E. and Uyeda,K.
  TITLE     Xylulose 5-phosphate mediates glucose-induced lipogenesis by
            xylulose 5-phosphate-activated protein phosphatase in rat liver
  JOURNAL   Proc Natl Acad Sci U S A 100 (9), 5107-5112 (2003)
   PUBMED   12684532
REFERENCE   3  (bases 1 to 1734)
  AUTHORS   Strack,S., Chang,D., Zaucha,J.A., Colbran,R.J. and Wadzinski,B.E.
  TITLE     Cloning and characterization of B delta, a novel regulatory subunit
            of protein phosphatase 2A
  JOURNAL   FEBS Lett 460 (3), 462-466 (1999)
   PUBMED   10556517
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081720.1.
            
            On Jun 10, 2007 this sequence version replaced NM_144746.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081720.1, AF180350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1734
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1734
                     /gene="Ppp2r2d"
                     /note="protein phosphatase 2, regulatory subunit B, delta"
                     /db_xref="GeneID:246255"
                     /db_xref="RGD:708356"
     exon            1..113
                     /gene="Ppp2r2d"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1468
                     /gene="Ppp2r2d"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 55 kDa
                     regulatory subunit B delta isoform"
                     /protein_id="NP_653347.2"
                     /db_xref="GeneID:246255"
                     /db_xref="RGD:708356"
                     /translation="MAGAGGGGCPTGGNDFQWCFSQVKGAVDEDVAEADIISTVEFNY
                     SGDLLATGDKGGRVVIFQREQENKGRAHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKI
                     NKIRWLPQQNAAHFLLSTNDKTIKLWKISERDKRAEGYNLKDEDGRLRDPFRITALRV
                     PILKPMDLMVEASPRRIFANAHTYHINSISVNSDHETYLSADDLRINLWHLEITDRSF
                     NIVDIKPANMEELTEVITAAEFHPHQCNVFVYSSSKGTIRLCDMRSSALCDRHAKFFE
                     EPEDPSSRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVWDLNMEGRPVETHQVHEY
                     LRSKLCSLYENDCIFDKFECCWNGSDSAIMTGSYNNFFRMFDRNTRRDVTLEASRENS
                     KPRASLKPRKVCSGGKRKKDEISVDSLDFNKKILHTAWHPMESIIAVAATNNLYIFQD
                     KIN"
     exon            114..206
                     /gene="Ppp2r2d"
                     /inference="alignment:Splign:2.1.0"
     exon            207..304
                     /gene="Ppp2r2d"
                     /inference="alignment:Splign:2.1.0"
     exon            305..470
                     /gene="Ppp2r2d"
                     /inference="alignment:Splign:2.1.0"
     exon            471..583
                     /gene="Ppp2r2d"
                     /inference="alignment:Splign:2.1.0"
     exon            584..761
                     /gene="Ppp2r2d"
                     /inference="alignment:Splign:2.1.0"
     exon            762..926
                     /gene="Ppp2r2d"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1188
                     /gene="Ppp2r2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1710
                     /gene="Ppp2r2d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggcggc ggcggtggcg gcagcggcag cggcggtggc ggccggggct gagcgctcgg
       61 agcgcctcgg tcggccgcgc tcagctgggc gcgtcccgcc cgcgccatgg caggagccgg
      121 aggtggcggc tgcccgacgg gcggcaacga cttccagtgg tgcttctcgc aggtgaaggg
      181 cgctgtcgac gaggacgtgg cggaagccga catcatctcc accgttgagt ttaactactc
      241 tggagacctt cttgcaacag gagacaaagg tggcagagtt gttattttcc aacgggaaca
      301 agagaataaa ggccgcgctc actctagggg agagtacaat gtttacagta cctttcagag
      361 tcatgagcca gagtttgact atttgaaaag tctagaaatt gaagaaaaaa ttaataaaat
      421 caggtggtta ccgcaacaga atgctgctca ttttctactc tctacaaatg ataaaactat
      481 taaattatgg aaaataagtg aacgagataa aagagcagaa ggttataact tgaaagatga
      541 agatggacga cttcgagacc catttagaat tacggcacta cgggttccaa tattgaagcc
      601 catggacctt atggtagaag caagtccacg acgaattttt gcaaatgctc atacatatca
      661 cataaattcc atttcagtaa atagtgatca tgaaacatat ctctctgcag atgatctgag
      721 aattaaccta tggcatttag aaatcacaga tagaagcttc aacattgtgg acatcaagcc
      781 tgctaacatg gaggagctga cagaagtcat cactgccgcg gagttccacc cacaccagtg
      841 caatgtattc gtctacagca gcagcaaggg gaccatcagg ctgtgtgaca tgcgttcttc
      901 tgccctctgt gataggcatg ccaagttttt tgaagagcca gaagatccca gcagtagatc
      961 ctttttctca gaaataatct catctatatc tgatgtcaag ttcagccaca gtggtcgata
     1021 catgatgacc agagactatc tgtcggtgaa ggtatgggac ctcaacatgg agggcaggcc
     1081 tgtcgagacc caccaggtac atgagtacct acgaagcaag ctctgctcct tgtatgagaa
     1141 tgactgcatc tttgacaagt tcgagtgctg ctggaatggt tcagacagtg ccattatgac
     1201 ggggtcctac aacaacttct ttagaatgtt tgatagaaac actcggaggg atgttacact
     1261 ggaagcctca agagagaaca gcaagccccg agccagcctg aagccccgga aagtgtgttc
     1321 agggggtaag aggaagaagg atgagattag cgtggacagt ttggacttca ataagaagat
     1381 ccttcacaca gcctggcacc ccatggagag cattattgct gtagctgcca ccaataactt
     1441 gtatatattc caggacaaaa ttaattaagg aactgactgg aggaccaagt gttgtcttgc
     1501 atacatacat aagccggtcg ttttcctgtc caaaaaaggc attgtcctct ccattgagaa
     1561 tagtgacgca cttctacttc cctcatagac acaggagaag aaggggtctc agctggagcc
     1621 ttgggagaga tgagtgctgc tgctgaaggg aaaacctact tgaagctgaa ttggtggact
     1681 ctgctcaata aaggccatta ctcaaatgta aaaaaaaaaa aaaaaaaaaa aaaa
//
