LOCUS       NM_022209               1987 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protein phosphatase 2, regulatory subunit B, beta
            (Ppp2r2b), transcript variant 1, mRNA.
ACCESSION   NM_022209
VERSION     NM_022209.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1987)
  AUTHORS   Crispin,J.C., Apostolidis,S.A., Finnell,M.I. and Tsokos,G.C.
  TITLE     Induction of PP2A Bbeta, a regulator of IL-2 deprivation-induced
            T-cell apoptosis, is deficient in systemic lupus erythematosus
  JOURNAL   Proc Natl Acad Sci U S A 108 (30), 12443-12448 (2011)
   PUBMED   21746932
REFERENCE   2  (bases 1 to 1987)
  AUTHORS   Wang,Y.C., Lee,C.M., Lee,L.C., Tung,L.C., Hsieh-Li,H.M.,
            Lee-Chen,G.J. and Su,M.T.
  TITLE     Mitochondrial dysfunction and oxidative stress contribute to the
            pathogenesis of spinocerebellar ataxia type 12 (SCA12)
  JOURNAL   J Biol Chem 286 (24), 21742-21754 (2011)
   PUBMED   21471219
REFERENCE   3  (bases 1 to 1987)
  AUTHORS   Vazquez,A., Kulkarni,D., Grochola,L.F., Bond,G.L., Barnard,N.,
            Toppmeyer,D., Levine,A.J. and Hirshfield,K.M.
  TITLE     A genetic variant in a PP2A regulatory subunit encoded by the
            PPP2R2B gene associates with altered breast cancer risk and
            recurrence
  JOURNAL   Int J Cancer 128 (10), 2335-2343 (2011)
   PUBMED   20669227
REFERENCE   4  (bases 1 to 1987)
  AUTHORS   Kimura,R., Morihara,T., Kudo,T., Kamino,K. and Takeda,M.
  TITLE     Association between CAG repeat length in the PPP2R2B gene and
            Alzheimer disease in the Japanese population
  JOURNAL   Neurosci Lett 487 (3), 354-357 (2011)
   PUBMED   21029765
REFERENCE   5  (bases 1 to 1987)
  AUTHORS   Brussino,A., Graziano,C., Giobbe,D., Ferrone,M., Dragone,E.,
            Arduino,C., Lodi,R., Tonon,C., Gabellini,A., Rinaldi,R.,
            Miccoli,S., Grosso,E., Bellati,M.C., Orsi,L., Migone,N. and
            Brusco,A.
  TITLE     Spinocerebellar ataxia type 12 identified in two Italian families
            may mimic sporadic ataxia
  JOURNAL   Mov Disord 25 (9), 1269-1273 (2010)
   PUBMED   20629122
REFERENCE   6  (bases 1 to 1987)
  AUTHORS   Dagda,R.K., Barwacz,C.A., Cribbs,J.T. and Strack,S.
  TITLE     Unfolding-resistant translocase targeting: a novel mechanism for
            outer mitochondrial membrane localization exemplified by the Bbeta2
            regulatory subunit of protein phosphatase 2A
  JOURNAL   J Biol Chem 280 (29), 27375-27382 (2005)
   PUBMED   15923182
REFERENCE   7  (bases 1 to 1987)
  AUTHORS   Dagda,R.K., Zaucha,J.A., Wadzinski,B.E. and Strack,S.
  TITLE     A developmentally regulated, neuron-specific splice variant of the
            variable subunit Bbeta targets protein phosphatase 2A to
            mitochondria and modulates apoptosis
  JOURNAL   J Biol Chem 278 (27), 24976-24985 (2003)
   PUBMED   12716901
REFERENCE   8  (bases 1 to 1987)
  AUTHORS   Strack,S., Zaucha,J.A., Ebner,F.F., Colbran,R.J. and Wadzinski,B.E.
  TITLE     Brain protein phosphatase 2A: developmental regulation and distinct
            cellular and subcellular localization by B subunits
  JOURNAL   J Comp Neurol 392 (4), 515-527 (1998)
   PUBMED   9514514
REFERENCE   9  (bases 1 to 1987)
  AUTHORS   Akiyama,N., Shima,H., Hatano,Y., Osawa,Y., Sugimura,T. and Nagao,M.
  TITLE     cDNA cloning of BR gamma, a novel brain-specific isoform of the B
            regulatory subunit of type-2A protein phosphatase
  JOURNAL   Eur J Biochem 230 (2), 766-772 (1995)
   PUBMED   7607250
REFERENCE   10 (bases 1 to 1987)
  AUTHORS   Hatano,Y., Shima,H., Haneji,T., Miura,A.B., Sugimura,T. and
            Nagao,M.
  TITLE     Expression of PP2A B regulatory subunit beta isotype in rat testis
  JOURNAL   FEBS Lett 324 (1), 71-75 (1993)
   PUBMED   8389301
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 11, 2022 this sequence version replaced NM_022209.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY251277.1, SRR26643298.73900.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               JAXUCZ010000018.1  35331341-35331615   c
            276-373             JAXUCZ010000018.1  35014486-35014583   c
            374-539             JAXUCZ010000018.1  35011465-35011630   c
            540-652             JAXUCZ010000018.1  35004678-35004790   c
            653-830             JAXUCZ010000018.1  34966451-34966628   c
            831-995             JAXUCZ010000018.1  34952810-34952974   c
            996-1165            JAXUCZ010000018.1  34926637-34926806   c
            1166-1257           JAXUCZ010000018.1  34907826-34907917   c
            1258-1987           JAXUCZ010000018.1  34904686-34905415   c
FEATURES             Location/Qualifiers
     source          1..1987
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..1987
                     /gene="Ppp2r2b"
                     /gene_synonym="Pppr2b2"
                     /note="protein phosphatase 2, regulatory subunit B, beta"
                     /db_xref="GeneID:60660"
                     /db_xref="RGD:631441"
     exon            1..275
                     /gene="Ppp2r2b"
                     /gene_synonym="Pppr2b2"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1537
                     /gene="Ppp2r2b"
                     /gene_synonym="Pppr2b2"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BRbeta B-regulatory subunit of protein phosphatase 2A"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 55 kDa
                     regulatory subunit B beta isoform isoform 1"
                     /protein_id="NP_071545.2"
                     /db_xref="GeneID:60660"
                     /db_xref="RGD:631441"
                     /translation="MKCFSRYLPYIFRPPNTILSSSCHTEADIISTVEFNHTGELLAT
                     GDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLP
                     QQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMD
                     LMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKP
                     ANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSN
                     RSFFSEIISSISDVKFSHSGRYIMTRDYLTAKVWDLNMENRPVETYQVHDYLRSKLCS
                     LYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILK
                     PRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN"
     exon            276..373
                     /gene="Ppp2r2b"
                     /gene_synonym="Pppr2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..539
                     /gene="Ppp2r2b"
                     /gene_synonym="Pppr2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..652
                     /gene="Ppp2r2b"
                     /gene_synonym="Pppr2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..830
                     /gene="Ppp2r2b"
                     /gene_synonym="Pppr2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..995
                     /gene="Ppp2r2b"
                     /gene_synonym="Pppr2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1165
                     /gene="Ppp2r2b"
                     /gene_synonym="Pppr2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1257
                     /gene="Ppp2r2b"
                     /gene_synonym="Pppr2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1987
                     /gene="Ppp2r2b"
                     /gene_synonym="Pppr2b2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtaaggcat tgcttcctag cgctgatggc aaaatgggac ccatctccag ttattccttg
       61 ggcttcccag ctctgcagat ctgggagaga acctacataa acatattggt gatgtagcca
      121 gctttcaagg ctgagagaat ccttatggat tcgggagact ggtttttcat ttagaatttt
      181 ctttttcctt tggaagatga aatgcttctc tcgttacctg ccttatatct tcagacctcc
      241 aaataccatc ctctcttcca gctgccacac tgaagctgac attatctcta cggtagaatt
      301 caaccacact ggagagttac tagcgacggg ggacaagggg ggtagggttg taatatttca
      361 gcgagaacag gagagtaaaa atcaggttca tcgtaggggt gaatacaatg tttacagcac
      421 attccagagc catgaacccg agttcgatta cctgaaaagt ttagaaatag aagaaaaaat
      481 caataaaata agatggctcc ctcaacaaaa tgcagcttac tttcttctgt ctaccaacga
      541 taaaactgtg aagctatgga aagttagtga gcgtgataag aggccagaag gctacaacct
      601 gaaagatgag gagggccggc tccgggatcc tgccaccatc acaaccctgc gggtgcctgt
      661 cctgagaccc atggacttga tggtggaggc caccccacga agagtgtttg ccaatgcgca
      721 cacataccac atcaactcca tatctgtcaa cagcgactat gagacctaca tgtctgctga
      781 tgacctgagg attaacctgt ggaactttga gataaccaat cagagtttta atatcgtgga
      841 catcaagcca gccaacatgg aggagctcac agaagtgatc acagcagccg agttccaccc
      901 ccaccactgc aacacctttg tatacagcag cagcaagggg acaatccggc tgtgtgacat
      961 gcgggcatct gcgctgtgtg acaggcacac caagtttttt gaagagccag aagatccaag
     1021 caatagatcg tttttctctg aaattatctc ttcaatttcg gatgtgaagt tcagccacag
     1081 tgggaggtat atcatgacca gagactatct gaccgcgaaa gtctgggatc tcaacatgga
     1141 aaatcgcccc gtagagacat accaggttca tgactacctc cgtagcaagt tgtgctccct
     1201 ctacgaaaat gactgcattt ttgataaatt cgagtgtgtg tggaatgggt cagacagcgt
     1261 catcatgacg ggctcctaca ataacttctt caggatgttc gaccgaaaca ccaagcgtga
     1321 tgtgaccctt gaggcctcaa gggaaaacag caaaccccgg gctatcctca aaccccgaaa
     1381 agtgtgcgtc gggggcaagc gaagaaaaga tgagatcagt gttgacagtc tggactttag
     1441 caaaaagatc ttgcatacag cttggcatcc ttcagaaaat attatagcag tggcggctac
     1501 aaataactta tatatattcc aggacaaggt taattaggag gacaagttac tacttagtct
     1561 cacatactga atactagtca aacaagtttt taaatgtttc tttgggtctt cattttgatg
     1621 cattgacttt catttccctc tgcataaaac aattggaata gaacttaaaa ggagttcaat
     1681 gttctcaact ccccaattct aagaaacgtc tgtcaaactc ggtaggcttg ggacacttct
     1741 gtttagagtt gagagctgcc aacggcagta actcttccac agtccactga atgtctgatg
     1801 cgttcgttca ttgcccagtt ctctctggtg ggttctgtgt tttgtttcta ggtgtctgct
     1861 gcgataaaat gagattgtct gtagtattta aggagaaaaa gagataaggt ttttttttta
     1921 attaagcaat tccatttgtt tgaaaaaaat caacaacaaa aaaataaaca ctgtttactc
     1981 ttaagaa
//
