LOCUS       NM_057116               4089 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus protein phosphatase 2, regulatory subunit B,
            gamma (Ppp2r2c), transcript variant 1, mRNA.
ACCESSION   NM_057116
VERSION     NM_057116.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4089)
  AUTHORS   Xiao,G., Lian,G., Wang,T., Chen,W., Zhuang,W., Luo,L., Wang,H. and
            Xie,L.
  TITLE     Zinc-mediated activation of CREB pathway in proliferation of
            pulmonary artery smooth muscle cells in pulmonary hypertension
  JOURNAL   Cell Commun Signal 19 (1), 103 (2021)
   PUBMED   34635097
  REMARK    GeneRIF: Zinc-mediated activation of CREB pathway in proliferation
            of pulmonary artery smooth muscle cells in pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4089)
  AUTHORS   Yan,L., Nairn,A.C., Palfrey,H.C. and Brady,M.J.
  TITLE     Glucose regulates EF-2 phosphorylation and protein translation by a
            protein phosphatase-2A-dependent mechanism in INS-1-derived 832/13
            cells
  JOURNAL   J Biol Chem 278 (20), 18177-18183 (2003)
   PUBMED   12644453
  REMARK    GeneRIF: PP2A has a role in glucose-regulated EF-2 phosphorylation
            and protein translation in rat cells
REFERENCE   3  (bases 1 to 4089)
  AUTHORS   Strack,S.
  TITLE     Overexpression of the protein phosphatase 2A regulatory subunit
            Bgamma promotes neuronal differentiation by activating the MAP
            kinase (MAPK) cascade
  JOURNAL   J Biol Chem 277 (44), 41525-41532 (2002)
   PUBMED   12191994
  REMARK    GeneRIF: PP2A/Bgamma is a positive regulator of MAP kinase
            signaling in neurons.
REFERENCE   4  (bases 1 to 4089)
  AUTHORS   Akiyama,N., Shima,H., Hatano,Y., Osawa,Y., Sugimura,T. and Nagao,M.
  TITLE     cDNA cloning of BR gamma, a novel brain-specific isoform of the B
            regulatory subunit of type-2A protein phosphatase
  JOURNAL   Eur J Biochem 230 (2), 766-772 (1995)
   PUBMED   7607250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Sep 30, 2022 this sequence version replaced NM_057116.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2298308.1,
                                           SRR22582419.1070249.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               JAXUCZ010000014.1  78155832-78156212   c
            382-479             JAXUCZ010000014.1  78100636-78100733   c
            480-645             JAXUCZ010000014.1  78097070-78097235   c
            646-758             JAXUCZ010000014.1  78095735-78095847   c
            759-936             JAXUCZ010000014.1  78092218-78092395   c
            937-1101            JAXUCZ010000014.1  78085867-78086031   c
            1102-1271           JAXUCZ010000014.1  78079561-78079730   c
            1272-1363           JAXUCZ010000014.1  78077238-78077329   c
            1364-4089           JAXUCZ010000014.1  78071274-78073999   c
FEATURES             Location/Qualifiers
     source          1..4089
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4089
                     /gene="Ppp2r2c"
                     /gene_synonym="Pr52"
                     /note="protein phosphatase 2, regulatory subunit B, gamma"
                     /db_xref="GeneID:117256"
                     /db_xref="RGD:620920"
     exon            1..381
                     /gene="Ppp2r2c"
                     /gene_synonym="Pr52"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1655
                     /gene="Ppp2r2c"
                     /gene_synonym="Pr52"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 55 kDa
                     regulatory subunit B gamma isoform isoform 1"
                     /protein_id="NP_476457.1"
                     /db_xref="GeneID:117256"
                     /db_xref="RGD:620920"
                     /translation="MGEDTDTRKINHSFLRDHSYVTEADVISTVEFNHTGELLATGDK
                     GGRVVIFQREPESKNAPHSQGEYDVYSTFQSHEPEFDYLKSLEIEEKINKIKWLPQQN
                     AAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMV
                     EVSPRRIFANGHTYHINSISVNSDCETYMSADDLRINLWHLAITDRSFNIVDIKPANM
                     EDLTEVITASEFHPHHCNLFVYSSSKGSLRLCDMRAAALCDKHSKLFEEPEDPSNRSF
                     FSEIISSVSDVKFSHSGRYMLTRDYLTVKVWDLNMEARPIETYQVHDYLRSKLCSLYE
                     SDCIFDKFECAWNGSDSVIMTGAYNNFFRMFDRNTKRDVTLEASRESSKPRAVLKPRR
                     VCVGGKRRRDDISVDSLDFTKKILHTAWHPAENIIAIAATNNLYIFQDKVNSDMH"
     exon            382..479
                     /gene="Ppp2r2c"
                     /gene_synonym="Pr52"
                     /inference="alignment:Splign:2.1.0"
     exon            480..645
                     /gene="Ppp2r2c"
                     /gene_synonym="Pr52"
                     /inference="alignment:Splign:2.1.0"
     exon            646..758
                     /gene="Ppp2r2c"
                     /gene_synonym="Pr52"
                     /inference="alignment:Splign:2.1.0"
     exon            759..936
                     /gene="Ppp2r2c"
                     /gene_synonym="Pr52"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1101
                     /gene="Ppp2r2c"
                     /gene_synonym="Pr52"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1271
                     /gene="Ppp2r2c"
                     /gene_synonym="Pr52"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1363
                     /gene="Ppp2r2c"
                     /gene_synonym="Pr52"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..4089
                     /gene="Ppp2r2c"
                     /gene_synonym="Pr52"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcgcgcg tcccctcgcc gccgccaccg ccaggcgccc ggacgcagcg cgaacggagc
       61 ggccgggatg tgcgcccggg ccccggcccg ccccacgctg cggccgccgc ctgcccgccg
      121 cacgctcgcc tgagcgcggc gcccacccgc cggtccccga ccacctgacc gcgatgcccg
      181 ccctcccggg ccccggcggc ccgagaccct gctaggctgc ggcggcatgg cccgcgcgcc
      241 cggcgcgacc tctgcggatt gcatcggtgt gcggcggcgg ggcatgccca gggcaccggg
      301 cgcggccttc aatgggcgag gacacggaca cgcggaaaat taaccacagc ttcctgcggg
      361 accacagcta tgtgacagaa gctgacgtca tctccactgt cgagttcaac cacactgggg
      421 aactgctggc cacaggtgac aagggtggcc gggtggttat cttccagcgg gaaccagaga
      481 gtaagaacgc acctcacagc cagggtgagt acgatgtgta cagcaccttc cagagccacg
      541 agcctgagtt tgactacctg aaaagcctgg agatagagga gaaaatcaac aagatcaaat
      601 ggctcccgca gcagaacgcc gcccactcgc tgctgtccac caatgataaa actattaaat
      661 tatggaagat taccgagcga gacaagaggc ccgagggcta caacctgaag gatgaggagg
      721 ggaagctgaa agacctgtcc acagtgacgt cactgcaggt gcctgtgctg aagcccatgg
      781 acttaatggt ggaagtgagc ccgagaagga tctttgccaa tggccacacc taccacatca
      841 actccatctc cgtcaacagc gactgcgaga cgtacatgtc agcggacgac ctgcgcatta
      901 acctctggca tctggccatc actgatcgga gcttcaacat cgtagacatc aagccagcca
      961 acatggagga cctcacggag gtgatcacag catctgagtt ccatccgcac cactgcaacc
     1021 tcttcgtcta cagcagcagc aagggctccc tgcggctctg tgacatgcgg gcagctgccc
     1081 tgtgcgacaa gcactccaag ctctttgaag agcccgagga ccccagcaac cgctccttct
     1141 tctcagagat catctcctcg gtgtccgacg tgaagttcag ccacagtggg cgctacatgc
     1201 tcacgaggga ttacctcact gtcaaggtct gggacctgaa catggaggcg aggcccatag
     1261 agacctacca ggtccatgac tacctgcgga gtaagctctg ctccctgtat gagagtgact
     1321 gcatcttcga caagtttgag tgtgcctgga atgggagtga cagtgtcatc atgacagggg
     1381 cctacaacaa cttcttccga atgtttgacc gcaacaccaa gcgggatgtg acgctggagg
     1441 cctcgaggga gagcagcaaa cccagagcgg tgctcaagcc aaggcgcgtg tgtgtgggtg
     1501 gcaagcggcg gcgtgatgac atcagtgtgg acagcttgga cttcaccaag aagatcctgc
     1561 acacggcctg gcacccagcg gagaacatca ttgccattgc agccaccaac aacctgtaca
     1621 tcttccagga taaggtcaat tctgacatgc actagctggc ctcagtggcc ctcccggcca
     1681 cctctgtaag aggacagggt gagcgtggtg gccattgtgg ggacatgagt ccctaggctg
     1741 gagtcggctt ggatggcgat tgccagttta aacaaaggaa aggaaggagc ctcagttaca
     1801 ggtggataaa atgggtgtgc ctggtgggtc tctgcccggg gctcctttgt ttacggccct
     1861 cctgtctcgg gctgggcctt ttattattat caggacttta ttcatgtccg gggtgggttc
     1921 ctatcagaga aagtcaagct ggtccatgat ggggctccag agagtgaagt tcacaagccg
     1981 gtcgggatct gcagatcctc acaggagcca gccatgggcc ctggctcaga tgctgcttca
     2041 tgttggatgt cggacagagc attctcactg agggttggtg atggcagctt gccccttggg
     2101 tgtttgggat gcctttctat attctaggtg ccaggccagg gcaggttctg agaagcagag
     2161 ccaaggtggt agggctaatc gtgaggcagg gctgggttcc ttgtgtgggt tttccaggct
     2221 gaggcaagtc ctaagaagca ggactgggga ccctgtgtgg ctgcagccct cacctcactg
     2281 ccgtccgttt gtgagtgccc actgcacgct gggcatggtg ctcagcccat ggtggctgtg
     2341 gctggatccc cgcagcccac tttgtggtgg cttcgctgtc acctttccat gctagccagt
     2401 cagtcgtctt cccgtggccg acagtgggtc ctgtccctga ctgtagaatc ctcacgccca
     2461 tcagacatgt gtccactcat ttctgtaact ctcagctgag atccaggctc tgctggagct
     2521 ggggtgtagt caccatcccc tctgtaccca ggagggaacc gaggctccga gcagagaggt
     2581 agggtgccca ggagtcccac cctgaggact gagttggtgt cccacgcagg tctttccata
     2641 ggctctttcc aacccaccac attggtgact agttttcaag catcattcca agggaaggcc
     2701 taagaaggga agcatcttca tgtcgtgcac tcagtgcagg tgcgctggtg acaagatgac
     2761 acgagagagg agaagagtgg cgtccgggct tgcctcccaa gatgcacttc acctacattg
     2821 tatctgcagc tttctcccca cccttccggc tgctccccaa ggaggttgca tgcagccagg
     2881 cagccccaga ggatgttttc tcagacctcc tgagggccac aggtgagtgg ccgtgtatag
     2941 tgacgcccac cccatcctca ctactgcaat cccagaactg cagggcttgg cattttgact
     3001 ctggaagcag agagcagagg ggctttggtt tttacaacac ggactgccac ccgggaaaca
     3061 gatgtgacag agcttttctt ctttctcagt ggatcaaggt atccttgtgt gtgtcaaagc
     3121 acaaaccgca tgcacactca cttccggccc acagaaactg ggtccgttac atttttttgc
     3181 cttttttttt tttttaagag tcaacgtgaa tgaagaatgt ttatcactgt aaaattcagg
     3241 cgctctggac agtattatat gtacatattg accctgattc aagttagcaa ctgaaagatc
     3301 ggcgactttc ccctcttgta aagaagttga agaatgtggc cagttgtata taaatcccat
     3361 tgaagcccaa atcctggtga gagggcctta cacactggcc ttggatctct ggcacaacct
     3421 ttgcagtttg gtgttagaga agatactcac cttgggagct ggaggctgct atgaggtcat
     3481 aggtttcaca cataatgtct tcaaagtcaa atcttacatg gtcttcaaaa ggagaggggt
     3541 cttgcacatg gccctagttt ccagacttct gttttaatgt cgggtaccaa aggtagaaag
     3601 gaaaaagaga gacagaaaaa gaacccaaaa gaaaaagtat gtctttggga cccgaagaaa
     3661 tcacccaggt tcagagcgga ctgctaatac taatgcgtgt tttgatcgag gaaaaaaaaa
     3721 gcgcggaggg gggaggggcg atgtgagaaa tcgcagaagg accagagctt tgcaagccac
     3781 agactttgcc actttgctct gcctaagttc tctggtcttg aatccatggc atttcccata
     3841 accactgcga cattgttggg gttttgagtt gttttcttct gctttggttc ttctccgagg
     3901 gtgaggccct tggagggtaa ttggatatat acgtgctggt aacatagtcg ggcccaatca
     3961 cttggggttc tgtggctcat aggtgcattc ttttttcttc agtgtctcac caattatcca
     4021 actgttgaat aaaattataa atatgttaat accagctttt tccaataaaa taacaaatgt
     4081 tacatctaa
//
