LOCUS       NM_001025418            3207 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus protein phosphatase 2 scaffold subunit A beta
            (Ppp2r1b), mRNA.
ACCESSION   NM_001025418 XM_236227
VERSION     NM_001025418.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3207)
  AUTHORS   Biesemann,C., Gronborg,M., Luquet,E., Wichert,S.P., Bernard,V.,
            Bungers,S.R., Cooper,B., Varoqueaux,F., Li,L., Byrne,J.A.,
            Urlaub,H., Jahn,O., Brose,N. and Herzog,E.
  TITLE     Proteomic screening of glutamatergic mouse brain synaptosomes
            isolated by fluorescence activated sorting
  JOURNAL   EMBO J 33 (2), 157-170 (2014)
   PUBMED   24413018
REFERENCE   2  (bases 1 to 3207)
  AUTHORS   Seshacharyulu,P., Pandey,P., Datta,K. and Batra,S.K.
  TITLE     Phosphatase: PP2A structural importance, regulation and its
            aberrant expression in cancer
  JOURNAL   Cancer Lett 335 (1), 9-18 (2013)
   PUBMED   23454242
  REMARK    Review article
REFERENCE   3  (bases 1 to 3207)
  AUTHORS   Guenebeaud,C., Goldschneider,D., Castets,M., Guix,C., Chazot,G.,
            Delloye-Bourgeois,C., Eisenberg-Lerner,A., Shohat,G., Zhang,M.,
            Laudet,V., Kimchi,A., Bernet,A. and Mehlen,P.
  TITLE     The dependence receptor UNC5H2/B triggers apoptosis via
            PP2A-mediated dephosphorylation of DAP kinase
  JOURNAL   Mol Cell 40 (6), 863-876 (2010)
   PUBMED   21172653
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098007.1.
            
            On Jul 15, 2005 this sequence version replaced XM_236227.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098007.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3207
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..3207
                     /gene="Ppp2r1b"
                     /note="protein phosphatase 2 scaffold subunit A beta"
                     /db_xref="GeneID:315648"
                     /db_xref="RGD:1304764"
     exon            1..116
                     /gene="Ppp2r1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..1808
                     /gene="Ppp2r1b"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase 2, regulatory subunit A, beta"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A beta isoform"
                     /protein_id="NP_001020589.1"
                     /db_xref="GeneID:315648"
                     /db_xref="RGD:1304764"
                     /translation="MAGAAGPGTVPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSI
                     KKLSTIALALGVERTRTELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLL
                     PPLESLATVEETVVRDKAVESLRQISQEHTPVALEAHFVPLVKRLASGDWFTSRTSAC
                     GLFSVCYPRASNAVKAEIRQHFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKTEIV
                     PLFTNLASDEQDSVRLLAVEACVSIAQLLSQDDLEALVMPTLRQAAEDKSWRVRYMVA
                     DKFSELQKAVGPKIALSDLIPAFQSLLRDCEAEVRAAAAHKVRELCENLPTEGRETVI
                     MNQILPYIKELVSDTNQHVKSALASVIMGLSTVLGKENTIEHLLPLFLAQLKDECPEV
                     RLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEF
                     FDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYL
                     HRMTTLFCINALSEACGKEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTN
                     ALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLALA"
     exon            117..207
                     /gene="Ppp2r1b"
                     /inference="alignment:Splign:2.1.0"
     exon            208..308
                     /gene="Ppp2r1b"
                     /inference="alignment:Splign:2.1.0"
     exon            309..541
                     /gene="Ppp2r1b"
                     /inference="alignment:Splign:2.1.0"
     exon            542..689
                     /gene="Ppp2r1b"
                     /inference="alignment:Splign:2.1.0"
     exon            690..845
                     /gene="Ppp2r1b"
                     /inference="alignment:Splign:2.1.0"
     exon            846..960
                     /gene="Ppp2r1b"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1031
                     /gene="Ppp2r1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1166
                     /gene="Ppp2r1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1340
                     /gene="Ppp2r1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1401
                     /gene="Ppp2r1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1556
                     /gene="Ppp2r1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1699
                     /gene="Ppp2r1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1791
                     /gene="Ppp2r1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..3170
                     /gene="Ppp2r1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatggcggg cgcagcaggg ccagggaccg ttccgggggc agcgggcgga gatggagacg
       61 attcactcta cccgatcgcg gttttaatcg acgagctccg caatgaggac gtgcagctcc
      121 gtctcaacag tattaagaag ttatcaacta ttgctctagc actcggggta gaaaggactc
      181 gaactgaact gctgcctttc cttacagata caatttatga tgaagatgag gtgctgttag
      241 ctcttgccga gcagctgggg aatttcactg gtttggtggg aggccctgac tttgcccact
      301 gtctgctgcc tcctttggaa agtttggcta cggtggagga gactgtcgtt cgagacaagg
      361 ctgtggagtc cctgaggcag atctcccagg agcacactcc cgttgccctg gaagctcatt
      421 ttgtacccct ggtgaagcgc ttagcaagtg gggattggtt cacatctcgc acatctgcat
      481 gcggtttgtt cagcgtttgc taccccagag cttcaaatgc tgtcaaggca gagatccgac
      541 agcacttccg ttccctgtgc tcggatgata caccaatggt gcgacgtgct gctgcttcca
      601 aattgggtga atttgcaaaa gttttggaat tagacagtgt taaaactgaa attgttccat
      661 tattcacgaa tctggcttca gatgaacagg attctgtgcg cctgctagct gtagaagcgt
      721 gtgtcagtat tgcccagcta ctgtctcagg atgacctgga agccttggta atgcctacac
      781 ttcggcaagc agcagaagat aaatcttggc gggttcgcta catggtggct gacaaatttt
      841 cagagctcca gaaagcggtg ggccctaaaa ttgcactcag tgacctcatc cccgccttcc
      901 agagcctcct cagagactgc gaggccgaag tccgagcagc cgctgcccac aaagtaagag
      961 agctttgtga gaacctgccc actgaaggca gagagaccgt gattatgaac caaatcctgc
     1021 cctatataaa ggaattagtg tctgatacca accaacatgt caagtcagcc ctagcttctg
     1081 taattatggg attatctaca gttttgggca aagagaatac cattgaacat cttctgcctc
     1141 tatttttagc tcaattaaag gatgagtgtc cagaagttcg tttaaatatc atctccaatt
     1201 tggattgtgt gaatgaagtg attggaatcc gtcagctctc tcagtctctc ctccctgcca
     1261 ttgtggaact ggctgaggac gccaagtgga gggtccgctt ggcgatcatt gagtacatgc
     1321 cgctgctggc tggccagctg ggtgtggagt tttttgatga aaagctgaat tctttgtgta
     1381 tggcctggct tgtggatcat gtctatgcca ttcgggaagc agcaaccaac aacctcatga
     1441 agttagtcca gaagtttggt accgagtggg cccagaacac catcgtcccc aaagtgttgg
     1501 taatggcaaa tgatccgaac tacttgcaca ggatgaccac cttattctgc attaatgccc
     1561 tctctgaagc ctgtggtaag gaaataacca ctaagcaaat gttgcctatc gtgttgaaaa
     1621 tggctggaga ccaggtggca aatgtccgct tcaatgtggc taagtcactg cagaagattg
     1681 gacccattct agacaccaac gccttgcagg gggaagtgaa gccggtgctg cagaaattag
     1741 gtcaggatga agacatggat gtcaaatatt ttgcacagga agctataagt gttcttgcct
     1801 tggcataaag aggaacagga gggaaaagcc tttactaaat tcttatcaca gatctctagt
     1861 caatgtgttc ttaccctggg tggagaaaaa tggaaacctt caagatctca tccaagcaga
     1921 tggcaacaac atagaagaaa tgagatttca gtgacttgac tctttctaaa catgaactca
     1981 gactggtttt acctctctgg tgggaagctg taacgctctc tgctgaccag ttgctgacac
     2041 tccctcgtgc agtcatccct tgggcttctc ccagggtttc tctccagcac cattgaggct
     2101 cctgcctcct cccttttgaa tcaggcccca gccacttacg attccagaca gagcctggat
     2161 ggatttggac cccgacacgg agtgcagtga atctcttact gtttacacgt atctgtgtgg
     2221 ctctccatct tcccaatgtt aagagtaaat ggcttagagt aacttacttt aactatctcc
     2281 ttggagagaa tattgaggtt tgactgtagt gaaagccacg tcctcctggt tacgatggtc
     2341 cgcatcagca tctcacttgg aaggagatgg gaaggctaac gaacggctgc tctggtctcc
     2401 atttgctcag ttggactgta atcatgtcat gcagaagccg gaagtgtctt gctgctaatg
     2461 tgtgatgttg aaacaatgtc aacggctcag cactgcgact gccttcaaaa gctcgtaaga
     2521 aactttagtg cctcccaccg agtcgtggtt ctactgtttc atcgtgaagc gttgtctcag
     2581 ggaagtgcag ggtgcactgg tccgggtttt gcctccagca gggttagtgg gcatcgtgct
     2641 gacgcgacac tgcactgtgc actgaagttt ggttgctcag tgtttccctg tggtgtgggt
     2701 gacgctagaa cattcttctg cttttacagt aaaatttcat taacttgtcc agaaatttaa
     2761 ggtggcaggt caagctgaag ggttttccag agcaaattgt gcttatggaa ggctgccgga
     2821 cactaatttt agggcgtatc tccttatcag tgggatgcct gtgaccagtc cccctgctct
     2881 gggccttcca ggagcagctc tgacacatca caccttttct gaatattttt ctggatagtt
     2941 taaatgtttc catctgactc cctgtcttga gtggacctag ttaatggggt tttactgcag
     3001 ccagttttac tcagtactct actcgtacca cgtagtttgg tgtttgcatt tgggtttccg
     3061 aattgttgat tttacttaca aatcctttta gatataacaa gccctgttct gttttgtgaa
     3121 ggcccaaaga tacctacaaa actttgtaca ttaaacagaa gttacctgaa aaaaaaaaaa
     3181 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
