LOCUS       NM_053999               2374 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus protein phosphatase 2, regulatory subunit B,
            alpha (Ppp2r2a), mRNA.
ACCESSION   NM_053999
VERSION     NM_053999.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2374)
  AUTHORS   Lubelwana Hafver,T., Wanichawan,P., Manfra,O., de Souza,G.A.,
            Lunde,M., Martinsen,M., Louch,W.E., Sejersted,O.M. and Carlson,C.R.
  TITLE     Mapping the in vitro interactome of cardiac sodium (Na+)-calcium
            (Ca2+) exchanger 1 (NCX1)
  JOURNAL   Proteomics 17 (17-18) (2017)
   PUBMED   28755400
REFERENCE   2  (bases 1 to 2374)
  AUTHORS   Weeks,K.L., Ranieri,A., Karas,A., Bernardo,B.C., Ashcroft,A.S.,
            Molenaar,C., McMullen,J.R. and Avkiran,M.
  TITLE     beta-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5)
            Nuclear Accumulation in Cardiomyocytes by B55alpha-PP2A-Mediated
            Dephosphorylation
  JOURNAL   J Am Heart Assoc 6 (4), e004861 (2017)
   PUBMED   28343149
  REMARK    GeneRIF: beta-AR stimulation induces HDAC5 nuclear accumulation in
            cardiomyocytes by a mechanism that is protein kinase A-dependent
            but requires B55alpha-PP2A-mediated dephosphorylation of
            Ser259/Ser498.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2374)
  AUTHORS   Biesemann,C., Gronborg,M., Luquet,E., Wichert,S.P., Bernard,V.,
            Bungers,S.R., Cooper,B., Varoqueaux,F., Li,L., Byrne,J.A.,
            Urlaub,H., Jahn,O., Brose,N. and Herzog,E.
  TITLE     Proteomic screening of glutamatergic mouse brain synaptosomes
            isolated by fluorescence activated sorting
  JOURNAL   EMBO J 33 (2), 157-170 (2014)
   PUBMED   24413018
REFERENCE   4  (bases 1 to 2374)
  AUTHORS   Gerner,L., Youssef,G. and O'Shaughnessy,R.F.
  TITLE     The protein phosphatase 2A regulatory subunit Ppp2r2a is required
            for Connexin-43 dephosphorlyation during epidermal barrier
            acquisition
  JOURNAL   Exp Dermatol 22 (11), 754-756 (2013)
   PUBMED   24433183
  REMARK    GeneRIF: Ppp2r2a is required for Connexin-43 dephosphorlyation
            during epidermal barrier acquisition
REFERENCE   5  (bases 1 to 2374)
  AUTHORS   Kurimchak,A., Haines,D.S., Garriga,J., Wu,S., De Luca,F.,
            Sweredoski,M.J., Deshaies,R.J., Hess,S. and Grana,X.
  TITLE     Activation of p107 by fibroblast growth factor, which is essential
            for chondrocyte cell cycle exit, is mediated by the protein
            phosphatase 2A/B55alpha holoenzyme
  JOURNAL   Mol Cell Biol 33 (16), 3330-3342 (2013)
   PUBMED   23775125
  REMARK    GeneRIF: Fibroblast growth factor 1, which induces maturation and
            cell cycle exit in chondrocytes, triggers rapid accumulation of
            retinoblastoma-like 1 (p107)-PP2A/B55-alpha complexes coinciding
            with retinoblastoma-like 1 (p107) dephosphorylation.
REFERENCE   6  (bases 1 to 2374)
  AUTHORS   Goedert,M., Satumtira,S., Jakes,R., Smith,M.J., Kamibayashi,C.,
            White,C.L. 3rd and Sontag,E.
  TITLE     Reduced binding of protein phosphatase 2A to tau protein with
            frontotemporal dementia and parkinsonism linked to chromosome 17
            mutations
  JOURNAL   J Neurochem 75 (5), 2155-2162 (2000)
   PUBMED   11032905
REFERENCE   7  (bases 1 to 2374)
  AUTHORS   Hatano,Y., Shima,H., Haneji,T., Miura,A.B., Sugimura,T. and
            Nagao,M.
  TITLE     Expression of PP2A B regulatory subunit beta isotype in rat testis
  JOURNAL   FEBS Lett 324 (1), 71-75 (1993)
   PUBMED   8389301
REFERENCE   8  (bases 1 to 2374)
  AUTHORS   Wickerts,C.J., Berg,B., Frostell,C., Schmidt,J., Blomqvist,H.,
            Rosblad,P.G., Kihlstrom,I., Messmer,K. and Hedenstierna,G.
  TITLE     Influence of hypertonic-hyperoncotic solution and furosemide on
            canine hydrostatic pulmonary oedema resorption
  JOURNAL   J Physiol 458, 425-438 (1992)
   PUBMED   1302272
REFERENCE   9  (bases 1 to 2374)
  AUTHORS   Pallas,D.C., Weller,W., Jaspers,S., Miller,T.B., Lane,W.S. and
            Roberts,T.M.
  TITLE     The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton
            protein which is apparently substituted for by T antigens in
            complexes with the 36- and 63-kilodalton PP2A subunits, bears
            little resemblance to T antigens
  JOURNAL   J Virol 66 (2), 886-893 (1992)
   PUBMED   1370560
REFERENCE   10 (bases 1 to 2374)
  AUTHORS   Mayer,R.E., Hendrix,P., Cron,P., Matthies,R., Stone,S.R., Goris,J.,
            Merlevede,W., Hofsteenge,J. and Hemmings,B.A.
  TITLE     Structure of the 55-kDa regulatory subunit of protein phosphatase
            2A: evidence for a neuronal-specific isoform
  JOURNAL   Biochemistry 30 (15), 3589-3597 (1991)
   PUBMED   1849734
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC128731.1.
            
            On Dec 10, 2006 this sequence version replaced NM_053999.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128731.1, M83298.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2374
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..2374
                     /gene="Ppp2r2a"
                     /gene_synonym="B55"
                     /note="protein phosphatase 2, regulatory subunit B, alpha"
                     /db_xref="GeneID:117104"
                     /db_xref="RGD:620919"
     exon            1..310
                     /gene="Ppp2r2a"
                     /gene_synonym="B55"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..1647
                     /gene="Ppp2r2a"
                     /gene_synonym="B55"
                     /EC_number="3.1.3.16"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 55 kDa
                     regulatory subunit B alpha isoform"
                     /protein_id="NP_446451.1"
                     /db_xref="GeneID:117104"
                     /db_xref="RGD:620919"
                     /translation="MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLA
                     TGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWL
                     PQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPM
                     DLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIK
                     PANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPS
                     NRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVWDLNMENRPVETYQVHEYLRSKLC
                     SLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVL
                     KPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN"
     exon            311..385
                     /gene="Ppp2r2a"
                     /gene_synonym="B55"
                     /inference="alignment:Splign:2.1.0"
     exon            386..483
                     /gene="Ppp2r2a"
                     /gene_synonym="B55"
                     /inference="alignment:Splign:2.1.0"
     exon            484..649
                     /gene="Ppp2r2a"
                     /gene_synonym="B55"
                     /inference="alignment:Splign:2.1.0"
     exon            650..762
                     /gene="Ppp2r2a"
                     /gene_synonym="B55"
                     /inference="alignment:Splign:2.1.0"
     exon            763..940
                     /gene="Ppp2r2a"
                     /gene_synonym="B55"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1105
                     /gene="Ppp2r2a"
                     /gene_synonym="B55"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1275
                     /gene="Ppp2r2a"
                     /gene_synonym="B55"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1367
                     /gene="Ppp2r2a"
                     /gene_synonym="B55"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..2350
                     /gene="Ppp2r2a"
                     /gene_synonym="B55"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcctgcc cctgccgccg gggccgccgt cgctgtccta gccgccgccg ctgccgccgc
       61 cgccgctgcc gtcttcaccg cgggagaagg agcacgagac aggacgcccc tgagtgaacg
      121 ccaccatcct gccgacagct ccgcccgggc tgcttccttt ccgcccaggt ccccgtcccc
      181 tcccccctca ggtgccatcc gcctccatcc gcgccctcga tccccccatc cccaggtgag
      241 ggggctgagc cccggtcgcg gaggcccgga cgagcccggc agggtcacca tttgcagcgc
      301 gacatggcag gagctggagg agggaatgat attcaatggt gtttttctca ggtgaaagga
      361 gcagttgatg atgacgtagc agaagcagat ataatttcta cagtagagtt taatcattct
      421 ggagaattac tagccacagg agataaaggt gggagagtcg tcatctttca acaagagcag
      481 gagaacaaaa tccagtctca tagcagagga gaatacaatg tttacagcac cttccagagc
      541 catgagccag aatttgacta cttgaaaagc ttagaaatag aagagaagat caacaaaatt
      601 aggtggttac cccagaaaaa tgctgcccag tttttattgt ctaccaatga taaaacaata
      661 aaattatgga aaatcagtga aagagacaaa agaccagaag gctataactt gaaagaggaa
      721 gatggaaggt atagagaccc tactacagtc actacactac gagtgccggt gtttaggccc
      781 atggatctaa tggtggaggc cagtccgcgg agaatatttg ccaacgccca tacctaccac
      841 atcaactcca tttctatcaa tagtgattat gaaacctact tatcagcaga tgatttgcga
      901 attaatctct ggcatctgga aattacagac aggagtttta atattgtgga cattaagcct
      961 gccaatatgg aggagctcac ggaggtgatc acagccgcag agttccatcc caacagctgt
     1021 aacacgtttg tgtacagcag cagtaaaggg accattcgct tatgtgacat gagggcatct
     1081 gcactctgtg acaggcattc taaactgttt gaagaacccg aagatcccag caacaggtcg
     1141 tttttttctg aaatcatctc ctcaatttct gatgtaaaat tcagccacag tggtcgctat
     1201 atgatgacta gagactattt gtcagtcaaa gtttgggact tgaatatgga aaacaggccc
     1261 gtggagacat accaggtaca cgaatacctc agaagtaaac tttgctcact gtatgaaaac
     1321 gactgcatat ttgacaaatt tgaatgttgt tggaatgggt ctgacagtgt tgtcatgact
     1381 ggatcctaca ataatttctt cagaatgttc gacaggaaca caaagcggga tataactcta
     1441 gaagcatcgc gagaaaacaa taagcctcgt acagttttga aaccacgcaa agtctgtgca
     1501 agtggcaagc gaaagaaaga tgaaataagt gttgacagtc tagacttcaa caagaaaatc
     1561 cttcatacag cctggcatcc caaggaaaac atcattgctg tagcgactac aaacaatctg
     1621 tatatatttc aagacaaagt gaattaggct ggcattctct gcagaggagc cacttcctgc
     1681 ttagtgagat agttgaatct agcattcgta cctataagag agcggtccat tgtggcgtcc
     1741 ctttccagtg tttgacagtg tgccattcaa caacacattt gatagccaca tggagaaagc
     1801 tgtgcggatg catcccgggc tgtttccatg tctgctagcc atttagggaa gggaagggca
     1861 cttttaattt aatgacttct tgcaccatct tgcctggtgg actggactgg actgtgtcag
     1921 cattgatgta ctccactttt tatgccttcc attgtgatga cgtcaaacac agtgaacgcc
     1981 ttcagtcatg ctatggaatt tgtgtatcct cattactgta tcatttgtgg ggtacatccc
     2041 tcccctcttt tttaaattaa atacagctca ttcttactgt ggcttgtagc attcctcctc
     2101 tctggcctcc tggactctcc cctccatctc ttatccttgc cctttccacc ttgtctccgt
     2161 ggtggcgtat taaaaaggaa gaacgaaagc acacaaaatg agtcagtttg gggtcagtgg
     2221 taatggggga ctatgttacg aacaaatgtt ttaataacag ttggctgtaa tcactccttg
     2281 ccatgtctgg cactgaaaat aaggaaaaaa aaaaaactac tactgaataa aagtgacaaa
     2341 gaatggagaa aaaaaaaaaa aaaaaaaaaa aaaa
//
